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Conserved domains on  [gi|1622851439|ref|XP_028686916|]
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fibronectin isoform X4 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.91e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.91e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1622851439   353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.50e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.50e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1622851439   413 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1540-1621 6.51e-21

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.01  E-value: 6.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1540 DVPRDLEVVAATPTSLLISWDAPAV---TVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622851439 1617 DSPAS 1621
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1450-1529 1.12e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 79.77  E-value: 1.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1450 DSPTGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPEHMSGRPREDRVPPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1622851439 1527 ESP 1529
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1995-2075 1.60e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 1.60e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1995 DAPSNLRFLATTPNSLLVSWQPPR---ARITGYIIKYEKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 2072 KSEP 2075
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
1359-1440 4.91e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.84  E-value: 4.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1359 PPPTDLRFTNIGPDTMRVTWAPPP--SIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1437 ESTP 1440
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1634-1714 1.74e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.30  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1634 DKPSQMQVTDVQDNSISVKWLPS---SSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNPNG 1710
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1711 ESQP 1714
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1058-1481 1.85e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.82  E-value: 1.85e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1058 PGSEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGS 1137
Cdd:COG3401    107 TNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1138 IVVSGLT-------PGVEYVYTIQVLRDGQERDAP---IVNKVVTPLSPPTNLHLETNPDTGVlTVSWERSTTPDITGYR 1207
Cdd:COG3401    187 VTSTTLVdgggdiePGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYR 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1208 ITTTPTNGQqgySLEEVVHADQSSCTFDNLSPGLEYNVSVYTV-KDDKESVP------ISDTIIPEVPQltDLSFVDITD 1280
Cdd:COG3401    266 VYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsnvvsvTTDLTPPAAPS--GLTATAVGS 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1281 SSIGLRWTPLNSSTIIGYRITVVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTA 1357
Cdd:COG3401    341 SSITLSWTASSDADVTGYNVYRSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1358 VPPPTDLRFTNiGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQhe 1437
Cdd:COG3401    418 ASAASGESLTA-SVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTG-- 494

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1622851439 1438 STPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1481
Cdd:COG3401    495 SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 186-230 1.93e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 1.93e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 230
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1814-1894 2.19e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1814 PAPTDLKFTQVTPTSLSAQWTPP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1891 TSRP 1894
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.30e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 2.30e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
812-883 2.80e-15

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 2.80e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622851439  812 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIFAV 883
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2317-2358 4.43e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.43e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1622851439  2317 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHE 2358
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-508 1.05e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.05e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1622851439   470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
1696-2066 1.14e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.05  E-value: 1.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1696 TVEYVVSVFAQNPNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEE 1775
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1776 DTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGP 1855
Cdd:COG3401    102 SVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1856 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET-I 1932
Cdd:COG3401    182 TTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1933 TGFQV--DAVPANGQTPVQRTIKPdvrSYTITGLQPGTDYKIYLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLAT 2005
Cdd:COG3401    262 TGYRVyrSNSGDGPFTKVATVTTT---SYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAV 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622851439 2006 TPNSLLVSWQPPR-ARITGYIIKYEKPGSSPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 2066
Cdd:COG3401    339 GSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
231-270 1.25e-14

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.25e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 270
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
711-1034 1.67e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 1.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  711 VTGETTPLSPlvaTSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNIPDLLPGRKY--- 786
Cdd:COG3401    227 TTPTTPPSAP---TGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTDTGLTNGTTYyyr 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  787 IVNVYEISEDGEQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGSSTELNLPETANS 864
Cdd:COG3401    302 VTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIAETVTTTS 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  865 VTLSDLQPGVQYNITIFAV----EENQESTPVFIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVD 940
Cdd:COG3401    382 YTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADG 461

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  941 VIPVNLPgehgqrlPISRNTFAEVTGLSPGVTYYFKVFAVNHGRESKPLTAEQTTKLDAPTNLQFVNETDSTVLVRWTPP 1020
Cdd:COG3401    462 GDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGAS 534

                          330
                   ....*....|....
gi 1622851439 1021 RARITGYRLTVGLT 1034
Cdd:COG3401    535 PVTVGASTGDVLIT 548
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2272-2316 2.67e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.67e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439  2272 CFDPYTVSHYAVGDEWERMSESGFKLLCHCLGFGSGHFRCDSSRW 2316
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 8.52e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.38  E-value: 8.52e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 97-140 2.12e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.52  E-value: 2.12e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439    97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 140
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 141-184 3.10e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.14  E-value: 3.10e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1622851439   141 CHEG--GQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 184
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2360-2399 8.95e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.95e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439 2360 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2399
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
619-688 2.59e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622851439  619 TPSQPNSHPIQWNAPQP--SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 52-89 2.15e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.15e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   52 CYDN--GKHYQINQQWERTYLGNALICTCYGGSRGFNCES 89
Cdd:cd00061      3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn3 pfam00041
Fibronectin type III domain;
2186-2244 4.90e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 4.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622851439 2186 TISW-APFQDTSE---YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEALKDQ 2244
Cdd:pfam00041   17 TVSWtPPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 6.63e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.32  E-value: 6.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  307 HCVTDS-GVVYSVGMQWLKTQGNKQMLCMCLGN--GVSCQET 345
Cdd:cd00061      2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.91e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.91e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1622851439   353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.50e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.50e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1622851439   413 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.97e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 1.97e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622851439  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.23e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.23e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622851439  414 NSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn3 pfam00041
Fibronectin type III domain;
1540-1621 6.51e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.01  E-value: 6.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1540 DVPRDLEVVAATPTSLLISWDAPAV---TVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622851439 1617 DSPAS 1621
Cdd:pfam00041   81 EGPPS 85
fn2 pfam00040
Fibronectin type II domain;
360-401 1.84e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 1.84e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn2 pfam00040
Fibronectin type II domain;
420-461 1.43e-18

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 80.69  E-value: 1.43e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  420 CHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1450-1529 1.12e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 79.77  E-value: 1.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1450 DSPTGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPEHMSGRPREDRVPPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1622851439 1527 ESP 1529
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1995-2075 1.60e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 1.60e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1995 DAPSNLRFLATTPNSLLVSWQPPR---ARITGYIIKYEKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 2072 KSEP 2075
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
1359-1440 4.91e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.84  E-value: 4.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1359 PPPTDLRFTNIGPDTMRVTWAPPP--SIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1437 ESTP 1440
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1634-1714 1.74e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.30  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1634 DKPSQMQVTDVQDNSISVKWLPS---SSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNPNG 1710
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1711 ESQP 1714
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1058-1481 1.85e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.82  E-value: 1.85e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1058 PGSEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGS 1137
Cdd:COG3401    107 TNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1138 IVVSGLT-------PGVEYVYTIQVLRDGQERDAP---IVNKVVTPLSPPTNLHLETNPDTGVlTVSWERSTTPDITGYR 1207
Cdd:COG3401    187 VTSTTLVdgggdiePGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYR 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1208 ITTTPTNGQqgySLEEVVHADQSSCTFDNLSPGLEYNVSVYTV-KDDKESVP------ISDTIIPEVPQltDLSFVDITD 1280
Cdd:COG3401    266 VYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsnvvsvTTDLTPPAAPS--GLTATAVGS 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1281 SSIGLRWTPLNSSTIIGYRITVVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTA 1357
Cdd:COG3401    341 SSITLSWTASSDADVTGYNVYRSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1358 VPPPTDLRFTNiGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQhe 1437
Cdd:COG3401    418 ASAASGESLTA-SVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTG-- 494

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1622851439 1438 STPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1481
Cdd:COG3401    495 SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538
fn3 pfam00041
Fibronectin type III domain;
1995-2075 1.13e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1995 DAPSNLRFLATTPNSLLVSWQPPRAR---ITGYIIKYEKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 2072 KSEP 2075
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1540-1622 1.87e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.68  E-value: 1.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1540 DVPRDLEVVAATPTSLLISWDAPAVT---VRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622851439 1617 DSPASS 1622
Cdd:cd00063     82 ESPPSE 87
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 186-230 1.93e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 1.93e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 230
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1814-1894 2.19e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1814 PAPTDLKFTQVTPTSLSAQWTPP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1891 TSRP 1894
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.30e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 2.30e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
812-883 2.80e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 2.80e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622851439  812 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIFAV 883
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2317-2358 4.43e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.43e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1622851439  2317 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHE 2358
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 811-899 6.32e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 6.32e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  811 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIFAVEEN 886
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622851439  887 QESTPVFIQQETT 899
Cdd:cd00063     81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-508 1.05e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.05e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1622851439   470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1696-2066 1.14e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.05  E-value: 1.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1696 TVEYVVSVFAQNPNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEE 1775
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1776 DTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGP 1855
Cdd:COG3401    102 SVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1856 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET-I 1932
Cdd:COG3401    182 TTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1933 TGFQV--DAVPANGQTPVQRTIKPdvrSYTITGLQPGTDYKIYLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLAT 2005
Cdd:COG3401    262 TGYRVyrSNSGDGPFTKVATVTTT---SYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAV 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622851439 2006 TPNSLLVSWQPPR-ARITGYIIKYEKPGSSPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 2066
Cdd:COG3401    339 GSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
231-270 1.25e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.25e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 270
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
711-1034 1.67e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 1.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  711 VTGETTPLSPlvaTSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNIPDLLPGRKY--- 786
Cdd:COG3401    227 TTPTTPPSAP---TGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTDTGLTNGTTYyyr 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  787 IVNVYEISEDGEQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGSSTELNLPETANS 864
Cdd:COG3401    302 VTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIAETVTTTS 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  865 VTLSDLQPGVQYNITIFAV----EENQESTPVFIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVD 940
Cdd:COG3401    382 YTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADG 461

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  941 VIPVNLPgehgqrlPISRNTFAEVTGLSPGVTYYFKVFAVNHGRESKPLTAEQTTKLDAPTNLQFVNETDSTVLVRWTPP 1020
Cdd:COG3401    462 GDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGAS 534

                          330
                   ....*....|....
gi 1622851439 1021 RARITGYRLTVGLT 1034
Cdd:COG3401    535 PVTVGASTGDVLIT 548
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 231-275 1.95e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.95e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTT 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2272-2316 2.67e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.67e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439  2272 CFDPYTVSHYAVGDEWERMSESGFKLLCHCLGFGSGHFRCDSSRW 2316
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1906-1985 6.90e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 6.90e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1906 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAVPANGQTPVQ-RTIKPDVRSYTITGLQPGTDYKIYLYTLNDNA 1981
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1982 RSSP 1985
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
908-988 7.32e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 7.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  908 PSPRDLQFVEVTDVKVTIMWTPPE---SAVTGYRVDVIPVNLpGEHGQRLPISRNTF-AEVTGLSPGVTYYFKVFAVNHG 983
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622851439  984 RESKP 988
Cdd:pfam00041   80 GEGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 8.52e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.38  E-value: 8.52e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 1.26e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.95  E-value: 1.26e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1359-1438 1.30e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 1.30e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1359 PPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1437 ES 1438
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1634-1721 1.77e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1634 DKPSQMQVTDVQDNSISVKWLPSS---SPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNPNG 1710
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1622851439 1711 ESQPLVQTAVT 1721
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1359-1440 2.09e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 2.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1359 PPPTDLRFTNIGPDTMRVTWAPPPSI--DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 1437 ESTP 1440
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
1268-1350 2.20e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 2.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1268 PQLTDLSFVDITDSSIGLRWTPL--NSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1345
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622851439 1346 ESAPT 1350
Cdd:pfam00041   81 EGPPS 85
fn1 pfam00039
Fibronectin type I domain;
561-599 2.42e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.42e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1450-1529 2.85e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1450 DSPTGIDFSDITANSFTVHWIAPRAT---ITGYRIRHHPEHMSGRPREDRVPPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 1622851439 1527 ESP 1529
Cdd:cd00063     82 ESP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 4.60e-13

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 65.43  E-value: 4.60e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622851439  559 DQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
186-225 8.13e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.64  E-value: 8.13e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 225
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1995-2073 9.88e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 9.88e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1995 DAPSNLRFLATTPNSLLVSWQPP-RARITGYIIKY--EKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  2072 KS 2073
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1542-1618 1.01e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 1.01e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1542 PRDLEVVAATPTSLLISWDAPAVT-----VRYYRITYGETGGNspVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1617 DS 1618
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 910-995 1.87e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  910 PRDLQFVEVTDVKVTIMWTPPE---SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVNHGRES 986
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 1622851439  987 KPLTAEQTT 995
Cdd:cd00063     84 PPSESVTVT 92
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 97-140 2.12e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.52  E-value: 2.12e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439    97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 140
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
2272-2311 2.63e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.10  E-value: 2.63e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439 2272 CFDPYTVSHYAVGDEWERMSESGFKLLCHCLGFGSGHFRC 2311
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 141-184 3.10e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.14  E-value: 3.10e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1622851439   141 CHEG--GQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 184
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
97-135 3.10e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 62.72  E-value: 3.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISC 135
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 811-889 3.84e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 3.84e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   811 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIFAVEE 885
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622851439   886 NQES 889
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2360-2399 8.95e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.95e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439 2360 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2399
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 95-136 9.31e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 9.31e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439   95 ETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGaGRGRISCT 136
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
fn1 pfam00039
Fibronectin type I domain;
2317-2354 1.96e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 60.41  E-value: 1.96e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439 2317 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKC 2354
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2270-2314 2.22e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.42  E-value: 2.22e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439 2270 DSCFDPYTVSHYAVGDEWERMSEsGFKLLCHCLGfGSGHFRCDSS 2314
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
619-688 2.59e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622851439  619 TPSQPNSHPIQWNAPQP--SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1450-1528 3.38e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 3.38e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1450 DSPTGIDFSDITANSFTVHWIAP-RATITGYRIRHHPEHMSGRPREDRV--PPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1527 ES 1528
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 184-227 4.71e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.65  E-value: 4.71e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622851439  184 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 227
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1814-1901 5.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 5.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1814 PAPTDLKFTQVTPTSLSAQWTPP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1890
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1622851439 1891 TSRPAQGVVTT 1901
Cdd:cd00063     82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
141-179 1.43e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.09  E-value: 1.43e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622851439  141 CHE--GGQSYKIGDTWRRPHETGgYMLECVCLGNGKGEWTC 179
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1634-1712 2.12e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 2.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1634 DKPSQMQVTDVQDNSISVKWLPSS-----SPVTGYRVTTTPKNGPgpTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNP 1708
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622851439  1709 NGES 1712
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 52-89 2.15e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.15e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   52 CYDN--GKHYQINQQWERTYLGNALICTCYGGSRGFNCES 89
Cdd:cd00061      3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2361-2401 2.45e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 2.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439  2361 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2401
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-508 2.63e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.34  E-value: 2.63e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  468 EICTTNE-GVMYRIGDQWDKQHDmGHMMRCTCVGNgRGEWTC 508
Cdd:cd00061      1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
fn1 pfam00039
Fibronectin type I domain;
524-555 4.15e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 4.15e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622851439  524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1265-1356 4.97e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 4.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1265 PEVPQltDLSFVDITDSSIGLRWTP--LNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLI 1342
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1622851439 1343 NGGESAPTTLTQQT 1356
Cdd:cd00063     79 GGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1724-1804 6.53e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 6.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1724 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDM 1800
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 1801 ESQP 1804
Cdd:cd00063     82 ESPP 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2316-2357 7.21e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 7.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622851439 2316 WCHDN--GVNYKIGEKWDRQGEnGQMMSCTCLGNgKGEFKCDPH 2357
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 229-273 1.27e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 1.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439  229 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 273
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 908-986 4.81e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.81e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   908 PSPRDLQFVEVTDVKVTIMWTPPESAV-TGYRVDVIPVNLPGEHGQR--LPISRNTFAEVTGLSPGVTYYFKVFAVNHGR 984
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439   985 ES 986
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 52-92 8.96e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 53.12  E-value: 8.96e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439    52 CYDN--GKHYQINQQWERTYL-GNALICTCYGGSRG-FNCESKPE 92
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1814-1885 9.92e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 9.92e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622851439  1814 PAPTDLKFTQVTPTSLSAQWTPPNV-QLTGYRV--RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYA 1885
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 139-181 1.02e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 53.10  E-value: 1.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439  139 NRCHEG--GQSYKIGDTWRRPHEtgGYMLECVCLGNgKGEWTCKP 181
Cdd:cd00061      1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-558 1.31e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 52.72  E-value: 1.31e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDPV 558
Cdd:cd00061      1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
2361-2396 5.58e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 5.58e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439 2361 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2396
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1175-1256 6.05e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 6.05e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1175 SPPTNLHLETNPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGYSLEEV-VHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1622851439  1254 KES 1256
Cdd:smart00060   81 GEG 83
fn1 pfam00039
Fibronectin type I domain;
52-87 9.95e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.00  E-value: 9.95e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   52 CYDN--GKHYQINQQWERTYL-GNALICTCYGGSRG-FNC 87
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1906-1980 2.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.57e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1906 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAVPANGQTpVQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDN 1980
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn3 pfam00041
Fibronectin type III domain;
2186-2244 4.90e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 4.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622851439 2186 TISW-APFQDTSE---YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEALKDQ 2244
Cdd:pfam00041   17 TVSWtPPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 606-688 1.14e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.14e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   606 PSSSGPVQVfiteTPSQPNSHPIQWNAPQPSHISKYILRWRPKN--SVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLIS 683
Cdd:smart00060    1 PSPPSNLRV----TDVTSTSVTLSWEPPPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                    ....*
gi 1622851439   684 IQQYG 688
Cdd:smart00060   77 VNGAG 81
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 6.63e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.32  E-value: 6.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  307 HCVTDS-GVVYSVGMQWLKTQGNKQMLCMCLGN--GVSCQET 345
Cdd:cd00061      2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 1.29e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.57  E-value: 1.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   308 CVTD-SGVVYSVGMQWLKTQGNKQML-CMCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 609-678 1.40e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 1.40e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622851439  609 SGPVQVFITETpsQPNSHPIQWNAPQP--SHISKYILRWRPKNSvGRWKEATI-PGHLNSYTIKGLKPGVVYE 678
Cdd:cd00063      2 SPPTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGS-GDWKEVEVtPGSETSYTLTGLKPGTEYE 71
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 4.91e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 4.91e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1622851439   353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 2.50e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.50e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1622851439   413 GNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 1.97e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 1.97e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622851439  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.23e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.23e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1622851439  414 NSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn3 pfam00041
Fibronectin type III domain;
1540-1621 6.51e-21

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 89.01  E-value: 6.51e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1540 DVPRDLEVVAATPTSLLISWDAPAV---TVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622851439 1617 DSPAS 1621
Cdd:pfam00041   81 EGPPS 85
fn2 pfam00040
Fibronectin type II domain;
360-401 1.84e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 1.84e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn2 pfam00040
Fibronectin type II domain;
420-461 1.43e-18

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 80.69  E-value: 1.43e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  420 CHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1450-1529 1.12e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 79.77  E-value: 1.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1450 DSPTGIDFSDITANSFTVHWIAPR---ATITGYRIRHHPEHMSGRPREDRVPPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1622851439 1527 ESP 1529
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1995-2075 1.60e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 1.60e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1995 DAPSNLRFLATTPNSLLVSWQPPR---ARITGYIIKYEKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 2072 KSEP 2075
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
1359-1440 4.91e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.84  E-value: 4.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1359 PPPTDLRFTNIGPDTMRVTWAPPP--SIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1437 ESTP 1440
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1634-1714 1.74e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 76.30  E-value: 1.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1634 DKPSQMQVTDVQDNSISVKWLPS---SSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNPNG 1710
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1711 ESQP 1714
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1058-1481 1.85e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.82  E-value: 1.85e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1058 PGSEYTVSLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGS 1137
Cdd:COG3401    107 TNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT 186

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1138 IVVSGLT-------PGVEYVYTIQVLRDGQERDAP---IVNKVVTPLSPPTNLHLETNPDTGVlTVSWERSTTPDITGYR 1207
Cdd:COG3401    187 VTSTTLVdgggdiePGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYR 265

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1208 ITTTPTNGQqgySLEEVVHADQSSCTFDNLSPGLEYNVSVYTV-KDDKESVP------ISDTIIPEVPQltDLSFVDITD 1280
Cdd:COG3401    266 VYRSNSGDG---PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdAAGNESAPsnvvsvTTDLTPPAAPS--GLTATAVGS 340

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1281 SSIGLRWTPLNSSTIIGYRITVVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTA 1357
Cdd:COG3401    341 SSITLSWTASSDADVTGYNVYRSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATT 417

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1358 VPPPTDLRFTNiGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQhe 1437
Cdd:COG3401    418 ASAASGESLTA-SVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTG-- 494

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 1622851439 1438 STPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1481
Cdd:COG3401    495 SLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTV 538
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1241-1766 1.02e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 1.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1241 LEYNVSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1320
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1321 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSI-DLTNFLVRYSPVKNE 1399
Cdd:COG3401    102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVaGAGVVVSPDTSATAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1400 EDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGL----DSPTGIDFSDITANSFTVHWIA-PRA 1474
Cdd:COG3401    180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPvTES 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1475 TITGYRIRhhpehmsgRPREDRVPPSR------NSITLTNLTPGTEYVVSIVALNGREEspllIGQQSTVSDV------- 1541
Cdd:COG3401    260 DATGYRVY--------RSNSGDGPFTKvatvttTSYTDTGLTNGTTYYYRVTAVDAAGN----ESAPSNVVSVttdltpp 327

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1542 --PRDLEVVAATPTSLLISWDAPA-VTVRYYRItYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDS 1618
Cdd:COG3401    328 aaPSGLTATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE 406

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1619 PASSKPISI---------------NYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGP 1683
Cdd:COG3401    407 SAPSEEVSAttasaasgesltasvDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTT 486

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1684 DQTEMTIEGLQPTVEYVVSVFAQNPNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPqgQVSRYRVTYSSPEDG 1763
Cdd:COG3401    487 ANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITD--LVSLTTSASSSVSGA 564


                   ...
gi 1622851439 1764 IHE 1766
Cdd:COG3401    565 GLG 567
fn3 pfam00041
Fibronectin type III domain;
1995-2075 1.13e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 1.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1995 DAPSNLRFLATTPNSLLVSWQPPRAR---ITGYIIKYEKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 2072 KSEP 2075
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1540-1622 1.87e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 73.68  E-value: 1.87e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1540 DVPRDLEVVAATPTSLLISWDAPAVT---VRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*.
gi 1622851439 1617 DSPASS 1622
Cdd:cd00063     82 ESPPSE 87
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 186-230 1.93e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 1.93e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 230
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1814-1894 2.19e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1814 PAPTDLKFTQVTPTSLSAQWTPP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1891 TSRP 1894
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 2.30e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 2.30e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
812-883 2.80e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.83  E-value: 2.80e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622851439  812 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIFAV 883
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2317-2358 4.43e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.43e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1622851439  2317 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHE 2358
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 811-899 6.32e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.14  E-value: 6.32e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  811 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIFAVEEN 886
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1622851439  887 QESTPVFIQQETT 899
Cdd:cd00063     81 GESPPSESVTVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-508 1.05e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.07  E-value: 1.05e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1622851439   470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1696-2066 1.14e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.05  E-value: 1.14e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1696 TVEYVVSVFAQNPNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEE 1775
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1776 DTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGP 1855
Cdd:COG3401    102 SVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVA 181

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1856 MKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGV--VTTLENVSPPRRARVTDATETTITISWRTKTET-I 1932
Cdd:COG3401    182 TTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdA 261

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1933 TGFQV--DAVPANGQTPVQRTIKPdvrSYTITGLQPGTDYKIYLYTLNDNARSSP--VVIDASTAI---DAPSNLRFLAT 2005
Cdd:COG3401    262 TGYRVyrSNSGDGPFTKVATVTTT---SYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGLTATAV 338

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622851439 2006 TPNSLLVSWQPPR-ARITGYIIKYEKPGSSPREVVPRPRPGvTEATITGLEPGTEYTIYVIA 2066
Cdd:COG3401    339 GSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTYYYKVTA 399
fn1 pfam00039
Fibronectin type I domain;
231-270 1.25e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.25e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 270
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
711-1034 1.67e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 79.28  E-value: 1.67e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  711 VTGETTPLSPlvaTSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNIPDLLPGRKY--- 786
Cdd:COG3401    227 TTPTTPPSAP---TGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTDTGLTNGTTYyyr 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  787 IVNVYEISEDGEQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGSSTELNLPETANS 864
Cdd:COG3401    302 VTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIAETVTTTS 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  865 VTLSDLQPGVQYNITIFAV----EENQESTPVFIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVD 940
Cdd:COG3401    382 YTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADG 461

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  941 VIPVNLPgehgqrlPISRNTFAEVTGLSPGVTYYFKVFAVNHGRESKPLTAEQTTKLDAPTNLQFVNETDSTVLVRWTPP 1020
Cdd:COG3401    462 GDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGAS 534

                          330
                   ....*....|....
gi 1622851439 1021 RARITGYRLTVGLT 1034
Cdd:COG3401    535 PVTVGASTGDVLIT 548
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 231-275 1.95e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.95e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   231 CNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTT 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2272-2316 2.67e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.67e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439  2272 CFDPYTVSHYAVGDEWERMSESGFKLLCHCLGFGSGHFRCDSSRW 2316
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1906-1985 6.90e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 6.90e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1906 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAVPANGQTPVQ-RTIKPDVRSYTITGLQPGTDYKIYLYTLNDNA 1981
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1622851439 1982 RSSP 1985
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
908-988 7.32e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.98  E-value: 7.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  908 PSPRDLQFVEVTDVKVTIMWTPPE---SAVTGYRVDVIPVNLpGEHGQRLPISRNTF-AEVTGLSPGVTYYFKVFAVNHG 983
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622851439  984 RESKP 988
Cdd:pfam00041   80 GEGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 8.52e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.38  E-value: 8.52e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 1.26e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.95  E-value: 1.26e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  470 CTTNE-GVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1359-1438 1.30e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 1.30e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1359 PPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1437 ES 1438
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
998-1076 1.42e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.21  E-value: 1.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  998 DAPTNLQFVNETDSTVLVRWTPPRAR---ITGYRLTVGLTRRGQP-RQYNVGPSVSKYPLRNLQPGSEYTVSLVAIKGNQ 1073
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1622851439 1074 ESP 1076
Cdd:pfam00041   81 EGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1634-1721 1.77e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1634 DKPSQMQVTDVQDNSISVKWLPSS---SPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNPNG 1710
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1622851439 1711 ESQPLVQTAVT 1721
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1359-1440 2.09e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 2.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1359 PPPTDLRFTNIGPDTMRVTWAPPPSI--DLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH 1436
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 1437 ESTP 1440
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
1268-1350 2.20e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 2.20e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1268 PQLTDLSFVDITDSSIGLRWTPL--NSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1345
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1622851439 1346 ESAPT 1350
Cdd:pfam00041   81 EGPPS 85
fn1 pfam00039
Fibronectin type I domain;
561-599 2.42e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.42e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  561 CQDSETGTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1450-1529 2.85e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.52  E-value: 2.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1450 DSPTGIDFSDITANSFTVHWIAPRAT---ITGYRIRHHPEHMSGRPREDRVPPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ...
gi 1622851439 1527 ESP 1529
Cdd:cd00063     82 ESP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 4.60e-13

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 65.43  E-value: 4.60e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622851439  559 DQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
186-225 8.13e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.64  E-value: 8.13e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439  186 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 225
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1995-2073 9.88e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 9.88e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1995 DAPSNLRFLATTPNSLLVSWQPP-RARITGYIIKY--EKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 2071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  2072 KS 2073
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1542-1618 1.01e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 65.71  E-value: 1.01e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1542 PRDLEVVAATPTSLLISWDAPAVT-----VRYYRITYGETGGNspVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRG 1616
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1617 DS 1618
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 910-995 1.87e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  910 PRDLQFVEVTDVKVTIMWTPPE---SAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVNHGRES 986
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 1622851439  987 KPLTAEQTT 995
Cdd:cd00063     84 PPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
727-798 1.88e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.74  E-value: 1.88e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622851439  727 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYEISEDGE 798
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 998-1084 1.96e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.96e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  998 DAPTNLQFVNETDSTVLVRWTPPR---ARITGYRLTVGLTRRGQPRQYNVGP-SVSKYPLRNLQPGSEYTVSLVAIKGNQ 1073
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1622851439 1074 ESPKATGV-FTT 1084
Cdd:cd00063     82 ESPPSESVtVTT 93
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 97-140 2.12e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.52  E-value: 2.12e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439    97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 140
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1175-1258 2.29e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.74  E-value: 2.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1175 SPPTNLHLeTNPDTGVLTVSWERSTTP--DITGYRITTTPTNGQQgYSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKD 1252
Cdd:pfam00041    1 SAPSNLTV-TDVTSTSLTVSWTPPPDGngPITGYEVEYRPKNSGE-PWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 1622851439 1253 DKESVP 1258
Cdd:pfam00041   79 GGEGPP 84
fn1 pfam00039
Fibronectin type I domain;
2272-2311 2.63e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.10  E-value: 2.63e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439 2272 CFDPYTVSHYAVGDEWERMSESGFKLLCHCLGFGSGHFRC 2311
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
808-1298 2.65e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.34  E-value: 2.65e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  808 TTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIFAVEENQ 887
Cdd:COG3401     54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAG 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  888 ESTPVFIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGqrlpisrntfaevtGL 967
Cdd:COG3401    134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--------------DI 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  968 SPGVTYYFKVFAVNHGRESKPLTAEQ----TTKLDAPTNLQFVNETDSTVLVRWTP-PRARITGYRLTVGLTRRGQPRQY 1042
Cdd:COG3401    200 EPGTTYYYRVAATDTGGESAPSNEVSvttpTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKV 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1043 NVGPSVSkYPLRNLQPGSEYTVSLVAIKGN-QESPKATGVFTTLQPGSSIPPYN---TEVTETTIVITWTPAP---RIGF 1115
Cdd:COG3401    280 ATVTTTS-YTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTPPAAPSGltaTAVGSSSITLSWTASSdadVTGY 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1116 KLGVRPSQGGEAPREVTSDSG-SIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLE-------TNPD 1187
Cdd:COG3401    359 NVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTasvdavpLTDV 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1188 TGVLTVSWERSTTPD---------ITGYRITTTPTNGQQGYSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVP 1258
Cdd:COG3401    439 AGATAAASAASNPGVsaavladggDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1622851439 1259 ISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGY 1298
Cdd:COG3401    519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 141-184 3.10e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 63.14  E-value: 3.10e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1622851439   141 CHEG--GQSYKIGDTWRRPHEtGGYMLECVCLGNGKGEWTCKPIAE 184
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
97-135 3.10e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 62.72  E-value: 3.10e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   97 CFDKYTGNTYRVGDTYERPKDS-MIWDCTCIGAGRGRISC 135
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 811-889 3.84e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.17  E-value: 3.84e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   811 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIFAVEE 885
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622851439   886 NQES 889
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2360-2399 8.95e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 8.95e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439 2360 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2399
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 95-136 9.31e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 9.31e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439   95 ETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGaGRGRISCT 136
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
fn1 pfam00039
Fibronectin type I domain;
2317-2354 1.96e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 60.41  E-value: 1.96e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439 2317 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKC 2354
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2270-2314 2.22e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.42  E-value: 2.22e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439 2270 DSCFDPYTVSHYAVGDEWERMSEsGFKLLCHCLGfGSGHFRCDSS 2314
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
619-688 2.59e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622851439  619 TPSQPNSHPIQWNAPQP--SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1450-1528 3.38e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 3.38e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1450 DSPTGIDFSDITANSFTVHWIAP-RATITGYRIRHHPEHMSGRPREDRV--PPSRNSITLTNLTPGTEYVVSIVALNGRE 1526
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1527 ES 1528
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 184-227 4.71e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.65  E-value: 4.71e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622851439  184 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 227
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1814-1901 5.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 5.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1814 PAPTDLKFTQVTPTSLSAQWTPP---NVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTL 1890
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1622851439 1891 TSRPAQGVVTT 1901
Cdd:cd00063     82 ESPPSESVTVT 92
fn1 pfam00039
Fibronectin type I domain;
141-179 1.43e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.09  E-value: 1.43e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622851439  141 CHE--GGQSYKIGDTWRRPHETGgYMLECVCLGNGKGEWTC 179
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1634-1712 2.12e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 2.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1634 DKPSQMQVTDVQDNSISVKWLPSS-----SPVTGYRVTTTPKNGPgpTKTKTAGPDQTEMTIEGLQPTVEYVVSVFAQNP 1708
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1622851439  1709 NGES 1712
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 52-89 2.15e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 2.15e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   52 CYDN--GKHYQINQQWERTYLGNALICTCYGGSRGFNCES 89
Cdd:cd00061      3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2361-2401 2.45e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.75  E-value: 2.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439  2361 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2401
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-508 2.63e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.34  E-value: 2.63e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  468 EICTTNE-GVMYRIGDQWDKQHDmGHMMRCTCVGNgRGEWTC 508
Cdd:cd00061      1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
fn1 pfam00039
Fibronectin type I domain;
524-555 4.15e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.94  E-value: 4.15e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622851439  524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1265-1356 4.97e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 4.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1265 PEVPQltDLSFVDITDSSIGLRWTP--LNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLI 1342
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1622851439 1343 NGGESAPTTLTQQT 1356
Cdd:cd00063     79 GGGESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1724-1804 6.53e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.89  E-value: 6.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1724 DRPKGLAFTDVDVDSIKIAWESPQ---GQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQGLRPGSEYTVSVVALHDDM 1800
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1622851439 1801 ESQP 1804
Cdd:cd00063     82 ESPP 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2316-2357 7.21e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 7.21e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622851439 2316 WCHDN--GVNYKIGEKWDRQGEnGQMMSCTCLGNgKGEFKCDPH 2357
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1810-2067 9.00e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 9.00e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1810 STAIPAPTDLKFTQVTPTSLSAQWTP-PNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKD 1888
Cdd:COG3401     46 VTTKESPGTLLVAAGLSSGGGLGTGGrAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTA 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1889 TLTSRPAQGVVTTLENVSPPRRARVTDATETTITIsWRTKTETITGFQVDAVPANGQTPVQRTIkPDVRSYTITGLQPGT 1968
Cdd:COG3401    126 TTATAVAGGAATAGTYALGAGLYGVDGANASGTTA-SSVAGAGVVVSPDTSATAAVATTSLTVT-STTLVDGGGDIEPGT 203

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1969 DYKIYLYTLNDNARSSPV----VIDASTAIDAPSNLRFLATTPNSLLVSWQP-PRARITGYIIKYEKPGSSPREVVPRPR 2043
Cdd:COG3401    204 TYYYRVAATDTGGESAPSnevsVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVATVT 283

                          250       260
                   ....*....|....*....|....
gi 1622851439 2044 pgVTEATITGLEPGTEYTIYVIAL 2067
Cdd:COG3401    284 --TTSYTDTGLTNGTTYYYRVTAV 305
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 998-1075 1.07e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 57.24  E-value: 1.07e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   998 DAPTNLQFVNETDSTVLVRWTPP-RARITGYRLTVGLTRRGQPRQY---NVGPSVSKYPLRNLQPGSEYTVSLVAIKGNQ 1073
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1074 ES 1075
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 229-273 1.27e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.42  E-value: 1.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439  229 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 273
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1175-1264 1.33e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1175 SPPTNLHLETNPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGYSLEeVVHADQSSCTFDNLSPGLEYNVSVYTVKD 1252
Cdd:cd00063      2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|..
gi 1622851439 1253 DKESVPISDTII 1264
Cdd:cd00063     80 GGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
1724-1804 1.40e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 56.65  E-value: 1.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1724 DRPKGLAFTDVDVDSIKIAWESP---QGQVSRYRVTYSSPEDGIHEL-FPAPdGEEDTAELQGLRPGSEYTVSVVALHDD 1799
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNeITVP-GTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1622851439 1800 MESQP 1804
Cdd:pfam00041   80 GEGPP 84
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
711-899 1.54e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 63.81  E-value: 1.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  711 VTGETTPLSPLVATSESVTE--ITASSFVVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPGRkYI 787
Cdd:COG4733    527 VPPQWPPVNVTTSESLSVVAqgTAVTTLTVSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAGD-YE 600

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  788 VNVYEISEDGEQSLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRPQ-APITGYRIVYSPSVEGSSTELNLPE- 860
Cdd:COG4733    601 VRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPVdADTLRTEIRYSTTGDWASATVAQALy 680

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1622851439  861 TANSVTLSDLQPGVQYNITIFAVEENQESTPVFIQQETT 899
Cdd:COG4733    681 PGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1906-1986 3.17e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 3.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1906 SPPRRARVTDATETTITISW---RTKTETITGFQVDAVPANGQTPVQ-RTIKPDVRSYTITGLQPGTDYKIYLYTLNDNA 1981
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*
gi 1622851439 1982 RSSPV 1986
Cdd:cd00063     82 ESPPS 86
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 908-986 4.81e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.81e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   908 PSPRDLQFVEVTDVKVTIMWTPPESAV-TGYRVDVIPVNLPGEHGQR--LPISRNTFAEVTGLSPGVTYYFKVFAVNHGR 984
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGiTGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439   985 ES 986
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 52-92 8.96e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 53.12  E-value: 8.96e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439    52 CYDN--GKHYQINQQWERTYL-GNALICTCYGGSRG-FNCESKPE 92
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1814-1885 9.92e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 9.92e-09
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622851439  1814 PAPTDLKFTQVTPTSLSAQWTPPNV-QLTGYRV--RVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYA 1885
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 139-181 1.02e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 53.10  E-value: 1.02e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439  139 NRCHEG--GQSYKIGDTWRRPHEtgGYMLECVCLGNgKGEWTCKP 181
Cdd:cd00061      1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-558 1.31e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 52.72  E-value: 1.31e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622851439  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDPV 558
Cdd:cd00061      1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
2361-2396 5.58e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 5.58e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439 2361 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2396
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1175-1256 6.05e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 6.05e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1175 SPPTNLHLETNPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGYSLEEV-VHADQSSCTFDNLSPGLEYNVSVYTVKDD 1253
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1622851439  1254 KES 1256
Cdd:smart00060   81 GEG 83
fn1 pfam00039
Fibronectin type I domain;
52-87 9.95e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.00  E-value: 9.95e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622851439   52 CYDN--GKHYQINQQWERTYL-GNALICTCYGGSRG-FNC 87
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 727-809 1.07e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.73  E-value: 1.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  727 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYEISEDGEQSLIL 803
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*.
gi 1622851439  804 STSQTT 809
Cdd:cd00063     88 SVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1906-1980 2.57e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.57e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1906 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAVPANGQTpVQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDN 1980
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 727-798 1.09e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.38  E-value: 1.09e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622851439   727 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVYEISEDGE 798
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVRAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
1092-1159 1.16e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.57  E-value: 1.16e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622851439 1092 PPYN---TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SDSGSIVVSGLTPGVEYVYTIQVLRDG 1159
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1271-1347 1.87e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 1.87e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622851439  1271 TDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGY--YTVTGLEPGIDYDISVITLINGGES 1347
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1190-1632 2.69e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 53.03  E-value: 2.69e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1190 VLTVSWERSTTPDITGYRITTTPTNGQQGYSLEEVVHADQSSCTFDnlspGLEYNVSVYTVKDdkesvpiSDTIIPEVPQ 1269
Cdd:COG4733    462 TLTVSTAYSETPEAGAVWAFGPDELETQLFRVVSIEENEDGTYTIT----AVQHAPEKYAAID-------AGAFDDVPPQ 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1270 ------LTDLSFVDITDSSIG----LRWTPLNSStiIGYRITVVA-AGEGIPIFEdfvdSSVGYYTVTGLEPGiDYDISV 1338
Cdd:COG4733    531 wppvnvTTSESLSVVAQGTAVttltVSWDAPAGA--VAYEVEWRRdDGNWVSVPR----TSGTSFEVPGIYAG-DYEVRV 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1339 ITLINGG------ESAPTTLTQQTAVPP-PTDLRFTNiGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD 1411
Cdd:COG4733    604 RAINALGvssawaASSETTVTGKTAPPPaPTGLTATG-GLGGITLSWSFPVDADTLRTEIRYSTTGDWASATVAQALYPG 682

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1412 NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDF--SDITANSFTVH--WIAPRATITGYRIRHHPEH 1487
Cdd:COG4733    683 NTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGILDAitGQILETELGQEldAIIQNATVAEVVAATVTDV 762

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1488 MSGRPREDRVPPSRNSITLTNLTPGTEYVVSIVALNGREEsplliGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVR 1567
Cdd:COG4733    763 TAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATG-----TAADAAGDASGGVTAGTSGTTGAGDTAASTTRVAA 837

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622851439 1568 YYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTE 1632
Cdd:COG4733    838 AVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADSTAASLTAIVI 902
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1876-2064 4.40e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 52.25  E-value: 4.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1876 ATKYEVSVYALKDT--LTSRPAQGVVTTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAVPANGQ-TPVQRTI 1952
Cdd:COG4733    508 AVQHAPEKYAAIDAgaFDDVPPQWPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNwVSVPRTS 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439 1953 KPdvrSYTITGLQPGtDYKIYLYTLNDNARSSPVVIDASTAI----DAPSNLRFLATTPNSLLV--SW-QPPRARITGYI 2025
Cdd:COG4733    586 GT---SFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTE 661

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1622851439 2026 IKYEKPGSSPREVVPRPRPGVTEATITGLEPGTEYTIYV 2064
Cdd:COG4733    662 IRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRA 700
fn3 pfam00041
Fibronectin type III domain;
2186-2244 4.90e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 4.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622851439 2186 TISW-APFQDTSE---YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEALKDQ 2244
Cdd:pfam00041   17 TVSWtPPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
615-948 9.01e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 9.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  615 FITETPSQPNSHPIQWNAPQPSHISKYILrWRPKNSVGRWKE-ATIPGhlNSYTIKGLKPGVVYEgqlisiqqYGhreVT 693
Cdd:COG3401    238 GLTATADTPGSVTLSWDPVTESDATGYRV-YRSNSGDGPFTKvATVTT--TSYTDTGLTNGTTYY--------YR---VT 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  694 RFDFTTTSTSTPVTSNTVTGETTPLSP--LVATSESVTEITassfvVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPS 770
Cdd:COG3401    304 AVDAAGNESAPSNVVSVTTDLTPPAAPsgLTATAVGSSSIT-----LSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETV 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  771 TATSVNIPDLLPGRKYIVNVYEISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPI------------ 838
Cdd:COG3401    378 TTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAAsaasnpgvsaav 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  839 --TGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIFAVEENQESTPVF-IQQETTGTPRSDTVPSPRDLQF 915
Cdd:COG3401    458 laDGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGAsAAAAVGGAPDGTPNVTGASPVT 537

                          330       340       350
                   ....*....|....*....|....*....|...
gi 1622851439  916 VEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPG 948
Cdd:COG3401    538 VGASTGDVLITDLVSLTTSASSSVSGAGLGSGN 570
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 606-688 1.14e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.14e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439   606 PSSSGPVQVfiteTPSQPNSHPIQWNAPQPSHISKYILRWRPKN--SVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLIS 683
Cdd:smart00060    1 PSPPSNLRV----TDVTSTSVTLSWEPPPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76


                    ....*
gi 1622851439   684 IQQYG 688
Cdd:smart00060   77 VNGAG 81
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1726-1802 1.28e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 1.28e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622851439  1726 PKGLAFTDVDVDSIKIAWESPQ-----GQVSRYRVTYSSPEDGIHELFPAPDgeEDTAELQGLRPGSEYTVSVVALHDDM 1800
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1622851439  1801 ES 1802
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1096-1161 4.58e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 4.58e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622851439  1096 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQE 1161
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 6.63e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.32  E-value: 6.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622851439  307 HCVTDS-GVVYSVGMQWLKTQGNKQMLCMCLGN--GVSCQET 345
Cdd:cd00061      2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 1.29e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 41.57  E-value: 1.29e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622851439   308 CVTD-SGVVYSVGMQWLKTQGNKQML-CMCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 609-678 1.40e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 1.40e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622851439  609 SGPVQVFITETpsQPNSHPIQWNAPQP--SHISKYILRWRPKNSvGRWKEATI-PGHLNSYTIKGLKPGVVYE 678
Cdd:cd00063      2 SPPTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGS-GDWKEVEVtPGSETSYTLTGLKPGTEYE 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1096-1161 5.43e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 5.43e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622851439 1096 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSDSG---SIVVSGLTPGVEYVYTIQVLRDGQE 1161
Cdd:cd00063     10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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