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Conserved domains on  [gi|1622854007|ref|XP_028687246|]
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sodium/calcium exchanger 1 isoform X11 [Macaca mulatta]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-935 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1752.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007   1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 481 IFEEDENFLVHLSNVKVSSEaseDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVGSE---DGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKGGFTI 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLN 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 641 TDEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE 720
Cdd:TIGR00845 634 ETITDDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGD 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 721 DDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAV 800
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAV 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 801 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFA 880
Cdd:TIGR00845 794 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFA 873

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622854007 881 FINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 935
Cdd:TIGR00845 874 FICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-935 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1752.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007   1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 481 IFEEDENFLVHLSNVKVSSEaseDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVGSE---DGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKGGFTI 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLN 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 641 TDEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE 720
Cdd:TIGR00845 634 ETITDDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGD 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 721 DDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAV 800
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAV 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 801 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFA 880
Cdd:TIGR00845 794 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFA 873

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622854007 881 FINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 935
Cdd:TIGR00845 874 FICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 251-387 1.41e-81

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 259.55  E-value: 1.41e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 251 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 329
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622854007 330 LKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 387
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 403-493 2.09e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 126.60  E-value: 2.09e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  403 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1622854007  483 EEDENFLVHLS 493
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
755-923 3.18e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 3.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 755 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 834
Cdd:COG0530   146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 835 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 911
Cdd:COG0530   225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                         170
                  ....*....|..
gi 1622854007 912 LFVLLWLLYIFF 923
Cdd:COG0530   281 LLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 783-922 2.19e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 783 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 857
Cdd:PRK10734  200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622854007 858 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 922
Cdd:PRK10734  272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-935 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1752.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007   1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 481 IFEEDENFLVHLSNVKVSSEaseDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVGSE---DGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKGGFTI 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLN 633

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 641 TDEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGE 720
Cdd:TIGR00845 634 ETITDDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAGD 713

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 721 DDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAV 800
Cdd:TIGR00845 714 DDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAV 793

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 801 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFA 880
Cdd:TIGR00845 794 VFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFA 873

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622854007 881 FINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF 935
Cdd:TIGR00845 874 FICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 251-387 1.41e-81

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 259.55  E-value: 1.41e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 251 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 329
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622854007 330 LKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 387
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
403-493 4.74e-42

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 148.17  E-value: 4.74e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 403 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 1622854007 483 EEDENFLVHLS 493
Cdd:pfam03160  81 EGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 403-493 2.09e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 126.60  E-value: 2.09e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  403 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1622854007  483 EEDENFLVHLS 493
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 534-624 7.02e-31

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 116.20  E-value: 7.02e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  534 AGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARgGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEY 613
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1622854007  614 EKNKTFFLEIG 624
Cdd:smart00237  80 EKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
534-624 9.16e-30

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 113.11  E-value: 9.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 534 AGIFTFEEPVTHVSESIGIMEVKVLRTSGA-RGNVIVPYKTIEGTARGGgEDFEDTCGELEFQNDEIVKTISVKVIDDEE 612
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 1622854007 613 YEKNKTFFLEIG 624
Cdd:pfam03160  80 YEGDENFFVLLS 91
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 762-926 1.31e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.45  E-value: 1.31e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 762 GWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVF 841
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 842 LGIGVAWSIAAIYHAANGEqfkvspgTLAFSVTLFTIFAFINVGVLLYRRRpeiggelggPRTAKLLTSCLFVLLWLLYI 921
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLL-------KLDLGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVYL 144


                  ....*
gi 1622854007 922 FFSSL 926
Cdd:pfam01699 145 VFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 77-248 2.41e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.35  E-value: 2.41e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  77 VYFVAMVYMFLGVSIIADRFMSSIEVITsqekeitikkpngettktTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGH 156
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLA------------------RVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 157 NftaGDLGPSTIVGSAAFNMFIIIALCVYV--VPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILsvisPGVVEVWEGLL 234
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 1622854007 235 TFFFFPICVVFAWV 248
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
755-923 3.18e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 3.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 755 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 834
Cdd:COG0530   146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 835 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 911
Cdd:COG0530   225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                         170
                  ....*....|..
gi 1622854007 912 LFVLLWLLYIFF 923
Cdd:COG0530   281 LLLALYLAYLAL 292
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
775-924 3.05e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 59.38  E-value: 3.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 775 LLTAFIGDLASHFGctigLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGIGVAWSIAAIy 854
Cdd:COG0530     3 LLVRGADALARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILGLAALIRPL- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 855 haangeqfKVSPGTLAFSVTLFTIFAFINVGVLLyrrrpeiggelggPRTAKLLTSCLFVLLWLLYIFFS 924
Cdd:COG0530    77 --------AVDRRVLRRDLPFLLLASLLLLALLL-------------DGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
134-252 2.63e-07

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 53.21  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 134 LTLMALGSSAPEILLSVIEVCGHNFtagDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI--KHLRVFFVTAAwsifa 211
Cdd:COG0530    24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPLAVDRRVlrRDLPFLLLASL----- 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622854007 212 ytwlyIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRR 252
Cdd:COG0530    96 -----LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 82-183 4.47e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 53.85  E-value: 4.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007   82 MVYMFLGVSIIADR-FMSSIEVITSQekeitikkpngettkttVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFTA 160
Cdd:TIGR00927  464 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVF---ISH 522

                           90       100
                   ....*....|....*....|...
gi 1622854007  161 GDLGPSTIVGSAAFNMFIIIALC 183
Cdd:TIGR00927  523 SNVGIGTIVGSAVFNILFVIGTC 545
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 770-885 4.98e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 49.63  E-value: 4.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 770 ILMIGLLTAFIG----------DLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVN 839
Cdd:TIGR00367   1 LLLIGYLILGLIlliygadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622854007 840 VFLGIGVAWSIAAIYHAANGEQFKVsPGTLAFSVTLFTIFAFINVG 885
Cdd:TIGR00367  80 ILLILGLSAIFSPIIVDKDWLRRDI-LFYLLVSILLLFFGLDGQIS 124
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 80-283 1.42e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.09  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  80 VAMVYMFLGVSII-ADRFMSSIEVITSqekeiTIKKPNgettkttvriwneTVSNLTLMALGSSAPEILLSVIEVCGHNf 158
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIAR-----HLGISP-------------LIIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 159 taGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkikhlrvfFVTAAWSIFAYTWLYIILSVIspgvvevwegLLTFFF 238
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRRDILFYLLVSIL----------LLFFGL 119

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622854007 239 F----PICVVFAWVAdrRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSK 283
Cdd:TIGR00367 120 DgqisRIDGVVLLIL--YIVYLLFLVKNERWVKYDTYTEENLDENNRRP 166
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 766-900 1.58e-04

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 44.62  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 766 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNVFLGIG 845
Cdd:TIGR00367 175 LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPE-LVVSLAAARKGLGDIAVGNVIGSNIFNILVGLG 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622854007 846 VAWSIAAIyhaangeQFKVSPGTLAFSVTLFTIFAFinvgVLLYRRRPEIGGELG 900
Cdd:TIGR00367 254 VPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG 297
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 766-880 1.90e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  766 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDqYADASIGNVTGSNAVNVFLGIG 845
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LGDMAVSSSVGSNIFDITVGLP 1016

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622854007  846 VAWsiaAIYHAANGEQ-FKVSPG------TLAFSVTLFTIFA 880
Cdd:TIGR00927 1017 VPW---LLFSLINGLQpVPVSSNglfcaiVLLFLMLLFVISS 1055
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 783-922 2.19e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 783 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 857
Cdd:PRK10734  200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622854007 858 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 922
Cdd:PRK10734  272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 770-847 1.12e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 42.33  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 770 ILMIGLLTAFIGD-----LASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGI 844
Cdd:PRK10734    7 LLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLIL 85


                  ...
gi 1622854007 845 GVA 847
Cdd:PRK10734   86 GLA 88
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 77-258 2.34e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 41.67  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007  77 VYFVAMVYMfLGvSIIADRFMSSIEVITSqekeiTIKKPngettkttvriwnETVSNLTLMALGSSAPEILLSVIEVCGH 156
Cdd:PLN03151  145 VWLVALFYL-LG-NTAADYFCCSLEKLSK-----LLRLP-------------PTVAGVTLLPLGNGAPDVFASIAAFVGK 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 157 NftAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKhlRVFFVTAAWSIFAYTWLYIILSVispGVVEVWEGLLtf 236
Cdd:PLN03151  205 D--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFLFTLVSLLVILMV---GKVTVGGAIA-- 275

                         170       180
                  ....*....|....*....|..
gi 1622854007 237 fFFPICVVFAWVADRRLLFYKY 258
Cdd:PLN03151  276 -FVSIYVVYAFLVAANEILRKH 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-245 4.44e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.12  E-value: 4.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622854007 127 WNETVSNLTLMALGSSAPEILLSVIEVC-GHnftaGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkIKHLRVFFVTA 205
Cdd:COG0530   184 VSELVIGLTIVAIGTSLPELATSIVAARkGE----DDLAVGNIIGSNIFNILLVLGIGALITP------IPVDPAVLSFD 253

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622854007 206 AWSIFAYTWLYIILsVISPGVVEVWEGLLTFFFFPICVVF 245
Cdd:COG0530   254 LPVMLAATLLLLGL-LRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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