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Conserved domains on  [gi|1622880162|ref|XP_028692413|]
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integrin alpha-IIb isoform X1 [Macaca mulatta]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 533-972 1.04e-179

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 532.67  E-value: 1.04e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  533 QPVVKASVQLLVQ-DSLNPAVKSCVLpqTKTPVSCFKIQMCVGATGHNIP-QKLSLNAELQLDRQ-KPRQGRRVLLLGSQ 609
Cdd:pfam08441    1 RPVVSVSASLQVEpNSINPEKKNCTL--TGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQkKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  610 QAGTTLNLDLGGKHSPICHTTMAFLRDEaeFRDKLSPIVLSLNVSLPPTEA------GMAPAVVLHGDTHVQEQTRIVLD 683
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLRVDPRapsdlpGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  684 CGEDDVCVPQLQLTASVT----GSPLLVGADNVLELQMDTANEGEGAYEAELSVHLPQGAHYMRARSNvEGFERLICNQK 759
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRRE-GSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  760 KENETRVVLCELGNPMKKNTQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPA 839
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  840 SLV---VAAEEGDREQnSLDSRGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQ-HSDLLYILDIQPQGGLQCFPQPPVN 915
Cdd:pfam08441  316 QVVggsVKGESAMKPR-SEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSnGKWLLYLLDVQGQGKGECSPQNEIN 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622880162  916 PLKVDWGLPTPSPSPVHPAHHKRDRRQiflPEPEQPSRLQDPVLVSCDS-APCTVVQC 972
Cdd:pfam08441  395 PLNLTQSLESSKPLRTSRVHHVVKRRD---VLKSEKATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 435-489 2.09e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.86  E-value: 2.09e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880162   435 YGRFGSAIAPLGDLDQDGYNDIAVAAPYGGPSGR-GQVLVFLGQSEGLSSRPSQVL 489
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 367-418 3.42e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 56.61  E-value: 3.42e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622880162   367 MASYFGHSVA-VTDVNGDGRHDLLVGAPLYMESradrklAEVGRVYLFLQPRG 418
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 496-536 2.54e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.22  E-value: 2.54e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622880162   496 GSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV 536
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 97-153 3.18e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 3.18e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622880162    97 NGSHFGFSLDFHKDSH--GRVAIVVGAPRtlGPSQEETGSVFLCPWRAEGGQCPSLLFD 153
Cdd:smart00191    1 PGSYFGYSVAGVGDVNgdGYPDLLVGAPR--ANDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 313-352 5.08e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.20  E-value: 5.08e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1622880162   313 FDGYWGYSVA-VGEFDGDlNTTEYVVGAPTWSWT--LGAVEIL 352
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGD-GYPDLLVGAPRANDAgeTGAVYVY 42
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 533-972 1.04e-179

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 532.67  E-value: 1.04e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  533 QPVVKASVQLLVQ-DSLNPAVKSCVLpqTKTPVSCFKIQMCVGATGHNIP-QKLSLNAELQLDRQ-KPRQGRRVLLLGSQ 609
Cdd:pfam08441    1 RPVVSVSASLQVEpNSINPEKKNCTL--TGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQkKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  610 QAGTTLNLDLGGKHSPICHTTMAFLRDEaeFRDKLSPIVLSLNVSLPPTEA------GMAPAVVLHGDTHVQEQTRIVLD 683
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLRVDPRapsdlpGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  684 CGEDDVCVPQLQLTASVT----GSPLLVGADNVLELQMDTANEGEGAYEAELSVHLPQGAHYMRARSNvEGFERLICNQK 759
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRRE-GSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  760 KENETRVVLCELGNPMKKNTQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPA 839
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  840 SLV---VAAEEGDREQnSLDSRGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQ-HSDLLYILDIQPQGGLQCFPQPPVN 915
Cdd:pfam08441  316 QVVggsVKGESAMKPR-SEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSnGKWLLYLLDVQGQGKGECSPQNEIN 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622880162  916 PLKVDWGLPTPSPSPVHPAHHKRDRRQiflPEPEQPSRLQDPVLVSCDS-APCTVVQC 972
Cdd:pfam08441  395 PLNLTQSLESSKPLRTSRVHHVVKRRD---VLKSEKATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 435-489 2.09e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.86  E-value: 2.09e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880162   435 YGRFGSAIAPLGDLDQDGYNDIAVAAPYGGPSGR-GQVLVFLGQSEGLSSRPSQVL 489
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 367-418 3.42e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 56.61  E-value: 3.42e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622880162   367 MASYFGHSVA-VTDVNGDGRHDLLVGAPLYMESradrklAEVGRVYLFLQPRG 418
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 371-413 2.95e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 53.28  E-value: 2.95e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622880162  371 FGHSVAVTDVNGDGRHDLLVGAPLYMESRAdrklaevGRVYLF 413
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 438-474 3.84e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622880162  438 FGSAIApLGDLDQDGYNDIAVAAPYGGPSGRGQVLVF 474
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 496-536 2.54e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.22  E-value: 2.54e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622880162   496 GSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV 536
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 97-153 3.18e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 3.18e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622880162    97 NGSHFGFSLDFHKDSH--GRVAIVVGAPRtlGPSQEETGSVFLCPWRAEGGQCPSLLFD 153
Cdd:smart00191    1 PGSYFGYSVAGVGDVNgdGYPDLLVGAPR--ANDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 499-530 2.80e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.33  E-value: 2.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622880162  499 FGFSLrGAVDIDDNGYPDLIVGAYGANQV---AVY 530
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGAgagAVY 34
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 313-352 5.08e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.20  E-value: 5.08e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1622880162   313 FDGYWGYSVA-VGEFDGDlNTTEYVVGAPTWSWT--LGAVEIL 352
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGD-GYPDLLVGAPRANDAgeTGAVYVY 42
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 533-972 1.04e-179

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 532.67  E-value: 1.04e-179
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  533 QPVVKASVQLLVQ-DSLNPAVKSCVLpqTKTPVSCFKIQMCVGATGHNIP-QKLSLNAELQLDRQ-KPRQGRRVLLLGSQ 609
Cdd:pfam08441    1 RPVVSVSASLQVEpNSINPEKKNCTL--TGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQkKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  610 QAGTTLNLDLGGKHSPICHTTMAFLRDEaeFRDKLSPIVLSLNVSLPPTEA------GMAPAVVLHGDTHVQEQTRIVLD 683
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLRVDPRapsdlpGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  684 CGEDDVCVPQLQLTASVT----GSPLLVGADNVLELQMDTANEGEGAYEAELSVHLPQGAHYMRARSNvEGFERLICNQK 759
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRRE-GSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  760 KENETRVVLCELGNPMKKNTQIGIAMLVSVGNLEEAGESVSFQLQIRSKNSQNPNSKIVLLDVPVRAEAQVELRGNSFPA 839
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  840 SLV---VAAEEGDREQnSLDSRGPKVEHTYELHNNGPGTVNGLHLSIHLPGQSQ-HSDLLYILDIQPQGGLQCFPQPPVN 915
Cdd:pfam08441  316 QVVggsVKGESAMKPR-SEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSnGKWLLYLLDVQGQGKGECSPQNEIN 394

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622880162  916 PLKVDWGLPTPSPSPVHPAHHKRDRRQiflPEPEQPSRLQDPVLVSCDS-APCTVVQC 972
Cdd:pfam08441  395 PLNLTQSLESSKPLRTSRVHHVVKRRD---VLKSEKATQTASVLLSCDSgARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 435-489 2.09e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.86  E-value: 2.09e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622880162   435 YGRFGSAIAPLGDLDQDGYNDIAVAAPYGGPSGR-GQVLVFLGQSEGLSSRPSQVL 489
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 367-418 3.42e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 56.61  E-value: 3.42e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1622880162   367 MASYFGHSVA-VTDVNGDGRHDLLVGAPLYMESradrklAEVGRVYLFLQPRG 418
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAPRANDA------GETGAVYVYFGSSG 47
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 371-413 2.95e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 53.28  E-value: 2.95e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622880162  371 FGHSVAVTDVNGDGRHDLLVGAPLYMESRAdrklaevGRVYLF 413
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAGA-------GAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 438-474 3.84e-09

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 52.90  E-value: 3.84e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1622880162  438 FGSAIApLGDLDQDGYNDIAVAAPYGGPSGRGQVLVF 474
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 496-536 2.54e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 51.22  E-value: 2.54e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1622880162   496 GSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRAQPVV 536
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 97-153 3.18e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.14  E-value: 3.18e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622880162    97 NGSHFGFSLDFHKDSH--GRVAIVVGAPRtlGPSQEETGSVFLCPWRAEGGQCPSLLFD 153
Cdd:smart00191    1 PGSYFGYSVAGVGDVNgdGYPDLLVGAPR--ANDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 447-519 3.73e-06

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 45.29  E-value: 3.73e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622880162  447 DLDQDGYNDIAVAapyggpsGRGQVLVFLGQSEGLSSRPSQVLdspfPTGSAFGFSLRgAVDIDDNGYPDLIV 519
Cdd:pfam13517    1 DLDGDGKLDLVVA-------NDGGLRLYLNNGDGTFTFITSVS----LGGGGGGLSVA-VGDLDGDGRLDLLV 61
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 379-458 4.70e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.21  E-value: 4.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622880162  379 DVNGDGRHDLLVGAPlymesradrklaevGRVYLFLQpRGPHTLGAPSLLLTGTqlyGRFGSAIApLGDLDQDGYNDIAV 458
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLN-NGDGTFTFITSVSLGG---GGGGLSVA-VGDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 499-530 2.80e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 36.33  E-value: 2.80e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622880162  499 FGFSLrGAVDIDDNGYPDLIVGAYGANQV---AVY 530
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGAgagAVY 34
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 313-352 5.08e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 36.20  E-value: 5.08e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1622880162   313 FDGYWGYSVA-VGEFDGDlNTTEYVVGAPTWSWT--LGAVEIL 352
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGD-GYPDLLVGAPRANDAgeTGAVYVY 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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