NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622883211|ref|XP_028692956|]
View 

lambda-crystallin homolog isoform X8 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK06129 super family cl35428
3-hydroxyacyl-CoA dehydrogenase; Validated
 2-262 5.14e-93

3-hydroxyacyl-CoA dehydrogenase; Validated


The actual alignment was detected with superfamily member PRK06129:

Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 278.46  E-value: 5.14e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   2 LFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKK 81
Cdd:PRK06129   20 VFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADADYVQESAPENLELKR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  82 KIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCP 161
Cdd:PRK06129   99 ALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSP 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 162 MRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EGMLSYCDRYsegmkhv 240
Cdd:PRK06129  179 VRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGGVADYAQRY------- 251

                         250       260
                  ....*....|....*....|..
gi 1622883211 241 lktfGPIpeFSRATAEKVNQDP 262
Cdd:PRK06129  252 ----GPM--YRRMAAERGQPVP 267
 
Name Accession Description Interval E-value
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 2-262 5.14e-93

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 278.46  E-value: 5.14e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   2 LFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKK 81
Cdd:PRK06129   20 VFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADADYVQESAPENLELKR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  82 KIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCP 161
Cdd:PRK06129   99 ALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSP 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 162 MRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EGMLSYCDRYsegmkhv 240
Cdd:PRK06129  179 VRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGGVADYAQRY------- 251

                         250       260
                  ....*....|....*....|..
gi 1622883211 241 lktfGPIpeFSRATAEKVNQDP 262
Cdd:PRK06129  252 ----GPM--YRRMAAERGQPVP 267
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 1-221 1.75e-73

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 227.69  E-value: 1.75e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   1 MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIqEAVEGAMHIQECVPEDLELK 80
Cdd:COG1250    19 AVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEE-EADAALARITPTTDL-AALADADLVIEAVPEDLDLK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  81 KKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQC 160
Cdd:COG1250    97 QEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGKT 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622883211 161 PMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 221
Cdd:COG1250   177 PVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP---MGPFELADL 233
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 1-164 1.88e-56

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 180.43  E-value: 1.88e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   1 MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVeGAMHIQECVPEDLELK 80
Cdd:pfam02737  16 QVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEE-EVDAALARISFTTDLAAAV-DADLVIEAVPENLELK 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  81 KKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQC 160
Cdd:pfam02737  94 RKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVATTVELAKKIGKT 173


                  ....
gi 1622883211 161 PMRV 164
Cdd:pfam02737 174 PVVV 177
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 17-199 4.36e-13

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 69.87  E-value: 4.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  17 QQQIRNALENIRKEMKLleqagalkGSLSAEEQLSLISGCPNIQeAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVI 96
Cdd:TIGR02441 375 QQQVFKGLNKKVKRKKI--------TSLERDSILSNLTPTLDYS-GFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCI 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  97 LSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRL 176
Cdd:TIGR02441 446 IASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKDTLASAVAVGLKQGKVVIVV-KDGPGFYTTRC 524

                         170       180
                  ....*....|....*....|...
gi 1622883211 177 QYAIISEAWRLVEEGiVSPSDLD 199
Cdd:TIGR02441 525 LGPMLAEVIRLLQEG-VDPKKLD 546
 
Name Accession Description Interval E-value
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 2-262 5.14e-93

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 278.46  E-value: 5.14e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   2 LFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKK 81
Cdd:PRK06129   20 VFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADADYVQESAPENLELKR 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  82 KIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCP 161
Cdd:PRK06129   99 ALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATLARAEALYRAAGQSP 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 162 MRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EGMLSYCDRYsegmkhv 240
Cdd:PRK06129  179 VRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGGVADYAQRY------- 251

                         250       260
                  ....*....|....*....|..
gi 1622883211 241 lktfGPIpeFSRATAEKVNQDP 262
Cdd:PRK06129  252 ----GPM--YRRMAAERGQPVP 267
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 1-221 1.75e-73

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 227.69  E-value: 1.75e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   1 MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIqEAVEGAMHIQECVPEDLELK 80
Cdd:COG1250    19 AVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEE-EADAALARITPTTDL-AALADADLVIEAVPEDLDLK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  81 KKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQC 160
Cdd:COG1250    97 QEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVATAVAFARRLGKT 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622883211 161 PMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 221
Cdd:COG1250   177 PVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP---MGPFELADL 233
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 1-164 1.88e-56

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 180.43  E-value: 1.88e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   1 MLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVeGAMHIQECVPEDLELK 80
Cdd:pfam02737  16 QVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEE-EVDAALARISFTTDLAAAV-DADLVIEAVPENLELK 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  81 KKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQC 160
Cdd:pfam02737  94 RKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVATTVELAKKIGKT 173


                  ....
gi 1622883211 161 PMRV 164
Cdd:pfam02737 174 PVVV 177
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 2-222 3.62e-56

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 184.21  E-value: 3.62e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   2 LFASGGFQVKLYDIEQqqirNALENIRKemKLLEQAGALKGSLSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKK 81
Cdd:PRK06130   22 LFARKGLQVVLIDVME----GALERARG--VIERALGVYAPLGIASAGMGRIRMEAGLAAAVSGADLVIEAVPEKLELKR 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  82 KIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCP 161
Cdd:PRK06130   96 DVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSPQTVATTMALLRSIGKRP 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622883211 162 MRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLN 222
Cdd:PRK06130  176 VLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLALTGPLEQRDMN 236
PRK07531 PRK07531
carnitine 3-dehydrogenase;
3-258 2.29e-51

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 176.47  E-value: 2.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   3 FASGGFQVKLYDIE---QQQIRNALENIRKEMKLLEQAgalkgSLSAEEQLSLisgCPNIQEAVEGAMHIQECVPEDLEL 79
Cdd:PRK07531   23 FLLAGIDVAVFDPHpeaERIIGEVLANAERAYAMLTDA-----PLPPEGRLTF---CASLAEAVAGADWIQESVPERLDL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  80 KKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQ 159
Cdd:PRK07531   95 KRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLPLVELVGGGKTSPETIRRAKEILREIGM 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 160 CPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLnAEGmlsycdrySEGMKH 239
Cdd:PRK07531  175 KPVHIAKEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRWAQMGLFETYRI-AGG--------EAGMRH 245

                         250       260       270
                  ....*....|....*....|....*....|
gi 1622883211 240 VLKTFGP-----------IPEFSRATAEKV 258
Cdd:PRK07531  246 FLAQFGPclkwpwtklmdVPDLDDALVDKI 275
PRK07066 PRK07066
L-carnitine dehydrogenase;
17-266 8.39e-43

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 149.99  E-value: 8.39e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  17 QQQIRNALENirkEMKLLEQAGALKGSlsAEEQLSLIsgcPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVI 96
Cdd:PRK07066   43 EAALRANVAN---AWPALERQGLAPGA--SPARLRFV---ATIEACVADADFIQESAPEREALKLELHERISRAAKPDAI 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  97 LSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRL 176
Cdd:PRK07066  115 IASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTAPEAVDAAMGIYRALGMRPLHVRKEVPGFIADRL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 177 QYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLnAEGmlsycdrySEGMKHVLKTFGP---------- 246
Cdd:PRK07066  195 LEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTL-AGG--------DAGMRHFMQQFGPalelpwtklv 265

                         250       260
                  ....*....|....*....|....*...
gi 1622883211 247 IPEFSRA--------TAEKVNQDPIQEL 266
Cdd:PRK07066  266 APELTDAlidrvvegTAEQQGPRSIKAL 293
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 3-236 5.54e-37

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 134.41  E-value: 5.54e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   3 FASGGFQVKLYDIEQQQI-------RNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQ--EAVEGAMHIQECV 73
Cdd:PRK08269    9 FAFAGHDVTLIDFKPRDAagwraldAEARAEIERTLAALVALGRIDAA-QADAVLARIAVVARDGaaDALADADLVFEAV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  74 PEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHAL 153
Cdd:PRK08269   88 PEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPAVVDRLAAL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 154 MKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRY 233
Cdd:PRK08269  168 LERIGKVPV-VCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRFAVLGLLEFIDWGGCDILYYASRY 246


                  ...
gi 1622883211 234 SEG 236
Cdd:PRK08269  247 LAG 249
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 3-216 1.18e-33

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 124.69  E-value: 1.18e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   3 FASGGFQVKLYDIEQQQIRNALENIRKEM-KLLEqagalKGSLSAEEQ---LSLISGCPNIQEAVEGAMHIqECVPEDLE 78
Cdd:PRK05808   22 CAVAGYDVVMVDISDAAVDRGLATITKSLdRLVK-----KGKMTEADKeaaLARITGTTDLDDLKDADLVI-EAATENMD 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  79 LKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIG 158
Cdd:PRK05808   96 LKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATSDATHEAVEALAKKIG 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622883211 159 QCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSegLGMRYAfIGPL 216
Cdd:PRK05808  176 KTPVEV-KNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMK--LGCNHP-IGPL 229
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 4-221 6.16e-33

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 126.88  E-value: 6.16e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   4 ASGGFQVKLYDIEQQQIRNALENIRKEM-KLLEqagalKGSLSAEE---QLSLISGCPNIQEAVEGAMHIqECVPEDLEL 79
Cdd:PRK08268   27 AQAGHTVLLYDARAGAAAAARDGIAARLaKLVE-----KGKLTAEQadaALARLRPVEALADLADCDLVV-EAIVERLDV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  80 KKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQciVA--HPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKI 157
Cdd:PRK08268  101 KQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPER--VAglHFFNPVPLMKLVEVVSGLATDPAVADALYALARAW 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622883211 158 GQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 221
Cdd:PRK08268  179 GKTPVRA-KDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFR---MGPFELMDL 238
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
3-217 3.88e-30

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 115.66  E-value: 3.88e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   3 FASGGFQVKLYDIEQQQirnaLENIRKEMKLLEQAGALKGSLSAEEQLSLISGCP---NIQEAVEGAMHIQECVPEDLEL 79
Cdd:PRK09260   20 FAVSGFQTTLVDIKQEQ----LESAQQEIASIFEQGVARGKLTEAARQAALARLSyslDLKAAVADADLVIEAVPEKLEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  80 KKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQ 159
Cdd:PRK09260   96 KKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSDETVQVAKEVAEQMGK 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622883211 160 CPMRVQkEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSegLGMRYAfIGPLE 217
Cdd:PRK09260  176 ETVVVN-EFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIR--LGLNFP-MGPLE 229
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
7-219 5.43e-29

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 112.34  E-value: 5.43e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   7 GFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSLSAEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQ 86
Cdd:PRK08293   26 GFDVTIYDISDEALEKAKERIAKLADRYVRDLEATKEAPAEAALNRITLTTDLAEAVKDADLVIEAVPEDPEIKGDFYEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  87 LDSIVDDRVILSSSTSCLMPSKL---------FAGLvhvkqcivaHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKI 157
Cdd:PRK08293  106 LAKVAPEKTIFATNSSTLLPSQFaeatgrpekFLAL---------HFANEIWKNNTAEIMGHPGTDPEVFDTVVAFAKAI 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622883211 158 GQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETM 219
Cdd:PRK08293  177 GMVPIVLKKEQPGYILNSLLVPFLSAALALWAKGVADPETIDKTWMIATGAP---MGPFGIL 235
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 2-217 1.63e-28

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 111.36  E-value: 1.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   2 LFASGGFQVKLYDIEQQQIRNALENIRKEMKLLeqagALKGSLS---AEEQLSLISGCPNIQEaVEGAMHIQECVPEDLE 78
Cdd:PLN02545   22 LAAAAGMDVWLLDSDPAALSRGLDSISSSLARL----VKKGKMSqeeADATLGRIRCTTNLEE-LRDADFIIEAIVESED 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  79 LKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIG 158
Cdd:PLN02545   97 LKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGADTSDEVFDATKALAERFG 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622883211 159 QCPMRVQkEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLE 217
Cdd:PLN02545  177 KTVVCSQ-DYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHP---MGPLH 231
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 2-221 4.56e-26

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 104.57  E-value: 4.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   2 LFASGGFQVKLYDIEQQQIRNALENIRKE----MKLLEqagalKGSLSAEEQLSLIS--GCPNIQEAVEGAMHIQECVPE 75
Cdd:PRK06035   21 VFARTGYDVTIVDVSEEILKNAMELIESGpyglRNLVE-----KGKMSEDEAKAIMAriRTSTSYESLSDADFIVEAVPE 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  76 DLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMK 155
Cdd:PRK06035   96 KLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAALTSEETFNTTVELSK 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622883211 156 KIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDlVMSEglgMRYAF-IGPLETMHL 221
Cdd:PRK06035  176 KIGKIPIEV-ADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDID-EMCK---LAFGFpMGPFELMDI 237
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 170-258 2.13e-19

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 81.49  E-value: 2.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 170 GFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAE--GMLSYCDRYSEGMKH---VLKTF 244
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGyhILEVLAEEFGDRAYRpppLLEKL 80

                          90
                  ....*....|....
gi 1622883211 245 GPIPEFSRATAEKV 258
Cdd:pfam00725  81 VEAGRLGRKTGKGF 94
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 4-226 6.00e-19

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 85.04  E-value: 6.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   4 ASGGFQVKLYDIEQQQIRNALENIRKEmklLEQAGAlKGSLSAEEQ---LSLISGCPNIQEAVEGAMHIqECVPEDLELK 80
Cdd:PRK07819   25 ARAGVDVLVFETTEELATAGRNRIEKS---LERAVS-RGKLTERERdaaLARLRFTTDLGDFADRQLVI-EAVVEDEAVK 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  81 KKIFAQLDSIV-DDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKI-G 158
Cdd:PRK07819  100 TEIFAELDKVVtDPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVTSEATVARAEEFASDVlG 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622883211 159 QCPMRVQKEvAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLG-----MRYA-FIGpLETMHLNAEGM 226
Cdd:PRK07819  180 KQVVRAQDR-SGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAhpmgpLRLSdLVG-LDTVKAIADSM 251
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 3-217 1.12e-18

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 84.29  E-value: 1.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   3 FASGGFQVKLYDIEQQQIRNALENIRKEMKllEQAGalKGSLSAEEQ---LSLISGCPNIQEAVEGAMHIqECVPEDLEL 79
Cdd:PRK07530   23 CALAGYDVLLNDVSADRLEAGLATINGNLA--RQVA--KGKISEEARaaaLARISTATDLEDLADCDLVI-EAATEDETV 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  80 KKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQ 159
Cdd:PRK07530   98 KRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATDEATFEAAKEFVTKLGK 177

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622883211 160 CPMrVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSegLGMRYAfIGPLE 217
Cdd:PRK07530  178 TIT-VAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMK--LGANHP-MGPLE 231
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
4-191 4.42e-16

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 78.78  E-value: 4.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211   4 ASGGFQVKLYDIEQQQIRNALENI---------RKEMKLLEQagalkgslsaEEQLSLISGCPNIQeAVEGAMHIQECVP 74
Cdd:PRK11154  330 TKAGLPVRIKDINPQGINHALKYSwdlldkkvkRRHLKPSER----------DKQMALISGTTDYR-GFKHADVVIEAVF 398

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  75 EDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALM 154
Cdd:PRK11154  399 EDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVIPHAKTSAETIATTVALA 478

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1622883211 155 KKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEG 191
Cdd:PRK11154  479 KKQGKTPI-VVRDGAGFYVNRILAPYINEAARLLLEG 514
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 17-199 4.36e-13

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 69.87  E-value: 4.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  17 QQQIRNALENIRKEMKLleqagalkGSLSAEEQLSLISGCPNIQeAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVI 96
Cdd:TIGR02441 375 QQQVFKGLNKKVKRKKI--------TSLERDSILSNLTPTLDYS-GFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCI 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211  97 LSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRL 176
Cdd:TIGR02441 446 IASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKDTLASAVAVGLKQGKVVIVV-KDGPGFYTTRC 524

                         170       180
                  ....*....|....*....|...
gi 1622883211 177 QYAIISEAWRLVEEGiVSPSDLD 199
Cdd:TIGR02441 525 LGPMLAEVIRLLQEG-VDPKKLD 546
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 132-217 1.27e-05

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 46.38  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622883211 132 PLVELVPHPETAPTTVDRTHALMKKIGQcPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGmrYA 211
Cdd:PRK08268  379 KRRTLMAAPATSPAARDAAHALFQQDGK-AVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLN--YP 455


                  ....*.
gi 1622883211 212 FiGPLE 217
Cdd:PRK08268  456 L-GPLA 460
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH