ELMO domain-containing protein 3 isoform X3 [Macaca mulatta]
Protein Classification
ELMO domain-containing protein( domain architecture ID 10520379)
ELMO domain-containing protein acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| ELMO_CED12 | pfam04727 | ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ... |
154-313 | 1.41e-39 | ||||
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment. : Pssm-ID: 461411 Cd Length: 161 Bit Score: 138.12 E-value: 1.41e-39
|
||||||||
| Name | Accession | Description | Interval | E-value | ||||
| ELMO_CED12 | pfam04727 | ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ... |
154-313 | 1.41e-39 | ||||
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment. Pssm-ID: 461411 Cd Length: 161 Bit Score: 138.12 E-value: 1.41e-39
|
||||||||
| Name | Accession | Description | Interval | E-value | ||||
| ELMO_CED12 | pfam04727 | ELMO/CED-12 family; This family represents a conserved domain which is found in a number of ... |
154-313 | 1.41e-39 | ||||
ELMO/CED-12 family; This family represents a conserved domain which is found in a number of eukaryotic proteins including CED-12, ELMO I and ELMO II. ELMO1 is a component of signalling pathways that regulate phagocytosis and cell migration and is the mammalian orthologue of the C. elegans gene, ced-12. CED-12 is required for the engulfment of dying cells and cell migration. In mammalian cells, ELMO1 interacts with Dock180 as part of the CrkII/Dock180/Rac pathway responsible for phagocytosis and cell migration. ELMO1 is ubiquitously expressed, although its expression is highest in the spleen, an organ rich in immune cells. ELMO1 has a PH domain and a polyproline sequence motif at its C terminus which are not present in this alignment. Pssm-ID: 461411 Cd Length: 161 Bit Score: 138.12 E-value: 1.41e-39
|
||||||||
| Blast search parameters | ||||
|
