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Conserved domains on  [gi|1622842585|ref|XP_028684732|]
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coronin-1C isoform X1 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-474 2.24e-110

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 338.02  E-value: 2.24e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585  80 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 158
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 159 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 238
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 239 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 317
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 318 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 397
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622842585 398 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 474
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-474 2.24e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 338.02  E-value: 2.24e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585  80 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 158
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 159 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 238
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 239 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 317
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 318 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 397
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622842585 398 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 474
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 5.29e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 5.29e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622842585  75 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 147-372 3.25e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 3.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 147 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 226
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 227 IIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 305
Cdd:cd00200   117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 306 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 372
Cdd:cd00200   193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
150-324 3.00e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 3.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 229
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 230 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 309
Cdd:COG2319   231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                         170
                  ....*....|....*
gi 1622842585 310 srMSERQLALWNPKN 324
Cdd:COG2319   307 --SDDGTVRLWDLAT 319
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-180 9.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.51e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622842585  150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 180
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 80-474 2.24e-110

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 338.02  E-value: 2.24e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585  80 SKFRHVFGQAVKNDQCYDDIRVSRVTWD-SSFCAVNPRFVAIIIEASGGGAflVLPLHKTGRIDKSYPTVCGHTGPVLDI 158
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 159 DWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAl 238
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 239 INLDDMHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGARPMRAIFLADGN-VFTTGFSRMSERQL 317
Cdd:PTZ00421  161 VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 318 ALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYlnTFSSKEPQRGMGYMPKRGL 397
Cdd:PTZ00421  240 MLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCS--SYSSVEPHKGLCMMPKWSL 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622842585 398 DVNKCEIARFFKLHERKCEPIIMTVPRK-SDL-FQDDLYPDTAGPEAALEAEEWFEGKNADPILISLkHGYIPGKNRDL 474
Cdd:PTZ00421  318 DTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDM-SAVFDGTSPEL 395
PTZ00420 PTZ00420
coronin; Provisional
 96-527 1.10e-66

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 225.98  E-value: 1.10e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585  96 YDDIRV-SRVTwDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRidksYPTVC---GHTGPVLDIDWCPHNDQVIASG 171
Cdd:PTZ00420   19 FDDLRIcSRVI-DSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR----KPPVIklkGHTSSILDLQFNPCFSEILASG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 172 SEDCTVMVWQIPENGLTLS-LTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEAL--INLDDMHSDM 248
Cdd:PTZ00420   94 SEDLTIRVWEIPHNDESVKeIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPKKLSSL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 249 iynvSWNRNGSLICTASKDKKVRVIDPRKQEIvAEKEKAHEGARPMRAIFL-----ADGNVFTTGFSRMSERQLALWNPK 323
Cdd:PTZ00420  174 ----KWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKLWDLK 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 324 NMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESpyVHYLNTFSSKEPQRGMGYMPKRGLDVNKCE 403
Cdd:PTZ00420  249 NTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDVYKCE 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 404 IARFFK-LHERKCEPIIMTVPRK-SDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHgyipGKNRDLKVVKK-- 479
Cdd:PTZ00420  327 IGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD----LTEDDLRITKKyk 402

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622842585 480 -------NILDSKPTANKKCDLInvpKKTTDTASVQNEAKLDEILKEIKSIKDTI 527
Cdd:PTZ00420  403 fvpqsfnSIIIGENYTSKRTSII---RQFTKKFTFFKKGEHNDGFSSVDSFKESV 454
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 75-140 5.29e-36

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 128.39  E-value: 5.29e-36
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622842585  75 RVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGR 140
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 147-372 3.25e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 3.25e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 147 TVCGHTGPVLDIDWCPHNDQvIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNA 226
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWD-------LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 227 IIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkAHEGarPMRAI-FLADGNVF 305
Cdd:cd00200   117 IKVWDVETGKCLTTLRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT-GHTG--EVNSVaFSPDGEKL 192

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 306 TTGFsrmSERQLALWNPKnMQEPIAL---HEmDTSNGVLlpfYDPDTSIIyLCGKGDSSIRYFEITDESP 372
Cdd:cd00200   193 LSSS---SDGTIKLWDLS-TGKCLGTlrgHE-NGVNSVA---FSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
150-324 3.00e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 3.00e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 229
Cdd:COG2319   160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 230 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 309
Cdd:COG2319   231 WDLATGKLLRTLTG-HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASG- 306

                         170
                  ....*....|....*
gi 1622842585 310 srMSERQLALWNPKN 324
Cdd:COG2319   307 --SDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
150-323 2.28e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 2.28e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIpENGltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 229
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL-ATG------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 230 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKEkaHEGARPMRAIFLADGNVFTTGf 309
Cdd:COG2319   189 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT--GHSGSVRSVAFSPDGRLLASG- 264

                         170
                  ....*....|....
gi 1622842585 310 srMSERQLALWNPK 323
Cdd:COG2319   265 --SADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
150-324 1.10e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 1.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARnVLLSAGCDNAIII 229
Cdd:COG2319   244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG-------ELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRL 314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 230 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGArPMRAIFLADGNVFTTGf 309
Cdd:COG2319   315 WDLATGKLLRTLTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL-TGHTGA-VTSVAFSPDGRTLASG- 390

                         170
                  ....*....|....*
gi 1622842585 310 SRmsERQLALWNPKN 324
Cdd:COG2319   391 SA--DGTVRLWDLAT 403
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 415-457 3.49e-21

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 86.41  E-value: 3.49e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622842585 415 CEPIIMTVPRKS-DLFQDDLYPDTAGPEAALEAEEWFEGKNADP 457
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-308 6.73e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 6.73e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQIPENgltlsltEPVVILEGHSKRVGIVAWHPTARNvLLSAGCDNAIII 229
Cdd:cd00200   133 GHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 230 WNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRKQEIVAEKeKAHEGarPMRAI-FLADGNVFTTG 308
Cdd:cd00200   204 WDLSTGKCLGTLRG-HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-SGHTN--SVTSLaWSPDGKRLASG 279
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-272 9.23e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.92  E-value: 9.23e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVWQipengltLSLTEPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIII 229
Cdd:cd00200   175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWD-------LSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1622842585 230 WNVGTGEALINLDdMHSDMIYNVSWNRNGSLICTASKDKKVRV 272
Cdd:cd00200   246 WDLRTGECVQTLS-GHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 198-372 1.08e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 198 LEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWNVGTGEALINLDDmHSDMIYNVSWNRNGSLICTASKDKKVRVIDPRK 277
Cdd:cd00200     5 LKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 278 QEIVAEKEkAHEGarPMRAI-FLADGNVFTTGfsrMSERQLALWNPKNMQEPIAL--HEMDTSNGVllpfYDPDTSIIYl 354
Cdd:cd00200    83 GECVRTLT-GHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLrgHTDWVNSVA----FSPDGTFVA- 151

                         170
                  ....*....|....*...
gi 1622842585 355 CGKGDSSIRYFEITDESP 372
Cdd:cd00200   152 SSSQDGTIKLWDLRTGKC 169
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-180 9.51e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 9.51e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622842585  150 GHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 180
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
147-180 5.98e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.98e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622842585 147 TVCGHTGPVLDIDWCPhNDQVIASGSEDCTVMVW 180
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-231 1.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.19e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622842585  193 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 231
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 245-274 2.17e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.17e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1622842585  245 HSDMIYNVSWNRNGSLICTASKDKKVRVID 274
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-181 4.11e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 4.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1622842585 137 KTGRIDKsypTVCGHTGPVLDIDWCPHNdQVIASGSEDCTVMVWQ 181
Cdd:cd00200   249 RTGECVQ---TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
193-231 6.12e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.12e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622842585 193 EPVVILEGHSKRVGIVAWHPTaRNVLLSAGCDNAIIIWN 231
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
245-274 7.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 7.38e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1622842585 245 HSDMIYNVSWNRNGSLICTASKDKKVRVID 274
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 160-257 1.23e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.03  E-value: 1.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622842585 160 WCPHNDqVIASGSEDCTV--------MVWQIPengltlsltepvviLEGHSKRVGIVAWHPTARnVLLSAGCDNAIIIWN 231
Cdd:pfam12894   3 WCPTMD-LIALATEDGELllhrlnwqRVWTLS--------------PDKEDLEVTSLAWRPDGK-LLAVGYSDGTVRLLD 66

                          90       100
                  ....*....|....*....|....*.
gi 1622842585 232 VGTGEALINLdDMHSDMIYNVSWNRN 257
Cdd:pfam12894  67 AENGKIVHHF-SAGSDLITCLGWGEN 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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