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Conserved domains on  [gi|1622853977|ref|XP_028687236|]
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sodium/calcium exchanger 1 isoform X5 [Macaca mulatta]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-963 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1742.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977   1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 481 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKGgfti 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAA---- 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 641 tgkylygqpvfrkvharehPILSTVITitdeyDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLI 720
Cdd:TIGR00845 630 -------------------LLLNETIT-----DDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLI 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 721 KKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILM 800
Cdd:TIGR00845 686 KKTNLALVVGTHSWREQFIEAITVSAGDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILM 765

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 801 IGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 880
Cdd:TIGR00845 766 IGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 845

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 881 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHI 960
Cdd:TIGR00845 846 IYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHI 925


                  ...
gi 1622853977 961 KGF 963
Cdd:TIGR00845 926 KGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-963 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1742.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977   1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 481 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKGgfti 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAA---- 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 641 tgkylygqpvfrkvharehPILSTVITitdeyDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLI 720
Cdd:TIGR00845 630 -------------------LLLNETIT-----DDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLI 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 721 KKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILM 800
Cdd:TIGR00845 686 KKTNLALVVGTHSWREQFIEAITVSAGDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILM 765

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 801 IGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 880
Cdd:TIGR00845 766 IGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 845

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 881 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHI 960
Cdd:TIGR00845 846 IYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHI 925


                  ...
gi 1622853977 961 KGF 963
Cdd:TIGR00845 926 KGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 251-387 2.03e-81

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 259.55  E-value: 2.03e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 251 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 329
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853977 330 LKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 387
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 403-493 1.93e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 126.60  E-value: 1.93e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  403 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1622853977  483 EEDENFLVHLS 493
Cdd:smart00237  80 EKDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
783-951 3.21e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 783 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 862
Cdd:COG0530   146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 863 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 939
Cdd:COG0530   225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                         170
                  ....*....|..
gi 1622853977 940 LFVLLWLLYIFF 951
Cdd:COG0530   281 LLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 811-950 2.23e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.64  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 811 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 885
Cdd:PRK10734  200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622853977 886 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 950
Cdd:PRK10734  272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-963 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1742.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977   1 MRRLSLSPTFSMGFHLLVIVALLFSHVDYVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFV 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARALTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVYFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  81 AMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTA 160
Cdd:TIGR00845  81 AMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 161 GDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP 240
Cdd:TIGR00845 161 GDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 241 ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDqddeEAR 320
Cdd:TIGR00845 241 LCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFLDGALVLEVKEFD----EAR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 321 REMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTEN 400
Cdd:TIGR00845 317 REMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEN 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 401 DPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD 480
Cdd:TIGR00845 397 DPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDD 476

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 481 IFEEDENFLVHLSNVKVSseaSEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRT 560
Cdd:TIGR00845 477 IFEEDEHFYVRLSNLRVG---SEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRT 553

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 561 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKGgfti 640
Cdd:TIGR00845 554 SGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAA---- 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 641 tgkylygqpvfrkvharehPILSTVITitdeyDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLI 720
Cdd:TIGR00845 630 -------------------LLLNETIT-----DDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLI 685

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 721 KKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILM 800
Cdd:TIGR00845 686 KKTNLALVVGTHSWREQFIEAITVSAGDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILM 765

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 801 IGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 880
Cdd:TIGR00845 766 IGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAA 845

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 881 IYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHI 960
Cdd:TIGR00845 846 IYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHI 925


                  ...
gi 1622853977 961 KGF 963
Cdd:TIGR00845 926 KGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 251-387 2.03e-81

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 259.55  E-value: 2.03e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 251 RRLLFYKYVYKRYRAGKQRGMIIEHEGDR-PSSKTEIEMDGKVVNSHVENFldGALVLEVDERDQDDEEARREMARILKE 329
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELgPKEGIEMLMDGKLVGSHVMEG--GAEGPVDDPEAKELDEARREVIRILKE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853977 330 LKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKA 387
Cdd:pfam16494  79 LKQKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
403-493 3.75e-42

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 148.55  E-value: 3.75e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 403 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 1622853977 483 EEDENFLVHLS 493
Cdd:pfam03160  81 EGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 403-493 1.93e-34

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 126.60  E-value: 1.93e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  403 VSKIFFEQGTYQCLENCGTVALTIIRRGGdLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDDIF 482
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGG-ARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1622853977  483 EEDENFLVHLS 493
Cdd:smart00237  80 EKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 534-624 6.32e-31

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 116.59  E-value: 6.32e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  534 AGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARgGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEY 613
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 1622853977  614 EKNKTFFLEIG 624
Cdd:smart00237  80 EKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
534-624 7.12e-30

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 113.50  E-value: 7.12e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 534 AGIFTFEEPVTHVSESIGIMEVKVLRTSGA-RGNVIVPYKTIEGTARGGgEDFEDTCGELEFQNDEIVKTISVKVIDDEE 612
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 1622853977 613 YEKNKTFFLEIG 624
Cdd:pfam03160  80 YEGDENFFVLLS 91
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 790-954 1.17e-25

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.84  E-value: 1.17e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 790 GWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVF 869
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 870 LGIGVAWSIAAIYHAANGEqfkvspgTLAFSVTLFTIFAFINVGVLLYRRRpeiggelggPRTAKLLTSCLFVLLWLLYI 949
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLL-------KLDLGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVYL 144


                  ....*
gi 1622853977 950 FFSSL 954
Cdd:pfam01699 145 VFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 77-248 2.33e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.73  E-value: 2.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  77 VYFVAMVYMFLGVSIIADRFMSSIEVITsqekeitikkpngettktTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGH 156
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLA------------------RVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 157 NftaGDLGPSTIVGSAAFNMFIIIALCVYV--VPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILsvisPGVVEVWEGLL 234
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 1622853977 235 TFFFFPICVVFAWV 248
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
783-951 3.21e-14

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 74.40  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 783 PPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYaDASIGNVTG 862
Cdd:COG0530   146 PKMSLWKALLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 863 SNAVNVFLGIGvawsIAAIYHaangeqfkvsPGTLAFSVTLFTIFAFINVGVLLY---RRRPEIGGelggprtaklLTSC 939
Cdd:COG0530   225 SNIFNILLVLG----IGALIT----------PIPVDPAVLSFDLPVMLAATLLLLgllRTGGRIGR----------WEGL 280

                         170
                  ....*....|..
gi 1622853977 940 LFVLLWLLYIFF 951
Cdd:COG0530   281 LLLALYLAYLAL 292
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
803-952 3.22e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 59.38  E-value: 3.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 803 LLTAFIGDLASHFGctigLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGIGVAWSIAAIy 882
Cdd:COG0530     3 LLVRGADALARRLG----ISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILGLAALIRPL- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 883 haangeqfKVSPGTLAFSVTLFTIFAFINVGVLLyrrrpeiggelggPRTAKLLTSCLFVLLWLLYIFFS 952
Cdd:COG0530    77 --------AVDRRVLRRDLPFLLLASLLLLALLL-------------DGTLSRIDGVILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
134-252 2.56e-07

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 53.21  E-value: 2.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 134 LTLMALGSSAPEILLSVIEVCGHNFtagDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKI--KHLRVFFVTAAwsifa 211
Cdd:COG0530    24 LTIVAFGTSLPELAVSVTAALDGSP---DIAVGNVVGSNIANILLILGLAALIRPLAVDRRVlrRDLPFLLLASL----- 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622853977 212 ytwlyIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRR 252
Cdd:COG0530    96 -----LLLALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 82-183 4.56e-07

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 54.23  E-value: 4.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977   82 MVYMFLGVSIIADR-FMSSIEVITSQekeitikkpngettkttVRIwNETVSNLTLMALGSSAPEILLSVIEVCghnFTA 160
Cdd:TIGR00927  464 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGVF---ISH 522

                           90       100
                   ....*....|....*....|...
gi 1622853977  161 GDLGPSTIVGSAAFNMFIIIALC 183
Cdd:TIGR00927  523 SNVGIGTIVGSAVFNILFVIGTC 545
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 798-913 5.07e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 49.63  E-value: 5.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 798 ILMIGLLTAFIG----------DLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVN 867
Cdd:TIGR00367   1 LLLIGYLILGLIlliygadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQ-PDIGVGNVIGSNIFN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622853977 868 VFLGIGVAWSIAAIYHAANGEQFKVsPGTLAFSVTLFTIFAFINVG 913
Cdd:TIGR00367  80 ILLILGLSAIFSPIIVDKDWLRRDI-LFYLLVSILLLFFGLDGQIS 124
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 80-283 1.41e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.09  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  80 VAMVYMFLGVSII-ADRFMSSIEVITSqekeiTIKKPNgettkttvriwneTVSNLTLMALGSSAPEILLSVIEVCGHNf 158
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIAR-----HLGISP-------------LIIGVTVVAIGTSLPELFTSLIASLMGQ- 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 159 taGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkikhlrvfFVTAAWSIFAYTWLYIILSVIspgvvevwegLLTFFF 238
Cdd:TIGR00367  65 --PDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRRDILFYLLVSIL----------LLFFGL 119

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1622853977 239 F----PICVVFAWVAdrRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSK 283
Cdd:TIGR00367 120 DgqisRIDGVVLLIL--YIVYLLFLVKNERWVKYDTYTEENLDENNRRP 166
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 794-928 1.56e-04

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 45.01  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 794 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNVFLGIG 873
Cdd:TIGR00367 175 LIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPE-LVVSLAAARKGLGDIAVGNVIGSNIFNILVGLG 253

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622853977 874 VAWSIAAIyhaangeQFKVSPGTLAFSVTLFTIFAFinvgVLLYRRRPEIGGELG 928
Cdd:TIGR00367 254 VPSLFMPI-------PVEPLAYNLDAPVMVIVTLLL----MLFFKTSMKLGRWEG 297
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 794-908 1.97e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  794 FIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDqYADASIGNVTGSNAVNVFLGIG 873
Cdd:TIGR00927  938 FLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKG-LGDMAVSSSVGSNIFDITVGLP 1016

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622853977  874 VAWsiaAIYHAANGEQ-FKVSPG------TLAFSVTLFTIFA 908
Cdd:TIGR00927 1017 VPW---LLFSLINGLQpVPVSSNglfcaiVLLFLMLLFVISS 1055
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 811-950 2.23e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.64  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 811 LASHFGC---TIGLkdsvtavVFVALGTSVPDtFASKVAATQDQYADASIGNVTGSNAVNV--FLGIGVAWSIAAIYHAA 885
Cdd:PRK10734  200 LANYFAIselTIGL-------TVIAIGTSLPE-LATAIAGARKGENDIAVGNIIGSNIFNIviVLGLPALISPGEINPLA 271

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622853977 886 NGEQFKVspgTLAFSVtLFTifafinvgVLLYRRRPEIGGELGGprtakLLTSCLFVLLWLLYIF 950
Cdd:PRK10734  272 FSRDYWV---MLLVSV-IFA--------LLCWRRKRRIGRGAGA-----LLLGGFIVWLAMLYWL 319
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 798-875 1.17e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 42.33  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 798 ILMIGLLTAFIGD-----LASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQyADASIGNVTGSNAVNVFLGI 872
Cdd:PRK10734    7 LLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNILLIL 85


                  ...
gi 1622853977 873 GVA 875
Cdd:PRK10734   86 GLA 88
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 77-258 2.09e-03

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 42.06  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977  77 VYFVAMVYMfLGvSIIADRFMSSIEVITSqekeiTIKKPngettkttvriwnETVSNLTLMALGSSAPEILLSVIEVCGH 156
Cdd:PLN03151  145 VWLVALFYL-LG-NTAADYFCCSLEKLSK-----LLRLP-------------PTVAGVTLLPLGNGAPDVFASIAAFVGK 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 157 NftAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKhlRVFFVTAAWSIFAYTWLYIILSVispGVVEVWEGLLtf 236
Cdd:PLN03151  205 D--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFLFTLVSLLVILMV---GKVTVGGAIA-- 275

                         170       180
                  ....*....|....*....|..
gi 1622853977 237 fFFPICVVFAWVADRRLLFYKY 258
Cdd:PLN03151  276 -FVSIYVVYAFLVAANEILRKH 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
127-245 4.55e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.12  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853977 127 WNETVSNLTLMALGSSAPEILLSVIEVC-GHnftaGDLGPSTIVGSAAFNMFIIIALCVYVVPdgetrkIKHLRVFFVTA 205
Cdd:COG0530   184 VSELVIGLTIVAIGTSLPELATSIVAARkGE----DDLAVGNIIGSNIFNILLVLGIGALITP------IPVDPAVLSFD 253

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622853977 206 AWSIFAYTWLYIILsVISPGVVEVWEGLLTFFFFPICVVF 245
Cdd:COG0530   254 LPVMLAATLLLLGL-LRTGGRIGRWEGLLLLALYLAYLAL 292
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 317-388 9.87e-03

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 37.84  E-value: 9.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622853977 317 EEARREMARILKELKQKHpEKEIEQLIELANYQVLSQQQKSRAFYRIQATRL-MTGAGNILKRHAADQARKAV 388
Cdd:COG0711    73 AEARKEAEAIAEEAKAEA-EAEAERIIAQAEAEIEQERAKALAELRAEVADLaVAIAEKILGKELDAAAQAAL 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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