NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622854569|ref|XP_028687358|]
View 

myelin transcription factor 1-like protein isoform X13 [Macaca mulatta]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 620-871 4.64e-122

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


:

Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 374.86  E-value: 4.64e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  620 YRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDSHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSS 699
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAKKYFCKPSSPSSSLTSSYAPSSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  700 SNLscgggssasstcsKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCaTRNPDMEVDENGTLDLSMNKQ 779
Cdd:pfam08474   81 SSS-------------SSSYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLS-AKPDDIEVDENGTLDLSMKKN 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  780 RPRD-SCCPILTPLEPMSPQQQAVM-NNRCFQLGEG-DCWDLPVDYTKMKprRIDEDESKDitPEDLDPFQEALEERRYP 856
Cdd:pfam08474  147 RPRGvTSGSVLTPLPPMSPQRQASLlNSRCYQALCAqDCWDLPVDYTKIK--RIDEEEKEE--PEDLDPFQELLEERKYP 222

                          250
                   ....*....|....*
gi 1622854569  857 GEVTIPSPKPKYPQC 871
Cdd:pfam08474  223 GEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 903-931 7.22e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 74.88  E-value: 7.22e-17
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  903 KCPTPGCDGSGHITGNYASHRSLSGCPRA 931
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 31-58 9.74e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.41  E-value: 9.74e-16
                           10        20
                   ....*....|....*....|....*...
gi 1622854569   31 CPTPGCDGSGHVSGKYARHRSVYGCPLA 58
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 952-980 1.05e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.41  E-value: 1.05e-15
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  952 RCPVPGCDGQGHITGKYASHRSASGCPLA 980
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 1006-1033 6.65e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 69.10  E-value: 6.65e-15
                           10        20
                   ....*....|....*....|....*...
gi 1622854569 1006 CPTPGCDGSGHVSGSFLTHRSLSGCPRA 1033
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 548-576 4.77e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.79  E-value: 4.77e-14
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  548 KCPTPGCTGRGHVNSNRNSHRSLSGCPIA 576
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 504-530 4.77e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


:

Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.79  E-value: 4.77e-14
                           10        20
                   ....*....|....*....|....*..
gi 1622854569  504 KCPTPGCDGTGHVTGLYPHHRSLSGCP 530
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1045-1125 1.70e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1045 EQMLTIKQRASngiENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLS 1124
Cdd:COG4372    101 EELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALS 177


                   .
gi 1622854569 1125 Q 1125
Cdd:COG4372    178 E 178
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 620-871 4.64e-122

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 374.86  E-value: 4.64e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  620 YRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDSHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSS 699
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAKKYFCKPSSPSSSLTSSYAPSSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  700 SNLscgggssasstcsKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCaTRNPDMEVDENGTLDLSMNKQ 779
Cdd:pfam08474   81 SSS-------------SSSYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLS-AKPDDIEVDENGTLDLSMKKN 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  780 RPRD-SCCPILTPLEPMSPQQQAVM-NNRCFQLGEG-DCWDLPVDYTKMKprRIDEDESKDitPEDLDPFQEALEERRYP 856
Cdd:pfam08474  147 RPRGvTSGSVLTPLPPMSPQRQASLlNSRCYQALCAqDCWDLPVDYTKIK--RIDEEEKEE--PEDLDPFQELLEERKYP 222

                          250
                   ....*....|....*
gi 1622854569  857 GEVTIPSPKPKYPQC 871
Cdd:pfam08474  223 GEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 903-931 7.22e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 74.88  E-value: 7.22e-17
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  903 KCPTPGCDGSGHITGNYASHRSLSGCPRA 931
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 31-58 9.74e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.41  E-value: 9.74e-16
                           10        20
                   ....*....|....*....|....*...
gi 1622854569   31 CPTPGCDGSGHVSGKYARHRSVYGCPLA 58
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 952-980 1.05e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.41  E-value: 1.05e-15
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  952 RCPVPGCDGQGHITGKYASHRSASGCPLA 980
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 1006-1033 6.65e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 69.10  E-value: 6.65e-15
                           10        20
                   ....*....|....*....|....*...
gi 1622854569 1006 CPTPGCDGSGHVSGSFLTHRSLSGCPRA 1033
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 548-576 4.77e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.79  E-value: 4.77e-14
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  548 KCPTPGCTGRGHVNSNRNSHRSLSGCPIA 576
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 504-530 4.77e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.79  E-value: 4.77e-14
                           10        20
                   ....*....|....*....|....*..
gi 1622854569  504 KCPTPGCDGTGHVTGLYPHHRSLSGCP 530
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1045-1125 1.70e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1045 EQMLTIKQRASngiENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLS 1124
Cdd:COG4372    101 EELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALS 177


                   .
gi 1622854569 1125 Q 1125
Cdd:COG4372    178 E 178
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1038-1116 6.76e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.86  E-value: 6.76e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622854569 1038 KKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESL 1116
Cdd:pfam05667  304 EKLQFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEEL 382
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1059-1137 7.24e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 7.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1059 ENDEEIKQLDEEIKELNESNSQM-------EADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANL---SQSLI 1128
Cdd:TIGR04523  565 EKNKEIEELKQTQKSLKKKQEEKqelidqkEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIkskKNKLK 644


                   ....*....
gi 1622854569 1129 HSLANIQLP 1137
Cdd:TIGR04523  645 QEVKQIKET 653
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 1061-1107 2.19e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 38.32  E-value: 2.19e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622854569 1061 DEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENK 1107
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEEND 70
 
Name Accession Description Interval E-value
MYT1 pfam08474
Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) ...
 620-871 4.64e-122

Myelin transcription factor 1; This domain is found in the myelin transcription factor 1 (MYT1) of chordates. MYT1 contains C2HC zinc finger domains (pfam01530) and is expressed in developing neurons of the central nervous system where it is involved in the selection of neuronal precursor cells.


Pssm-ID: 462489 [Multi-domain]  Cd Length: 237  Bit Score: 374.86  E-value: 4.64e-122
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  620 YRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDSHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSS 699
Cdd:pfam08474    1 YRNNVPTTTPRANLAKELEKYSKTSFDYASFDAQVFGKRTLAPKVQGQDTSPKGFDAKKYFCKPSSPSSSLTSSYAPSSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  700 SNLscgggssasstcsKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCaTRNPDMEVDENGTLDLSMNKQ 779
Cdd:pfam08474   81 SSS-------------SSSYDYTHDMEAAHMAATAILNLSTRCREMPENLSTKPQDLS-AKPDDIEVDENGTLDLSMKKN 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569  780 RPRD-SCCPILTPLEPMSPQQQAVM-NNRCFQLGEG-DCWDLPVDYTKMKprRIDEDESKDitPEDLDPFQEALEERRYP 856
Cdd:pfam08474  147 RPRGvTSGSVLTPLPPMSPQRQASLlNSRCYQALCAqDCWDLPVDYTKIK--RIDEEEKEE--PEDLDPFQELLEERKYP 222

                          250
                   ....*....|....*
gi 1622854569  857 GEVTIPSPKPKYPQC 871
Cdd:pfam08474  223 GEVTIPSPKPKYPPC 237
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 903-931 7.22e-17

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 74.88  E-value: 7.22e-17
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  903 KCPTPGCDGSGHITGNYASHRSLSGCPRA 931
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 31-58 9.74e-16

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.41  E-value: 9.74e-16
                           10        20
                   ....*....|....*....|....*...
gi 1622854569   31 CPTPGCDGSGHVSGKYARHRSVYGCPLA 58
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 952-980 1.05e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 71.41  E-value: 1.05e-15
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  952 RCPVPGCDGQGHITGKYASHRSASGCPLA 980
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 1006-1033 6.65e-15

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 69.10  E-value: 6.65e-15
                           10        20
                   ....*....|....*....|....*...
gi 1622854569 1006 CPTPGCDGSGHVSGSFLTHRSLSGCPRA 1033
Cdd:pfam01530    2 CPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 548-576 4.77e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.79  E-value: 4.77e-14
                           10        20
                   ....*....|....*....|....*....
gi 1622854569  548 KCPTPGCTGRGHVNSNRNSHRSLSGCPIA 576
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCPYA 29
zf-C2HC pfam01530
Zinc finger, C2HC type; This is a DNA binding zinc finger domain.
 504-530 4.77e-14

Zinc finger, C2HC type; This is a DNA binding zinc finger domain.


Pssm-ID: 460240  Cd Length: 29  Bit Score: 66.79  E-value: 4.77e-14
                           10        20
                   ....*....|....*....|....*..
gi 1622854569  504 KCPTPGCDGTGHVTGLYPHHRSLSGCP 530
Cdd:pfam01530    1 KCPTPGCDGSGHVSGKYATHRSLSGCP 27
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1045-1125 1.70e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.28  E-value: 1.70e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1045 EQMLTIKQRASngiENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLS 1124
Cdd:COG4372    101 EELESLQEEAE---ELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALS 177


                   .
gi 1622854569 1125 Q 1125
Cdd:COG4372    178 E 178
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1062-1127 2.72e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 44.51  E-value: 2.72e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622854569 1062 EEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSL 1127
Cdd:COG4372     80 EELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEI 145
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1062-1126 6.42e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 43.35  E-value: 6.42e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622854569 1062 EEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQS 1126
Cdd:COG4372     66 EELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQ 130
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 1038-1116 6.76e-04

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 43.86  E-value: 6.76e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622854569 1038 KKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESL 1116
Cdd:pfam05667  304 EKLQFTNEAPAATSSPPTKVETEEELQQQREEELEELQEQLEDLESSIQELEKEIKKLESSIKQVEEELEELKEQNEEL 382
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1059-1137 7.24e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.86  E-value: 7.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1059 ENDEEIKQLDEEIKELNESNSQM-------EADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANL---SQSLI 1128
Cdd:TIGR04523  565 EKNKEIEELKQTQKSLKKKQEEKqelidqkEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIkskKNKLK 644


                   ....*....
gi 1622854569 1129 HSLANIQLP 1137
Cdd:TIGR04523  645 QEVKQIKET 653
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1062-1127 8.70e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 8.70e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622854569 1062 EEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSL 1127
Cdd:COG4372    108 EEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1059-1127 1.18e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 1.18e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622854569 1059 ENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSL 1127
Cdd:COG4372     70 QARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQI 138
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 1049-1128 1.25e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.09  E-value: 1.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1049 TIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENK-------VIEQQNESLLHELA 1121
Cdd:TIGR04523  350 ELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQqkdeqikKLQQEKELLEKEIE 429


                   ....*..
gi 1622854569 1122 NLSQSLI 1128
Cdd:TIGR04523  430 RLKETII 436
Atg16_CCD cd22887
Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family ...
 1061-1107 2.19e-03

Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; The Atg16 family includes Saccharomyces cerevisiae Atg16 (also called cytoplasm to vacuole targeting protein 11, CVT11, or SAP18), human autophagy-related protein 16-1 (also called APG16-like 1, ATG16L1, or APG16L) and autophagy-related protein 16-2 (also called APG16-like 2, ATG16L2, WD repeat-containing protein 80 or WDR80), and similar proteins. Atg16 stabilizes the Atg5-Atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The Atg5-Atg12/Atg16 complex is required for efficient promotion of Atg8-conjugation to phosphatidylethanolamine and Atg8 localization to the pre-autophagosomal structure (PAS). Similarly, human ATG16L1 plays an essential role in autophagy and acts as a molecular scaffold which mediates protein-protein interactions essential for autophagosome formation. ATG16L2, though structurally similar to ATG16L1 and able to form a complex with the autophagy proteins Atg5 and Atg12, is not essential for autophagy. Single-nucleotide polymorphisms in ATG16L1 is associated with an increased risk of developing Crohn disease. Saccharomyces cerevisiae Atg16 contains an N-terminal domain (NTD) that interacts with the Atg5-Atg12 protein conjugate and a coiled-coil domain (CCD) that dimerizes and mediates self-assembly. Human ATG16L1 and ATG16L2 also contains an N-terminal region that binds Atg5, a CCD homologous to the yeast CCD, and a WD40 domain that represents approximately 50% of the full-length protein. This model corresponds to the CCD of Atg16 family proteins.


Pssm-ID: 439196 [Multi-domain]  Cd Length: 91  Bit Score: 38.32  E-value: 2.19e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622854569 1061 DEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENK 1107
Cdd:cd22887     24 EEEIKDLEEELKEKNKANEILNDELIALQIENNLLEEKLRKLQEEND 70
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1059-1127 3.81e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 3.81e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622854569 1059 ENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSL 1127
Cdd:COG4942     24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1036-1127 6.02e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 6.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1036 AMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKEL---NESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQ- 1111
Cdd:COG4717     45 AMLLERLEKEADELFKPQGRKPELNLKELKELEEELKEAeekEEEYAELQEELEELEEELEELEAELEELREELEKLEKl 124

                           90
                   ....*....|....*..
gi 1622854569 1112 -QNESLLHELANLSQSL 1127
Cdd:COG4717    125 lQLLPLYQELEALEAEL 141
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1050-1123 6.69e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 6.69e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622854569 1050 IKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANL 1123
Cdd:COG4942     36 IAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEL 109
FapA pfam03961
Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta ...
 1056-1134 9.93e-03

Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta solenoid domain of FapA and its homologs. Members of this family include FapA (flagellar assembly protein A) found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction. This entry shows similarity to pfam03775 suggesting a similar functional role.


Pssm-ID: 461111 [Multi-domain]  Cd Length: 272  Bit Score: 39.21  E-value: 9.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854569 1056 NGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITT-----MESNLKTIEEENKVIEQQNESLLHELANLSQSLIHS 1130
Cdd:pfam03961  150 DFPELKEKLEELEKELEELEEELEKLKKRLKKLPKKARGqlppeKREQLEKLLETKNKLSEELEELEEELKELKEELESL 229


                   ....
gi 1622854569 1131 LANI 1134
Cdd:pfam03961  230 LGEG 233
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH