|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
36-435 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 579.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 36 SLT-RRRDAERRYTSSSADSEEGKTP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGANFTLRELGLGEV 113
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 114 TSPHGTLYRTDIGLPHCGYSMGASSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENT---ETG 190
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKsdnENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 191 APLHCSSASSTPIEQSPSPPPSPpaNESQRRLLGNGVAQPTPDSDSEEEFVPNSFLVKSGSASLGVAAnDHPGGLQNHAR 270
Cdd:pfam06484 161 PPIPPSSSSSSPVEQHSPPPPSL--NENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPS-EQPPNFQNHSR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 271 LRTPPPPLSHTHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPASgaQEPAHAQDNWLLNSNIPLETRnlgkq 350
Cdd:pfam06484 238 LRTPPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQST--QESVQLQDSWVLNSNVPLETR----- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 351 pflgtlqdnliemdilgasrhdgaygdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPS 429
Cdd:pfam06484 310 ----------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPY 361
|
....*.
gi 1622865605 430 KYCNWK 435
Cdd:pfam06484 362 KYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1317-1658 |
7.34e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 169.25 E-value: 7.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1317 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYY----LTTDPmSGA 1386
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1387 VFLSDTNSRRVFKIKSTVVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1464
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1465 RRIDQNGIISTLLGsndlTSARPLSCDSVMdiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1542
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1543 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1622
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 1622865605 1623 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1658
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2780-2857 |
3.35e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 138.13 E-value: 3.35e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865605 2780 EEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMR 2857
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1684-2556 |
5.67e-34 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 144.13 E-value: 5.67e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1684 FDTTGKHLYTQSLPTGDYLYNFTYTGDGDVTLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGH 1763
Cdd:COG3209 184 VGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTT 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1764 ELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAF 1843
Cdd:COG3209 264 GAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTG 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1844 YTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFG 1923
Cdd:COG3209 344 GTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAA 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1924 RRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSlWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYD 2003
Cdd:COG3209 424 GALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGA-ATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTL 502
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2004 QAGRIISRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASV 2083
Cdd:COG3209 503 DDTLGGTTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTT 582
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2084 IQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQI 2163
Cdd:COG3209 583 GTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGT 662
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2164 FRFTEEGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAY 2243
Cdd:COG3209 663 TGTGTGVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTT 741
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2244 GRMKEVQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSP 2323
Cdd:COG3209 742 GTLTTTSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVIT 820
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2324 GNSARLTPL-----RYDLRDRITRLGDVQykmdEDGFLRQRggdiFEYNSAGLLIKAynRAGGWSVRYRYDGLGRRVSSK 2398
Cdd:COG3209 821 VGSGGGTDLqdrtyTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTSRT 890
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2399 SSHSHHLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYT 2478
Cdd:COG3209 891 DGGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYD 949
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865605 2479 AYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhELWQHLSssnimpFNLYMFKNNNPISNS 2556
Cdd:COG3209 950 PFGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-PIGLAGG------LNLYAYVGNNPVNYV 1020
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2477-2556 |
4.16e-11 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 60.98 E-value: 4.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2477 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwqhlsssnimPF------NLYMFKNN 2550
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 1622865605 2551 NPISNS 2556
Cdd:TIGR03696 67 NPVNWV 72
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
928-958 |
2.29e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.83 E-value: 2.29e-09
10 20 30
....*....|....*....|....*....|.
gi 1622865605 928 SMETACGDSKDNDGDGLVDCMDPDCCLQPLC 958
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1327-1658 |
1.41e-08 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 58.49 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1327 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilELRNKDFRHSHSpahkyyLTTDPmSGAVFLSDTNSRRVFKI--K 1401
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIdpK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1402 STVVvkdlvknsEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRID-QNGIISTLLG 1478
Cdd:COG4257 89 TGEI--------TTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1479 snDLTSARplscdsvmdisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAI 1558
Cdd:COG4257 141 --PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYAL 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1559 HATLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLA 1638
Cdd:COG4257 184 PTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVA 237
|
330 340
....*....|....*....|
gi 1622865605 1639 VCADGELYVADLGNIRIRFI 1658
Cdd:COG4257 238 VDGDGRVWFAESGANRIVRF 257
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1975-2393 |
2.48e-08 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 60.02 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1975 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRIISRIFADGKTWSYTYLEKS---MVLLLHSQRQYIFEFDK 2044
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYSLNVVSgdiTDITTPDGRETKFYYND 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2045 NDRLSSVTMPNvarqTLETIRsvgyyrniyqppegnasviqDFTEDGHLLhtfylgtgrrviykygklsklAETLYDTTK 2124
Cdd:NF041261 479 GNQLTSVTSPD----GLESRR--------------------EYDEPGRLV---------------------SETSRSGET 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2125 VSFTYDETAGMLKTINLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR 2204
Cdd:NF041261 514 TRYRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYR 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2205 -YDD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKK 2274
Cdd:NF041261 582 rYDNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTL 654
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2275 ELKvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYK 2349
Cdd:NF041261 655 TNE-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQ 727
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1622865605 2350 MDEDGFLRQrggdiFEYNSAGLLIkaynraggwSVRYRYDGLGR 2393
Cdd:NF041261 728 YDEHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2203-2539 |
4.33e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 52.70 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2203 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2264
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2265 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2335
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2336 lrDRITRLGDVqyKMDEDGFLRQrggdiFEYNSAGLLIkAYNRAGGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2415
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2416 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2495
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865605 2496 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWQHLSSSNI 2539
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1362-1662 |
1.48e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.01 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1362 RNKDFRHSHSPAhKY--YLTTDPMSGAVFLSDTNSRRVfkikstvVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1435
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1436 kateATLTNPRGITVDKFGLIYFVDGT---MIRRID-QNGIISTLLGS----NDLTSARPLScdsvmdiSQVrLEWPTDL 1507
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1508 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1555
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1556 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1607
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1622865605 1608 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1662
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
659-817 |
2.37e-05 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 48.85 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 659 DNCPSNCYGNGDCISGTCH-----------------CFLGFLGPD---CGRASCpvlcsGNGQ----------YMKGRCL 708
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTPKascCGGVTC-----GAGQtcdaktntcvYVKGYCS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 709 C-HSGWKGAECDVPTNQCIDVACSNHGT---CIMG-----------------TCIC-NPG-YK-GESC-----------E 753
Cdd:pfam19232 85 AdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGfgawiweldpatnsgvwRCRCaNGSlYNsAHECspladqtlcaaE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 754 EVD-----------------------CMDPTCSGRGVC--VRGECHCSVGWGGTNCETPRAtcldqCSGHGTFLPDTGLC 808
Cdd:pfam19232 165 NLDpnalvpassvpafaaygwgnqpvLINKSTAGAAVPspLAGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQC 239
|
....*....
gi 1622865605 809 SCDPSWTGH 817
Cdd:pfam19232 240 ACNIDFSGH 248
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
841-884 |
4.60e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 43.00 E-value: 4.60e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1622865605 841 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 884
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
730-753 |
5.53e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.54 E-value: 5.53e-04
10 20
....*....|....*....|....*...
gi 1622865605 730 CSNHGTCIMG----TCICNPGYKGESCE 753
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1775-1807 |
5.94e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.94e-04
10 20 30
....*....|....*....|....*....|...
gi 1622865605 1775 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1807
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Ten_N |
pfam06484 |
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ... |
36-435 |
0e+00 |
|
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).
Pssm-ID: 461932 [Multi-domain] Cd Length: 367 Bit Score: 579.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 36 SLT-RRRDAERRYTSSSADSEEGKTP-QKSYSSSETLKAYDQDARLAYGSRVKDMVPQEAEEFCRTGANFTLRELGLGEV 113
Cdd:pfam06484 1 SLTkRRRDKERRYTSSSADSEECRVPtQKSYSSSETLKAFDHDSRMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICEP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 114 TSPHGTLYRTDIGLPHCGYSMGASSDADMEADTVLSPEHPVRLWGRSTRSGRSSCLSSRANSNLTLTDTEHENT---ETG 190
Cdd:pfam06484 81 SPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKsdnENG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 191 APLHCSSASSTPIEQSPSPPPSPpaNESQRRLLGNGVAQPTPDSDSEEEFVPNSFLVKSGSASLGVAAnDHPGGLQNHAR 270
Cdd:pfam06484 161 PPIPPSSSSSSPVEQHSPPPPSL--NENQRPLLGNNASHPILDSDPDEEFSPNSYLVRTGSGPQSAPS-EQPPNFQNHSR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 271 LRTPPPPLSHTHTPNQHHAASINSLNRGNFTPRSNPSPAPTdHSLSGEPPASgaQEPAHAQDNWLLNSNIPLETRnlgkq 350
Cdd:pfam06484 238 LRTPPPPLPPPHKQNQHHHPSINSLNRSSLTNRRNPSPAPT-ASLPAELQST--QESVQLQDSWVLNSNVPLETR----- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 351 pflgtlqdnliemdilgasrhdgaygdgHFLFKPG-GTSPLFCTTSPGYPLTSSTVYSPPPRPLPRSTFARPAFNLKKPS 429
Cdd:pfam06484 310 ----------------------------HFLFKTGtGTTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPY 361
|
....*.
gi 1622865605 430 KYCNWK 435
Cdd:pfam06484 362 KYCSWK 367
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1317-1658 |
7.34e-46 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 169.25 E-value: 7.34e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1317 GLADGNKLLA----PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHKYY----LTTDPmSGA 1386
Cdd:cd14953 11 GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGGAAAQFNtpsgVAVDA-AGN 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1387 VFLSDTNSRRVFKIKSTVVVKdlvknseVVAGTGDQclpfddtRCGDGGKATEATLTNPRGITVDKFGLIYFVDGT--MI 1464
Cdd:cd14953 90 LYVADTGNHRIRKITPDGVVS-------TLAGTGTA-------GFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGnhRI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1465 RRIDQNGIISTLLGsndlTSARPLSCDSVMdiSQVRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGRpmh 1542
Cdd:cd14953 156 RKITPDGVVTTVAG----TGGAGYAGDGPA--TAAQFNNPTGVAVDAAGN-LYVADrgNHRIRKITPDGVVTTVAGT--- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1543 cqvpGIDHFLLSKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcFSGD 1622
Cdd:cd14953 226 ----GTAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVAGGGAG-----------FSGD 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 1622865605 1623 DGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1658
Cdd:cd14953 288 GGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
|
|
| Tox-GHH |
pfam15636 |
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ... |
2780-2857 |
3.35e-38 |
|
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.
Pssm-ID: 464783 Cd Length: 78 Bit Score: 138.13 E-value: 3.35e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865605 2780 EEKARVLELARQRAVRQAWAREQQRLREGEEGLRAWTEGEKQQVLSTGRVQGYDGFFVISVEQYPELSDSANNIHFMR 2857
Cdd:pfam15636 1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
1684-2556 |
5.67e-34 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 144.13 E-value: 5.67e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1684 FDTTGKHLYTQSLPTGDYLYNFTYTGDGDVTLITDNNGNMVNVRRDSTGMPLWLVVPDGQVYWVTMGTNSALKSVTTQGH 1763
Cdd:COG3209 184 VGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTT 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1764 ELAMMTYHGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSFRSDTDSSVHVQVETSSKDDVTITTNLSASGAF 1843
Cdd:COG3209 264 GAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTG 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1844 YTLLQDQVRNSYYIGADGSLRLLLANGMEVALQTEPHLLAGTVNPTVGKRNVTLPIDNGLNLVEWRQRKEQARGQVTVFG 1923
Cdd:COG3209 344 GTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAA 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1924 RRLRVHNRNLLSLDFDRVTRTEKIYDDHRKFTLRILYDQAGRPSlWSPSSRLNGVNVTYSPGGHIAGIQRGIMSERMEYD 2003
Cdd:COG3209 424 GALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGA-ATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTL 502
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2004 QAGRIISRIFADGKTWSYTYLEKSMVLLLHSQRQYIFEFDKNDRLSSVTMPNVARQTLETIRSVGYYRNIYQPPEGNASV 2083
Cdd:COG3209 503 DDTLGGTTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTT 582
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2084 IQDFTEDGHLLHTFYLGTGRRVIYKYGKLSKLAETLYDTTKVSFTYDETAGMLKTINLQNEGFTCTIRYRQIGPLIDRQI 2163
Cdd:COG3209 583 GTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGT 662
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2164 FRFTEEGMVNARFDYNYDNSFRVTSmQAVINETPLPIDLYRYDDVSGKTEQFGKFGVIYYDINQIITTAVMTHTKHFDAY 2243
Cdd:COG3209 663 TGTGTGVTAGLTTLATGGTTVGGGT-GTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTT 741
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2244 GRMKEVQYEIFRSLMYWmTVQYDNMGRVVKKELKVGPYANTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNLHLLSP 2323
Cdd:COG3209 742 GTLTTTSTTTTTTAGAL-TYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVIT 820
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2324 GNSARLTPL-----RYDLRDRITRLGDVQykmdEDGFLRQRggdiFEYNSAGLLIKAynRAGGWSVRYRYDGLGRRVSSK 2398
Cdd:COG3209 821 VGSGGGTDLqdrtyTYDAAGNITSITDAL----RAGTLTQT----YTYDALGRLTSA--TDPGTTESYTYDANGNLTSRT 890
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2399 SSHSHHLQFFYADLtnPTKVTHlynhSSSEITSLYYDLQGHlfamelssgdefyiaCDNIGTPLAVFSGTGLMIKQILYT 2478
Cdd:COG3209 891 DGGTTTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYD 949
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865605 2479 AYGEIYMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhELWQHLSssnimpFNLYMFKNNNPISNS 2556
Cdd:COG3209 950 PFGNLLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-PIGLAGG------LNLYAYVGNNPVNYV 1020
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1322-1658 |
4.75e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.99 E-value: 4.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1322 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRHSHSPAHkyyLTTDPmSGAVFLSDTNSRRVFK 1399
Cdd:cd05819 5 GELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGNHRIQK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1400 IKStvvvkdlvkNSEVVAGTGdqclpfddtrcGDGGKATEatLTNPRGITVDKFGLIYFVDgTM---IRRIDQNGIISTL 1476
Cdd:cd05819 81 FDP---------DGNFLASFG-----------GSGDGDGE--FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDGEFLTT 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1477 LGSNDLTSARplscdsvmdisqvrLEWPTDLAINPmDNSLYVLDnnvvlqiSENHQVRIVAgrpmhcqvPGiDHFLL--- 1553
Cdd:cd05819 138 FGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVFD--------PD-GNFLTtfg 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1554 SKVAIHATLESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGAPSGcdckndancdcfsgddgyaKDAKLNT 1633
Cdd:cd05819 187 STGTGPGQFNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGFGGNGNFLG-------------------SDGQFNR 244
|
330 340
....*....|....*....|....*
gi 1622865605 1634 PSSLAVCADGELYVADLGNIRIRFI 1658
Cdd:cd05819 245 PSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1442-1726 |
7.74e-18 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 86.22 E-value: 7.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1442 LTNPRGITVDKFGLIYFVDGTM--IRRIDQNGIISTLLGSNDltsarplscdsvmdISQVRLEWPTDLAINPmDNSLYVL 1519
Cdd:cd05819 7 LNNPQGIAVDSSGNIYVADTGNnrIQVFDPDGNFITSFGSFG--------------SGDGQFNEPAGVAVDS-DGNLYVA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1520 D--NNVVLQISENHQVRIVAGRPmhcqvpGIDHFLLSkvaihatleSATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1597
Cdd:cd05819 72 DtgNHRIQKFDPDGNFLASFGGS------GDGDGEFN---------GPRGIAVDSSGNIYVADTGN---HRIQKFDPDGE 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1598 ISLVAGAPSGCDckndancdcfsgddgyakdAKLNTPSSLAVCADGELYVADLGNIRIRFIrknkpflntqnmyelsSPI 1677
Cdd:cd05819 134 FLTTFGSGGSGP-------------------GQFNGPTGVAVDSDGNIYVADTGNHRIQVF----------------DPD 178
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1622865605 1678 DQELYLFDTTGKHLYTQSLPTGDylynfTYTGDGDVtLITDNNGNMVNV 1726
Cdd:cd05819 179 GNFLTTFGSTGTGPGQFNYPTGI-----AVDSDGNI-YVADSGNNRVQV 221
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1314-1527 |
2.54e-14 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 76.80 E-value: 2.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1314 SCNGLADGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNilelrnkdfrhshspahkyylttdpmsgavflsd 1391
Cdd:cd14953 176 AGDGPATAAQFNNPTGVAVDAAGNLYVADRgnHRIRKITPDGVVTT---------------------------------- 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1392 tnsrrvfkikstvvvkdlvknsevVAGTGDQclPFddtrcGDGGKATEATLTNPRGITVDKFGLIYFVD---GTmIRRID 1468
Cdd:cd14953 222 ------------------------VAGTGTA--GF-----SGDGGATAAQLNNPTGVAVDAAGNLYVADsgnHR-IRKIT 269
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865605 1469 QNGIISTLLGSndlTSARPLSCDSVmdiSQVRLEWPTDLAINPmDNSLYVLD--NNVVLQI 1527
Cdd:cd14953 270 PAGVVTTVAGG---GAGFSGDGGPA---TSAQFNNPTGVAVDA-AGNLYVADtgNNRIRKI 323
|
|
| NHL |
cd05819 |
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ... |
1320-1589 |
2.52e-13 |
|
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.
Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 72.74 E-value: 2.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1320 DGNKLLAPVALTCGSDGSLYVGDF--NYIRRIFPSGNVTN---ILELRNKDFRHshsPahkYYLTTDPmSGAVFLSDTNS 1394
Cdd:cd05819 50 GDGQFNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLAsfgGSGDGDGEFNG---P---RGIAVDS-SGNIYVADTGN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1395 RRVFKIKStvvvkdlvkNSEVVAGTGdqclpfddtrcgdGGKATEATLTNPRGITVDKFGLIYFVDGT--MIRRIDQNGI 1472
Cdd:cd05819 123 HRIQKFDP---------DGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDGN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1473 ISTLLGSNDLTSArplscdsvmdisqvRLEWPTDLAINPMDNsLYVLD--NNVVLQISENHQVRIVAGrpmhcqvpgidh 1550
Cdd:cd05819 181 FLTTFGSTGTGPG--------------QFNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNG------------ 233
|
250 260 270
....*....|....*....|....*....|....*....
gi 1622865605 1551 fllSKVAIHATLESATALAVSHNGVLYIAETDEKKINRI 1589
Cdd:cd05819 234 ---NFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
2477-2556 |
4.16e-11 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 60.98 E-value: 4.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2477 YTAYGEIyMDTNPNFQIIIGYHGGLYDPLTKLVHMGRRDYDVLAGRWTSPDhelwqhlsssnimPF------NLYMFKNN 2550
Cdd:TIGR03696 1 YDPYGEV-LSESGAAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-------------PIglggglNLYAYVGN 66
|
....*.
gi 1622865605 2551 NPISNS 2556
Cdd:TIGR03696 67 NPVNWV 72
|
|
| acid_disulf_rpt |
NF033662 |
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ... |
928-958 |
2.29e-09 |
|
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.
Pssm-ID: 411265 [Multi-domain] Cd Length: 32 Bit Score: 54.83 E-value: 2.29e-09
10 20 30
....*....|....*....|....*....|.
gi 1622865605 928 SMETACGDSKDNDGDGLVDCMDPDCCLQPLC 958
Cdd:NF033662 2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
|
|
| NHL_PKND_like |
cd14952 |
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ... |
1384-1655 |
6.88e-09 |
|
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 59.14 E-value: 6.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1384 SGAVFLSDTNSRRVFKikstvvvkdlvknseVVAGTGDQC-LPFDDtrcgdggkateatLTNPRGITVDKFGLIYFVDGt 1462
Cdd:cd14952 20 AGNVYVADSGNNRVLK---------------LAAGSTTQTvLPFTG-------------LYQPQGVAVDAAGTVYVTDF- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1463 mirriDQNGIISTLLGSNDLTsarPLSCDSvmdisqvrLEWPTDLAINPMDNsLYVLD--NNVVLqisenhqvRIVAGRP 1540
Cdd:cd14952 71 -----GNNRVLKLAAGSTTQT---VLPFTG--------LNDPTGVAVDAAGN-VYVADtgNNRVL--------KLAAGSN 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1541 MHCQVPgidhFllskvaihATLESATALAVSHNGVLYIAETDEkkiNRIRQvttsgeisLVAGA------Psgcdcknda 1614
Cdd:cd14952 126 TQTVLP----F--------TGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAGSttqtvlP--------- 173
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1622865605 1615 ncdcFSGddgyakdakLNTPSSLAVCADGELYVADLGNIRI 1655
Cdd:cd14952 174 ----FTG---------LNSPSGVAVDTAGNVYVTDHGNNRV 201
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1327-1658 |
1.41e-08 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 58.49 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1327 PVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTnilELRNKDFRHSHSpahkyyLTTDPmSGAVFLSDTNSRRVFKI--K 1401
Cdd:COG4257 19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT---EYPLGGGSGPHG------IAVDP-DGNLWFTDNGNNRIGRIdpK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1402 STVVvkdlvknsEVVAGTGDQCLPFddtrcgdggkateatltnprGITVDKFGLIYFVDGT--MIRRID-QNGIISTLLG 1478
Cdd:COG4257 89 TGEI--------TTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1479 snDLTSARplscdsvmdisqvrlewPTDLAINPmDNSLYVLDNnvvlqisENHQVRIVAGRPMHcqvpgidhflLSKVAI 1558
Cdd:COG4257 141 --PTGGAG-----------------PYGIAVDP-DGNLWVTDF-------GANAIGRIDPDTGT----------LTEYAL 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1559 HATLESATALAVSHNGVLYIAETDEKKINRIRqvTTSGEISLVAGAPSGCDckndancdcfsgddgyakdaklntPSSLA 1638
Cdd:COG4257 184 PTPGAGPRGLAVDPDGNLWVADTGSGRIGRFD--PKTGTVTEYPLPGGGAR------------------------PYGVA 237
|
330 340
....*....|....*....|
gi 1622865605 1639 VCADGELYVADLGNIRIRFI 1658
Cdd:COG4257 238 VDGDGRVWFAESGANRIVRF 257
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
1975-2393 |
2.48e-08 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 60.02 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1975 LNGVNVTYSPGGhiAGIQRGIMSE-------RMEYDQAGRIISRIFADGKTWSYTYLEKS---MVLLLHSQRQYIFEFDK 2044
Cdd:NF041261 401 LNRREVLHTEGE--GGLKRVVKKEhadgsvtRSGYDAAGRLTAQTDAAGRRTEYSLNVVSgdiTDITTPDGRETKFYYND 478
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2045 NDRLSSVTMPNvarqTLETIRsvgyyrniyqppegnasviqDFTEDGHLLhtfylgtgrrviykygklsklAETLYDTTK 2124
Cdd:NF041261 479 GNQLTSVTSPD----GLESRR--------------------EYDEPGRLV---------------------SETSRSGET 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2125 VSFTYDETAGMLKTINLQNEGFTCTIRYRQIGplidrQIFRFTEEGMVNARFDYNydnsfRVTSMQAVINETPlpIDLYR 2204
Cdd:NF041261 514 TRYRYDDPHSELPATTTDATGSTKQMTWSRYG-----QLLAFTDCSGYQTRYEYD-----RFGQMTAVHREEG--ISTYR 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2205 -YDD----VSGKTEQfGKFGVIYY----DINQIITTAVMTHTKHFDAYGR-MKEVQYEIFRSLmywmtvQYDNMGRVVKK 2274
Cdd:NF041261 582 rYDNrgqlTSVKDAQ-GRETRYEYnaagDLTAVITPDGNRSETQYDAWGKaVSTTQGGLTRSM------EYDAAGRITTL 654
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2275 ELKvgpyaNTTRYSYEYDADGQLQTVSINDKPLWRYSYDLNGNlhLLSPGNSARLTPLRYDLRDRITRL---GDV--QYK 2349
Cdd:NF041261 655 TNE-----NGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGK--LTQSEDEGLVTLWHYDESDRITHRtvnGEPaeQWQ 727
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1622865605 2350 MDEDGFLRQrggdiFEYNSAGLLIkaynraggwSVRYRYDGLGR 2393
Cdd:NF041261 728 YDEHGWLTD-----ISHLSEGHRV---------AVHYGYDDKGR 757
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1444-1655 |
4.43e-07 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 54.21 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1444 NPRGITVDKFGLIYFVD--GTMIRRIDQNGIISTLLGSndlTSARPLScdsvmdisqvrLEWPTDLAINPmDNSLYVLDn 1521
Cdd:cd14956 108 APRGVAVDADGNLYVADfgNQRIQKFDPDGSFLRQWGG---TGIEPGS-----------FNYPRGVAVDP-DGTLYVAD- 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1522 nvvlqiSENHQVrivagrpmhcQVPGIDHFLLSKVAIHAT----LESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGE 1597
Cdd:cd14956 172 ------TYNDRI----------QVFDNDGAFLRKWGGRGTgpgqFNYPYGIAIDPDGNVFVADFGN---NRIQKFTADGT 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865605 1598 ISLVAGAPSGcdckndancdcfsgddgyaKDAKLNTPSSLAVCADGELYVADLGNIRI 1655
Cdd:cd14956 233 FLTSWGSPGT-------------------GPGQFKNPWGVVVDADGTVYVADSNNNRV 271
|
|
| RHS_core |
NF041261 |
RHS element core protein; |
2203-2539 |
4.33e-06 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 52.70 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2203 YRYDDVSGKTEQFGKFGVIY---YDINQIITTAVMT-----HT----------KHFDAYGRMKEVQYEIFRSLmywmTVQ 2264
Cdd:NF041261 367 YRYDDTGRVTEQLNPAGLSYryqYEQDRITITDSLNrrevlHTegegglkrvvKKEHADGSVTRSGYDAAGRL----TAQ 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2265 YDNMGRVVKKELKV---------GPYANTTRYSYeyDADGQLQTVSINDKPLWRYSYDLNGNLhLLSPGNSARLTPLRYD 2335
Cdd:NF041261 443 TDAAGRRTEYSLNVvsgditditTPDGRETKFYY--NDGNQLTSVTSPDGLESRREYDEPGRL-VSETSRSGETTRYRYD 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2336 lrDRITRLGDVqyKMDEDGFLRQrggdiFEYNSAGLLIkAYNRAGGWSVRYRYDGLGRRVSSKSSHSHHLqffYADLTNP 2415
Cdd:NF041261 520 --DPHSELPAT--TTDATGSTKQ-----MTWSRYGQLL-AFTDCSGYQTRYEYDRFGQMTAVHREEGIST---YRRYDNR 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 2416 TKVTHLYNHSSSEiTSLYYDLQGHLFAMELSSGDEFYIACDNIGTPLAVFSGtGLMiKQILYTAYGEIYMDTNPNfqiii 2495
Cdd:NF041261 587 GQLTSVKDAQGRE-TRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQG-GLT-RSMEYDAAGRITTLTNEN----- 658
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1622865605 2496 GYHGG-LYDPLTKLVHMG-------RRDYDvLAGRWTSPDHE----LWQHLSSSNI 2539
Cdd:NF041261 659 GSHSTfLYDALDRLVQQRgfdgrtqRYHYD-LTGKLTQSEDEglvtLWHYDESDRI 713
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1440-1658 |
6.19e-06 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 50.40 E-value: 6.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1440 ATLTNPRGITVDKFGLIYFVD--GTMIRRID-QNGIISTllgsndltsarplscdsvmdISQVRLEWPTDLAINPmDNSL 1516
Cdd:COG4257 14 APGSGPRDVAVDPDGAVWFTDqgGGRIGRLDpATGEFTE--------------------YPLGGGSGPHGIAVDP-DGNL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1517 YVLD--NNVVLQIS-ENHQVRIVAGrpmhcqvPGIDHFLlskvaihatlesaTALAVSHNGVLYIAETDekkINRIRQVT 1593
Cdd:COG4257 73 WFTDngNNRIGRIDpKTGEITTFAL-------PGGGSNP-------------HGIAFDPDGNLWFTDQG---GNRIGRLD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1594 T-SGEISLV-----AGAPSGCDCKND---------ANC-DCFSGDDG----YAKDAKLNTPSSLAVCADGELYVADLGNI 1653
Cdd:COG4257 130 PaTGEVTEFplptgGAGPYGIAVDPDgnlwvtdfgANAiGRIDPDTGtlteYALPTPGAGPRGLAVDPDGNLWVADTGSG 209
|
....*
gi 1622865605 1654 RIRFI 1658
Cdd:COG4257 210 RIGRF 214
|
|
| PLN02919 |
PLN02919 |
haloacid dehalogenase-like hydrolase family protein |
1362-1662 |
1.48e-05 |
|
haloacid dehalogenase-like hydrolase family protein
Pssm-ID: 215497 [Multi-domain] Cd Length: 1057 Bit Score: 51.01 E-value: 1.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1362 RNKDFRHSHSPAhKY--YLTTDPMSGAVFLSDTNSRRVfkikstvVVKDLVKNSEV-VAGTGDQCL---PFDDtrcgdgg 1435
Cdd:PLN02919 556 KDNDPRLLTSPL-KFpgKLAIDLLNNRLFISDSNHNRI-------VVTDLDGNFIVqIGSTGEEGLrdgSFED------- 620
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1436 kateATLTNPRGITVDKFGLIYFVDGT---MIRRID-QNGIISTLLGS----NDLTSARPLScdsvmdiSQVrLEWPTDL 1507
Cdd:PLN02919 621 ----ATFNRPQGLAYNAKKNLLYVADTenhALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDV 688
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1508 AINPMDNSLYV------------LDNNVVLQISENHQVRIVAGR----PMHCQVPGI------DHFLLSK---------- 1555
Cdd:PLN02919 689 CFEPVNEKVYIamagqhqiweynISDGVTRVFSGDGYERNLNGSsgtsTSFAQPSGIslspdlKELYIADsesssirald 768
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1556 ----------------------------VAIHATLESATALAVSHNGVLYIAETDEKKINRIRQVTtsGEISLVAGAPSG 1607
Cdd:PLN02919 769 lktggsrllaggdptfsdnlfkfgdhdgVGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTGKA 846
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1622865605 1608 cdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNK 1662
Cdd:PLN02919 847 ------------GFKDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
|
|
| DUF5885 |
pfam19232 |
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ... |
659-817 |
2.37e-05 |
|
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.
Pssm-ID: 437064 Cd Length: 265 Bit Score: 48.85 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 659 DNCPSNCYGNGDCISGTCH-----------------CFLGFLGPD---CGRASCpvlcsGNGQ----------YMKGRCL 708
Cdd:pfam19232 10 DDCTPPCGGTQVCIDRQCKdntlacttdaqcgtcmtCVAGACTPKascCGGVTC-----GAGQtcdaktntcvYVKGYCS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 709 C-HSGWKGAECDVPTNQCIDVACSNHGT---CIMG-----------------TCIC-NPG-YK-GESC-----------E 753
Cdd:pfam19232 85 AdHPCPSGSACDTAKNACIAQPPYGPDSgkgCVRGfgawiweldpatnsgvwRCRCaNGSlYNsAHECspladqtlcaaE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 754 EVD-----------------------CMDPTCSGRGVC--VRGECHCSVGWGGTNCETPRAtcldqCSGHGTFLPDTGLC 808
Cdd:pfam19232 165 NLDpnalvpassvpafaaygwgnqpvLINKSTAGAAVPspLAGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQC 239
|
....*....
gi 1622865605 809 SCDPSWTGH 817
Cdd:pfam19232 240 ACNIDFSGH 248
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1445-1678 |
3.09e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 48.42 E-value: 3.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1445 PRGITVDKFGLIYFVD--GTMIRRIDQNGIISTLLGSNDltsarplscdsvmdISQVRLEWPTDLAINPMDNsLYVLDnn 1522
Cdd:cd14957 20 PRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVAD-- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1523 vvlqiSENHQVRIvagrpmhcqvpgidhFLLSKVAIHA---------TLESATALAVSHNGVLYIAETDEkkiNRIrQVT 1593
Cdd:cd14957 83 -----TDNNRIQV---------------FNSSGVYQYSigtggsgdgQFNGPYGIAVDSNGNIYVADTGN---HRI-QVF 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1594 TSgeislvAGAPsgcdckndancdCFSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFIRKNKPFLNT-----Q 1668
Cdd:cd14957 139 TS------SGTF------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQYTfgssgS 200
|
250
....*....|
gi 1622865605 1669 NMYELSSPID 1678
Cdd:cd14957 201 GPGQFSDPYG 210
|
|
| NHL_like_3 |
cd14956 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1434-1655 |
4.23e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 48.05 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1434 GGKATEA-TLTNPRGITVDKFGLIYFVDGT--MIRRIDQNGIISTLLGSNdltSARPLSCDSvmdisqvrlewPTDLAIN 1510
Cdd:cd14956 50 GTTGDGPgQFGRPRGLAVDKDGWLYVADYWgdRIQVFTLTGELQTIGGSS---GSGPGQFNA-----------PRGVAVD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1511 PmDNSLYVLD--NNVVLQISENHQ-VRIVAGRPmhcQVPGidHFLlskvaihatleSATALAVSHNGVLYIAETdekKIN 1587
Cdd:cd14956 116 A-DGNLYVADfgNQRIQKFDPDGSfLRQWGGTG---IEPG--SFN-----------YPRGVAVDPDGTLYVADT---YND 175
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622865605 1588 RIRQVTTSGEISLVAGAPSGcdckndancdcFSGDdgyakdakLNTPSSLAVCADGELYVADLGNIRI 1655
Cdd:cd14956 176 RIQVFDNDGAFLRKWGGRGT-----------GPGQ--------FNYPYGIAIDPDGNVFVADFGNNRI 224
|
|
| DSL |
pfam01414 |
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ... |
841-884 |
4.60e-05 |
|
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.
Pssm-ID: 460202 Cd Length: 46 Bit Score: 43.00 E-value: 4.60e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1622865605 841 CEDGWMGAACDqRACHPRCAE--HGTC-RDGKCECSPGWNGEHCTIA 884
Cdd:pfam01414 1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
|
|
| NHL_like_2 |
cd14957 |
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ... |
1563-1722 |
4.91e-05 |
|
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271327 [Multi-domain] Cd Length: 280 Bit Score: 48.03 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1563 ESATALAVSHNGVLYIAETDEkkiNRIRQVTTSGEISLVAGapsgcdckndancdcfSGDDGyakDAKLNTPSSLAVCAD 1642
Cdd:cd14957 65 NSPYGIAVDSNGNIYVADTDN---NRIQVFNSSGVYQYSIG----------------TGGSG---DGQFNGPYGIAVDSN 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1643 GELYVADLGNIRIRFIRKNKPFLNT-----QNMYELSSP----IDQE--LYLFDTTGK--HLYTqslPTGDYLYNFTYTG 1709
Cdd:cd14957 123 GNIYVADTGNHRIQVFTSSGTFSYSigsggTGPGQFNGPqgiaVDSDgnIYVADTGNHriQVFT---SSGTFQYTFGSSG 199
|
170
....*....|....*....
gi 1622865605 1710 DGDVTLIT------DNNGN 1722
Cdd:cd14957 200 SGPGQFSDpygiavDSDGN 218
|
|
| NHL_like_1 |
cd14953 |
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ... |
1598-1658 |
7.78e-05 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271323 [Multi-domain] Cd Length: 323 Bit Score: 47.52 E-value: 7.78e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622865605 1598 ISLVAGAPSGcdckndancdcfSGDDGYAKDAKLNTPSSLAVCADGELYVADLGNIRIRFI 1658
Cdd:cd14953 1 VSTVAGSGTA------------GFSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKI 49
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1327-1468 |
8.18e-05 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 46.94 E-value: 8.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1327 PVALTCGSDGSLYVGDF--NYIRRIFPSGNVTNILELRNKDFRhshsPahkYYLTTDPmSGAVFLSDTNSRRVFKIkstv 1404
Cdd:COG4257 147 PYGIAVDPDGNLWVTDFgaNAIGRIDPDTGTLTEYALPTPGAG----P---RGLAVDP-DGNLWVADTGSGRIGRF---- 214
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622865605 1405 vvkdlvknsevvagtgdqclpfdDTRCGDGGK-ATEATLTNPRGITVDKFGLIYFVDGT--MIRRID 1468
Cdd:COG4257 215 -----------------------DPKTGTVTEyPLPGGGARPYGVAVDGDGRVWFAESGanRIVRFD 258
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
1771-1811 |
2.77e-04 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 40.65 E-value: 2.77e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1622865605 1771 HGNSGLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQVSSF 1811
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1569-1659 |
3.39e-04 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 45.65 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1569 AVSHNGVLYIAETdekKINRIRQV-TTSGEISLVAGapsgcdckndancdcfSGDDGYA-KDAKLNTPSSLAVCADGELY 1646
Cdd:cd14951 202 AALPDGSVYVADT---YNHKIKRVdPATGEVSTLAG----------------TGKAGYKdLEAQFSEPSGLVVDGDGRLY 262
|
90
....*....|...
gi 1622865605 1647 VADLGNIRIRFIR 1659
Cdd:cd14951 263 VADTNNHRIRRLD 275
|
|
| EGF_CA |
cd00054 |
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
730-753 |
5.53e-04 |
|
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.
Pssm-ID: 238011 Cd Length: 38 Bit Score: 39.54 E-value: 5.53e-04
10 20
....*....|....*....|....*...
gi 1622865605 730 CSNHGTCIMG----TCICNPGYKGESCE 753
Cdd:cd00054 11 CQNGGTCVNTvgsyRCSCPPGYTGRNCE 38
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
1775-1807 |
5.94e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.50 E-value: 5.94e-04
10 20 30
....*....|....*....|....*....|...
gi 1622865605 1775 GLLATKSNENGWTTFYEYDSFGRLTNVTFPTGQ 1807
Cdd:pfam05593 5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| NHL_like_5 |
cd14963 |
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ... |
1323-1581 |
6.08e-04 |
|
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.20 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1323 KLLAPVALTCGSDGSLYVGDFnYIRRI--F-PSGnvtnilelrnkDFRHSHspAHKYYLTTDPMSGAVFLSDTNSRrVFK 1399
Cdd:cd14963 54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDG-----------KFLKYF--PEKKDRVKLISPAGLAIDDGKLY-VSD 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1400 IK-STVVVKDLvknsevvagTGDQCLPFddtrcGDGGKAtEATLTNPRGITVDKFGLIYFVDgTMIRRI---DQNG-IIS 1474
Cdd:cd14963 119 VKkHKVIVFDL---------EGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVAD-SGNGRIqvfDKNGkFIK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1475 TLLGSNDLTSArplscdsvmdisqvrLEWPTDLAINPmDNSLYVLDN--NVVLQISENHQVRIVAGRpmhcqvPGIDhfl 1552
Cdd:cd14963 183 ELNGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD--- 237
|
250 260
....*....|....*....|....*....
gi 1622865605 1553 lskvaiHATLESATALAVSHNGVLYIAET 1581
Cdd:cd14963 238 ------DGQFNLPNGLFIDDDGRLYVTDR 260
|
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
729-752 |
9.53e-04 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 9.53e-04
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
859-881 |
3.84e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 3.84e-03
|
| NHL-2_like |
cd14951 |
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ... |
1435-1537 |
4.15e-03 |
|
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.
Pssm-ID: 271321 [Multi-domain] Cd Length: 334 Bit Score: 42.18 E-value: 4.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1435 GKATEATLTNPRGITVDKFGLIYFVDgTM---IRRID-QNGIISTLLGSNDLTSarplscdsvmDISQVRLEWPTDLAIN 1510
Cdd:cd14951 188 GPGAEALLQHPLGVAALPDGSVYVAD-TYnhkIKRVDpATGEVSTLAGTGKAGY----------KDLEAQFSEPSGLVVD 256
|
90 100
....*....|....*....|....*..
gi 1622865605 1511 PmDNSLYVLDNNvvlqiseNHQVRIVA 1537
Cdd:cd14951 257 G-DGRLYVADTN-------NHRIRRLD 275
|
|
| Vgb |
COG4257 |
Streptogramin lyase [Defense mechanisms]; |
1322-1400 |
4.29e-03 |
|
Streptogramin lyase [Defense mechanisms];
Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 41.93 E-value: 4.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622865605 1322 NKLLAPVALTCGSDGSLYVGDF--NYIRRIFP-SGNVTNilelrnkdFRHSHSPAHKYYLTTDPmSGAVFLSDTNSRRVF 1398
Cdd:COG4257 185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255
|
..
gi 1622865605 1399 KI 1400
Cdd:COG4257 256 RF 257
|
|
| EGF |
pfam00008 |
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ... |
730-750 |
5.75e-03 |
|
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Pssm-ID: 394967 Cd Length: 31 Bit Score: 36.59 E-value: 5.75e-03
|
| EGF_2 |
pfam07974 |
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins. |
795-819 |
6.40e-03 |
|
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.17 E-value: 6.40e-03
|
| |
