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Conserved domains on  [gi|1622847421|ref|XP_028685950|]
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nuclear receptor corepressor 2 isoform X19 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
66-154 1.47e-41

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 148.08  E-value: 1.47e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   66 LTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIE 145
Cdd:pfam15784    1 YYPQVEAISPTLPSPEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPSE 80

                   ....*....
gi 1622847421  146 SKHRSLVQI 154
Cdd:pfam15784   81 SKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
531-574 7.68e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.83  E-value: 7.68e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622847421  531 RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYK 574
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
357-400 1.08e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11661:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 46  Bit Score: 47.22  E-value: 1.08e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622847421  357 WSEQEKETFREKFMQHPKNFGLI-ASFLERKTVAECVLYYYLTKK 400
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PHA03247 super family cl33720
large tegument protein UL36; Provisional
675-1143 1.26e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  675 AAKDTGqnGPQPPAtqSTDGPPPEPPTPPPEDIPAPTEPTPASEATGPPTPPPAPPSPSVPPPVVPKEEKEEEAAAVSPV 754
Cdd:PHA03247  2544 ASDDAG--DPPPPL--PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPP 2619
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  755 EEGEEQKPPAAEELAVDTGKAEEPIKSECTEQAEEGPAKGKDAEASEATAEGalkaekkeggsgRATTAkgSGAPQDSDS 834
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG------------RAAQA--SSPPQRPRR 2685
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  835 SATcsadevdEPEGGDKNRLLSPRPSLLTPTGDPRAnASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPA 914
Cdd:PHA03247  2686 RAA-------RPTVGSLTSLADPPPPPPTPEPAPHA-LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  915 PPPPQHLQPESDAPqqpgssPRGKSRSPAPAADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGlPFPVPPREVIKASPHAP 994
Cdd:PHA03247  2758 ARPPTTAGPPAPAP------PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA-PAAALPPAASPAGPLPP 2830
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  995 DPSAFSYAPPGHPLPL-------GLHDTARPVLPRPPTISnPPPLISSAKHPsvlerqigaisqgmsvqlhvPYSEHAKA 1067
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPppslplgGSVAPGGDVRRRPPSRS-PAAKPAAPARP--------------------PVRRLARP 2889
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421 1068 PVGPVTMGLPLPMD-------------PKKLAPFSGVKQEQLSPRGQAGPPESLGvPTAQEASVlrGTALGSVPG---GS 1131
Cdd:PHA03247  2890 AVSRSTESFALPPDqperppqpqapppPQPQPQPPPPPQPQPPPPPPPRPQPPLA-PTTDPAGA--GEPSGAVPQpwlGA 2966
                          490
                   ....*....|....*
gi 1622847421 1132 ITKG---IPSTRVPS 1143
Cdd:PHA03247  2967 LVPGrvaVPRFRVPQ 2981
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
25-383 8.72e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 51.61  E-value: 8.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   25 MEFIESKRP-----RLELLPDPLLRPSPLLAAGQPAGSEDLTKDRSLTGKLEPVSppsppHTDPELELVPPRLSKE--EL 97
Cdd:TIGR02169  626 VEDIEAARRlmgkyRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLR-----ERLEGLKRELSSLQSElrRI 700
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   98 IQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPvspppIESKHRSLVQIIYDENRKKAEAAHRI--LEGLGP 175
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE-----LEEDLSSLEQEIENVKSELKELEARIeeLEEDLH 775
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  176 QVELPLyNQPSDtRQYHENIKINQAMRKKLILYFKR-------------RNHARKQWEQKFCQRYDQLMEAWEKKV---- 238
Cdd:TIGR02169  776 KLEEAL-NDLEA-RLSHSRIPEIQAELSKLEEEVSRiearlreieqklnRLTLEKEYLEKEIQELQEQRIDLKEQIksie 853
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  239 ERIEN-NPRRRAKESKVREY------YEKQFPEIRKQR-ELQERM---QSRVGQrgsgLSMSAARSEHEVSEIIDGLSEQ 307
Cdd:TIGR02169  854 KEIENlNGKKEELEEELEELeaalrdLESRLGDLKKERdELEAQLrelERKIEE----LEAQIEKKRKRLSELKAKLEAL 929
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  308 EN----LEKQMRQLAVIPPMLYDADQ------------QRIKFINM-------------NGLMADPMKVYKDR----QVM 354
Cdd:TIGR02169  930 EEelseIEDPKGEDEEIPEEELSLEDvqaelqrveeeiRALEPVNMlaiqeyeevlkrlDELKEKRAKLEEERkailERI 1009
                          410       420
                   ....*....|....*....|....*....
gi 1622847421  355 NMWSEQEKETFREKFMQHPKNFGLIASFL 383
Cdd:TIGR02169 1010 EEYEKKKREVFMEAFEAINENFNEIFAEL 1038
RSC8 super family cl34960
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
458-566 5.62e-04

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


The actual alignment was detected with superfamily member COG5259:

Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 45.26  E-value: 5.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  458 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRrKGRITRSMANEANS--------EEAITPQ--QSAELASMELN 527
Cdd:COG5259    196 ENYSPSLKSPKKESQGKVDELKDHSEKHPSSCSCCGN-KSFNTRYHNLRAEKynscsecyDQGRFPSefTSSDFKPVTIS 274
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622847421  528 ESSR---WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQC 566
Cdd:COG5259    275 LLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQC 316
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
66-154 1.47e-41

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 148.08  E-value: 1.47e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   66 LTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIE 145
Cdd:pfam15784    1 YYPQVEAISPTLPSPEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPSE 80

                   ....*....
gi 1622847421  146 SKHRSLVQI 154
Cdd:pfam15784   81 SKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
531-574 7.68e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.83  E-value: 7.68e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622847421  531 RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYK 574
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
531-576 1.34e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.39  E-value: 1.34e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1622847421   531 RWTEEEMETAKKGLLEHG-RNWSAIARMVGSKTVSQCKNFYFNYKKR 576
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
531-574 1.89e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 57.97  E-value: 1.89e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622847421  531 RWTEEEMETAKKGLLEHG-RNWSAIARMVGSKTVSQCKNFYFNYK 574
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
357-400 1.08e-06

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 47.22  E-value: 1.08e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622847421  357 WSEQEKETFREKFMQHPKNFGLI-ASFLERKTVAECVLYYYLTKK 400
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
675-1143 1.26e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  675 AAKDTGqnGPQPPAtqSTDGPPPEPPTPPPEDIPAPTEPTPASEATGPPTPPPAPPSPSVPPPVVPKEEKEEEAAAVSPV 754
Cdd:PHA03247  2544 ASDDAG--DPPPPL--PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPP 2619
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  755 EEGEEQKPPAAEELAVDTGKAEEPIKSECTEQAEEGPAKGKDAEASEATAEGalkaekkeggsgRATTAkgSGAPQDSDS 834
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG------------RAAQA--SSPPQRPRR 2685
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  835 SATcsadevdEPEGGDKNRLLSPRPSLLTPTGDPRAnASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPA 914
Cdd:PHA03247  2686 RAA-------RPTVGSLTSLADPPPPPPTPEPAPHA-LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  915 PPPPQHLQPESDAPqqpgssPRGKSRSPAPAADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGlPFPVPPREVIKASPHAP 994
Cdd:PHA03247  2758 ARPPTTAGPPAPAP------PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA-PAAALPPAASPAGPLPP 2830
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  995 DPSAFSYAPPGHPLPL-------GLHDTARPVLPRPPTISnPPPLISSAKHPsvlerqigaisqgmsvqlhvPYSEHAKA 1067
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPppslplgGSVAPGGDVRRRPPSRS-PAAKPAAPARP--------------------PVRRLARP 2889
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421 1068 PVGPVTMGLPLPMD-------------PKKLAPFSGVKQEQLSPRGQAGPPESLGvPTAQEASVlrGTALGSVPG---GS 1131
Cdd:PHA03247  2890 AVSRSTESFALPPDqperppqpqapppPQPQPQPPPPPQPQPPPPPPPRPQPPLA-PTTDPAGA--GEPSGAVPQpwlGA 2966
                          490
                   ....*....|....*
gi 1622847421 1132 ITKG---IPSTRVPS 1143
Cdd:PHA03247  2967 LVPGrvaVPRFRVPQ 2981
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
357-396 2.80e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 45.96  E-value: 2.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622847421  357 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYY 396
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
25-383 8.72e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.61  E-value: 8.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   25 MEFIESKRP-----RLELLPDPLLRPSPLLAAGQPAGSEDLTKDRSLTGKLEPVSppsppHTDPELELVPPRLSKE--EL 97
Cdd:TIGR02169  626 VEDIEAARRlmgkyRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLR-----ERLEGLKRELSSLQSElrRI 700
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   98 IQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPvspppIESKHRSLVQIIYDENRKKAEAAHRI--LEGLGP 175
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE-----LEEDLSSLEQEIENVKSELKELEARIeeLEEDLH 775
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  176 QVELPLyNQPSDtRQYHENIKINQAMRKKLILYFKR-------------RNHARKQWEQKFCQRYDQLMEAWEKKV---- 238
Cdd:TIGR02169  776 KLEEAL-NDLEA-RLSHSRIPEIQAELSKLEEEVSRiearlreieqklnRLTLEKEYLEKEIQELQEQRIDLKEQIksie 853
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  239 ERIEN-NPRRRAKESKVREY------YEKQFPEIRKQR-ELQERM---QSRVGQrgsgLSMSAARSEHEVSEIIDGLSEQ 307
Cdd:TIGR02169  854 KEIENlNGKKEELEEELEELeaalrdLESRLGDLKKERdELEAQLrelERKIEE----LEAQIEKKRKRLSELKAKLEAL 929
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  308 EN----LEKQMRQLAVIPPMLYDADQ------------QRIKFINM-------------NGLMADPMKVYKDR----QVM 354
Cdd:TIGR02169  930 EEelseIEDPKGEDEEIPEEELSLEDvqaelqrveeeiRALEPVNMlaiqeyeevlkrlDELKEKRAKLEEERkailERI 1009
                          410       420
                   ....*....|....*....|....*....
gi 1622847421  355 NMWSEQEKETFREKFMQHPKNFGLIASFL 383
Cdd:TIGR02169 1010 EEYEKKKREVFMEAFEAINENFNEIFAEL 1038
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
357-400 8.05e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 8.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622847421   357 WSEQEKETFREKFMQHP-KNFGLIASFLERKTVAECVLYYYLTKK 400
Cdd:smart00717    4 WTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
458-566 5.62e-04

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 45.26  E-value: 5.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  458 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRrKGRITRSMANEANS--------EEAITPQ--QSAELASMELN 527
Cdd:COG5259    196 ENYSPSLKSPKKESQGKVDELKDHSEKHPSSCSCCGN-KSFNTRYHNLRAEKynscsecyDQGRFPSefTSSDFKPVTIS 274
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622847421  528 ESSR---WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQC 566
Cdd:COG5259    275 LLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQC 316
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
66-154 1.47e-41

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 148.08  E-value: 1.47e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   66 LTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIE 145
Cdd:pfam15784    1 YYPQVEAISPTLPSPEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPSE 80

                   ....*....
gi 1622847421  146 SKHRSLVQI 154
Cdd:pfam15784   81 SKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
531-574 7.68e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 64.83  E-value: 7.68e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622847421  531 RWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYK 574
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
531-576 1.34e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.39  E-value: 1.34e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1622847421   531 RWTEEEMETAKKGLLEHG-RNWSAIARMVGSKTVSQCKNFYFNYKKR 576
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
531-574 1.89e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 57.97  E-value: 1.89e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622847421  531 RWTEEEMETAKKGLLEHG-RNWSAIARMVGSKTVSQCKNFYFNYK 574
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
357-400 1.08e-06

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 47.22  E-value: 1.08e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622847421  357 WSEQEKETFREKFMQHPKNFGLI-ASFLERKTVAECVLYYYLTKK 400
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PHA03247 PHA03247
large tegument protein UL36; Provisional
675-1143 1.26e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  675 AAKDTGqnGPQPPAtqSTDGPPPEPPTPPPEDIPAPTEPTPASEATGPPTPPPAPPSPSVPPPVVPKEEKEEEAAAVSPV 754
Cdd:PHA03247  2544 ASDDAG--DPPPPL--PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPP 2619
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  755 EEGEEQKPPAAEELAVDTGKAEEPIKSECTEQAEEGPAKGKDAEASEATAEGalkaekkeggsgRATTAkgSGAPQDSDS 834
Cdd:PHA03247  2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLG------------RAAQA--SSPPQRPRR 2685
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  835 SATcsadevdEPEGGDKNRLLSPRPSLLTPTGDPRAnASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPA 914
Cdd:PHA03247  2686 RAA-------RPTVGSLTSLADPPPPPPTPEPAPHA-LVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  915 PPPPQHLQPESDAPqqpgssPRGKSRSPAPAADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGlPFPVPPREVIKASPHAP 994
Cdd:PHA03247  2758 ARPPTTAGPPAPAP------PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA-PAAALPPAASPAGPLPP 2830
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  995 DPSAFSYAPPGHPLPL-------GLHDTARPVLPRPPTISnPPPLISSAKHPsvlerqigaisqgmsvqlhvPYSEHAKA 1067
Cdd:PHA03247  2831 PTSAQPTAPPPPPGPPppslplgGSVAPGGDVRRRPPSRS-PAAKPAAPARP--------------------PVRRLARP 2889
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421 1068 PVGPVTMGLPLPMD-------------PKKLAPFSGVKQEQLSPRGQAGPPESLGvPTAQEASVlrGTALGSVPG---GS 1131
Cdd:PHA03247  2890 AVSRSTESFALPPDqperppqpqapppPQPQPQPPPPPQPQPPPPPPPRPQPPLA-PTTDPAGA--GEPSGAVPQpwlGA 2966
                          490
                   ....*....|....*
gi 1622847421 1132 ITKG---IPSTRVPS 1143
Cdd:PHA03247  2967 LVPGrvaVPRFRVPQ 2981
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
357-396 2.80e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 45.96  E-value: 2.80e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622847421  357 WSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYY 396
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
778-1051 5.15e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.00  E-value: 5.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  778 PIKSECTEQaEEGPAKGKDAEASEATAEGalkaeKKEGGSGRATTAKGSGAPQDSDSSATCSADEVDEPEGGDKNRLLSP 857
Cdd:PTZ00449   498 PIEEEDSDK-HDEPPEGPEASGLPPKAPG-----DKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSK 571
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  858 RPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQHLQPesdAPQQPGSSPRG 937
Cdd:PTZ00449   572 IPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP---PPQRPSSPERP 648
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  938 KS-RSPAPAADKEAEKPVFFPAFAAE--------AQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAfsyappgHPL 1008
Cdd:PTZ00449   649 EGpKIIKSPKPPKSPKPPFDPKFKEKfyddyldaAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-------RPL 721
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1622847421 1009 PlglhdtarPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQ 1051
Cdd:PTZ00449   722 P--------PKLPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEE 756
PHA03247 PHA03247
large tegument protein UL36; Provisional
828-1150 6.50e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 6.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  828 APQDSDSSATCSADEVDEPEggDKNRLLSPRpsllTPTGDPRANASPQ------KPLDLKQLKQRAAAIPPIVTKVHEPP 901
Cdd:PHA03247  2574 APRPSEPAVTSRARRPDAPP--QSARPRAPV----DDRGDPRGPAPPSplppdtHAPDPPPPSPSPAANEPDPHPPPTVP 2647
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  902 REDAAPTKPAPPAPPPPQHLQPESDAPQqPGSSPRGksrsPAPAADKEAEKPVFFPAFAAEAQKLPGD-PPCWTSGLPFP 980
Cdd:PHA03247  2648 PPERPRDDPAPGRVSRPRRARRLGRAAQ-ASSPPQR----PRRRAARPTVGSLTSLADPPPPPPTPEPaPHALVSATPLP 2722
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  981 VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVP 1060
Cdd:PHA03247  2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPW 2802
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421 1061 YSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQeQLSPRGQAGPPESlgvPTAQEASVlrgtalgsVPGGSITKGIPSTR 1140
Cdd:PHA03247  2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPP---SLPLGGSV--------APGGDVRRRPPSRS 2870
                          330
                   ....*....|
gi 1622847421 1141 VPSDSAITYR 1150
Cdd:PHA03247  2871 PAAKPAAPAR 2880
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
25-383 8.72e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 51.61  E-value: 8.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   25 MEFIESKRP-----RLELLPDPLLRPSPLLAAGQPAGSEDLTKDRSLTGKLEPVSppsppHTDPELELVPPRLSKE--EL 97
Cdd:TIGR02169  626 VEDIEAARRlmgkyRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLR-----ERLEGLKRELSSLQSElrRI 700
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   98 IQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPvspppIESKHRSLVQIIYDENRKKAEAAHRI--LEGLGP 175
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE-----LEEDLSSLEQEIENVKSELKELEARIeeLEEDLH 775
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  176 QVELPLyNQPSDtRQYHENIKINQAMRKKLILYFKR-------------RNHARKQWEQKFCQRYDQLMEAWEKKV---- 238
Cdd:TIGR02169  776 KLEEAL-NDLEA-RLSHSRIPEIQAELSKLEEEVSRiearlreieqklnRLTLEKEYLEKEIQELQEQRIDLKEQIksie 853
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  239 ERIEN-NPRRRAKESKVREY------YEKQFPEIRKQR-ELQERM---QSRVGQrgsgLSMSAARSEHEVSEIIDGLSEQ 307
Cdd:TIGR02169  854 KEIENlNGKKEELEEELEELeaalrdLESRLGDLKKERdELEAQLrelERKIEE----LEAQIEKKRKRLSELKAKLEAL 929
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  308 EN----LEKQMRQLAVIPPMLYDADQ------------QRIKFINM-------------NGLMADPMKVYKDR----QVM 354
Cdd:TIGR02169  930 EEelseIEDPKGEDEEIPEEELSLEDvqaelqrveeeiRALEPVNMlaiqeyeevlkrlDELKEKRAKLEEERkailERI 1009
                          410       420
                   ....*....|....*....|....*....
gi 1622847421  355 NMWSEQEKETFREKFMQHPKNFGLIASFL 383
Cdd:TIGR02169 1010 EEYEKKKREVFMEAFEAINENFNEIFAEL 1038
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
357-399 2.44e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 43.33  E-value: 2.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622847421  357 WSEQEKETFREKFMQHP-KNFGLIASFLERKTVAECVLYYYLTK 399
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
683-1105 2.78e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 2.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  683 GPQPPATQSTDGPPPEPPTPPpediPAPTEPTPASEATGPPTPPPAPPSPSVPPPVVPKEEKEEEAAAVSPVEEGEEQKP 762
Cdd:PHA03247  2682 RPRRRAARPTVGSLTSLADPP----PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  763 PAAEELAVDTGKAEEPIKSECTEQAEEGPAKGKDAEASEATAEGALKAEKKEGGSGRATTAKGSGAPQDSDSSATCSADE 842
Cdd:PHA03247  2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT 2837
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  843 VDEPEGGDKNRLLSPRPSLlTPTGD----PRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPP 918
Cdd:PHA03247  2838 APPPPPGPPPPSLPLGGSV-APGGDvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  919 QHLQPESDAPQQPGSSPRGKSRSPAPAAdkeaekPVFFPAFAAEAQklPGDPPCWTSGL---PFPVPPREVIKASPHAPD 995
Cdd:PHA03247  2917 PQPQPQPPPPPQPQPPPPPPPRPQPPLA------PTTDPAGAGEPS--GAVPQPWLGALvpgRVAVPRFRVPQPAPSREA 2988
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  996 PSAFSYAPPGHPLP--------LGLHDTARPvlprpptisNPPPLISSAKHPSVLERqigaiSQGMSVQLHVPYSEHAKA 1067
Cdd:PHA03247  2989 PASSTPPLTGHSLSrvsswassLALHEETDP---------PPVSLKQTLWPPDDTED-----SDADSLFDSDSERSDLEA 3054
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|
gi 1622847421 1068 PvGPVTmglPLPMDPKKLAPFSGVKQ--EQLSPRGQAGPP 1105
Cdd:PHA03247  3055 L-DPLP---PEPHDPFAHEPDPATPEagARESPSSQFGPP 3090
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
357-400 8.05e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.21  E-value: 8.05e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1622847421   357 WSEQEKETFREKFMQHP-KNFGLIASFLERKTVAECVLYYYLTKK 400
Cdd:smart00717    4 WTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
532-573 5.57e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 39.99  E-value: 5.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622847421  532 WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNY 573
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRK 42
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
458-566 5.62e-04

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 45.26  E-value: 5.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  458 DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRrKGRITRSMANEANS--------EEAITPQ--QSAELASMELN 527
Cdd:COG5259    196 ENYSPSLKSPKKESQGKVDELKDHSEKHPSSCSCCGN-KSFNTRYHNLRAEKynscsecyDQGRFPSefTSSDFKPVTIS 274
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622847421  528 ESSR---WTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQC 566
Cdd:COG5259    275 LLIRdknWSRQELLLLLEGIEMYGDDWDKVARHVGTKTKEQC 316
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
91-336 5.72e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 5.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421   91 RLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKppepekpvspppIESKHRSLVQIIYDENRKKAEAAHRIl 170
Cdd:TIGR02168  245 QEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEE------------LQKELYALANEISRLEQQKQILRERL- 311
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  171 eglgpqvelplynqpsdtRQYHENIKINQAMRKKLilyFKRRNHARK---QWEQKFCQ---RYDQLMEAWEKKVERIENN 244
Cdd:TIGR02168  312 ------------------ANLERQLEELEAQLEEL---ESKLDELAEelaELEEKLEElkeELESLEAELEELEAELEEL 370
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  245 PRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQEnLEKQMRQLAVIPPML 324
Cdd:TIGR02168  371 ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAE-LKELQAELEELEEEL 449
                          250
                   ....*....|..
gi 1622847421  325 YDADQQRIKFIN 336
Cdd:TIGR02168  450 EELQEELERLEE 461
PHA03379 PHA03379
EBNA-3A; Provisional
856-1190 2.26e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 43.51  E-value: 2.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  856 SPRPslltPTGDPRanasPQKPLDLKQLKQRAAAI---PPIVTKVHEPPREDAAPTKPAPPAPPPPQHLQPESDAPQQPG 932
Cdd:PHA03379   415 TPRP----PVEKPR----PEVPQSLETATSHGSAQvpePPPVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEPGDQLPG 486
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421  933 SSPRGKsrsPAPAADKEAEKPVFFPAFAAEAQkLPGDPPcwtsglpfpvpprevikaSPHAPDPSafsyapPGHPLPLGL 1012
Cdd:PHA03379   487 VVQDGR---PACAPVPAPAGPIVRPWEASLSQ-VPGVAF------------------APVMPQPM------PVEPVPVPT 538
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421 1013 HDTARPVLPRPPTISNPPPLISSAkhpsvlerqigaisqgmSVQLHVPYSEHAKAPvGPVTMGLPLPM--DPKKLAPFSG 1090
Cdd:PHA03379   539 VALERPVCPAPPLIAMQGPGETSG-----------------IVRVRERWRPAPWTP-NPPRSPSQMSVrdRLARLRAEAQ 600
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622847421 1091 VKQE----QLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRgSITHGTPADVLYKGT 1166
Cdd:PHA03379   601 PYQAsvevQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQPQYFDLPLQQ-PISQGAPLAPLRASM 679
                          330       340
                   ....*....|....*....|....*
gi 1622847421 1167 ITR-IIGEDSPSRLDRSREDSLPKG 1190
Cdd:PHA03379   680 GPVpPVPATQPQYFDIPLTEPINQG 704
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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