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Conserved domains on  [gi|1622872427|ref|XP_028690959|]
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cyclin-dependent kinase inhibitor 2A [Macaca mulatta]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-125 5.19e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 5.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 86
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIV 169

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622872427  87 AVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYLRAA 125
Cdd:COG0666   170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-125 5.19e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 5.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 86
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIV 169

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622872427  87 AVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYLRAA 125
Cdd:COG0666   170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 42-148 1.44e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427  42 QVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLAVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARY 121
Cdd:PTZ00322   88 QLAASGDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166

                          90       100
                  ....*....|....*....|....*..
gi 1622872427 122 LraaaggtrgSSHARIDAAEGPSGIPD 148
Cdd:PTZ00322  167 L---------SRHSQCHFELGANAKPD 184
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-122 2.96e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 2.96e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622872427  47 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLAVLHRAGARLDVHDawGRLPVDLAEERGHRDVARYL 122
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLL 80
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-125 5.19e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.07  E-value: 5.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 86
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLaAYNGNLEIVKLLLEAGADVNAQDNDGNT-PLHLAAANGNLEIV 169

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622872427  87 AVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYLRAA 125
Cdd:COG0666   170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-127 2.85e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.15  E-value: 2.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 86
Cdd:COG0666   124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaAANGNLEIVKLLLEAGADVNARDNDGET-PLHLAAENGHLEIV 202

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622872427  87 AVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYLRAAAG 127
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-140 7.87e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 7.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRP-IQVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTL 86
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDNDGETPlHLAAENGHLEIVKLLLEAGADVNAKDNDGKT-ALDLAAENGNLEIV 235

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622872427  87 AVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYLRAAAGGTRGSSHARIDAA 140
Cdd:COG0666   236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 42-148 1.44e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.51  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427  42 QVMMMGSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLAVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARY 121
Cdd:PTZ00322   88 QLAASGDAVGARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166

                          90       100
                  ....*....|....*....|....*..
gi 1622872427 122 LraaaggtrgSSHARIDAAEGPSGIPD 148
Cdd:PTZ00322  167 L---------SRHSQCHFELGANAKPD 184
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-125 5.89e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 47.26  E-value: 5.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLA 87
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1622872427  88 VLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYLRAA 125
Cdd:COG0666   105 LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
Ank_2 pfam12796
Ankyrin repeats (3 copies);
47-122 2.96e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 2.96e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622872427  47 GSARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLDTLAVLHRAGARLDVHDawGRLPVDLAEERGHRDVARYL 122
Cdd:pfam12796   8 GNLELVKLLLENGADANLQDKNGRT-ALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLL 80
PHA03095 PHA03095
ankyrin-like protein; Provisional
 16-108 3.06e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 42.32  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427  16 RVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS--ARVAELLLLHGAEPNCADPATLTrPVHDAAREGFLD--TLAVLHR 91
Cdd:PHA03095   62 VKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAttLDVIKLLIKAGADVNAKDKVGRT-PLHVYLSGFNINpkVIRLLLR 140

                          90
                  ....*....|....*..
gi 1622872427  92 AGARLDVHDAWGRLPVD 108
Cdd:PHA03095  141 KGADVNALDLYGMTPLA 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
8-100 8.33e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.33  E-value: 8.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQV-MMMGSARVAELLLLHGAEPNCADPATltrPVHDAAREGFLDTL 86
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLaAKNGHLEIVKLLLEHADVNLKDNGRT---ALHYAARSGHLEIV 77

                          90
                  ....*....|....
gi 1622872427  87 AVLHRAGARLDVHD 100
Cdd:pfam12796  78 KLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 50-110 2.92e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 2.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622872427  50 RVAELLLLHGAEPNCADpATLTRPVHDAAREGFLDTLAVLHRAGARLDVHDAWGRLPVDLA 110
Cdd:PHA02878  182 RLTELLLSYGANVNIPD-KTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS 241
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 4-105 2.95e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.85  E-value: 2.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   4 SADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMM-GSARVAELLLLHGAEPNCAD------PATLTRPVHD 76
Cdd:PLN03192  622 AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAeDHVDMVRLLIMNGADVDKANtdddfsPTELRELLQK 701

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622872427  77 ---AAREGFLDTLAVLHRAGARlDVHDAWGRL 105
Cdd:PLN03192  702 relGHSITIVDSVPADEPDLGR-DGGSRPGRL 732
Ank_4 pfam13637
Ankyrin repeats (many copies);
8-56 3.36e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 3.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622872427   8 LATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQ-VMMMGSARVAELLL 56
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDGNGETALHfAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 10-122 4.36e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.24  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427  10 TAAARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGS----ARVAELLLLHGAEPNCADPATLTrPVHDAAREGF-LD 84
Cdd:PHA03095   20 LNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSsekvKDIVRLLLEAGADVNAPERCGFT-PLHLYLYNATtLD 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622872427  85 TLAVLHRAGARLDVHDAWGRLP--VDLAEERGHRDVARYL 122
Cdd:PHA03095   99 VIKLLIKAGADVNAKDKVGRTPlhVYLSGFNINPKVIRLL 138
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 20-113 5.33e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.89  E-value: 5.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427  20 VRALLEAGALPNAPNSYGRRPIQVMMMGSARVAEL--LLLHGAEPNCADPATLTrPVHDAAR-EGFLDTLAVLHRAGARL 96
Cdd:PHA02876  290 VPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIrtLIMLGADVNAADRLYIT-PLHQASTlDRNKDIVITLLELGANV 368

                          90
                  ....*....|....*..
gi 1622872427  97 DVHDAWGRLPVDLAEER 113
Cdd:PHA02876  369 NARDYCDKTPIHYAAVR 385
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-122 6.44e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 6.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622872427  75 HDAAREGFLDTLAVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYL 122
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLL 49
Ank_4 pfam13637
Ankyrin repeats (many copies);
71-122 9.55e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 9.55e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622872427  71 TRPVHDAAREGFLDTLAVLHRAGARLDVHDAWGRLPVDLAEERGHRDVARYL 122
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
PHA03095 PHA03095
ankyrin-like protein; Provisional
 13-120 1.12e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.08  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427  13 ARGRVEEVRALLEAGALPNAPNSYGRRPIQVMMMGSARVAEL---LLLHGAEPNCADpATLTRPVHDAAreGFLDTLAVL 89
Cdd:PHA03095  198 FKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLvlpLLIAGISINARN-RYGQTPLHYAA--VFNNPRACR 274

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622872427  90 H--RAGARLDVHDAWGRLPVDLAEERGHRDVAR 120
Cdd:PHA03095  275 RliALGADINAVSSDGNTPLSLMVRNNNGRAVR 307
PHA02946 PHA02946
ankyin-like protein; Provisional
 1-97 7.45e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 35.41  E-value: 7.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622872427   1 MEPSADWL---ATAAARGRVEE-VRALLEAGALPNAPNSYGRRPIQVM-MMGSARVAELLLLHGAEPNCADPATLTrPVH 75
Cdd:PHA02946   32 IEPSGNYHilhAYCGIKGLDERfVEELLHRGYSPNETDDDGNYPLHIAsKINNNRIVAMLLTHGADPNACDKQHKT-PLY 110

                          90       100
                  ....*....|....*....|....
gi 1622872427  76 --DAAREGFLDTLAVLHRAGARLD 97
Cdd:PHA02946  111 ylSGTDDEVIERINLLVQYGAKIN 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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