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Conserved domains on  [gi|1622855128|ref|XP_028687511|]
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echinoderm microtubule-associated protein-like 6 isoform X3 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
57-397 1.01e-39

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.53  E-value: 1.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKDvHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GTVRLWD 190
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPyqpnrvvscgvkhikfwtlcgnaltakrgifgktgDLQTILclacakeditySGAL 216
Cdd:COG2319    191 LATGKLLRTLTGHTGAVRSVAFSP-----------------------------------DGKLLA-----------SGSA 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  217 NGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWK 292
Cdd:COG2319    225 DGTVRLWdlATGKLLRTLTG-HSGSVRSVAFSPDGrlLASGSADGTVRLWDLATG-----ELLRTLTGHSG-GVNSVAFS 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  293 AD--RLLAGTQDSEI--FEVivrERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EE 367
Cdd:COG2319    298 PDgkLLASGSDDGTVrlWDL---ATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTG 373
                          330       340       350
                   ....*....|....*....|....*....|
gi 1622855128  368 AVRSVAFSPDGSQLALGMKDGSFIVLRVRD 397
Cdd:COG2319    374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
725-1026 3.05e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 137.08  E-value: 3.05e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  725 GHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWK 804
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  805 KGEKIATTRGHKDKIFVVKCNPHHvdKLVTVGIKH--IKFWQQAGGGFTSkrgTFGsiGKLETMMCVSYGRMEDLVFSGA 882
Cdd:cd00200     82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVETGKCLT---TLR--GHTDWVNSVAFSPDGTFVASSS 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  883 ATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRS---ALSTSSKGLLL 955
Cdd:cd00200    155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYLL 234
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622855128  956 ednpsiraitlghghiLVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWE 1026
Cdd:cd00200    235 ----------------ASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
1471-1956 4.30e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 4.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1471 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSl 1550
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1551 gaakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1627
Cdd:COG2319     80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1628 WDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASN 1707
Cdd:COG2319    147 WD----------LATGKLLR---------------------------------TLTGH-SGAVTSVAFSPDGKLLASGSD 182
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1708 DGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1785
Cdd:COG2319    183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1786 AVGSSEHTVDFYDLTQGTNLNRIGyckDIPSFVIQMDFSADGKYIqVSTGAYKR-QVHEVPLGKQvteamviekitwasw 1864
Cdd:COG2319    262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKL--------------- 322
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1865 tsvlgdevigIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVS 1944
Cdd:COG2319    323 ----------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
                          490
                   ....*....|..
gi 1622855128 1945 tGGDDCSVFVWR 1956
Cdd:COG2319    390 -GSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
880-1266 3.15e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 3.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  880 SGAATGDIFIWKDILLLKTVKAHDGPVF--AMYALDKGFVTGGKDGIVELWDdmferclktyaikrsALSTSSKGLLLED 957
Cdd:COG2319     55 AGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWD---------------LATGLLLRTLTGH 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  958 NPSIRAITLGH-GHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHP---LLpicATVSDDKTLRIWELSAQH 1031
Cdd:COG2319    120 TGAVRSVAFSPdGKTLAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGK 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1032 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYN 1111
Cdd:COG2319    196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWD 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1112 VLTSKRVGICKGASSYITHIDWDSRGKLLqvnsgakeqlffeAPRGKRHIIRpseiekiQWDTWTcvlgPTCEGIWPAHS 1191
Cdd:COG2319    275 LATGELLRTLTGHSGGVNSVAFSPDGKLL-------------ASGSDDGTVR-------LWDLAT----GKLLRTLTGHT 330
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622855128 1192 DitDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKkyvGHSAHVANVRWLHNDSVLLTvGGADTALMIW 1266
Cdd:COG2319    331 G--AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
2-48 5.47e-20

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 85.68  E-value: 5.47e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622855128    2 ADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYN 48
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
668-715 5.68e-20

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 85.68  E-value: 5.68e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622855128  668 KREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNR 715
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
521-826 3.15e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 3.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  521 INSVDANYSSSVLVSGDDFGLVKLFRfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWRFipegvsn 600
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWD---LETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWDL------- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  601 gmletapqEGGTDSYS-EESDSDLSDVpeldsDIEQETQI----NYDRQVYKEDLPQLKQQSKEKNHvvpflkrekapED 675
Cdd:cd00200     81 --------ETGECVRTlTGHTSYVSSV-----AFSPDGRIlsssSRDKTIKVWDVETGKCLTTLRGH-----------TD 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  676 SLklqfihgyrgydcrNNLFYTQAGEVVYHIAA--VAVVYN-RQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAA 752
Cdd:cd00200    137 WV--------------NSVAFSPDGTFVASSSQdgTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGT 200
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622855128  753 IHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNP 826
Cdd:cd00200    201 IKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
HELP super family cl04081
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
1350-1401 7.88e-13

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


The actual alignment was detected with superfamily member pfam03451:

Pssm-ID: 460922  Cd Length: 72  Bit Score: 65.27  E-value: 7.88e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622855128 1350 KNNITKKKKLVEE-LALDHVFGYRGFDCRNNLHYLNDGtDIIFHTAAAGIVQN 1401
Cdd:pfam03451   20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
COG4946 super family cl27624
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
368-466 6.41e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


The actual alignment was detected with superfamily member COG4946:

Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 48.11  E-value: 6.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  368 AVRSVAFSPDGSQLA-LGMKDGSF-IVLR--VRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA-QRYK 442
Cdd:COG4946    344 RERLPAWSPDGKSIAyFSDASGEYeLYIApaDGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLAsGKVR 423
                           90       100
                   ....*....|....*....|....
gi 1622855128  443 KIGEcSKSLSFITHIDWSLDSKYL 466
Cdd:COG4946    424 KVDT-DGYGDGISDLAWSPDSKWL 446
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
57-397 1.01e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.53  E-value: 1.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKDvHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GTVRLWD 190
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPyqpnrvvscgvkhikfwtlcgnaltakrgifgktgDLQTILclacakeditySGAL 216
Cdd:COG2319    191 LATGKLLRTLTGHTGAVRSVAFSP-----------------------------------DGKLLA-----------SGSA 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  217 NGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWK 292
Cdd:COG2319    225 DGTVRLWdlATGKLLRTLTG-HSGSVRSVAFSPDGrlLASGSADGTVRLWDLATG-----ELLRTLTGHSG-GVNSVAFS 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  293 AD--RLLAGTQDSEI--FEVivrERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EE 367
Cdd:COG2319    298 PDgkLLASGSDDGTVrlWDL---ATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTG 373
                          330       340       350
                   ....*....|....*....|....*....|
gi 1622855128  368 AVRSVAFSPDGSQLALGMKDGSFIVLRVRD 397
Cdd:COG2319    374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
57-353 1.62e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 1.62e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKdVHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:cd00200      5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPYqpNRVVSCGVKH--IKFWTL-CGNALTAKRGIFGktgdlqTILCLA-CAKEDITY 212
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD------WVNSVAfSPDGTFVA 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  213 SGALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIdLRETEQGykglsIRS 288
Cdd:cd00200    152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGT-LRGHENG-----VNS 224
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622855128  289 VCWKADRLL--AGTQDS--EIFEVivrERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 353
Cdd:cd00200    225 VAFSPDGYLlaSGSEDGtiRVWDL---RTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
725-1026 3.05e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.08  E-value: 3.05e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  725 GHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWK 804
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  805 KGEKIATTRGHKDKIFVVKCNPHHvdKLVTVGIKH--IKFWQQAGGGFTSkrgTFGsiGKLETMMCVSYGRMEDLVFSGA 882
Cdd:cd00200     82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVETGKCLT---TLR--GHTDWVNSVAFSPDGTFVASSS 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  883 ATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRS---ALSTSSKGLLL 955
Cdd:cd00200    155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYLL 234
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622855128  956 ednpsiraitlghghiLVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWE 1026
Cdd:cd00200    235 ----------------ASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
708-1140 5.68e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 5.68e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  708 AVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCL 787
Cdd:COG2319     59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTL 135
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  788 VSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPhhvD--KLVTVGI-KHIKFWQqagggftskrgtfgsigkle 864
Cdd:COG2319    136 ASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWD-------------------- 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  865 tmmcvsygrmedlvfsgAATGDifiwkdilLLKTVKAHDGPVFAM-YALD-KGFVTGGKDGIVELWDdmferclktyaik 942
Cdd:COG2319    191 -----------------LATGK--------LLRTLTGHTGAVRSVaFSPDgKLLASGSADGTVRLWD------------- 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  943 rsalstsskglllednpsiraitlghghilvgTKNGEILeidksgpmtLLVQGHmEGEVWGLAAHP---LLpicATVSDD 1019
Cdd:COG2319    233 --------------------------------LATGKLL---------RTLTGH-SGSVRSVAFSPdgrLL---ASGSAD 267
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1020 KTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLA 1099
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLA 346
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1622855128 1100 VASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1140
Cdd:COG2319    347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
1471-1956 4.30e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 4.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1471 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSl 1550
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1551 gaakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1627
Cdd:COG2319     80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1628 WDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASN 1707
Cdd:COG2319    147 WD----------LATGKLLR---------------------------------TLTGH-SGAVTSVAFSPDGKLLASGSD 182
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1708 DGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1785
Cdd:COG2319    183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1786 AVGSSEHTVDFYDLTQGTNLNRIGyckDIPSFVIQMDFSADGKYIqVSTGAYKR-QVHEVPLGKQvteamviekitwasw 1864
Cdd:COG2319    262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKL--------------- 322
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1865 tsvlgdevigIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVS 1944
Cdd:COG2319    323 ----------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
                          490
                   ....*....|..
gi 1622855128 1945 tGGDDCSVFVWR 1956
Cdd:COG2319    390 -GSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
880-1266 3.15e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 3.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  880 SGAATGDIFIWKDILLLKTVKAHDGPVF--AMYALDKGFVTGGKDGIVELWDdmferclktyaikrsALSTSSKGLLLED 957
Cdd:COG2319     55 AGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWD---------------LATGLLLRTLTGH 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  958 NPSIRAITLGH-GHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHP---LLpicATVSDDKTLRIWELSAQH 1031
Cdd:COG2319    120 TGAVRSVAFSPdGKTLAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGK 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1032 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYN 1111
Cdd:COG2319    196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWD 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1112 VLTSKRVGICKGASSYITHIDWDSRGKLLqvnsgakeqlffeAPRGKRHIIRpseiekiQWDTWTcvlgPTCEGIWPAHS 1191
Cdd:COG2319    275 LATGELLRTLTGHSGGVNSVAFSPDGKLL-------------ASGSDDGTVR-------LWDLAT----GKLLRTLTGHT 330
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622855128 1192 DitDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKkyvGHSAHVANVRWLHNDSVLLTvGGADTALMIW 1266
Cdd:COG2319    331 G--AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1413-1763 1.21e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 1.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1413 HTDDILCLTVNQHPKYrnVVATSQIGTtpsIHVWDamtKHTLSMLRCF--HSKGVNYVNFSATGKLLVSVGVDpeHTITV 1490
Cdd:cd00200      8 HTGGVTCVAFSPDGKL--LATGSGDGT---IKVWD---LETGELLRTLkgHTGPVRDVAASADGTYLASGSSD--KTIRL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1491 WRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAgsallykKGVIGSLGAAKMQTMLSVAF-GANNLT 1569
Cdd:cd00200     78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTDWVNSVAFsPDGTFV 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1570 FTGAINGDVYVW--KDHFLIRlVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRCRAfqletgqlve 1647
Cdd:cd00200    151 ASSSQDGTIKLWdlRTGKCVA-TLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLG---------- 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1648 cvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSl 1727
Cdd:cd00200    214 ---------------------------------TLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS- 258
                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1622855128 1728 GHAAR--CAAYSPDGEMVAIGMKNgefvillvNSLKVW 1763
Cdd:cd00200    259 GHTNSvtSLAWSPDGKRLASGSAD--------GTIRIW 288
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
2-48 5.47e-20

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 85.68  E-value: 5.47e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622855128    2 ADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYN 48
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
668-715 5.68e-20

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 85.68  E-value: 5.68e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622855128  668 KREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNR 715
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
895-1221 1.53e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 1.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  895 LLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD---DMFERCLKTYAIKRSALSTSSKGLLL----EDNpSIRait 965
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYLasgsSDK-TIR--- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  966 lghghiLVGTKNGEILEIdksgpmtllVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRC 1045
Cdd:cd00200     77 ------LWDLETGECVRT---------LTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1046 CAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYNVLTSKRVGICKGAS 1125
Cdd:cd00200    141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1126 SYITHIDWDSRGKLLQvnSGAKEQlffeaprgkrhIIRpseiekiQWDTWTCVLGPTCEGiwpaHSdiTDVNAASLTKDC 1205
Cdd:cd00200    220 NGVNSVAFSPDGYLLA--SGSEDG-----------TIR-------VWDLRTGECVQTLSG----HT--NSVTSLAWSPDG 273
                          330
                   ....*....|....*.
gi 1622855128 1206 SLLATGDDFGFVKLFS 1221
Cdd:cd00200    274 KRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
521-826 3.15e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 3.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  521 INSVDANYSSSVLVSGDDFGLVKLFRfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWRFipegvsn 600
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWD---LETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWDL------- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  601 gmletapqEGGTDSYS-EESDSDLSDVpeldsDIEQETQI----NYDRQVYKEDLPQLKQQSKEKNHvvpflkrekapED 675
Cdd:cd00200     81 --------ETGECVRTlTGHTSYVSSV-----AFSPDGRIlsssSRDKTIKVWDVETGKCLTTLRGH-----------TD 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  676 SLklqfihgyrgydcrNNLFYTQAGEVVYHIAA--VAVVYN-RQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAA 752
Cdd:cd00200    137 WV--------------NSVAFSPDGTFVASSSQdgTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGT 200
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622855128  753 IHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNP 826
Cdd:cd00200    201 IKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
1350-1401 7.88e-13

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 65.27  E-value: 7.88e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622855128 1350 KNNITKKKKLVEE-LALDHVFGYRGFDCRNNLHYLNDGtDIIFHTAAAGIVQN 1401
Cdd:pfam03451   20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
368-466 6.41e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 48.11  E-value: 6.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  368 AVRSVAFSPDGSQLA-LGMKDGSF-IVLR--VRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA-QRYK 442
Cdd:COG4946    344 RERLPAWSPDGKSIAyFSDASGEYeLYIApaDGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLAsGKVR 423
                           90       100
                   ....*....|....*....|....
gi 1622855128  443 KIGEcSKSLSFITHIDWSLDSKYL 466
Cdd:COG4946    424 KVDT-DGYGDGISDLAWSPDSKWL 446
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
1682-1715 2.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1622855128  1682 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1715
Cdd:smart00320    8 LKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
105-136 3.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.68e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1622855128   105 HTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1682-1715 4.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 4.50e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622855128 1682 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1715
Cdd:pfam00400    7 LEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
315-353 8.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 8.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622855128  315 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 353
Cdd:pfam00400    2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
760-802 1.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.36e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1622855128   760 TLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWD 802
Cdd:smart00320    1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
57-397 1.01e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.53  E-value: 1.01e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKDvHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGT--VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GTVRLWD 190
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPyqpnrvvscgvkhikfwtlcgnaltakrgifgktgDLQTILclacakeditySGAL 216
Cdd:COG2319    191 LATGKLLRTLTGHTGAVRSVAFSP-----------------------------------DGKLLA-----------SGSA 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  217 NGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWK 292
Cdd:COG2319    225 DGTVRLWdlATGKLLRTLTG-HSGSVRSVAFSPDGrlLASGSADGTVRLWDLATG-----ELLRTLTGHSG-GVNSVAFS 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  293 AD--RLLAGTQDSEI--FEVivrERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EE 367
Cdd:COG2319    298 PDgkLLASGSDDGTVrlWDL---ATGKLLRTLTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTG 373
                          330       340       350
                   ....*....|....*....|....*....|
gi 1622855128  368 AVRSVAFSPDGSQLALGMKDGSFIVLRVRD 397
Cdd:COG2319    374 AVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
57-466 2.68e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 2.68e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKDvHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:COG2319     74 LLGHTAAVLSVAFSPDGRLLASASADGT--VRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPyqpnrvvscgvkhikfwtlcgnaltakrgifgkTGDLqtilcLAcakeditySGAL 216
Cdd:COG2319    149 LATGKLLRTLTGHSGAVTSVAFSP---------------------------------DGKL-----LA--------SGSD 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  217 NGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDfkpitkidlreteqgykglsirsvcwk 292
Cdd:COG2319    183 DGTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLA--------------------------- 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  293 adrllagtqdseifevivreRDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEE-AVRS 371
Cdd:COG2319    235 --------------------TGKLLRTLTGH-SGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSgGVNS 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  372 VAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQrykkiGECSKSL 451
Cdd:COG2319    294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT-----GELLRTL 368
                          410
                   ....*....|....*....
gi 1622855128  452 ----SFITHIDWSLDSKYL 466
Cdd:COG2319    369 tghtGAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
57-438 5.24e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 5.24e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKDvHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:COG2319     32 LLGLAAAVASLAASPDGARLAAGAGDLT--LLLLDAAAGALLATLLG-HTAAVLSVAFSPDGRLLASASAD--GTVRLWD 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPyQPNRVVSCGV-KHIKFWtlcgNALTAKRgIFGKTGDLQTILCLAC-AKEDITYSG 214
Cdd:COG2319    107 LATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSAdGTVRLW----DLATGKL-LRTLTGHSGAVTSVAFsPDGKLLASG 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  215 ALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDfkpiTKiDLRETEQGYKGlSIRSVC 290
Cdd:COG2319    181 SDDGTVRLWdlATGKLLRTLTG-HTGAVRSVAFSPDGklLASGSADGTVRLWDLA----TG-KLLRTLTGHSG-SVRSVA 253
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  291 WKAD--RLLAGTQDSEIfEVIVRERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNMEEA 368
Cdd:COG2319    254 FSPDgrLLASGSADGTV-RLWDLATGELLRTLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG 331
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622855128  369 -VRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA 438
Cdd:COG2319    332 aVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
57-353 1.62e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.85  E-value: 1.62e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   57 FLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKdVHTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:cd00200      5 LKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLK-GHTGPVRDVAASADGTYLASGSSD--KTIRLWD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  137 WRKGKLLASATGHSDRIFDISWDPYqpNRVVSCGVKH--IKFWTL-CGNALTAKRGIFGktgdlqTILCLA-CAKEDITY 212
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPD--GRILSSSSRDktIKVWDVeTGKCLTTLRGHTD------WVNSVAfSPDGTFVA 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  213 SGALNGDIYVW--KGLNLVRTIQGaHSAGIFSMYACEEG--FATGGRDGCIRLWDTDFKPITKIdLRETEQGykglsIRS 288
Cdd:cd00200    152 SSSQDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGT-LRGHENG-----VNS 224
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622855128  289 VCWKADRLL--AGTQDS--EIFEVivrERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 353
Cdd:cd00200    225 VAFSPDGYLlaSGSEDGtiRVWDL---RTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
725-1026 3.05e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.08  E-value: 3.05e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  725 GHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWK 804
Cdd:cd00200      7 GHTGGVTCVAFSPDGKLLATG--SGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSD--KTIRLWDLE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  805 KGEKIATTRGHKDKIFVVKCNPHHvdKLVTVGIKH--IKFWQQAGGGFTSkrgTFGsiGKLETMMCVSYGRMEDLVFSGA 882
Cdd:cd00200     82 TGECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDktIKVWDVETGKCLT---TLR--GHTDWVNSVAFSPDGTFVASSS 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  883 ATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWDDMFERCLKTYAIKRS---ALSTSSKGLLL 955
Cdd:cd00200    155 QDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENgvnSVAFSPDGYLL 234
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622855128  956 ednpsiraitlghghiLVGTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWE 1026
Cdd:cd00200    235 ----------------ASGSEDGTIRVWDlRTGECVQTLSGH-TNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
708-1140 5.68e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.58  E-value: 5.68e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  708 AVAVVYNRQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCL 787
Cdd:COG2319     59 TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA--SADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTL 135
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  788 VSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPhhvD--KLVTVGI-KHIKFWQqagggftskrgtfgsigkle 864
Cdd:COG2319    136 ASGSAD--GTVRLWDLATGKLLRTLTGHSGAVTSVAFSP---DgkLLASGSDdGTVRLWD-------------------- 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  865 tmmcvsygrmedlvfsgAATGDifiwkdilLLKTVKAHDGPVFAM-YALD-KGFVTGGKDGIVELWDdmferclktyaik 942
Cdd:COG2319    191 -----------------LATGK--------LLRTLTGHTGAVRSVaFSPDgKLLASGSADGTVRLWD------------- 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  943 rsalstsskglllednpsiraitlghghilvgTKNGEILeidksgpmtLLVQGHmEGEVWGLAAHP---LLpicATVSDD 1019
Cdd:COG2319    233 --------------------------------LATGKLL---------RTLTGH-SGSVRSVAFSPdgrLL---ASGSAD 267
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1020 KTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLA 1099
Cdd:COG2319    268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLA 346
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1622855128 1100 VASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL 1140
Cdd:COG2319    347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
1471-1956 4.30e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.19  E-value: 4.30e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1471 SATGKLLVSVGVDPEHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSl 1550
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1551 gaakmqTMLSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKL 1627
Cdd:COG2319     80 ------AVLSVAFSPDGRLLaSASADGTVRLWDlATGLLLRTLTGHTGAVRSV-AFSPDGkTLASGS------ADGTVRL 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1628 WDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASN 1707
Cdd:COG2319    147 WD----------LATGKLLR---------------------------------TLTGH-SGAVTSVAFSPDGKLLASGSD 182
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1708 DGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFL 1785
Cdd:COG2319    183 DGTVRLWDLATGKLLRTLT-GHTGavRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLL 261
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1786 AVGSSEHTVDFYDLTQGTNLNRIGyckDIPSFVIQMDFSADGKYIqVSTGAYKR-QVHEVPLGKQvteamviekitwasw 1864
Cdd:COG2319    262 ASGSADGTVRLWDLATGELLRTLT---GHSGGVNSVAFSPDGKLL-ASGSDDGTvRLWDLATGKL--------------- 322
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1865 tsvlgdevigIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDfpcTEKFAKHKRYFGHSAHVTNIRFSYDDKYVVS 1944
Cdd:COG2319    323 ----------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD---LATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389
                          490
                   ....*....|..
gi 1622855128 1945 tGGDDCSVFVWR 1956
Cdd:COG2319    390 -GSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
1420-1800 1.76e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 1.76e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1420 LTVNQHPKYRNVVATSQIGTT-------PSIHVWDAMTKHTLSMLRcFHSKGVNYVNFSATGKLLVSVGVDpeHTITVWR 1492
Cdd:COG2319     72 ATLLGHTAAVLSVAFSPDGRLlasasadGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDGKTLASGSAD--GTVRLWD 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1493 WQEGAKVASRGGHLERIFVVEFRPDSdTQFVSVGV-KHMKFWTLAGSALLYKkgVIGSLGAAkmqtmLSVAFGANNLTF- 1570
Cdd:COG2319    149 LATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDdGTVRLWDLATGKLLRT--LTGHTGAV-----RSVAFSPDGKLLa 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1571 TGAINGDVYVW--KDHFLIRLVaKAHTGPVFTMyTTLRDG-LIVTGGkerptkEGGAVKLWDqemkrcrafqLETGQLVE 1647
Cdd:COG2319    221 SGSADGTVRLWdlATGKLLRTL-TGHSGSVRSV-AFSPDGrLLASGS------ADGTVRLWD----------LATGELLR 282
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1648 cvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSl 1727
Cdd:COG2319    283 ---------------------------------TLTGH-SGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT- 327
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622855128 1728 GHAA--RCAAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT 1800
Cdd:COG2319    328 GHTGavRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
718-1071 4.89e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.02  E-value: 4.89e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  718 HSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHS 797
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAFSPDGKTLASG--SADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLASGSDD--GT 185
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  798 IVFWDWKKGEKIATTRGHKDKIFVVKCNPHHvDKLVTVGI-KHIKFWQQAGGGFtskRGTFGsiGKLETMMCVSY---GR 873
Cdd:COG2319    186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSAdGTVRLWDLATGKL---LRTLT--GHSGSVRSVAFspdGR 259
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  874 medLVFSGAATGDIFIW--KDILLLKTVKAHDGPVFAM-YALD-KGFVTGGKDGIVELWDdmferclktyaikrsalsts 949
Cdd:COG2319    260 ---LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVaFSPDgKLLASGSDDGTVRLWD-------------------- 316
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  950 skglllednpsiraitlghghilvgTKNGEILEIdksgpmtllVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWELSA 1029
Cdd:COG2319    317 -------------------------LATGKLLRT---------LTGH-TGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1622855128 1030 QHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADT 1071
Cdd:COG2319    362 GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
274-844 1.03e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 1.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  274 LRETEQGYKGLSIRSVCWKADRLLAGTQDSEIFEVIVRERDKPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 353
Cdd:COG2319     28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTVRLWD 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  354 LADHALIARCNM-EEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPV 432
Cdd:COG2319    107 LATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  433 DVYAVAQrykkiGECSKSL----SFITHIDWSLDSKYLqtndgagerlfykmpsgksltskeeikgipwaswtcvkgpev 508
Cdd:COG2319    187 RLWDLAT-----GKLLRTLtghtGAVRSVAFSPDGKLL------------------------------------------ 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  509 sgiwpkytevtdinsvdanysssvlVSGDDFGLVKLFRfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSV 588
Cdd:COG2319    220 -------------------------ASGSADGTVRLWD---LATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-GSADGTV 270
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  589 FQWRfipegvsngmletapqeggtdsyseesdsdlsdvpeldsdieqetqinydrqvykedlpqlkqqskeknhvvpflk 668
Cdd:COG2319    271 RLWD---------------------------------------------------------------------------- 274
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  669 rekapedslklqfihgyrgydcrnnlfyTQAGEVVyhiaavavvynrqqhsqRLYLGHDDDILSLTIHPVKDYVATGqvG 748
Cdd:COG2319    275 ----------------------------LATGELL-----------------RTLTGHSGGVNSVAFSPDGKLLASG--S 307
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  749 RDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHH 828
Cdd:COG2319    308 DDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDD--GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDG 384
                          570
                   ....*....|....*..
gi 1622855128  829 vDKLVTVGI-KHIKFWQ 844
Cdd:COG2319    385 -RTLASGSAdGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
880-1266 3.15e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 3.15e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  880 SGAATGDIFIWKDILLLKTVKAHDGPVF--AMYALDKGFVTGGKDGIVELWDdmferclktyaikrsALSTSSKGLLLED 957
Cdd:COG2319     55 AGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWD---------------LATGLLLRTLTGH 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  958 NPSIRAITLGH-GHILV-GTKNGEILEID-KSGPMTLLVQGHmEGEVWGLAAHP---LLpicATVSDDKTLRIWELSAQH 1031
Cdd:COG2319    120 TGAVRSVAFSPdGKTLAsGSADGTVRLWDlATGKLLRTLTGH-SGAVTSVAFSPdgkLL---ASGSDDGTVRLWDLATGK 195
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1032 RMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYN 1111
Cdd:COG2319    196 LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWD 274
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1112 VLTSKRVGICKGASSYITHIDWDSRGKLLqvnsgakeqlffeAPRGKRHIIRpseiekiQWDTWTcvlgPTCEGIWPAHS 1191
Cdd:COG2319    275 LATGELLRTLTGHSGGVNSVAFSPDGKLL-------------ASGSDDGTVR-------LWDLAT----GKLLRTLTGHT 330
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622855128 1192 DitDVNAASLTKDCSLLATGDDFGFVKLFSYPVKGQHARFKkyvGHSAHVANVRWLHNDSVLLTvGGADTALMIW 1266
Cdd:COG2319    331 G--AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLAS-GSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
943-1266 1.45e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.46  E-value: 1.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  943 RSALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHmEGEVWGLAAHPLLPICATVSDDKTL 1022
Cdd:COG2319     24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH-TAAVLSVAFSPDGRLLASASADGTV 102
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1023 RIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVAS 1102
Cdd:COG2319    103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-GKLLASGS 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1103 HDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAKEqlffeaprgkrhiIRpseiekiQWDtwtcVLGPT 1182
Cdd:COG2319    182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-------------VR-------LWD----LATGK 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1183 CEGIWPAHSDitDVNAASLTKDCSLLATGDDFGFVKLFSyPVKGQHARFKKyvGHSAHVANVRWLHNDSVLLTvGGADTA 1262
Cdd:COG2319    238 LLRTLTGHSG--SVRSVAFSPDGRLLASGSADGTVRLWD-LATGELLRTLT--GHSGGVNSVAFSPDGKLLAS-GSDDGT 311

                   ....
gi 1622855128 1263 LMIW 1266
Cdd:COG2319    312 VRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
1401-1718 4.64e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 4.64e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1401 NLSTGSQSFYLE-HTDDILCLTVnqHPKYRNVVATSQIGTtpsIHVWDAMTKHTLSMLRCfHSKGVNYVNFSATGKLLVS 1479
Cdd:COG2319    106 DLATGLLLRTLTgHTGAVRSVAF--SPDGKTLASGSADGT---VRLWDLATGKLLRTLTG-HSGAVTSVAFSPDGKLLAS 179
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1480 VGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTqFVSVGV-KHMKFWTLAGSALLYKKGviGSLGAAkmqtm 1558
Cdd:COG2319    180 GSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKL-LASGSAdGTVRLWDLATGKLLRTLT--GHSGSV----- 249
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1559 LSVAFGANNLTF-TGAINGDVYVWK-DHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDqemkrcr 1636
Cdd:COG2319    250 RSVAFSPDGRLLaSGSADGTVRLWDlATGELLRTLTGHSGGVNSVAFSPDGKLLASGS------DDGTVRLWD------- 316
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1637 afqLETGQLV-------ECVRSVC-RGKGKILV-GTKDGEI----IEVGEKNAAsnilIDGHmEGEIWGLATHPSKDLFI 1703
Cdd:COG2319    317 ---LATGKLLrtltghtGAVRSVAfSPDGKTLAsGSDDGTVrlwdLATGELLRT----LTGH-TGAVTSVAFSPDGRTLA 388
                          330
                   ....*....|....*
gi 1622855128 1704 SASNDGTARIWDLAD 1718
Cdd:COG2319    389 SGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
723-929 9.62e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 9.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  723 YLGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWD 802
Cdd:cd00200     89 LTGHTSYVSSVAFSPDGRILSSS--SRDKTIKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQD--GTIKLWD 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  803 WKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGgftSKRGTFgsIGKLETMMCVSYGRMEDLVFSGA 882
Cdd:cd00200    164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG---KCLGTL--RGHENGVNSVAFSPDGYLLASGS 238
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622855128  883 ATGDIFIW--KDILLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD 929
Cdd:cd00200    239 EDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkrLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1413-1763 1.21e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 1.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1413 HTDDILCLTVNQHPKYrnVVATSQIGTtpsIHVWDamtKHTLSMLRCF--HSKGVNYVNFSATGKLLVSVGVDpeHTITV 1490
Cdd:cd00200      8 HTGGVTCVAFSPDGKL--LATGSGDGT---IKVWD---LETGELLRTLkgHTGPVRDVAASADGTYLASGSSD--KTIRL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1491 WRWQEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAgsallykKGVIGSLGAAKMQTMLSVAF-GANNLT 1569
Cdd:cd00200     78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTDWVNSVAFsPDGTFV 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1570 FTGAINGDVYVW--KDHFLIRlVAKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRCRAfqletgqlve 1647
Cdd:cd00200    151 ASSSQDGTIKLWdlRTGKCVA-TLTGHTGEVNSVAFSPDGEKLLSSS------SDGTIKLWDLSTGKCLG---------- 213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1648 cvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSl 1727
Cdd:cd00200    214 ---------------------------------TLRGH-ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS- 258
                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1622855128 1728 GHAAR--CAAYSPDGEMVAIGMKNgefvillvNSLKVW 1763
Cdd:cd00200    259 GHTNSvtSLAWSPDGKRLASGSAD--------GTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
228-466 1.30e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.30e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  228 LVRTIQGaHSAGIFSM--YACEEGFATGGRDGCIRLWDTDFKpitkiDLRETEQGYKGlSIRSVCWKAD--RLLAGTQDS 303
Cdd:cd00200      1 LRRTLKG-HTGGVTCVafSPDGKLLATGSGDGTIKVWDLETG-----ELLRTLKGHTG-PVRDVAASADgtYLASGSSDK 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  304 EIFevIVRERDKPML-ILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALIARCNM-EEAVRSVAFSPDGSQL 381
Cdd:cd00200     74 TIR--LWDLETGECVrTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFV 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  382 ALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVAQRyKKIGECSKSLSFITHIDWSL 461
Cdd:cd00200    151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSP 229

                   ....*
gi 1622855128  462 DSKYL 466
Cdd:cd00200    230 DGYLL 234
WD40 COG2319
WD40 repeat [General function prediction only];
521-1112 1.47e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 1.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  521 INSVDANYSSSVLVSGDDFGLVKLFRfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWRfipegvsn 600
Cdd:COG2319     81 VLSVAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGKTLAS-GSADGTVRLWD-------- 148
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  601 gmletapqeggtdsyseesdsdlsdvpeldsdieqetqinydrqvykedlpqlkqqskeknhvvpflkrekapedslklq 680
Cdd:COG2319        --------------------------------------------------------------------------------
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  681 fihgyrgydcrnnlfyTQAGEVVYHIAavavvynrqqhsqrlylGHDDDILSLTIHPVKDYVATGqvGRDAAIHVWDTQT 760
Cdd:COG2319    149 ----------------LATGKLLRTLT-----------------GHSGAVTSVAFSPDGKLLASG--SDDGTVRLWDLAT 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  761 LKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFvvkcnphhvdklvtvgikhi 840
Cdd:COG2319    194 GKLLRTLTG-HTGAVRSVAFSPDGKLLASGSAD--GTVRLWDLATGKLLRTLTGHSGSVR-------------------- 250
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  841 kfwqqagggftskrgtfgsigkletmmcvsygrmeDLVFSgaatgdifiwkdilllktvkaHDGPVFAmyaldkgfvTGG 920
Cdd:COG2319    251 -----------------------------------SVAFS---------------------PDGRLLA---------SGS 265
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  921 KDGIVELWDdmferclktyaikrsalstsskglllednpsiraitlghghilvgTKNGEILEidksgpmtlLVQGHmEGE 1000
Cdd:COG2319    266 ADGTVRLWD---------------------------------------------LATGELLR---------TLTGH-SGG 290
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1001 VWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH 1080
Cdd:COG2319    291 VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTG 370
                          570       580       590
                   ....*....|....*....|....*....|..
gi 1622855128 1081 RKEMISDIKFSKDtGKYLAVASHDNFVDIYNV 1112
Cdd:COG2319    371 HTGAVTSVAFSPD-GRTLASGSADGTVRLWDL 401
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
2-48 5.47e-20

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 85.68  E-value: 5.47e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622855128    2 ADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYN 48
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYD 71
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
668-715 5.68e-20

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 85.68  E-value: 5.68e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622855128  668 KREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNR 715
Cdd:pfam03451   25 QKKEPPDKKLKLEWVYGYRGKDCRSNLYYLPTGEIVYFTAAVVVLYDV 72
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1461-1798 1.01e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 1.01e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1461 HSKGVNYVNFSATGKLLVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSdTQFVSVGVKHM-KFWTLAGSA 1539
Cdd:cd00200      8 HTGGVTCVAFSPDGKLLATGSGD--GTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTiRLWDLETGE 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1540 LLYkkgvigSLGAAKmQTMLSVAFGANNLTFTGAI-NGDVYVWK-DHFLIRLVAKAHTGPVFTMyTTLRDGLIVTGGKEr 1617
Cdd:cd00200     85 CVR------TLTGHT-SYVSSVAFSPDGRILSSSSrDKTIKVWDvETGKCLTTLRGHTDWVNSV-AFSPDGTFVASSSQ- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1618 ptkeGGAVKLWDqemkrcrafqLETGQLVEcvrsvcrgkgkilvgtkdgeiievgeknaasniLIDGHmEGEIWGLATHP 1697
Cdd:cd00200    156 ----DGTIKLWD----------LRTGKCVA---------------------------------TLTGH-TGEVNSVAFSP 187
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1698 SKDLFISASNDGTARIWDLADKKLLnKVSLGH--AARCAAYSPDGEMVAIGMKNGefvillvnSLKVW-GKKRDRK---- 1770
Cdd:cd00200    188 DGEKLLSSSSDGTIKLWDLSTGKCL-GTLRGHenGVNSVAFSPDGYLLASGSEDG--------TIRVWdLRTGECVqtls 258
                          330       340       350
                   ....*....|....*....|....*....|.
gi 1622855128 1771 ---SAIQDIRISPDNRFLAVGSSEHTVDFYD 1798
Cdd:cd00200    259 ghtNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1592-1956 3.54e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 3.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1592 KAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRC-RAFQLETGQlVECVRSVCRGKgKILVGTKDGEIIE 1670
Cdd:cd00200      6 KGHTGGVTCVAFSPDGKLLATGS------GDGTIKVWDLETGELlRTLKGHTGP-VRDVAASADGT-YLASGSSDKTIRL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1671 VGEKNAASNILIDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLnKVSLGH--AARCAAYSPDGEMVAIGMK 1748
Cdd:cd00200     78 WDLETGECVRTLTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL-TTLRGHtdWVNSVAFSPDGTFVASSSQ 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1749 NGefvillvnSLKVW----GKKRDR----KSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDipsFVIQ 1820
Cdd:cd00200    156 DG--------TIKLWdlrtGKCVATltghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN---GVNS 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1821 MDFSADGKYIqvstgaykrqvhevplgkqvteamviekitwaswTSVLGDEVIGIWprnadkadvncacvthaglNIVTG 1900
Cdd:cd00200    225 VAFSPDGYLL----------------------------------ASGSEDGTIRVW-------------------DLRTG 251
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622855128 1901 DdfglvklfdfpctekfaKHKRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVWR 1956
Cdd:cd00200    252 E-----------------CVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
895-1221 1.53e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 1.53e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  895 LLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD---DMFERCLKTYAIKRSALSTSSKGLLL----EDNpSIRait 965
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDletGELLRTLKGHTGPVRDVAASADGTYLasgsSDK-TIR--- 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  966 lghghiLVGTKNGEILEIdksgpmtllVQGHmEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKKGGRC 1045
Cdd:cd00200     77 ------LWDLETGECVRT---------LTGH-TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1046 CAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHHRKEMISDIKFSKDtGKYLAVASHDNFVDIYNVLTSKRVGICKGAS 1125
Cdd:cd00200    141 VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1126 SYITHIDWDSRGKLLQvnSGAKEQlffeaprgkrhIIRpseiekiQWDTWTCVLGPTCEGiwpaHSdiTDVNAASLTKDC 1205
Cdd:cd00200    220 NGVNSVAFSPDGYLLA--SGSEDG-----------TIR-------VWDLRTGECVQTLSG----HT--NSVTSLAWSPDG 273
                          330
                   ....*....|....*.
gi 1622855128 1206 SLLATGDDFGFVKLFS 1221
Cdd:cd00200    274 KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
339-929 8.70e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 8.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  339 LAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSP 418
Cdd:COG2319      9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  419 DGSYLAVGSNDGPVDVYAVAQRyKKIGECSKSLSFITHIDWSLDSKYLqtndgagerlfykmpsgksltskeeikgipwa 498
Cdd:COG2319     89 DGRLLASASADGTVRLWDLATG-LLLRTLTGHTGAVRSVAFSPDGKTL-------------------------------- 135
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  499 swtcvkgpevsgiwpkytevtdinsvdanysssvlVSGDDFGLVKLFRfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWv 578
Cdd:COG2319    136 -----------------------------------ASGSADGTVRLWD---LATGKLLRTLTGHSGAVTSVAFSPDGKL- 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  579 LSTGGADHSVFQWRfipegvsngmletapqeggtdsyseesdsdlsdvpeldsdieqetqinydrqvykedlpqlkqqsk 658
Cdd:COG2319    177 LASGSDDGTVRLWD------------------------------------------------------------------ 190
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  659 eknhvvpflkrekapedslklqfihgyrgydcrnnlfyTQAGEVVyhiaavavvynrqqhsqRLYLGHDDDILSLTIHPV 738
Cdd:COG2319    191 --------------------------------------LATGKLL-----------------RTLTGHTGAVRSVAFSPD 215
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  739 KDYVATGqvGRDAAIHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDK 818
Cdd:COG2319    216 GKLLASG--SADGTVRLWDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSAD--GTVRLWDLATGELLRTLTGHSGG 290
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  819 IFVVKCNPhhvD--KLVTVGI-KHIKFWQQAGGgftSKRGTFGsiGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDI 893
Cdd:COG2319    291 VNSVAFSP---DgkLLASGSDdGTVRLWDLATG---KLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGTVRLWdlATG 362
                          570       580       590
                   ....*....|....*....|....*....|....*...
gi 1622855128  894 LLLKTVKAHDGPVFAMYALDKG--FVTGGKDGIVELWD 929
Cdd:COG2319    363 ELLRTLTGHTGAVTSVAFSPDGrtLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1682-1956 1.11e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 1.11e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1682 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSlGHAA--RCAAYSPDGEMVAIGMKNgefvillvNS 1759
Cdd:cd00200      5 LKGH-TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK-GHTGpvRDVAASADGTYLASGSSD--------KT 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1760 LKVW----GKKRDR----KSAIQDIRISPDNRFLAVGSSEHTVDFYDLTQGTNLNRIGYCKDipsFVIQMDFSADGKYIq 1831
Cdd:cd00200     75 IRLWdletGECVRTltghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFV- 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1832 vstgaykrqvhevplgkqvteamviekitwaswTSVLGDEVIGIWprNAD-----------KADVNCACVTHAGLNIVTG 1900
Cdd:cd00200    151 ---------------------------------ASSSQDGTIKLW--DLRtgkcvatltghTGEVNSVAFSPDGEKLLSS 195
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622855128 1901 DDFGLVKLFDFpctEKFAKHKRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVWR 1956
Cdd:cd00200    196 SSDGTIKLWDL---STGKCLGTLRGHENGVNSVAFSPDGYLLAS-GSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
55-179 2.70e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 2.70e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   55 KFFLGHNDDIISLALHPDKTLVATGqvGKEPYICIWDSYNVQTVSILKDvHTHGVACLAFDSDGQRLASVGLDakNTVCI 134
Cdd:COG2319    282 RTLTGHSGGVNSVAFSPDGKLLASG--SDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDD--GTVRL 356
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622855128  135 WDWRKGKLLASATGHSDRIFDISWDPyQPNRVVSCGV-KHIKFWTL 179
Cdd:COG2319    357 WDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSAdGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
46-177 6.91e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 6.91e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128   46 VYNTREHS-QKFFLGHNDDIISLALHPDKTLVATGQVGKEpyICIWDSYNVQTVSILKdVHTHGVACLAFDSDGQRLASV 124
Cdd:cd00200    161 LWDLRTGKcVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT--IKLWDLSTGKCLGTLR-GHENGVNSVAFSPDGYLLASG 237
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622855128  125 GLDakNTVCIWDWRKGKLLASATGHSDRIFDISWDPyQPNRVVSCGV-KHIKFW 177
Cdd:cd00200    238 SED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSAdGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1560-1830 1.40e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.40e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1560 SVAFGA-NNLTFTGAINGDVYVWK---DHFLIRLvaKAHTGPVFTMYTTLRDGLIVTGGkerptkEGGAVKLWDQEMKRC 1635
Cdd:cd00200     14 CVAFSPdGKLLATGSGDGTIKVWDletGELLRTL--KGHTGPVRDVAASADGTYLASGS------SDKTIRLWDLETGEC 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1636 -RAFQLETGQlvecVRSVC-RGKGKILVGT-KDGEIIEVGEKNAASNILIDGHmEGEIWGLATHPSKDLFISASNDGTAR 1712
Cdd:cd00200     86 vRTLTGHTSY----VSSVAfSPDGRILSSSsRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTIK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1713 IWDLADKKLLnKVSLGH--AARCAAYSPDGEMVAIGMKNGefvillvnSLKVWGKKRDR--------KSAIQDIRISPDN 1782
Cdd:cd00200    161 LWDLRTGKCV-ATLTGHtgEVNSVAFSPDGEKLLSSSSDG--------TIKLWDLSTGKclgtlrghENGVNSVAFSPDG 231
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1622855128 1783 RFLAVGSSEHTVDFYDLTQGTNLNRI-GYckdiPSFVIQMDFSADGKYI 1830
Cdd:cd00200    232 YLLASGSEDGTIRVWDLRTGECVQTLsGH----TNSVTSLAWSPDGKRL 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
521-826 3.15e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 3.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  521 INSVDANYSSSVLVSGDDFGLVKLFRfpcLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLStGGADHSVFQWRFipegvsn 600
Cdd:cd00200     12 VTCVAFSPDGKLLATGSGDGTIKVWD---LETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLWDL------- 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  601 gmletapqEGGTDSYS-EESDSDLSDVpeldsDIEQETQI----NYDRQVYKEDLPQLKQQSKEKNHvvpflkrekapED 675
Cdd:cd00200     81 --------ETGECVRTlTGHTSYVSSV-----AFSPDGRIlsssSRDKTIKVWDVETGKCLTTLRGH-----------TD 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  676 SLklqfihgyrgydcrNNLFYTQAGEVVYHIAA--VAVVYN-RQQHSQRLYLGHDDDILSLTIHPVKDYVATGqvGRDAA 752
Cdd:cd00200    137 WV--------------NSVAFSPDGTFVASSSQdgTIKLWDlRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS--SSDGT 200
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622855128  753 IHVWDTQTLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWDWKKGEKIATTRGHKDKIFVVKCNP 826
Cdd:cd00200    201 IKLWDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSED--GTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
1367-1629 7.46e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 7.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1367 HVFGYRGFDCRNNLHYL----NDGTDIIFhtaaagivqNLSTGSQSFYLE-HTDDILCLTVNQHPKYrnVVATSQIGTtp 1441
Cdd:cd00200     50 HTGPVRDVAASADGTYLasgsSDKTIRLW---------DLETGECVRTLTgHTSYVSSVAFSPDGRI--LSSSSRDKT-- 116
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1442 sIHVWDAMTKHTLSMLRCfHSKGVNYVNFSATGKLLVSVGVDpeHTITVWRWQEGAKVASRGGHLERIFVVEFRPDSDTQ 1521
Cdd:cd00200    117 -IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQD--GTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1522 FVSVGVKHMKFWTLAGSALLYkkgvigsLGAAKMQTMLSVAFGANNLTFT-GAINGDVYVWK-DHFLIRLVAKAHTGPVF 1599
Cdd:cd00200    193 LSSSSDGTIKLWDLSTGKCLG-------TLRGHENGVNSVAFSPDGYLLAsGSEDGTIRVWDlRTGECVQTLSGHTNSVT 265
                          250       260       270
                   ....*....|....*....|....*....|
gi 1622855128 1600 TMYTTLRDGLIVTGGkerptkEGGAVKLWD 1629
Cdd:cd00200    266 SLAWSPDGKRLASGS------ADGTIRIWD 289
HELP pfam03451
HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm ...
1350-1401 7.88e-13

HELP motif; The founding member of the EMAP protein family is the 75 kDa Echinoderm Microtubule-Associated Protein, so-named for its abundance in sea urchin, sand dollar and starfish eggs. The Hydrophobic EMAP-Like Protein (HELP) motif was identified initially in the human EMAP-Like Protein 2 (EML2) and subsequently in the entire EMAP Protein family. The HELP motif is approximately 60-70 amino acids in length and is conserved amongst metazoans. Although the HELP motif is hydrophobic, there is no evidence that EMAP-Like Proteins are membrane-associated. All members of the EMAP-Like Protein family, identified to-date, are constructed with an amino terminal HELP motif followed by a WD domain. In C. elegans, EMAP-Like Protein-1 (ELP-1) is required for touch sensation indicating that ELP-1 may play a role in mechanosensation. The localization of ELP-1 to microtubules and adhesion sites implies that ELP-1 may transmit forces between the body surface and the touch receptor neurons.


Pssm-ID: 460922  Cd Length: 72  Bit Score: 65.27  E-value: 7.88e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622855128 1350 KNNITKKKKLVEE-LALDHVFGYRGFDCRNNLHYLNDGtDIIFHTAAAGIVQN 1401
Cdd:pfam03451   20 KDDLDQKKEPPDKkLKLEWVYGYRGKDCRSNLYYLPTG-EIVYFTAAVVVLYD 71
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1699-1830 3.23e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.38  E-value: 3.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1699 KDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAI-GMKNGEFVILLVNSLKVWGKKRDRKSAiQDIR 1777
Cdd:COG3391     80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVaDSGNGRVSVIDTATGKVVATIPVGAGP-HGIA 158
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622855128 1778 ISPDNRFLAVGSSE-HTVDFY----DLTQGTNLNRIgyckDIPSFVIQMDFSADGKYI 1830
Cdd:COG3391    159 VDPDGKRLYVANSGsNTVSVIvsviDTATGKVVATI----PVGGGPVGVAVSPDGRRL 212
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
368-466 6.41e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 48.11  E-value: 6.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  368 AVRSVAFSPDGSQLA-LGMKDGSF-IVLR--VRDMTEVVHIKDRKEVIHEMKFSPDGSYLAVGSNDGPVDVYAVA-QRYK 442
Cdd:COG4946    344 RERLPAWSPDGKSIAyFSDASGEYeLYIApaDGSGEPKQLTLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLAsGKVR 423
                           90       100
                   ....*....|....*....|....
gi 1622855128  443 KIGEcSKSLSFITHIDWSLDSKYL 466
Cdd:COG4946    424 KVDT-DGYGDGISDLAWSPDSKWL 446
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1691-1802 1.83e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 1.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128 1691 WGLATHPSKD-LFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDGEMVAIGMKNGEFVILLV-----NSLKVWg 1764
Cdd:COG3391    113 RGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVSVIVsvidtATGKVV- 191
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1622855128 1765 KKRDRKSAIQDIRISPDNRFLAV--------GSSEHTVDFYDLTQG 1802
Cdd:COG3391    192 ATIPVGGGPVGVAVSPDGRRLYVanrgsntsNGGSNTVSVIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
1682-1715 2.82e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1622855128  1682 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1715
Cdd:smart00320    8 LKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
105-136 3.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.68e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1622855128   105 HTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1682-1715 4.50e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 4.50e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622855128 1682 IDGHmEGEIWGLATHPSKDLFISASNDGTARIWD 1715
Cdd:pfam00400    7 LEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
315-353 8.52e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 8.52e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622855128  315 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 353
Cdd:pfam00400    2 KLLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
760-802 1.36e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 1.36e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1622855128   760 TLKCLSLLKGqHQRGVCALDFSADGKCLVSVGLDdfHSIVFWD 802
Cdd:smart00320    1 SGELLKTLKG-HTGPVTSVAFSPDGKYLASGSDD--GTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
315-353 1.98e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 1.98e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1622855128   315 KPMLILQGHcEGELWALALHPKKPLAVTGSDDRSVRLWS 353
Cdd:smart00320    3 ELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
105-136 2.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.05e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622855128  105 HTHGVACLAFDSDGQRLASVGLDakNTVCIWD 136
Cdd:pfam00400   10 HTGSVTSLAFSPDGKLLASGSDD--GTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
1734-1798 2.62e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.80  E-value: 2.62e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622855128 1734 AAYSPDGEMVAIGMKNGEFVILLVNSLKVWGKKRD-RKSAIQDIRISPDNRFLAVGSSEHTVDFYD 1798
Cdd:pfam12894    1 MSWCPTMDLIALATEDGELLLHRLNWQRVWTLSPDkEDLEVTSLAWRPDGKLLAVGYSDGTVRLLD 66
WD40 pfam00400
WD domain, G-beta repeat;
1921-1955 3.16e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 3.16e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1622855128 1921 KRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVW 1955
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLAS-GSDDGTVKVW 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
339-430 5.00e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 5.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  339 LAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQL-ALGMKDGSFIVLRVRDMTEVVHIKDRKEViHEMKFS 417
Cdd:COG3391     82 LYVANSGSGRVSVIDLATGKVVATIPVGGGPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVD 160
                           90
                   ....*....|...
gi 1622855128  418 PDGSYLAVGSNDG 430
Cdd:COG3391    161 PDGKRLYVANSGS 173
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
1916-1955 5.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 5.97e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1622855128  1916 KFAKHKRYFGHSAHVTNIRFSYDDKYVVStGGDDCSVFVW 1955
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLAS-GSDDGTIKLW 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
329-425 6.38e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.45  E-value: 6.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622855128  329 WALALHPK-KPLAVTGSDDRSVRLWSLADHALIARCNMEEAVRSVAFSPDGSQLALGMKDGSFI-----VLRVRDMTEVV 402
Cdd:COG3391    113 RGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVsvivsVIDTATGKVVA 192
                           90       100
                   ....*....|....*....|...
gi 1622855128  403 HIkDRKEVIHEMKFSPDGSYLAV 425
Cdd:COG3391    193 TI-PVGGGPVGVAVSPDGRRLYV 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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