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Conserved domains on  [gi|1622841654|ref|XP_028684520|]
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opioid growth factor receptor isoform X3 [Macaca mulatta]

Protein Classification

OGFr_N and KLF9_13_N-like domain-containing protein( domain architecture ID 10519883)

OGFr_N and KLF9_13_N-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OGFr_N pfam04664
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors ...
 180-387 2.11e-142

Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.


:

Pssm-ID: 461383  Cd Length: 208  Bit Score: 413.65  E-value: 2.11e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 180 DCNGDTPNLSFYRNEIRFLPNGCFIEDILQNWRDNYDLLEDNHSYIQWLFPLREPGVNWHAKPLTLREVEVFKSSQEIQE 259
Cdd:pfam04664   1 DQPNDMANLKFYKNEIPFQPDGIYIEEFLQKWKGDYDKLEHNHSYIQWLFPLREPGVNWRAKPLTPKEIEAFKKSEEAKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 260 RLVRAYELMLGFYGIRLEDRGTGTVGRAQNYQKRFQNLNWRSHNNLRITRILKSLGELGLEHFQAPLVRFFLEETLVRQE 339
Cdd:pfam04664  81 RLLKSYKLMLGFYGIELLDEKTGEVKRASNWQERFQNLNRNSHNNLRITRILKSLGELGYEHYQAPLVRFFLEETLVHFT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622841654 340 LPGVRQSALDYFMFAVRCRNQRRQLVHFAWEHFRPRCKFVWGPPDKLR 387
Cdd:pfam04664 161 LPNVKQSALDYFVFTVRDKRERRELVRFAWQHYKPRGKFVWGPWDKLQ 208
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 391-655 2.51e-05

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 2.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  391 PSSWPRLLEGSRKAEEEGSPGDPDHKASTQGRTCGPEHSKG-RGRVDEGPQPRSVEPQDAGPLERSQGDEAGGYGEDGPE 469
Cdd:PHA03307   128 PSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASsRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPP 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  470 PLSPKESKKRKLELSRREQPPTEPGPQSASevekialnleGCALSQGSLRTGTQEVGGQDPGEAVQPCPQPLGARVADKV 549
Cdd:PHA03307   208 RRSSPISASASSPAPAPGRSAADDAGASSS----------DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNG 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  550 RKRRRVDeGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAgPAGDEPA 629
Cdd:PHA03307   278 PSSRPGP-ASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPS-RSPSPSR 355

                          250       260
                   ....*....|....*....|....*.
gi 1622841654  630 ESPSETPGPSPAGPAGDEPAKAGEAA 655
Cdd:PHA03307   356 PPPPADPSSPRKRPRPSRAPSSPAAS 381
 
Name Accession Description Interval E-value
OGFr_N pfam04664
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors ...
 180-387 2.11e-142

Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.


Pssm-ID: 461383  Cd Length: 208  Bit Score: 413.65  E-value: 2.11e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 180 DCNGDTPNLSFYRNEIRFLPNGCFIEDILQNWRDNYDLLEDNHSYIQWLFPLREPGVNWHAKPLTLREVEVFKSSQEIQE 259
Cdd:pfam04664   1 DQPNDMANLKFYKNEIPFQPDGIYIEEFLQKWKGDYDKLEHNHSYIQWLFPLREPGVNWRAKPLTPKEIEAFKKSEEAKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 260 RLVRAYELMLGFYGIRLEDRGTGTVGRAQNYQKRFQNLNWRSHNNLRITRILKSLGELGLEHFQAPLVRFFLEETLVRQE 339
Cdd:pfam04664  81 RLLKSYKLMLGFYGIELLDEKTGEVKRASNWQERFQNLNRNSHNNLRITRILKSLGELGYEHYQAPLVRFFLEETLVHFT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622841654 340 LPGVRQSALDYFMFAVRCRNQRRQLVHFAWEHFRPRCKFVWGPPDKLR 387
Cdd:pfam04664 161 LPNVKQSALDYFVFTVRDKRERRELVRFAWQHYKPRGKFVWGPWDKLQ 208
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 391-655 2.51e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 2.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  391 PSSWPRLLEGSRKAEEEGSPGDPDHKASTQGRTCGPEHSKG-RGRVDEGPQPRSVEPQDAGPLERSQGDEAGGYGEDGPE 469
Cdd:PHA03307   128 PSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASsRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPP 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  470 PLSPKESKKRKLELSRREQPPTEPGPQSASevekialnleGCALSQGSLRTGTQEVGGQDPGEAVQPCPQPLGARVADKV 549
Cdd:PHA03307   208 RRSSPISASASSPAPAPGRSAADDAGASSS----------DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNG 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  550 RKRRRVDeGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAgPAGDEPA 629
Cdd:PHA03307   278 PSSRPGP-ASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPS-RSPSPSR 355

                          250       260
                   ....*....|....*....|....*.
gi 1622841654  630 ESPSETPGPSPAGPAGDEPAKAGEAA 655
Cdd:PHA03307   356 PPPPADPSSPRKRPRPSRAPSSPAAS 381
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 483-648 5.94e-04

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 41.34  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 483 LSRREQPPTEPGPQSASEVEkiALNLEgCALSqgslRTGTQEVGGQDPGEAV--------QPCPQPLGARV-ADKvrkRR 553
Cdd:cd21576    24 LHRRAPDPEGAGGAAGSEVG--AAPPE-SALP----GPGPPGPAWVPPLLQVpapspgagGAAPHLLAASVlADL---RG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 554 RVDEGSGDSAVVAsdgaqTLALAGCPAP-SGYPKAGHSENGVEEDTEGRTGPkEGTPGSPsETPGPSPAGPAGDEPAESP 632
Cdd:cd21576    94 GAGEGSREDSGEA-----PRASSGSSDPaRGSSPTLGSEPAPASGEDAVSGP-ESSFGAP-AIPSAPAAPGAPAVSGEVP 166

                         170
                  ....*....|....*.
gi 1622841654 633 SETPGPSPAGPAGDEP 648
Cdd:cd21576   167 GGAPGAGPAPAAGPAP 182
OGFr_III pfam04680
Opioid growth factor receptor repeat; Proline-rich repeat found only in a human opioid growth ...
 611-630 6.54e-04

Opioid growth factor receptor repeat; Proline-rich repeat found only in a human opioid growth factor receptor.


Pssm-ID: 282527  Cd Length: 20  Bit Score: 37.23  E-value: 6.54e-04
                          10        20
                  ....*....|....*....|
gi 1622841654 611 SPSETPGPSPAGPAGDEPAE 630
Cdd:pfam04680   1 APEETLGPRAAPPAGDEPAE 20
 
Name Accession Description Interval E-value
OGFr_N pfam04664
Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors ...
 180-387 2.11e-142

Opioid growth factor receptor (OGFr) conserved region; Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.


Pssm-ID: 461383  Cd Length: 208  Bit Score: 413.65  E-value: 2.11e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 180 DCNGDTPNLSFYRNEIRFLPNGCFIEDILQNWRDNYDLLEDNHSYIQWLFPLREPGVNWHAKPLTLREVEVFKSSQEIQE 259
Cdd:pfam04664   1 DQPNDMANLKFYKNEIPFQPDGIYIEEFLQKWKGDYDKLEHNHSYIQWLFPLREPGVNWRAKPLTPKEIEAFKKSEEAKR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 260 RLVRAYELMLGFYGIRLEDRGTGTVGRAQNYQKRFQNLNWRSHNNLRITRILKSLGELGLEHFQAPLVRFFLEETLVRQE 339
Cdd:pfam04664  81 RLLKSYKLMLGFYGIELLDEKTGEVKRASNWQERFQNLNRNSHNNLRITRILKSLGELGYEHYQAPLVRFFLEETLVHFT 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1622841654 340 LPGVRQSALDYFMFAVRCRNQRRQLVHFAWEHFRPRCKFVWGPPDKLR 387
Cdd:pfam04664 161 LPNVKQSALDYFVFTVRDKRERRELVRFAWQHYKPRGKFVWGPWDKLQ 208
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 391-655 2.51e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 2.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  391 PSSWPRLLEGSRKAEEEGSPGDPDHKASTQGRTCGPEHSKG-RGRVDEGPQPRSVEPQDAGPLERSQGDEAGGYGEDGPE 469
Cdd:PHA03307   128 PSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASsRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPP 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  470 PLSPKESKKRKLELSRREQPPTEPGPQSASevekialnleGCALSQGSLRTGTQEVGGQDPGEAVQPCPQPLGARVADKV 549
Cdd:PHA03307   208 RRSSPISASASSPAPAPGRSAADDAGASSS----------DSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNG 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  550 RKRRRVDeGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAgPAGDEPA 629
Cdd:PHA03307   278 PSSRPGP-ASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPS-RSPSPSR 355

                          250       260
                   ....*....|....*....|....*.
gi 1622841654  630 ESPSETPGPSPAGPAGDEPAKAGEAA 655
Cdd:PHA03307   356 PPPPADPSSPRKRPRPSRAPSSPAAS 381
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 524-666 2.03e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.59  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 524 EVGGQDPGEAVQPCPQPLGARVADKVRKRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGVEEDTEGRTG 603
Cdd:PRK07764  587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622841654 604 ----PKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPSPAGPAGDEPAKAGEAAEVQDTEAKPSA 666
Cdd:PRK07764  667 dgwpAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP 733
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 519-655 2.79e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 519 RTGTQEVGGQDPGEAVQPCPQPLGARVADkvrkrRRVDEGSGDSAVVASDGAqtlALAGCPAPSGYPKAGHSENGVEEDT 598
Cdd:PRK07764  377 RLERLERRLGVAGGAGAPAAAAPSAAAAA-----PAAAPAPAAAAPAAAAAP---APAAAPQPAPAPAPAPAPPSPAGNA 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622841654 599 EGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPSPAGPAGDEPAKAGEAA 655
Cdd:PRK07764  449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
PHA03169 PHA03169
hypothetical protein; Provisional
 588-664 3.05e-04

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 43.81  E-value: 3.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 588 GHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGP-SPAGPAGDEPAK-------AGEAAEVQD 659
Cdd:PHA03169   96 GSESVGSPTPSPSGSAEELASGLSPENTSGSSPESPASHSPPPSPPSHPGPhEPAPPESHNPSPnqqpssfLQPSHEDSP 175


                  ....*
gi 1622841654 660 TEAKP 664
Cdd:PHA03169  176 EEPEP 180
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 401-669 3.14e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 3.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  401 SRKAEEEGSPGDPDHKASTQGRTCGPEHSKGRGRVDEGPQPRSVEPQDAGPLE-RSQGDEAGGYGEDGPEPLSPKEskKR 479
Cdd:PHA03307    63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDpPPPTPPPASPPPSPAPDLSEML--RP 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  480 KLELSRREQPPTEPGPQSASEVEKIALNLEGCALSQGSLRTGTQEVGGqdPGEAVQPCPQPLGARVADKVRKRRRVDEGS 559
Cdd:PHA03307   141 VGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSS--PPAEPPPSTPPAAASPRPPRRSSPISASAS 218

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  560 GDSAVVASDGA----QTLALAGCPAPSGYPKAGHSENGVEEDTEGRTGPKEGTPGSP-SETPGPSPAGPAGDEPAESPSE 634
Cdd:PHA03307   219 SPAPAPGRSAAddagASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWnGPSSRPGPASSSSSPRERSPSP 298

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1622841654  635 TPGPSPAGPAGDEPAKAGEAAEVQDTEAKPSAKSG 669
Cdd:PHA03307   299 SPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSS 333
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
526-671 5.39e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 526 GGQDPGEAVQPcpqplgaRVADKVRKRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENG-------VEEDT 598
Cdd:PRK07003  364 GGGAPGGGVPA-------RVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEappaapaPPATA 436

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622841654 599 EGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPSpAGPAGDEPAKAGEAAEVQDTEAKPSAKSGKA 671
Cdd:PRK07003  437 DRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSA-SAPASDAPPDAAFEPAPRAAAPSAATPAAVP 508
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 483-648 5.94e-04

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 41.34  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 483 LSRREQPPTEPGPQSASEVEkiALNLEgCALSqgslRTGTQEVGGQDPGEAV--------QPCPQPLGARV-ADKvrkRR 553
Cdd:cd21576    24 LHRRAPDPEGAGGAAGSEVG--AAPPE-SALP----GPGPPGPAWVPPLLQVpapspgagGAAPHLLAASVlADL---RG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 554 RVDEGSGDSAVVAsdgaqTLALAGCPAP-SGYPKAGHSENGVEEDTEGRTGPkEGTPGSPsETPGPSPAGPAGDEPAESP 632
Cdd:cd21576    94 GAGEGSREDSGEA-----PRASSGSSDPaRGSSPTLGSEPAPASGEDAVSGP-ESSFGAP-AIPSAPAAPGAPAVSGEVP 166

                         170
                  ....*....|....*.
gi 1622841654 633 SETPGPSPAGPAGDEP 648
Cdd:cd21576   167 GGAPGAGPAPAAGPAP 182
OGFr_III pfam04680
Opioid growth factor receptor repeat; Proline-rich repeat found only in a human opioid growth ...
 611-630 6.54e-04

Opioid growth factor receptor repeat; Proline-rich repeat found only in a human opioid growth factor receptor.


Pssm-ID: 282527  Cd Length: 20  Bit Score: 37.23  E-value: 6.54e-04
                          10        20
                  ....*....|....*....|
gi 1622841654 611 SPSETPGPSPAGPAGDEPAE 630
Cdd:pfam04680   1 APEETLGPRAAPPAGDEPAE 20
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 493-645 8.01e-04

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 42.27  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 493 PGPQSASE-VEKIALNLEGCALSQGSLRTGTQEVGGQDPGEAVQPcpQPLGARVADKVRKRRRVDEGSGDSAVVASDGAQ 571
Cdd:PRK13108  282 PGALRGSEyVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQP--DDVAEAVKAEVAEVTDEVAAESVVQVADRDGES 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 572 TLAL----------AGCPAPSGYPKAGHSENGVEE---DTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGP 638
Cdd:PRK13108  360 TPAVeetseadierEQPGDLAGQAPAAHQVDAEAAsaaPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELAVAGPGD 439


                  ....*..
gi 1622841654 639 SPAGPAG 645
Cdd:PRK13108  440 DPAEPDG 446
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
493-659 8.33e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.53  E-value: 8.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 493 PGPQSASEVEKIALNLEGCALSQGSLRTGTQEVGGQDPGEAVQPCPQPLGARVADKV-RKRRRVDEGSGDSAVVASDGAQ 571
Cdd:PRK07003  383 PGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGdDAADGDAPVPAKANARASADSR 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 572 TLALAGCPAPSGYPK---AGHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPSPAGPAGDEP 648
Cdd:PRK07003  463 CDERDAQPPADSGSAsapASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAP 542

                         170
                  ....*....|..
gi 1622841654 649 -AKAGEAAEVQD 659
Cdd:PRK07003  543 aARAGGAAAALD 554
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 613-671 1.26e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 42.18  E-value: 1.26e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622841654  613 SETPGPSPAGPAGDEPAESPSETPGPSPAGPAGDEPAKAGEAAEVQDTEAKPSAKSGKA 671
Cdd:PRK12270    35 DYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAA 93
PHA03169 PHA03169
hypothetical protein; Provisional
 468-666 1.94e-03

hypothetical protein; Provisional


Pssm-ID: 223003 [Multi-domain]  Cd Length: 413  Bit Score: 41.11  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 468 PEPLSPKESKKRKLELSRREQPPTEPGPQSASEVEKIALNLEGCALSQGSlrtGTQEVGGQDPGEAVQpcpQPLGARVAD 547
Cdd:PHA03169   46 PAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESRHGEKEERGQGGPSGS---GSESVGSPTPSPSGS---AEELASGLS 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 548 KVRKRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGvEEDTEGRTGPKEGTPGSpSETPGPSPAGPAGDE 627
Cdd:PHA03169  120 PENTSGSSPESPASHSPPPSPPSHPGPHEPAPPESHNPSPNQQPSS-FLQPSHEDSPEEPEPPT-SEPEPDSPGPPQSET 197

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1622841654 628 PAESPSE-TPGPSPAGPAGDEPAKA-----GEAAEVQDTEAKPSA 666
Cdd:PHA03169  198 PTSSPPPqSPPDEPGEPQSPTPQQApspntQQAVEHEDEPTEPER 242
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
530-671 2.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.37  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 530 PGEAVQP---CPQPLGARVADKVRKRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSEngvEEDTEGRTGPKE 606
Cdd:PRK07003  406 AGAALAPkaaAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQP---PADSGSASAPAS 482

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622841654 607 GTPGSPSETPGPSPAGPAgdEPAESPSETPGPSPAGPAGDEPAKAGE----AAEVQDTEAKPSAKSGKA 671
Cdd:PRK07003  483 DAPPDAAFEPAPRAAAPS--AATPAAVPDARAPAAASREDAPAAAAPpapeARPPTPAAAAPAARAGGA 549
OGFr_III pfam04680
Opioid growth factor receptor repeat; Proline-rich repeat found only in a human opioid growth ...
 631-650 2.93e-03

Opioid growth factor receptor repeat; Proline-rich repeat found only in a human opioid growth factor receptor.


Pssm-ID: 282527  Cd Length: 20  Bit Score: 35.69  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|
gi 1622841654 631 SPSETPGPSPAGPAGDEPAK 650
Cdd:pfam04680   1 APEETLGPRAAPPAGDEPAE 20
PHA03247 PHA03247
large tegument protein UL36; Provisional
 461-666 3.33e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 3.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  461 GGYGEDGPEPLSPKESKKRKLELSRREQPPTEPGPQSASEVEKIALNLEGCALSQGSLRTGTQEVGGQDPG--EAVQPCP 538
Cdd:PHA03247   262 GEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEEDDEDGamEVVSPLP 341

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  539 QPlGARVADKVRKRRRVDEGSGDSAVVASDGAQTLALAGcPAPSGYPKAGHSENGVEEDTEGRTGPKEGTP---GSPSET 615
Cdd:PHA03247   342 RP-RQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRAS-LPTRKRRSARHAATPFARGPGGDDQTRPAAPvpaSVPTPA 419

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1622841654  616 PGPSPAG----PAGDEPAESPSETPGPSPAgPAGDEPAKAGEAAEVQDTEAKPSA 666
Cdd:PHA03247   420 PTPVPASapppPATPLPSAEPGSDDGPAPP-PERQPPAPATEPAPDDPDDATRKA 473
PHA03378 PHA03378
EBNA-3B; Provisional
 528-644 3.36e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 3.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 528 QDPGEAVQPCPQPLGARVAdkvrkRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGVEEDTEGRTGPKEG 607
Cdd:PHA03378  695 QPPPRAPTPMRPPAAPPGR-----AQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAA 769

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1622841654 608 TPGSPSETPGPSpAGPAgdePAESPSETPGPSP---AGPA 644
Cdd:PHA03378  770 APGAPTPQPPPQ-APPA---PQQRPRGAPTPQPppqAGPT 805
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 576-646 3.54e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 40.37  E-value: 3.54e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622841654 576 AGCPAPSGYPkaghsengveeDTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPSPAGPAGD 646
Cdd:PHA03264  272 GGSPAPPGDD-----------RPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDGAAGGEPKPGPPRPAPD 331
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 425-664 4.48e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 4.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 425 GPEHSKGRGRVDEGPQPRSVEPQdAGPLERSQGDEAGGYGEDGPEPLSPKESKKRKLELSRREQPPTEPGPQSASeveki 504
Cdd:PRK07764  599 GPPAPASSGPPEEAARPAAPAAP-AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAK----- 672

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 505 alnlegcALSQGSLRTGTQEVGGQDPGEAVQPCPQPLGARVAdkvrkrRRVDEGSGDSAVVASDGAQTLALAGCPAPSGY 584
Cdd:PRK07764  673 -------AGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAA------TPPAGQADDPAAQPPQAAQGASAPSPAADDPV 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 585 PKAGHSENGVEEDTEGRTGPkeGTPGSPSETPGPSPAGPAGDEPAESPSETPGPSPAGPAGDEPAKAGEAAEVQDTEAKP 664
Cdd:PRK07764  740 PLPPEPDDPPDPAGAPAQPP--PPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGAKK 817
PHA03247 PHA03247
large tegument protein UL36; Provisional
 381-671 4.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  381 GPPDKLRRFKPSSWPRLLEGSRKAEEEGSPGDPDHKASTQGRTCGPE--HSKGRGRVDEGPQPrsvEPQDAGPLERSQGD 458
Cdd:PHA03247  2579 EPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDppPPSPSPAANEPDPH---PPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  459 EAGG---------YGEDGPEPLSPKESKKRK---------LELSRREQPPTEPGPQSASEVekialnlegcalSQGSLRT 520
Cdd:PHA03247  2656 PAPGrvsrprrarRLGRAAQASSPPQRPRRRaarptvgslTSLADPPPPPPTPEPAPHALV------------SATPLPP 2723

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  521 GTQEVGGQDPGEAVQPCPQPL--GARVADKVRKRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPkAGHSENGVEEDT 598
Cdd:PHA03247  2724 GPAAARQASPALPAAPAPPAVpaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS-LSESRESLPSPW 2802

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622841654  599 EGRTGPKEGTPGSPSETPGPSPAGPAgdEPAESPSETPGPSPAGPAGDEPAKAGEAAEVQDTEAKPSAKSGKA 671
Cdd:PHA03247  2803 DPADPPAAVLAPAAALPPAASPAGPL--PPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAA 2873
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 560-671 6.06e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654  560 GDSAVVASDGAQTLALAGCPAPSGyPKAGHSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAESPSETPGPS 639
Cdd:PHA03307    51 AAVTVVAGAAACDRFEPPTGPPPG-PGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPS 129

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1622841654  640 PAGPAGDEPAKAGEAAEVQDTEAKPSAKSGKA 671
Cdd:PHA03307   130 PAPDLSEMLRPVGSPGPPPAASPPAAGASPAA 161
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
529-671 7.25e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.47  E-value: 7.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622841654 529 DPGEAVQPCPQPLGARVADKVRKRRRVDEGSGDSAVVASDGAQTLALAGCPAPSGYPKAGHSENGVEEDTEGRTGPKEGT 608
Cdd:PRK12323  402 PPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA 481

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622841654 609 PGSPSETPGPSPAG--PAGDEPAESPSETPGPSPAGPAGDEPAKAGEAAEVQDTEAKPSAKSGKA 671
Cdd:PRK12323  482 RAAPAAAPAPADDDppPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPA 546
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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