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Conserved domains on  [gi|1622840262|ref|XP_028684179|]
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matrix metalloproteinase-24 isoform X2 [Macaca mulatta]

Protein Classification

M10A family metallopeptidase( domain architecture ID 12021161)

M10A family metallopeptidase similar to matrix metalloproteinases with a C-terminal hemopexin repeat-containing domain that may be endopeptidases that degrade various components of the extracellular matrix; also contains a possible peptidoglycan binding domain at the N-terminus and a DUF3377 domain at the C-terminal end

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 322-514 9.05e-72

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


:

Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 228.74  E-value: 9.05e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 322 PNICDG-NFNTVALFRGEMFVFKDRWFWRLRNNRvQEGYPMQIEQFWKGLPARIDAAYERAD-GRFVFFKGDKYWVFKEV 399
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGK-PPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 400 TVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPK-PITVWKGIPQAPQGAFISKEG 478
Cdd:cd00094    80 NLEPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKlIETDFPGVPDKVDAAFRWLDG 159

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1622840262 479 YYtYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 514
Cdd:cd00094   160 YY-YFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 161-272 7.80e-55

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


:

Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 182.82  E-value: 7.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 161 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYheiksdrKEADIMIFFASGFHGDSSPFDGEGGF 240
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVST-------GEADIMIGFGRGDHGDGYPFDGPGGV 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622840262 241 LAHAYFPGPGIGGDTHFDSDEPWTLGNANHDG 272
Cdd:pfam00413  74 LAHAFFPGPGLGGDIHFDDDETWTVGSDPPHG 105
DUF3377 pfam11857
Domain of unknown function (DUF3377); This domain is functionally uncharacterized. This domain ...
 520-590 3.43e-31

Domain of unknown function (DUF3377); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 70 amino acids in length.


:

Pssm-ID: 463374  Cd Length: 72  Bit Score: 115.88  E-value: 3.43e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622840262 520 ERRKERRLPQDDVDIMVTINDV-PGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 590
Cdd:pfam11857   1 DREEDRHEEEDEVDIVVVIDDVaSGTVNAIAVVVPLVLLLCILVLIYAIVQFQRKGTPRRLLYCKRSLQDWV 72
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 81-133 2.23e-09

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


:

Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 53.29  E-value: 2.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622840262  81 QNWLKSYGYllpYDSRASAlHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWM 133
Cdd:pfam01471   9 QRYLNRLGY---YPGPVDG-YFGPSTEAAVKAFQRAFGLPVDGIVDPETLAAL 57
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 322-514 9.05e-72

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 228.74  E-value: 9.05e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 322 PNICDG-NFNTVALFRGEMFVFKDRWFWRLRNNRvQEGYPMQIEQFWKGLPARIDAAYERAD-GRFVFFKGDKYWVFKEV 399
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGK-PPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 400 TVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPK-PITVWKGIPQAPQGAFISKEG 478
Cdd:cd00094    80 NLEPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKlIETDFPGVPDKVDAAFRWLDG 159

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1622840262 479 YYtYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 514
Cdd:cd00094   160 YY-YFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 161-272 7.80e-55

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 182.82  E-value: 7.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 161 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYheiksdrKEADIMIFFASGFHGDSSPFDGEGGF 240
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVST-------GEADIMIGFGRGDHGDGYPFDGPGGV 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622840262 241 LAHAYFPGPGIGGDTHFDSDEPWTLGNANHDG 272
Cdd:pfam00413  74 LAHAFFPGPGLGGDIHFDDDETWTVGSDPPHG 105
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 161-270 3.08e-51

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 173.16  E-value: 3.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 161 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEiksdrkEADIMIFFASGFHGDSSPFDGEGGF 240
Cdd:cd04278     1 KWSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQ------EADIRISFARGNHGDGYPFDGPGGT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622840262 241 LAHAYFPGpGIGGDTHFDSDEPWTLGNANH 270
Cdd:cd04278    75 LAHAFFPG-GIGGDIHFDDDEQWTLGSDSG 103
DUF3377 pfam11857
Domain of unknown function (DUF3377); This domain is functionally uncharacterized. This domain ...
 520-590 3.43e-31

Domain of unknown function (DUF3377); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 70 amino acids in length.


Pssm-ID: 463374  Cd Length: 72  Bit Score: 115.88  E-value: 3.43e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622840262 520 ERRKERRLPQDDVDIMVTINDV-PGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 590
Cdd:pfam11857   1 DREEDRHEEEDEVDIVVVIDDVaSGTVNAIAVVVPLVLLLCILVLIYAIVQFQRKGTPRRLLYCKRSLQDWV 72
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 421-466 2.80e-11

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 58.35  E-value: 2.80e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622840262 421 IDTALRWEPvGKTYFFKGERYWRYSEERRatDPGYPKPITVWKGIP 466
Cdd:pfam00045   1 IDAAFEDRD-GKTYFFKGRKYWRFDPQRV--EPGYPKLISDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 421-466 4.90e-10

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 54.94  E-value: 4.90e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622840262  421 IDTALRWePVGKTYFFKGERYWRYSEERRatDPGYPKPIT-VWKGIP 466
Cdd:smart00120   1 IDAAFEL-RDGKTYFFKGDKYWRFDPKRV--DPGYPKLISsFFPGLP 44
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 81-133 2.23e-09

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 53.29  E-value: 2.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622840262  81 QNWLKSYGYllpYDSRASAlHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWM 133
Cdd:pfam01471   9 QRYLNRLGY---YPGPVDG-YFGPSTEAAVKAFQRAFGLPVDGIVDPETLAAL 57
 
Name Accession Description Interval E-value
HX cd00094
Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 322-514 9.05e-72

Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.


Pssm-ID: 238046 [Multi-domain]  Cd Length: 194  Bit Score: 228.74  E-value: 9.05e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 322 PNICDG-NFNTVALFRGEMFVFKDRWFWRLRNNRvQEGYPMQIEQFWKGLPARIDAAYERAD-GRFVFFKGDKYWVFKEV 399
Cdd:cd00094     1 PDACDPlSFDAVTTLRGELYFFKGRYFWRLSPGK-PPGSPFLISSFWPSLPSPVDAAFERPDtGKIYFFKGDKYWVYTGK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 400 TVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPK-PITVWKGIPQAPQGAFISKEG 478
Cdd:cd00094    80 NLEPGYPKPISDLGFPPTVKQIDAALRWPDNGKTYFFKGDKYWRYDEKTQKMDPGYPKlIETDFPGVPDKVDAAFRWLDG 159

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1622840262 479 YYtYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 514
Cdd:cd00094   160 YY-YFFKGDQYWRFDPRSKEVRVGYPLKISSDWLGC 194
Peptidase_M10 pfam00413
Matrixin; The members of this family are enzymes that cleave peptides. These proteases require ...
 161-272 7.80e-55

Matrixin; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis.


Pssm-ID: 425668 [Multi-domain]  Cd Length: 159  Bit Score: 182.82  E-value: 7.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 161 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYheiksdrKEADIMIFFASGFHGDSSPFDGEGGF 240
Cdd:pfam00413   1 KWRKKNLTYRILNYTPDLPRAEVRRAIRRAFKVWSEVTPLTFTEVST-------GEADIMIGFGRGDHGDGYPFDGPGGV 73

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622840262 241 LAHAYFPGPGIGGDTHFDSDEPWTLGNANHDG 272
Cdd:pfam00413  74 LAHAFFPGPGLGGDIHFDDDETWTVGSDPPHG 105
ZnMc_MMP cd04278
Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are ...
 161-270 3.08e-51

Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate specification, cell migration, tissue repair, tumorigenesis, gain or loss of tissue-specific functions, and apoptosis. In many instances, they are anchored to cell membranes via trans-membrane domains, and their activity is controlled via TIMPs (tissue inhibitors of metalloproteinases).


Pssm-ID: 239805 [Multi-domain]  Cd Length: 157  Bit Score: 173.16  E-value: 3.08e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622840262 161 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEiksdrkEADIMIFFASGFHGDSSPFDGEGGF 240
Cdd:cd04278     1 KWSKTNLTYRILNYPPDLPRDDVRRAIARAFRVWSDVTPLTFREVTSGQ------EADIRISFARGNHGDGYPFDGPGGT 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622840262 241 LAHAYFPGpGIGGDTHFDSDEPWTLGNANH 270
Cdd:cd04278    75 LAHAFFPG-GIGGDIHFDDDEQWTLGSDSG 103
DUF3377 pfam11857
Domain of unknown function (DUF3377); This domain is functionally uncharacterized. This domain ...
 520-590 3.43e-31

Domain of unknown function (DUF3377); This domain is functionally uncharacterized. This domain is found in eukaryotes. This presumed domain is about 70 amino acids in length.


Pssm-ID: 463374  Cd Length: 72  Bit Score: 115.88  E-value: 3.43e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622840262 520 ERRKERRLPQDDVDIMVTINDV-PGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTYYKRPVQEWV 590
Cdd:pfam11857   1 DREEDRHEEEDEVDIVVVIDDVaSGTVNAIAVVVPLVLLLCILVLIYAIVQFQRKGTPRRLLYCKRSLQDWV 72
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 421-466 2.80e-11

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 58.35  E-value: 2.80e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622840262 421 IDTALRWEPvGKTYFFKGERYWRYSEERRatDPGYPKPITVWKGIP 466
Cdd:pfam00045   1 IDAAFEDRD-GKTYFFKGRKYWRFDPQRV--EPGYPKLISDFPGLP 43
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 421-466 4.90e-10

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 54.94  E-value: 4.90e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622840262  421 IDTALRWePVGKTYFFKGERYWRYSEERRatDPGYPKPIT-VWKGIP 466
Cdd:smart00120   1 IDAAFEL-RDGKTYFFKGDKYWRFDPKRV--DPGYPKLISsFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 374-412 8.32e-10

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 54.11  E-value: 8.32e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1622840262 374 IDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGEL 412
Cdd:pfam00045   1 IDAAFEDRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDF 39
PG_binding_1 pfam01471
Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This ...
 81-133 2.23e-09

Putative peptidoglycan binding domain; This domain is composed of three alpha helices. This domain is found at the N or C terminus of a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. This family is found N-terminal to the catalytic domain of matrixins. The domain is found to bind peptidoglycan experimentally.


Pssm-ID: 460223 [Multi-domain]  Cd Length: 57  Bit Score: 53.29  E-value: 2.23e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622840262  81 QNWLKSYGYllpYDSRASAlHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWM 133
Cdd:pfam01471   9 QRYLNRLGY---YPGPVDG-YFGPSTEAAVKAFQRAFGLPVDGIVDPETLAAL 57
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 374-418 3.65e-09

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 52.63  E-value: 3.65e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1622840262  374 IDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPR 418
Cdd:smart00120   1 IDAAFELRDGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLPC 45
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 336-371 4.18e-08

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 49.55  E-value: 4.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1622840262  336 RGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLP 371
Cdd:smart00120   9 DGKTYFFKGDKYWRFDPKRVDPGYPKLISSFFPGLP 44
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 334-371 1.11e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 45.25  E-value: 1.11e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1622840262 334 LFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWkGLP 371
Cdd:pfam00045   7 DRDGKTYFFKGRKYWRFDPQRVEPGYPKLISDFP-GLP 43
Hemopexin pfam00045
Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 470-514 1.91e-06

Hemopexin; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metallopeptidases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs).


Pssm-ID: 395000 [Multi-domain]  Cd Length: 44  Bit Score: 44.86  E-value: 1.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1622840262 470 QGAFISKEGYyTYFYKGRDYWKFDNQKlsVEPGYPRNILRD-WMGC 514
Cdd:pfam00045   2 DAAFEDRDGK-TYFFKGRKYWRFDPQR--VEPGYPKLISDFpGLPC 44
HX smart00120
Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. ...
 471-513 2.52e-06

Hemopexin-like repeats; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs).


Pssm-ID: 214524 [Multi-domain]  Cd Length: 45  Bit Score: 44.54  E-value: 2.52e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1622840262  471 GAFISKEGYyTYFYKGRDYWKFDNQKlsVEPGYPRNILRDWMG 513
Cdd:smart00120   3 AAFELRDGK-TYFFKGDKYWRFDPKR--VDPGYPKLISSFFPG 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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