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Conserved domains on  [gi|1622830883|ref|XP_028686413|]
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macrophage colony-stimulating factor 1 isoform X2 [Macaca mulatta]

Protein Classification

CSF-1 and PRK14959 domain-containing protein( domain architecture ID 10526391)

protein containing domains CSF-1, PRK14959, and PHA03247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 41-179 1.92e-97

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


:

Pssm-ID: 398810  Cd Length: 140  Bit Score: 281.17  E-value: 1.92e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622830883  41 HMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK 120
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622830883 121 SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECS 179
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCS 139
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 41-179 1.92e-97

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 281.17  E-value: 1.92e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622830883  41 HMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK 120
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622830883 121 SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECS 179
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCS 139
 
Name Accession Description Interval E-value
CSF-1 pfam05337
Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a ...
 41-179 1.92e-97

Macrophage colony stimulating factor-1 (CSF-1); Colony stimulating factor 1 (CSF-1) is a homodimeric polypeptide growth factor whose primary function is to regulate the survival, proliferation, differentiation, and function of cells of the mononuclear phagocytic lineage. This lineage includes mononuclear phagocytic precursors, blood monocytes, tissue macrophages, osteoclasts, and microglia of the brain, all of which possess cell surface receptors for CSF-1. The protein has also been linked with male fertility and mutations in the Csf-1 gene have been found to cause osteopetrosis and failure of tooth eruption. Structurally these are short-chain 4-helical cytokines.


Pssm-ID: 398810  Cd Length: 140  Bit Score: 281.17  E-value: 1.92e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622830883  41 HMIGSGHLQSLQRLIDSQMETSCQITFEFVDQEQLKDPVCYLKKAFLLVQDIMEDTMRFRDNTPNAIAIVQLQELSLRLK 120
Cdd:pfam05337   1 HMIGNGHLKVLQQLIDSQMETSCQIAFEFVDQEQLDDPVCYLKKAFLLVQDIMEDTMRFKDNTPNANAIVQLQELSLRLK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622830883 121 SCFTKDYEEHDKACVRTFYETPLQLLEKVKNVFNETKNLLDKDWNIFSKNCNNSFAECS 179
Cdd:pfam05337  81 SCFTKDYEEQDKACVRTFHETPLQLLEKIKNVFNETKNLLEKDWNIFSKNCNNSFAKCS 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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