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Conserved domains on  [gi|1622853066|ref|XP_028687142|]
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ankyrin repeat and MYND domain-containing protein 1 isoform X2 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
80-186 2.44e-22

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 98.10  E-value: 2.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMK--TR 157
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 1622853066  158 lFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-819 2.21e-19

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 2.21e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  604 RMALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAalp 682
Cdd:COG0666     88 NTLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGN-TPLHLAA--- 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  683 gEEG-VQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEReDDN 761
Cdd:COG0666    162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAEN-GHL 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853066  762 KVVKELLTHGADPNLPLTKGlGSALCIACDLtyehqrsvdERLALIDRLINHGADILK 819
Cdd:COG0666    200 EIVKLLLEAGADVNAKDNDG-KTALDLAAEN---------GNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-419 6.67e-10

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 6.67e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  346 ERLSTEMILKAEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
zf-MYND pfam01753
MYND finger;
933-973 1.91e-09

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.96  E-value: 1.91e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622853066  933 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 973
Cdd:pfam01753    1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
DUF2857 super family cl12747
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 565-640 8.34e-04

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


The actual alignment was detected with superfamily member pfam11198:

Pssm-ID: 431719  Cd Length: 174  Bit Score: 41.49  E-value: 8.34e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853066  565 NFSIELSQAMLERSAQSHSLLKMASPSLCTSSFDKGTMRRMALSMIERRKRWQTIKLLLRRGADPNLcrvpMQALF 640
Cdd:pfam11198   24 GFSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.44e-22

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 98.10  E-value: 2.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMK--TR 157
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 1622853066  158 lFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-819 2.21e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 2.21e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  604 RMALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAalp 682
Cdd:COG0666     88 NTLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGN-TPLHLAA--- 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  683 gEEG-VQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEReDDN 761
Cdd:COG0666    162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAEN-GHL 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853066  762 KVVKELLTHGADPNLPLTKGlGSALCIACDLtyehqrsvdERLALIDRLINHGADILK 819
Cdd:COG0666    200 EIVKLLLEAGADVNAKDNDG-KTALDLAAEN---------GNLEIVKLLLEAGADLNA 247
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-186 1.09e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 85.27  E-value: 1.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   85 WQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYG-TMYMKTRLFQGLY 163
Cdd:PLN03185    28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGyQRYPNGDVFEGSW 107

                           90       100
                   ....*....|....*....|...
gi 1622853066  164 KADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185   108 IQGLQEGPGKYTWANGNVYLGDM 130
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-419 6.67e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 6.67e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  346 ERLSTEMILKAEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
zf-MYND pfam01753
MYND finger;
933-973 1.91e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.96  E-value: 1.91e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622853066  933 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 973
Cdd:pfam01753    1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
639-776 2.14e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  639 LFLAVKAGDVDGVRLLLEHGARTDICFPPQlgtLTPLHIAAAlpgEEGVQIVELLL-HAITDVDAEasdkdstyksgkld 717
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNG---RTALHLAAK---NGHLEIVKLLLeHADVNLKDN-------------- 60

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622853066  718 llpsslklsnepgppqayysmdtplpeegGRTALHMACeREDDNKVVKELLTHGADPNL 776
Cdd:pfam12796   61 -----------------------------GRTALHYAA-RSGHLEIVKLLLEKGADINV 89
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 376-428 2.21e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 2.21e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622853066  376 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLVYYP 428
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 618-817 3.46e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.82  E-value: 3.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  618 TIKLLLRRGADPNLCRV----PMQALfLAVKAGDVDGVRLLLEHGARTDICFPPqlgTLTPLHIAAALPGEEgVQIVELL 693
Cdd:PHA03100    88 IVKLLLEYGANVNAPDNngitPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNSD---GENLLHLYLESNKID-LKILKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  694 LHAITDVDAeasdKDstyksgKLDLLPSslklsnepgppqayYSMDTPLPEEGGRTALHMACEREDDNkVVKELLTHGAD 773
Cdd:PHA03100   163 IDKGVDINA----KN------RVNYLLS--------------YGVPINIKDVYGFTPLHYAVYNNNPE-FVKYLLDLGAN 217

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1622853066  774 PNLPLTKGLgSALCIACDltyehqrsvDERLALIDRLINHGADI 817
Cdd:PHA03100   218 PNLVNKYGD-TPLHIAIL---------NNNKEIFKLLLNNGPSI 251
Ank_2 pfam12796
Ankyrin repeats (3 copies);
356-419 1.77e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 1.77e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCgADVNKCsDEGLTAL 419
Cdd:pfam12796    5 AKNGNLE-LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTAL 65
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-776 2.53e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 2.53e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 1622853066   747 GRTALHMACEReDDNKVVKELLTHGADPNL 776
Cdd:smart00248    2 GRTPLHLAAEN-GNLEVVKLLLDKGADINA 30
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 7.19e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.47  E-value: 7.19e-05
                           10        20
                   ....*....|....*....|...
gi 1622853066  114 YHGQFYRDHCHGLGTYTWPDGSS 136
Cdd:pfam02493    1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 4.28e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.48  E-value: 4.28e-04
                            10        20
                    ....*....|....*....|.
gi 1622853066   113 SYHGQFYRDHCHGLGTYTWPD 133
Cdd:smart00698    2 RYEGEWRNGKRHGRGVYTYAN 22
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 565-640 8.34e-04

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 41.49  E-value: 8.34e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853066  565 NFSIELSQAMLERSAQSHSLLKMASPSLCTSSFDKGTMRRMALSMIERRKRWQTIKLLLRRGADPNLcrvpMQALF 640
Cdd:pfam11198   24 GFSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 381-410 3.68e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.68e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1622853066   381 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 410
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.44e-22

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 98.10  E-value: 2.44e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMK--TR 157
Cdd:COG4642    139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYAdgDR 218

                           90       100
                   ....*....|....*....|....*....
gi 1622853066  158 lFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    219 -YEGEFKNGKRHGQGTLTYADGDRYEGEF 246
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.90e-20

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 91.94  E-value: 2.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMKT-RL 158
Cdd:COG4642    116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANgDV 195

                           90       100
                   ....*....|....*....|....*...
gi 1622853066  159 FQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    196 YEGEFKNGQRHGQGTYTYADGDRYEGEF 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-819 2.21e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 2.21e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  604 RMALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAalp 682
Cdd:COG0666     88 NTLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGN-TPLHLAA--- 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  683 gEEG-VQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEReDDN 761
Cdd:COG0666    162 -ANGnLEIVKLLLEAGADVNARDND----------------------------------------GETPLHLAAEN-GHL 199

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622853066  762 KVVKELLTHGADPNLPLTKGlGSALCIACDLtyehqrsvdERLALIDRLINHGADILK 819
Cdd:COG0666    200 EIVKLLLEAGADVNAKDNDG-KTALDLAAEN---------GNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-186 2.47e-19

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 89.25  E-value: 2.47e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMymktrlf 159
Cdd:COG4642    185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTM------- 257

                           90       100
                   ....*....|....*....|....*..
gi 1622853066  160 qglykadqrfgpgveTYPDGSQDVGLW 186
Cdd:COG4642    258 ---------------TYADGSVYEGEW 269
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-186 1.09e-16

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 85.27  E-value: 1.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   85 WQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYG-TMYMKTRLFQGLY 163
Cdd:PLN03185    28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGyQRYPNGDVFEGSW 107

                           90       100
                   ....*....|....*....|...
gi 1622853066  164 KADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185   108 IQGLQEGPGKYTWANGNVYLGDM 130
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
604-817 1.35e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 81.54  E-value: 1.35e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  604 RMALSMIERRKRWQTIKLLLRRGADPNLCRVPMQ-ALFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAAlp 682
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNtLLHAAARNGDLEIVKLLLEAGA--DVNARDKDGE-TPLHLAAY-- 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  683 gEEGVQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEReDDNK 762
Cdd:COG0666    130 -NGNLEIVKLLLEAGADVNAQDND----------------------------------------GNTPLHLAAAN-GNLE 167

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622853066  763 VVKELLTHGADPNLPLTKGlGSALCIACDltyehqrsvDERLALIDRLINHGADI 817
Cdd:COG0666    168 IVKLLLEAGADVNARDNDG-ETPLHLAAE---------NGHLEIVKLLLEAGADV 212
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
606-818 5.86e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.53  E-value: 5.86e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  606 ALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQALFLAVKAGDVDGVRLLLEHGARTDIcfPPQLGTlTPLHIAAalpgE 684
Cdd:COG0666    123 PLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNA--RDNDGE-TPLHLAA----E 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  685 EG-VQIVELLLHAITDVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDDNkV 763
Cdd:COG0666    196 NGhLEIVKLLLEAGADVNAKDND----------------------------------------GKTALDLAAENGNLE-I 234

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622853066  764 VKELLTHGADPNLPLTKGLGSALCIACDLTYEHQRSVDERLALIDRLINHGADIL 818
Cdd:COG0666    235 VKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
77-186 1.68e-12

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 68.83  E-value: 1.68e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   77 QLVQGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642     90 DGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYAD 169

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1622853066  157 -RLFQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:COG4642    170 gDRYEGEFKNGKRHGQGTLTYANGDVYEGEF 200
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
346-419 6.67e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 6.67e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  346 ERLSTEMILKAEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     85 DGGNTLLHAAARNGDLE-IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
619-817 8.07e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.12  E-value: 8.07e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  619 IKLLLRRGADPNLCRVPMQALFLAVKAGDVDGVRLLLEHGARTDIcfpPQLGTLTPLHIAAAlpgEEGVQIVELLLHAIT 698
Cdd:COG0666     38 LLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA---KDDGGNTLLHAAAR---NGDLEIVKLLLEAGA 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  699 DVDAEASDkdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACeREDDNKVVKELLTHGADPNLPL 778
Cdd:COG0666    112 DVNARDKD----------------------------------------GETPLHLAA-YNGNLEIVKLLLEAGADVNAQD 150

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1622853066  779 TKGLgSALCIACDltyehqrsvDERLALIDRLINHGADI 817
Cdd:COG0666    151 NDGN-TPLHLAAA---------NGNLEIVKLLLEAGADV 179
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 79-155 1.17e-09

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 62.54  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   79 VQGVQE------WQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTM 152
Cdd:PLN03185   108 IQGLQEgpgkytWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187


                   ...
gi 1622853066  153 YMK 155
Cdd:PLN03185   188 YPA 190
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
350-419 1.83e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.83e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  350 TEMILKAEEGNHDWIcGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666    122 TPLHLAAYNGNLEIV-KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPL 190
zf-MYND pfam01753
MYND finger;
933-973 1.91e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 53.96  E-value: 1.91e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622853066  933 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 973
Cdd:pfam01753    1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
639-776 2.14e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.51  E-value: 2.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  639 LFLAVKAGDVDGVRLLLEHGARTDICFPPQlgtLTPLHIAAAlpgEEGVQIVELLL-HAITDVDAEasdkdstyksgkld 717
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNG---RTALHLAAK---NGHLEIVKLLLeHADVNLKDN-------------- 60

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622853066  718 llpsslklsnepgppqayysmdtplpeegGRTALHMACeREDDNKVVKELLTHGADPNL 776
Cdd:pfam12796   61 -----------------------------GRTALHYAA-RSGHLEIVKLLLEKGADINV 89
Ank_2 pfam12796
Ankyrin repeats (3 copies);
618-702 4.04e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 54.74  E-value: 4.04e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  618 TIKLLLRRGADPNLCRV-PMQALFLAVKAGDVDGVRLLLEHGARTDicfppQLGTLTPLHIAAalpgEEG-VQIVELLLH 695
Cdd:pfam12796   12 LVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                   ....*..
gi 1622853066  696 AITDVDA 702
Cdd:pfam12796   83 KGADINV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
356-421 2.66e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 2.66e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853066  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSM 421
Cdd:COG0666    161 AANGNLE-IVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 87-186 1.15e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 55.99  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   87 DGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGTmYMKTR--LFQGLYK 164
Cdd:PLN03185     7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGTDgtTYKGRWR 85

                           90       100
                   ....*....|....*....|..
gi 1622853066  165 ADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185    86 LNLKHGLGYQRYPNGDVFEGSW 107
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-776 1.66e-07

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 48.05  E-value: 1.66e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622853066  747 GRTALHMACEREDDNKVVKELLTHGADPNL 776
Cdd:pfam00023    2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNA 31
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 376-428 2.21e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.20  E-value: 2.21e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622853066  376 DVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMCFLVYYP 428
Cdd:PHA03100   186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
350-419 2.46e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 2.46e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  350 TEMILKAEEGNHDWICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666     55 ALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 80-186 3.40e-06

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 50.99  E-value: 3.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066   80 QGVQEWQDGCMYRGEFGLNMKLGYGEFSWPTGESYHGQFYRDHCHGLGTYTWPDGSSFTGTFYLSHREGYGT-MYMKTRL 158
Cdd:PLN03185    46 NGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKyTWANGNV 125

                           90       100
                   ....*....|....*....|....*...
gi 1622853066  159 FQGLYKADQRFGPGVETYPDGSQDVGLW 186
Cdd:PLN03185   126 YLGDMKGGKMSGKGTLTWVSGDSYEGQW 153
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 618-817 3.46e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.82  E-value: 3.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  618 TIKLLLRRGADPNLCRV----PMQALfLAVKAGDVDGVRLLLEHGARTDICFPPqlgTLTPLHIAAALPGEEgVQIVELL 693
Cdd:PHA03100    88 IVKLLLEYGANVNAPDNngitPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNSD---GENLLHLYLESNKID-LKILKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  694 LHAITDVDAeasdKDstyksgKLDLLPSslklsnepgppqayYSMDTPLPEEGGRTALHMACEREDDNkVVKELLTHGAD 773
Cdd:PHA03100   163 IDKGVDINA----KN------RVNYLLS--------------YGVPINIKDVYGFTPLHYAVYNNNPE-FVKYLLDLGAN 217

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1622853066  774 PNLPLTKGLgSALCIACDltyehqrsvDERLALIDRLINHGADI 817
Cdd:PHA03100   218 PNLVNKYGD-TPLHIAIL---------NNNKEIFKLLLNNGPSI 251
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 607-816 3.61e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.76  E-value: 3.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  607 LSMIERRKRWQTIKLLLRRGADPNLCRVPMQA-LFLAVKAGDVDGVRLLLEHGARTDICFPPQlgTLTPLHIAAALpgeE 685
Cdd:PHA02875    39 IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESeLHDAVEEGDVKAVEELLDLGKFADDVFYKD--GMTPLHLATIL---K 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  686 GVQIVELLLHAITDVDAEASDKDSTYK----SGKLDLLPSSLKlsnepgppqayYSMDTPLPEEGGRTALHMACEREDdN 761
Cdd:PHA02875   114 KLDIMKLLIARGADPDIPNTDKFSPLHlavmMGDIKGIELLID-----------HKACLDIEDCCGCTPLIIAMAKGD-I 181

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622853066  762 KVVKELLTHGADPNLPLTKGLGSALCIACDltyehqrsvDERLALIDRLINHGAD 816
Cdd:PHA02875   182 AICKMLLDSGANIDYFGKNGCVAALCYAIE---------NNKIDIVRLFIKRGAD 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 606-790 6.28e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 6.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  606 ALSMIERRKRWQTIKLLLRRGADPN-LCRVPMQALFLAVKAGDVDGVRLLLEHGARTDIcfPPQLGTlTPLHIAAALPge 684
Cdd:PHA02878   171 ALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA--RDKCGN-TPLHISVGYC-- 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  685 EGVQIVELLLHAITDVDAEASDKdstyksgkldllpsslklsnepgppqayysmdtplpeegGRTALHMACEREDdnkVV 764
Cdd:PHA02878   246 KDYDILKLLLEHGVDVNAKSYIL---------------------------------------GLTALHSSIKSER---KL 283

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1622853066  765 KELLTHGADPNL-------PLTKGLGSALCIAC 790
Cdd:PHA02878   284 KLLLEYGADINSlnsykltPLSSAVKQYLCINI 316
Ank_2 pfam12796
Ankyrin repeats (3 copies);
356-419 1.77e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 1.77e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCgADVNKCsDEGLTAL 419
Cdd:pfam12796    5 AKNGNLE-LVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLK-DNGRTAL 65
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 747-776 2.53e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.80  E-value: 2.53e-05
                            10        20        30
                    ....*....|....*....|....*....|
gi 1622853066   747 GRTALHMACEReDDNKVVKELLTHGADPNL 776
Cdd:smart00248    2 GRTPLHLAAEN-GNLEVVKLLLDKGADINA 30
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 7.19e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.47  E-value: 7.19e-05
                           10        20
                   ....*....|....*....|...
gi 1622853066  114 YHGQFYRDHCHGLGTYTWPDGSS 136
Cdd:pfam02493    1 YEGEWKNGKRHGKGVYTWPDGDR 23
Ank_4 pfam13637
Ankyrin repeats (many copies);
382-419 1.17e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.17e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1622853066  382 GYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETAL 38
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 4.28e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 38.48  E-value: 4.28e-04
                            10        20
                    ....*....|....*....|.
gi 1622853066   113 SYHGQFYRDHCHGLGTYTWPD 133
Cdd:smart00698    2 RYEGEWRNGKRHGRGVYTYAN 22
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 747-775 6.40e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 6.40e-04
                           10        20
                   ....*....|....*....|....*....
gi 1622853066  747 GRTALHMACeREDDNKVVKELLTHGADPN 775
Cdd:pfam13606    2 GNTPLHLAA-RNGRLEIVKLLLENGADIN 29
DUF2857 pfam11198
Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.
 565-640 8.34e-04

Protein of unknown function (DUF2857); This is a bacterial family of uncharacterized proteins.


Pssm-ID: 431719  Cd Length: 174  Bit Score: 41.49  E-value: 8.34e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853066  565 NFSIELSQAMLERSAQSHSLLKMASPSLCTSSFDKGTMRRMALSMIERRKRWQTIKLLLRRGADPNLcrvpMQALF 640
Cdd:pfam11198   24 GFSPEELDALKSLSLEDLHYLSNARVSFLRVTVDHDVLRRLLAQAREEQERRQLIDRALRLGASIEL----MARLF 95
Ank_2 pfam12796
Ankyrin repeats (3 copies);
356-409 1.24e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.94  E-value: 1.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  356 AEEGNHDwICGILKDNFASADVADakGYTVLAAAATHCHNDIVNLLLDCGADVN 409
Cdd:pfam12796   38 AKNGHLE-IVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGADIN 88
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 381-413 1.36e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 1.36e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622853066  381 KGYTVL-AAAATHCHNDIVNLLLDCGADVNKCSD 413
Cdd:pfam00023    1 DGNTPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
356-419 1.98e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 41.48  E-value: 1.98e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622853066  356 AEEGNHDwICGILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:COG0666    194 AENGHLE-IVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
Ank_2 pfam12796
Ankyrin repeats (3 copies);
386-419 2.00e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.56  E-value: 2.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1622853066  386 LAAAATHCHNDIVNLLLDCGADVNKCSDEGLTAL 419
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTAL 34
Ank_4 pfam13637
Ankyrin repeats (many copies);
636-694 2.23e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622853066  636 MQALFLAVKAGDVDGVRLLLEHGA---RTDICFppqlgtLTPLHIAAAlpgEEGVQIVELLL 694
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 381-410 3.68e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.03  E-value: 3.68e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1622853066   381 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 410
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_5 pfam13857
Ankyrin repeats (many copies);
367-422 3.73e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 3.73e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622853066  367 ILKDNFASADVADAKGYTVLAAAATHCHNDIVNLLLDCGADVNKCSDEGLTALSMC 422
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
751-817 4.37e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 4.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622853066  751 LHMACEReDDNKVVKELLTHGADPNLPLTKGLgSALCIACD----------LTYEHQRSVDE------------RLALID 808
Cdd:pfam12796    1 LHLAAKN-GNLELVKLLLENGADANLQDKNGR-TALHLAAKnghleivkllLEHADVNLKDNgrtalhyaarsgHLEIVK 78


                   ....*....
gi 1622853066  809 RLINHGADI 817
Cdd:pfam12796   79 LLLEKGADI 87
Ank_2 pfam12796
Ankyrin repeats (3 copies);
617-663 4.86e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 4.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622853066  617 QTIKLLLRRgADPNLCRVPMQALFLAVKAGDVDGVRLLLEHGARTDI 663
Cdd:pfam12796   44 EIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 381-410 5.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 5.52e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622853066  381 KGYTVLAAAATHCHNDIVNLLLDCGADVNK 410
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA03095 PHA03095
ankyrin-like protein; Provisional
 747-819 8.39e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.01  E-value: 8.39e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622853066  747 GRTALH--MACEREDDNKVVKELLTHGADPNLPLTKGLGSALCIACDltyehqrsvDERLALIDRLINHGADILK 819
Cdd:PHA03095    47 GKTPLHlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYN---------ATTLDVIKLLIKAGADVNA 112
Ank_5 pfam13857
Ankyrin repeats (many copies);
733-776 8.80e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 8.80e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622853066  733 QAYYSMDTPLPEEGGRTALHMACEReDDNKVVKELLTHGADPNL 776
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKY-GALEIVRVLLAYGVDLNL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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