BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 196 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGIS 275
Cdd:cd18385     1 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGIS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622859927 276 IPELREACDYLCISFEYSTIKCRDLSALMH 305
Cdd:cd18385    81 IPELREACDYLCISFDYSTIKCRDLSALMH 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 196 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGIS 275
Cdd:cd18385     1 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGIS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622859927 276 IPELREACDYLCISFEYSTIKCRDLSALMH 305
Cdd:cd18385    81 IPELREACDYLCISFDYSTIKCRDLSALMH 110

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927  200 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHnftrpnEKGEYEVaEGIGSTVFRAILDYYKTGIIRCPDGiSIPEL 279
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKES------DKSEIYL-DDVSPEDFRALLNFLYTGKLDLPEE-NVEEL 73

                   ....*....
gi 1622859927  280 REACDYLCI 288
Cdd:smart00225  74 LELADYLQI 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 196 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGIS 275
Cdd:cd18385     1 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGIS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622859927 276 IPELREACDYLCISFEYSTIKCRDLSALMH 305
Cdd:cd18385    81 IPELREACDYLCISFDYSTIKCRDLSALMH 110

BTB/POZ domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 199 RVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPE 278
Cdd:pfam16017   1 RLTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSSMERNFTRPNEKGEYEIAEGISSTVFRAILDYYKTGVIRCPPSVSIPE 80

                          90       100
                  ....*....|....*....|....*.
gi 1622859927 279 LREACDYLCISFEYSTIKCRDLSALM 304
Cdd:pfam16017  81 LREACDYLLIPFDATTIKCQNLRALL 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 200 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREhnFTRPNEKGEYEVAEGigSTVFRAILDYYKTGIIRCPDGISIPEL 279
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGRE--FTFPNETGEYFIDRD--PTVFRTILNYYRTGKLNCPDGISIPDL 76

                  ....*..
gi 1622859927 280 REACDYL 286
Cdd:cd18187    77 REECDFY 83

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927  200 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHnftrpnEKGEYEVaEGIGSTVFRAILDYYKTGIIRCPDGiSIPEL 279
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKES------DKSEIYL-DDVSPEDFRALLNFLYTGKLDLPEE-NVEEL 73

                   ....*....
gi 1622859927  280 REACDYLCI 288
Cdd:smart00225  74 LELADYLQI 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana FH protein interacting protein FIP2 and similar proteins; FIP2 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 200 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFgSGREHnfTRPNEKGEYEV-AEGigsTVFRAILDYYKTGIIRCP--DGISI 276
Cdd:cd18376     1 VKLNVGGQKFTTTLDTLTKDPDSMLAAMF-SGRHS--LKKDEDGSYFIdRDG---THFRHILNYLRDGEVKIPteDRSVL 74

                          90
                  ....*....|..
gi 1622859927 277 PELREACDYLCI 288
Cdd:cd18376    75 KELLEEAEYYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622859927 214 SIFTAQPNTMLGRMFGSGREHNFTRpNEKGEYEV-AEGIgstVFRAILDYYKTGIIRCPDGisIPE----LREA 282
Cdd:cd18367    19 STLIKDPDSLLGRMFSGKNRQELAR-DSKGRYFLdRDGV---LFRYILDYLRNQKLVLPEN--FPErerlKREA 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622859927 207 TRFVVDPSIFTAQPNTMLGRMFGSGREHnftRPNEKGEYEV-AEGigsTVFRAILDYYKTGIIRCP-DGISIPELREACD 284
Cdd:cd18316     8 TLFTTSRSTLLKDPDSLLAALFSGRWPL---PRDEDGSIFIdRDP---ELFRHILNFLRTGKLPLPsDFVELEELLAEAE 81

                  ..
gi 1622859927 285 YL 286
Cdd:cd18316    82 FY 83