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Conserved domains on  [gi|1622878157|ref|XP_028691968|]
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solute carrier family 13 member 2 isoform X2 [Macaca mulatta]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 1-446 5.28e-103

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 321.24  E-value: 5.28e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPIILFPMMGIMDA----SEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIVGVR 76
Cdd:pfam00939  40 TIVGWILEPLPMAVIALFAISLSAILIGTLLakalSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKR 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  77 PalLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnleegsNNPTFELQEPSpqkeetkpdngqalpvt 156
Cdd:pfam00939 120 T--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER----------------- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 157 sapsegrvhlsqehlRLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVILLLL 236
Cdd:pfam00939 171 ---------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVILLLL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 237 AWLWLQILFLGFNFRKNfgtgekmqeqqqAAYGIIQTEHRLLGPMTFAEKAISVLFVILVLLWFTREpgfflgwgnlaFP 316
Cdd:pfam00939 233 APLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG-----------SL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 317 NatgesmVSDGTVAIFIGVIMFIIPskfpgltqdpenpgklkaplgLLDWK-TANQKMPWNIVLLLGGGYALAKGSERSG 395
Cdd:pfam00939 290 N------IDATTVAIIGLALMLLLR---------------------ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSG 342

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622878157 396 LSEWLGNKLTPLQS--VPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:pfam00939 343 FIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAV 395
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 457-596 8.38e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 457 ASHSRPRPSASTLSTSCSPALWPPPWPSCCLWPPH--------------PMPSSSLSGESKcwIWPGRDSCSTSLESWSS 522
Cdd:pfam03154 194 AATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpqrlPSPHPPLQPMTQ--PPPPSQVSPQPLPQPSL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 523 HWPSTAG-----ASPSSACTPSPPGLIP-TPQPSACPGRPTPPCQAPRLGRSPSAMP--RKTYPVPTPLSQEGTPQAPSS 594
Cdd:pfam03154 272 HGQMPPMphslqTGPSHMQHPVPPQPFPlTPQSSQSQVPPGPSPAAPGQSQQRIHTPpsQSQLQSQQPPREQPLPPAPLS 351


                  ..
gi 1622878157 595 RP 596
Cdd:pfam03154 352 MP 353
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 1-446 5.28e-103

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 321.24  E-value: 5.28e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPIILFPMMGIMDA----SEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIVGVR 76
Cdd:pfam00939  40 TIVGWILEPLPMAVIALFAISLSAILIGTLLakalSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKR 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  77 PalLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnleegsNNPTFELQEPSpqkeetkpdngqalpvt 156
Cdd:pfam00939 120 T--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER----------------- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 157 sapsegrvhlsqehlRLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVILLLL 236
Cdd:pfam00939 171 ---------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVILLLL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 237 AWLWLQILFLGFNFRKNfgtgekmqeqqqAAYGIIQTEHRLLGPMTFAEKAISVLFVILVLLWFTREpgfflgwgnlaFP 316
Cdd:pfam00939 233 APLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG-----------SL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 317 NatgesmVSDGTVAIFIGVIMFIIPskfpgltqdpenpgklkaplgLLDWK-TANQKMPWNIVLLLGGGYALAKGSERSG 395
Cdd:pfam00939 290 N------IDATTVAIIGLALMLLLR---------------------ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSG 342

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622878157 396 LSEWLGNKLTPLQS--VPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:pfam00939 343 FIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAV 395
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 1-446 2.89e-72

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 237.87  E-value: 2.89e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPIILFPMMGIMDASEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIVGVRPALL 80
Cdd:cd01115     7 AAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  81 MLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQassnleegsnnptfelqepspqkeetkpdngqalpvtsaps 160
Cdd:cd01115    87 LLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISP----------------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 161 egrvhlsqehlrltQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGnvvNFASWFSFAFPTMVIllllawlw 240
Cdd:cd01115   126 --------------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGF---SFFEFTPIGLPLLII-------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 241 lqilflgfnfrknfgtgekmqeqqqaaygiiqtehrllgpmtfaekaisvlfVILVLLWFTREPGFFLGWGNLAFPNA-T 319
Cdd:cd01115   181 ----------------------------------------------------GLLYLWFIFRLAVLIITIVLLAALAAiT 208

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 320 GESMVSDGTVAIFIGVIMFiipskfpgltqdpenpgklkaplGLLDWKTANQKMPWNIVLLLGGGYALAKGSERSGLSEW 399
Cdd:cd01115   209 GLLPVSVAIAIGAIVLVFG-----------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAAL 265

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1622878157 400 LGNKLTP-LQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:cd01115   266 IAEALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSI 313
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
47-446 7.48e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 210.01  E-value: 7.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  47 VGGLLVAITVEHWNLHKRIALRVLLIVGVRPALLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLhssqassNLEE 126
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL-------GSEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 127 GSNNPTFelqepspqkeetkpdngqalpvtsapsegrvhlsqehlrltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 206
Cdd:COG0471    74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 207 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLwlqilFLGFNFRKNFGTGEKMQEqqqaaygIIQTEHRLLGPMTFAEK 286
Cdd:COG0471   111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWL-----VLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 287 AISVLFVILVLLWFTrepGFFLGwgnlafpnatgesmVSDGTVAIFIGVIMFIIpskfpgltqdpenpgklkaplGLLDW 366
Cdd:COG0471   176 IALAIFALTVLLWIT---GSLHG--------------IPIAVVALLGAVLLLLT---------------------GVLTW 217

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 367 KTANQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILAS 445
Cdd:COG0471   218 KDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAIS 297


                  .
gi 1622878157 446 M 446
Cdd:COG0471   298 L 298
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 1-445 1.04e-37

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 145.56  E-value: 1.04e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPI-ILFPMMGIMDASEVS--MEYLKDSNI-LFVGGLLVAITVEHWNLHKRIALRVLLIVGVR 76
Cdd:TIGR00785  20 AIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFKnaLSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  77 PALL-MLGFMLVTAFLSMWISNTA-TSAMMVPIAHAVLDQLHSSQassnleegsnnptfelqEPSPQKeetkpdngqalp 154
Cdd:TIGR00785 100 TLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKP-----------------EKSPRK------------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 155 vtsapsegrvhlsqehlrLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQinsLFPQNGNVVNFASWFSFAFPTMVILL 234
Cdd:TIGR00785 151 ------------------IGKYLMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 235 LLAWLWLQILFlgfnfrknfgTGEKMQEQQQAAygIIQTEHRLLGPMTFAEKAISVLFVILVLLWFTrepGFFLGwgnla 314
Cdd:TIGR00785 210 LLVPLLLYVLF----------PPELKLKDEVDL--WAKEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG----- 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 315 fpnatgesmVSDGTVAIFIGVIMFIipskfpgltqdpenpgklkapLGLLDWKTANQ-KMPWNIVLLLGGGYALAKGSER 393
Cdd:TIGR00785 270 ---------INASVVALLAVVLMLF---------------------LGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKK 319

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622878157 394 SGLSEWLGNKLTPLQSVPTPAIGVILSLLVATF--TECTSNVATTTIFLPILAS 445
Cdd:TIGR00785 320 SGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFS 373
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 457-596 8.38e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 457 ASHSRPRPSASTLSTSCSPALWPPPWPSCCLWPPH--------------PMPSSSLSGESKcwIWPGRDSCSTSLESWSS 522
Cdd:pfam03154 194 AATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpqrlPSPHPPLQPMTQ--PPPPSQVSPQPLPQPSL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 523 HWPSTAG-----ASPSSACTPSPPGLIP-TPQPSACPGRPTPPCQAPRLGRSPSAMP--RKTYPVPTPLSQEGTPQAPSS 594
Cdd:pfam03154 272 HGQMPPMphslqTGPSHMQHPVPPQPFPlTPQSSQSQVPPGPSPAAPGQSQQRIHTPpsQSQLQSQQPPREQPLPPAPLS 351


                  ..
gi 1622878157 595 RP 596
Cdd:pfam03154 352 MP 353
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 456-613 8.96e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 8.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  456 TASHSRPRPSASTLSTScSPALWPPPWPSCCLWPPHPMPSSSLSGESkcwiwPGRDSCStsleswsshwPSTAGASPSSA 535
Cdd:PHA03307   274 GWNGPSSRPGPASSSSS-PRERSPSPSPSSPGSGPAPSSPRASSSSS-----SSRESSS----------SSTSSSSESSR 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  536 CTPSPPGliPTPQPSACPGRPTPPCQAPRLGRSPSAMPRKTYPVPTP----------------LSQEGTPQAPSSRPMAF 599
Cdd:PHA03307   338 GAAVSPG--PSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAgrptrrraraavagraRRRDATGRFPAGRPRPS 415

                          170
                   ....*....|....*.
gi 1622878157  600 LL--CVCKEGVYAQFP 613
Cdd:PHA03307   416 PLdaGAASGAFYARYP 431
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 1-446 5.28e-103

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 321.24  E-value: 5.28e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPIILFPMMGIMDA----SEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIVGVR 76
Cdd:pfam00939  40 TIVGWILEPLPMAVIALFAISLSAILIGTLLakalSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKR 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  77 PalLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnleegsNNPTFELQEPSpqkeetkpdngqalpvt 156
Cdd:pfam00939 120 T--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA----------FGSDPEKGSER----------------- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 157 sapsegrvhlsqehlRLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVILLLL 236
Cdd:pfam00939 171 ---------------RIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVILLLL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 237 AWLWLQILFLGFNFRKNfgtgekmqeqqqAAYGIIQTEHRLLGPMTFAEKAISVLFVILVLLWFTREpgfflgwgnlaFP 316
Cdd:pfam00939 233 APLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGG-----------SL 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 317 NatgesmVSDGTVAIFIGVIMFIIPskfpgltqdpenpgklkaplgLLDWK-TANQKMPWNIVLLLGGGYALAKGSERSG 395
Cdd:pfam00939 290 N------IDATTVAIIGLALMLLLR---------------------ILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSG 342

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622878157 396 LSEWLGNKLTPLQS--VPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:pfam00939 343 FIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYLFASATAHTAAMLPIFAAV 395
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 1-446 2.89e-72

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 237.87  E-value: 2.89e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPIILFPMMGIMDASEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIVGVRPALL 80
Cdd:cd01115     7 AAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  81 MLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQassnleegsnnptfelqepspqkeetkpdngqalpvtsaps 160
Cdd:cd01115    87 LLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISP----------------------------------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 161 egrvhlsqehlrltQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGnvvNFASWFSFAFPTMVIllllawlw 240
Cdd:cd01115   126 --------------SRLLMPLAFAASIGGMLTLIGTPPNLVASGYLESLGGQGF---SFFEFTPIGLPLLII-------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 241 lqilflgfnfrknfgtgekmqeqqqaaygiiqtehrllgpmtfaekaisvlfVILVLLWFTREPGFFLGWGNLAFPNA-T 319
Cdd:cd01115   181 ----------------------------------------------------GLLYLWFIFRLAVLIITIVLLAALAAiT 208

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 320 GESMVSDGTVAIFIGVIMFiipskfpgltqdpenpgklkaplGLLDWKTANQKMPWNIVLLLGGGYALAKGSERSGLSEW 399
Cdd:cd01115   209 GLLPVSVAIAIGAIVLVFG-----------------------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAAL 265

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1622878157 400 LGNKLTP-LQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:cd01115   266 IAEALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSI 313
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
47-446 7.48e-62

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 210.01  E-value: 7.48e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  47 VGGLLVAITVEHWNLHKRIALRVLLIVGVRPALLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLhssqassNLEE 126
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAAL-------GSEK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 127 GSNNPTFelqepspqkeetkpdngqalpvtsapsegrvhlsqehlrltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 206
Cdd:COG0471    74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 207 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLwlqilFLGFNFRKNFGTGEKMQEqqqaaygIIQTEHRLLGPMTFAEK 286
Cdd:COG0471   111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWL-----VLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 287 AISVLFVILVLLWFTrepGFFLGwgnlafpnatgesmVSDGTVAIFIGVIMFIIpskfpgltqdpenpgklkaplGLLDW 366
Cdd:COG0471   176 IALAIFALTVLLWIT---GSLHG--------------IPIAVVALLGAVLLLLT---------------------GVLTW 217

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 367 KTANQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILAS 445
Cdd:COG0471   218 KDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAIS 297


                  .
gi 1622878157 446 M 446
Cdd:COG0471   298 L 298
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 2-453 5.42e-41

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 153.94  E-value: 5.42e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   2 ALFWCTEALPLAVTALFPIILFPMMGIMDASEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIvGVRPALLM 81
Cdd:cd00625     1 YVLIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  82 LGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQassnleegsnnptfelqepspqkeetkpdngqalpvtsapse 161
Cdd:cd00625    80 LLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP------------------------------------------ 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 162 grvhlsqehlrlTQCMSLCVCYSASIGGIATLTGTAPNLVlqgqINSLFPqngnvVNFASWFSFAFPTMVILLLLAWLWL 241
Cdd:cd00625   118 ------------PVPLLLALAFAANIGGAATPIGNPPNLI----IASLSG-----LGFLDFLAFMAPPALGLLLLLLGLL 176

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 242 QILFLGFNFRKNFGTGEKMQEQQQAAYGIIQtehrllgpmtfaeKAISVLFVILVLLWFtrepGFFLGWGNLAfpnatge 321
Cdd:cd00625   177 YLLFRKKLLLPDEDKLTVLAEPLPARPLLKK-------------FLLLALLLLLLFVLL----FFFLIPLGLI------- 232

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 322 smvsdGTVAIFIGVIMFIIpskfpgltqdpenpgklkaplgLLDWKTANQKMPWNIVLLLGGGYALAKGSERSGLSEWLG 401
Cdd:cd00625   233 -----ALLGALLLLLLLVR----------------------GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLA 285

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622878157 402 NKLTPLQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILASMDGDQGQL 453
Cdd:cd00625   286 ELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLAPPEPAW 337
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 1-445 1.04e-37

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 145.56  E-value: 1.04e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPI-ILFPMMGIMDASEVS--MEYLKDSNI-LFVGGLLVAITVEHWNLHKRIALRVLLIVGVR 76
Cdd:TIGR00785  20 AIVGWILEPLPLPVTALLAIpIIAVLLGVLSAFKFKnaLSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGT 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  77 PALL-MLGFMLVTAFLSMWISNTA-TSAMMVPIAHAVLDQLHSSQassnleegsnnptfelqEPSPQKeetkpdngqalp 154
Cdd:TIGR00785 100 TLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLLPLLGSKP-----------------EKSPRK------------ 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 155 vtsapsegrvhlsqehlrLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQinsLFPQNGNVVNFASWFSFAFPTMVILL 234
Cdd:TIGR00785 151 ------------------IGKYLMLGIAYSASIGSSGFLTGSAPNALAAGI---LSKILGIQISWGDWFLAGLPLGIILL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 235 LLAWLWLQILFlgfnfrknfgTGEKMQEQQQAAygIIQTEHRLLGPMTFAEKAISVLFVILVLLWFTrepGFFLGwgnla 314
Cdd:TIGR00785 210 LLVPLLLYVLF----------PPELKLKDEVDL--WAKEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG----- 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 315 fpnatgesmVSDGTVAIFIGVIMFIipskfpgltqdpenpgklkapLGLLDWKTANQ-KMPWNIVLLLGGGYALAKGSER 393
Cdd:TIGR00785 270 ---------INASVVALLAVVLMLF---------------------LGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKK 319

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622878157 394 SGLSEWLGNKLTPLQSVPTPAIGVILSLLVATF--TECTSNVATTTIFLPILAS 445
Cdd:TIGR00785 320 SGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYFFASNTAHTAALVPIFFS 373
CitMHS pfam03600
Citrate transporter;
2-446 9.84e-33

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 128.97  E-value: 9.84e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   2 ALFWCTEALPLAVTALFPIILFPMMGIMDASEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIALRVLLIVGVRPALLM 81
Cdd:pfam03600   1 YVLIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  82 LGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnleegsnnptfelqePSPqkeetkpdngqalpvtsapse 161
Cdd:pfam03600  81 VALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP-------------------PSP--------------------- 120

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 162 grvhlsqehlrltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVillllawlwl 241
Cdd:pfam03600 121 ---------------LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLL---------- 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 242 qilFLGFNFRKNFGTGEKMQEQQQAAYGIIQTEHRLLgpmtfaekaisVLFVILVLLWFTrepGFFLGWgnlafpnatge 321
Cdd:pfam03600 176 ---PLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLL-----------AISALVLALVIL---GFLLLS----------- 227

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 322 smvsdgtVAIFIGVIMFIIpskfpgltqdpenpgklkapLGLLDWKTANQKMPWNIVLLLGGGYALAKGSERSGLSEWLG 401
Cdd:pfam03600 228 -------VLALAGALLLLL--------------------TGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALA 280

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1622878157 402 NKLTPLqsVPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:pfam03600 281 DALGGL--SGLLVALALILWLSALLSAFISNVPTAALMAPIIVGM 323
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
1-116 1.53e-09

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 60.17  E-value: 1.53e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEA---LPLAVTALFPIILFPMMGIMDASEVSmeylKDSN----ILFVGGLLVAITVEHWNLHKRIALRVL-LI 72
Cdd:COG0471   184 TVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAY----KSIPwgvlLLFGGGLALGAALEKTGLAAWLADALLpLL 259

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622878157  73 VGVRPALLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLH 116
Cdd:COG0471   260 GGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
10-447 3.32e-09

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 59.37  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  10 LPLAVTALFPIILFPMMGIMDASEVsMEYLkDSNILFVggLLVAITV----EHWNLHKRIALRVLLIVGVRPALLMLGFM 85
Cdd:COG1055    23 LNRAVAALLGAALLLLLGVVSLEDA-LEAI-DWNTILF--LLGMMIIvailDESGFFEWLAIKLARRAKGSPRRLLWLLG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  86 LVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassnleegsnnptfelqepspqkeetkpdngqALPVtsapsegrvh 165
Cdd:COG1055    99 LLTALLSAFLDNDTTALLLTPVVLAIARRLGLN---------------------------------PVPF---------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 166 lsqehlrltqCMSLCVcySASIGGIATLTGTAPNLVLQGQINslfpqngnvVNFASWFSFAF-PTMVILLLLAWlwlqil 244
Cdd:COG1055   136 ----------LIAIVF--AANIGGAATPIGNPTNIMIASAGG---------LSFLDFLANLFpPSLVSLLVTLL------ 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 245 FLGFNFRKNFGTGEKMQEQQQAAygiiQTEHRLLgpmtfaekAISVLFVILVLLwftrepGFFLGwgnlafpNATGesmV 324
Cdd:COG1055   189 VLYLLFRKELPAAPDLEDDPKEA----IKDRRLL--------RISLLVLALLLV------GFVLH-------SFLG---L 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 325 SDGTVAIFIGVIMFIIpSKFpgltqDPENpgKLKaplglldwktanqKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKL 404
Cdd:COG1055   241 PPALIALLGAAVLLLL-ARV-----DVRE--VLK-------------KVDWSTLLFFIGLFVVVGGLENTGLLDLLAELL 299

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1622878157 405 TPLQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILASMD 447
Cdd:COG1055   300 ASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLG 342
CitMHS pfam03600
Citrate transporter;
1-121 3.26e-07

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 52.70  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157   1 MALFWCTEALPLAVTALFPIILFPMMGIMDASEVSMEYLKDSNILFVGGLLVAITVEHWNLHKRIAlrVLLIVGVRPALL 80
Cdd:pfam03600 215 VLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALA--DALGGLSGLLVA 292

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622878157  81 MLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQAS 121
Cdd:pfam03600 293 LALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPD 333
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 457-596 8.38e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 49.00  E-value: 8.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 457 ASHSRPRPSASTLSTSCSPALWPPPWPSCCLWPPH--------------PMPSSSLSGESKcwIWPGRDSCSTSLESWSS 522
Cdd:pfam03154 194 AATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpqrlPSPHPPLQPMTQ--PPPPSQVSPQPLPQPSL 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 523 HWPSTAG-----ASPSSACTPSPPGLIP-TPQPSACPGRPTPPCQAPRLGRSPSAMP--RKTYPVPTPLSQEGTPQAPSS 594
Cdd:pfam03154 272 HGQMPPMphslqTGPSHMQHPVPPQPFPlTPQSSQSQVPPGPSPAAPGQSQQRIHTPpsQSQLQSQQPPREQPLPPAPLS 351


                  ..
gi 1622878157 595 RP 596
Cdd:pfam03154 352 MP 353
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 456-613 8.96e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 8.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  456 TASHSRPRPSASTLSTScSPALWPPPWPSCCLWPPHPMPSSSLSGESkcwiwPGRDSCStsleswsshwPSTAGASPSSA 535
Cdd:PHA03307   274 GWNGPSSRPGPASSSSS-PRERSPSPSPSSPGSGPAPSSPRASSSSS-----SSRESSS----------SSTSSSSESSR 337

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  536 CTPSPPGliPTPQPSACPGRPTPPCQAPRLGRSPSAMPRKTYPVPTP----------------LSQEGTPQAPSSRPMAF 599
Cdd:PHA03307   338 GAAVSPG--PSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAgrptrrraraavagraRRRDATGRFPAGRPRPS 415

                          170
                   ....*....|....*.
gi 1622878157  600 LL--CVCKEGVYAQFP 613
Cdd:PHA03307   416 PLdaGAASGAFYARYP 431
PHA03247 PHA03247
large tegument protein UL36; Provisional
 462-598 3.82e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  462 PRPSASTLSTSCSPAlwPPPWPSCCLWPPHPM-PSSSLSGESKCWIWPGRDSCSTSLESWSSHW-----------PSTAG 529
Cdd:PHA03247  2741 PPAVPAGPATPGGPA--RPARPPTTAGPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpadppaavlaPAAAL 2818

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622878157  530 ASPSSACTPSPPGLIPTPQPSACPGRPTPPCQAPRLGRSPSAMPRKTYPVPTPLSQEGTPQAPSSRPMA 598
Cdd:PHA03247  2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLA 2887
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 450-589 7.61e-05

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.85  E-value: 7.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 450 QGQLCPTASHSRPRPSastlSTSCSPALwPPPWPSCclwpPHPMPSSSLSGESKCwiwPGRDSCSTSLESWSSHWPSTag 529
Cdd:PHA02682   79 QSPLAPSPACAAPAPA----CPACAPAA-PAPAVTC----PAPAPACPPATAPTC---PPPAVCPAPARPAPACPPST-- 144

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622878157 530 aspsSACTPSPPGLIPTPQPSACPG---RPTPPCQAPrlgrSPSAMPRKTYPVPTPLSQEGTP 589
Cdd:PHA02682  145 ----RQCPPAPPLPTPKPAPAAKPIflhNQLPPPDYP----AASCPTIETAPAASPVLEPRIP 199
PHA03247 PHA03247
large tegument protein UL36; Provisional
 455-600 9.89e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 9.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  455 PTASHSRPRPSASTLSTSCSPALWPPPWPSCCLWPPHPMPSSSLSGESKC-WIWPGRD-------SCSTSLESWSSHWPS 526
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgSVAPGGDvrrrppsRSPAAKPAAPARPPV 2883

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  527 TAGASP-------SSACTPSPPGLIPTPQPSACPGRPTPPCQAPRLGRSPSAMPRKTYPVPTPLSQEGTPQAPSSRPMAF 599
Cdd:PHA03247  2884 RRLARPavsrsteSFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW 2963


                   .
gi 1622878157  600 L 600
Cdd:PHA03247  2964 L 2964
PHA03247 PHA03247
large tegument protein UL36; Provisional
 451-596 4.68e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 4.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  451 GQLCPTASHSRPRPSASTLSTSCSPALWPPPWPSCCLwPPHPMPSSSLSGESKCWIW---------PGRDSCSTSLESWS 521
Cdd:PHA03247  2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL-TRPAVASLSESRESLPSPWdpadppaavLAPAAALPPAASPA 2825

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  522 SHWPSTAGASPSSACTPSPP--------GLI----------PTPQPSACPGRPTPPcQAPRLGRSPSAMPRKTYPVPtPL 583
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPGPpppslplgGSVapggdvrrrpPSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALP-PD 2903

                          170
                   ....*....|...
gi 1622878157  584 SQEGTPQAPSSRP 596
Cdd:PHA03247  2904 QPERPPQPQAPPP 2916
PHA03378 PHA03378
EBNA-3B; Provisional
 453-596 4.96e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 4.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 453 LCPTASHSRPRPSASTLSTSC---SPALWPPPWPSCCLWPPHPMPSSSLSGESKCWIWPGRDSCSTSLESW--------- 520
Cdd:PHA03378  569 LGPLQIQPLTSPTTSQLASSApsyAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQpitfnvlvf 648

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 521 -SSHWP---------STAGASPSSACTPSPPGLIPTPQPSACPGRPTPPCQAPRLGRSPSAMPRK-------TYPVPTPL 583
Cdd:PHA03378  649 pTPHQPpqveitpykPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRaqrpaaaTGRARPPA 728

                         170
                  ....*....|...
gi 1622878157 584 SQEGTPQAPSSRP 596
Cdd:PHA03378  729 AAPGRARPPAAAP 741
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 448-601 4.99e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.62  E-value: 4.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  448 GDQGQLCPTASHSRPRPSASTLSTSCSPALWPPPWPScclwPPHPMPSSSLSgeskcwiwpgrdscstSLESWSSHWPST 527
Cdd:PHA03307    38 GSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPG----PGTEAPANESR----------------STPTWSLSTLAP 97

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622878157  528 AGASPSSACTP----SPPGLIPTPQPSACPGRPTPPCQAPRLGRSPSAMPRKTYPVPTPLSQEGTPQ-APSSRPMAFLL 601
Cdd:PHA03307    98 ASPAREGSPTPpgpsSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASdAASSRQAALPL 176
PHA03378 PHA03378
EBNA-3B; Provisional
 456-598 6.30e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.13  E-value: 6.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 456 TASHSRPRPSASTLSTSCSPALWPPPWPscclwPPHPMPSsslsgeskcwiwPGRDSCSTSLESWSSHWPSTAGASPSSA 535
Cdd:PHA03378  678 PTGANTMLPIQWAPGTMQPPPRAPTPMR-----PPAAPPG------------RAQRPAAATGRARPPAAAPGRARPPAAA 740

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622878157 536 CTPSPPgliptpqPSACPGRPTPPCQAPRLGRSPSAMPRKtypvPTPLSQEGTPQAPSSRPMA 598
Cdd:PHA03378  741 PGRARP-------PAAAPGRARPPAAAPGRARPPAAAPGA----PTPQPPPQAPPAPQQRPRG 792
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 492-598 1.25e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.21  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 492 PMPSSSLSGESkcwiwPGRDSCSTSLESWSSHWPSTAgaSPSSACT-PSPPGLIPTPQPSAcpgrPTPPCQAPRLGRSPs 570
Cdd:pfam05109 476 PTPAGTTSGAS-----PVTPSPSPRDNGTESKAPDMT--SPTSAVTtPTPNATSPTPAVTT----PTPNATSPTLGKTS- 543

                          90       100
                  ....*....|....*....|....*...
gi 1622878157 571 amPRKTYPVPTPLSQEGTPQAPSSRPMA 598
Cdd:pfam05109 544 --PTSAVTTPTPNATSPTPAVTTPTPNA 569
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 44-115 1.26e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 41.47  E-value: 1.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622878157  44 ILFVGGLLVAITVEHwNLHKRIALRVLLIVGVRPALLMLGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 115
Cdd:cd01116    52 LLLGMMIIVSILSET-GVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVL 122
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 524-598 1.81e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.47  E-value: 1.81e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622878157 524 WPSTAGASPSSACTPSPPglIPTPQPSACPGRPTPPCQAPRLGRSPSA--MPRKTYPVPTPLSQEGTPQAPSSRPMA 598
Cdd:PRK14954  381 APSPAGSPDVKKKAPEPD--LPQPDRHPGPAKPEAPGARPAELPSPASapTPEQQPPVARSAPLPPSPQASAPRNVA 455
PHA03247 PHA03247
large tegument protein UL36; Provisional
 455-598 1.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  455 PTASHSRPRPSAS--TLSTSCSPALWPPPWPscclwPPHPMPSSSLSGESkcwIWPGRdscstsleswsshwPSTAGASP 532
Cdd:PHA03247  2676 ASSPPQRPRRRAArpTVGSLTSLADPPPPPP-----TPEPAPHALVSATP---LPPGP--------------AAARQASP 2733

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622878157  533 SSACTPSPPgliPTPQPSACPGRPTPPCQ--------APRLGRSPSAMPRKTYPVPTPLS-QEGTPQAPSSRPMA 598
Cdd:PHA03247  2734 ALPAAPAPP---AVPAGPATPGGPARPARppttagppAPAPPAAPAAGPPRRLTRPAVASlSESRESLPSPWDPA 2805
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 525-596 1.90e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 41.41  E-value: 1.90e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622878157  525 PSTAGASPSSACTPSPpglIPTPQPSAcPGRPTPPCQAPRLGRSPSAMPRKTY----PVPTPLSQEGTPQAPSSRP 596
Cdd:pfam15324  972 SVPGDLPTKETLLPTP---VPTPQPTP-PCSPPSPLKEPSPVKTPDSSPCVSEhdffPVKEIPPEKGADTGPAVSL 1043
PHA03247 PHA03247
large tegument protein UL36; Provisional
 475-595 2.21e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  475 PALWPPPWPSCCLWPPHPMPSSSLSGESKCWIWPGRDSCSTSL-----ESWSSHWPSTAGASPSSACTPSPPGLIPTPQP 549
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPrapvdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622878157  550 SACPG---RPTPPCQAPRLGRSPS--AMPRKTYPVPTPLSQEGTPQAPSSR 595
Cdd:PHA03247  2636 NEPDPhppPTVPPPERPRDDPAPGrvSRPRRARRLGRAAQASSPPQRPRRR 2686
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
318-446 2.35e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 40.88  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157 318 ATGESMVSDGTVAIFIGVIMFIipskfpgltqdpenpgklkapLGLLDWKTANQKMPWNIVLLLGGGYALAKGSERSGLS 397
Cdd:COG1055    17 ILEPRGLNRAVAALLGAALLLL---------------------LGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622878157 398 EWLGNKLTPLQSVPTPAIGVILSLLVATFTECTSNVATTTIFLPILASM 446
Cdd:COG1055    76 EWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAI 124
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 454-574 3.66e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622878157  454 CPTASHSRPRPSA-STLSTSCSPALWPPPWPSCclwpphPMPSSSLSGESKCWIWPGRDSCSTSLESWSSHWPstagasP 532
Cdd:PHA03307   813 SRTASKRKSRSHTpDGGSESSGPARPPGAAARP------PPARSSESSKSKPAAAGGRARGKNGRRRPRPPEP------R 880

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622878157  533 SSACTPSPPGLIPTPQPSACPGRPTPPCQAPRLGRSPSAMPR 574
Cdd:PHA03307   881 ARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKLGPMPPGGPD 922
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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