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Conserved domains on  [gi|1622838921|ref|XP_028683800|]
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reticulon-4 receptor [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-260 1.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  60 QRIFLHGNRISHVPAaSFRACRNLTILWLHSNVLARIDAAAFAGLALlEQLDLSDNaQLRSVdPATFHGLGRLHTLHLDR 139
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNL-KSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 140 CGLQELgPGLFRGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLLLHQNRVAHVHP 219
Cdd:COG4886   192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1622838921 220 HAfrDLGRLMTLYLFANNLSALPAEALAPLRALQYLRLNDN 260
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-260 1.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  60 QRIFLHGNRISHVPAaSFRACRNLTILWLHSNVLARIDAAAFAGLALlEQLDLSDNaQLRSVdPATFHGLGRLHTLHLDR 139
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNL-KSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 140 CGLQELgPGLFRGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLLLHQNRVAHVHP 219
Cdd:COG4886   192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1622838921 220 HAfrDLGRLMTLYLFANNLSALPAEALAPLRALQYLRLNDN 260
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.11e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.11e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622838921 156 LQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRV 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-260 2.12e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 129 LGRLHTLHLDRCGLQELGpgLFRGLAALQYLYLQDNALQALPDdtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLL 208
Cdd:cd21340     1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 209 LHQNRVAHV------------H---------------PHAFRDLGR-LMTLYLFANNLSALpaEALAPLRALQYLRLNDN 260
Cdd:cd21340    75 LGGNRISVVeglenltnleelHienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN 152
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-260 4.83e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  82 NLTILWLHSNVLARIDAAAFAGLALLEQLDLSDNaQLRSVDPatfHGLGRLHTLHLDRCGLQELG---PGLFRGLAALQY 158
Cdd:PLN00113  165 SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN-QLVGQIP---RELGQMKSLKWIYLGYNNLSgeiPYEIGGLTSLNH 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 159 LYLQDNALQALPDDTFRDLGNLTHLFLHGNRIS-SVPERAFrGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANN 237
Cdd:PLN00113  241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         170       180
                  ....*....|....*....|...
gi 1622838921 238 LSALPAEALAPLRALQYLRLNDN 260
Cdd:PLN00113  320 FTGKIPVALTSLPRLQVLQLWSN 342
LRR smart00370
Leucine-rich repeats, outliers;
177-200 3.22e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.72  E-value: 3.22e-04
                           10        20
                   ....*....|....*....|....
gi 1622838921  177 LGNLTHLFLHGNRISSVPERAFRG 200
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
60-260 1.83e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 1.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  60 QRIFLHGNRISHVPAaSFRACRNLTILWLHSNVLARIDAAAFAGLALlEQLDLSDNaQLRSVdPATFHGLGRLHTLHLDR 139
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNL-KSLDLSNN-QLTDL-PEELGNLTNLKELDLSN 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 140 CGLQELgPGLFRGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLLLHQNRVAHVHP 219
Cdd:COG4886   192 NQITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP 267

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1622838921 220 HAfrDLGRLMTLYLFANNLSALPAEALAPLRALQYLRLNDN 260
Cdd:COG4886   268 LA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL 306
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
81-260 3.77e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.16  E-value: 3.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  81 RNLTILWLHSNVLARIDAAAFAGLALLEQLDLSDN------AQLRSVD---------PATFHGLGRLHTLHLDRCGLQEL 145
Cdd:COG4886    72 LLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeelsnlTNLESLDlsgnqltdlPEELANLTNLKELDLSNNQLTDL 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 146 GPGLFrGLAALQYLYLQDNALQALPDDtFRDLGNLTHLFLHGNRISSVPErAFRGLHSLDRLLLHQNRVAHVhPHAFRDL 225
Cdd:COG4886   152 PEPLG-NLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANL 227

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1622838921 226 GRLMTLYLFANNLSALPaeALAPLRALQYLRLNDN 260
Cdd:COG4886   228 TNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-260 8.77e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 8.77e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  82 NLTILWLHSNVLARIDAAAFAGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLqelgpglFRGLAALQYLYL 161
Cdd:COG4886    48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDL 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 162 QDNALQALPDDtFRDLGNLTHLFLHGNRISSVPErAFRGLHSLDRLLLHQNRVAHVhPHAFRDLGRLMTLYLFANNLSAL 241
Cdd:COG4886   121 SGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                         170
                  ....*....|....*....
gi 1622838921 242 PaEALAPLRALQYLRLNDN 260
Cdd:COG4886   198 P-EPLGNLTNLEELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
156-214 1.11e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 68.32  E-value: 1.11e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622838921 156 LQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRV 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
131-190 2.03e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 67.55  E-value: 2.03e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 131 RLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRI 190
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-260 2.12e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.43  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 129 LGRLHTLHLDRCGLQELGpgLFRGLAALQYLYLQDNALQALPDdtFRDLGNLTHLFLHGNRISSVPEraFRGLHSLDRLL 208
Cdd:cd21340     1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 209 LHQNRVAHV------------H---------------PHAFRDLGR-LMTLYLFANNLSALpaEALAPLRALQYLRLNDN 260
Cdd:cd21340    75 LGGNRISVVeglenltnleelHienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNN 152
LRR_8 pfam13855
Leucine rich repeat;
179-238 2.99e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 2.99e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 179 NLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNL 238
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-264 1.77e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.57  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  62 IFLHGNRISHVPAasFRACRNLTILWLHSNVLARIDaaAFAGLALLEQLDLSDNaQLRSVDPatFHGLGRLHTLHLDR-- 139
Cdd:cd21340     7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNN-QIEKIEN--LENLVNLKKLYLGGnr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 140 ----CGLQelgpglfrGLAALQYLYLQDnalQALPDD---TFRD------LGNLTHLFLHGNRISSVpeRAFRGLHSLDR 206
Cdd:cd21340    80 isvvEGLE--------NLTNLEELHIEN---QRLPPGeklTFDPrslaalSNSLRVLNISGNNIDSL--EPLAPLRNLEQ 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622838921 207 LLLHQNRVahvhphafrdlgrlmtlylfaNNLSALpAEALAPLRALQYLRLNDNPwVC 264
Cdd:cd21340   147 LDASNNQI---------------------SDLEEL-LDLLSSWPSLRELDLTGNP-VC 181
LRR_8 pfam13855
Leucine rich repeat;
203-261 5.47e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 5.47e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622838921 203 SLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPAEALAPLRALQYLRLNDNP 261
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 62-194 6.90e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 6.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  62 IFLHGNRISHVPAASFraCRNLTILWLHSNVLARIDAAAFAGLAllEQLDLSDNA-----------QLR----------- 119
Cdd:cd21340    29 LYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIENLENLVNL--KKLYLGGNRisvveglenltNLEelhienqrlpp 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 120 ----SVDPATFHGLGR-LHTLHLDRCGLQELGPglFRGLAALQYLYLQDNALQALPD--DTFRDLGNLTHLFLHGNRISS 192
Cdd:cd21340   105 geklTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK 182


                  ..
gi 1622838921 193 VP 194
Cdd:cd21340   183 KP 184
LRR_8 pfam13855
Leucine rich repeat;
110-166 1.99e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 1.99e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1622838921 110 LDLSDNaQLRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNAL 166
Cdd:pfam13855   6 LDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 82-260 4.83e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  82 NLTILWLHSNVLARIDAAAFAGLALLEQLDLSDNaQLRSVDPatfHGLGRLHTLHLDRCGLQELG---PGLFRGLAALQY 158
Cdd:PLN00113  165 SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASN-QLVGQIP---RELGQMKSLKWIYLGYNNLSgeiPYEIGGLTSLNH 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 159 LYLQDNALQALPDDTFRDLGNLTHLFLHGNRIS-SVPERAFrGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANN 237
Cdd:PLN00113  241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         170       180
                  ....*....|....*....|...
gi 1622838921 238 LSALPAEALAPLRALQYLRLNDN 260
Cdd:PLN00113  320 FTGKIPVALTSLPRLQVLQLWSN 342
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
4-260 3.66e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.23  E-value: 3.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921   4 ASAGGSR--LLAWVLWLQaWRVAAPCPGA------------CVCYNEPKVTTScpQQGLQAVPAGIPASSQRIFLHGNRI 69
Cdd:PRK15370  135 SSASGSKdaVNYELIWSE-WVKEAPAKEAanreeavqrmrdCLKNNKTELRLK--ILGLTTIPACIPEQITTLILDNNEL 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921  70 SHVPAaSFRAcrNLTILWLHSNVLARIdaaAFAGLALLEQLDLSDN--AQLRSVDPATfhglgrLHTLHLDRCGLQELGP 147
Cdd:PRK15370  212 KSLPE-NLQG--NIKTLYANSNQLTSI---PATLPDTIQEMELSINriTELPERLPSA------LQSLDLFHNKISCLPE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 148 GLFRGLaalQYLYLQDNALQALPDDTfrdLGNLTHLFLHGNRISSVPERAFRGLHSLD------------------RLLL 209
Cdd:PRK15370  280 NLPEEL---RYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPGLKTLEagenaltslpaslppelqVLDV 353

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622838921 210 HQNRVAhVHPHAFRDlgRLMTLYLFANNLSALPAEALAplrALQYLRLNDN 260
Cdd:PRK15370  354 SKNQIT-VLPETLPP--TITTLDVSRNALTNLPENLPA---ALQIMQASRN 398
LRR smart00370
Leucine-rich repeats, outliers;
177-200 3.22e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 37.72  E-value: 3.22e-04
                           10        20
                   ....*....|....*....|....
gi 1622838921  177 LGNLTHLFLHGNRISSVPERAFRG 200
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
177-200 3.22e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 37.72  E-value: 3.22e-04
                           10        20
                   ....*....|....*....|....
gi 1622838921  177 LGNLTHLFLHGNRISSVPERAFRG 200
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 137-260 3.55e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 137 LDRCGLQE--LGPGLFRGLAALQYLY---LQDNALQALPDDTFRDLGNLTHLFLHGNRIS-SVPEraFRGLHSLDRLLLH 210
Cdd:PLN00113  406 LRRVRLQDnsFSGELPSEFTKLPLVYfldISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD--SFGSKRLENLDLS 483

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622838921 211 QNRVAHVHPHAFRDLGRLMTLYLFANNLSALPAEALAPLRALQYLRLNDN 260
Cdd:PLN00113  484 RNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 108-261 7.40e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 7.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 108 EQLDLSDNaQLRSVDPAT---FHGLG---RLHTLHLDRCGLQELGPGLFRGL---AALQYLYLQDNALQALPDDT----F 174
Cdd:cd00116    54 KELCLSLN-ETGRIPRGLqslLQGLTkgcGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLlakgL 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 175 RDLG-NLTHLFLHGNRISSVPER----AFRGLHSLDRLLLHQNRV----AHVHPHAFRDLGRLMTLYLFANNL-----SA 240
Cdd:cd00116   133 KDLPpALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIgdagIRALAEGLKANCNLEVLDLNNNGLtdegaSA 212

                         170       180
                  ....*....|....*....|.
gi 1622838921 241 LpAEALAPLRALQYLRLNDNP 261
Cdd:cd00116   213 L-AETLASLKSLEVLNLGDNN 232
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
155-261 1.30e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 155 ALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRvahvhphAFRDLGRLMTLYLF 234
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLS 121

                          90       100
                  ....*....|....*....|....*..
gi 1622838921 235 ANNLSALPAEaLAPLRALQYLRLNDNP 261
Cdd:COG4886   122 GNQLTDLPEE-LANLTNLKELDLSNNQ 147
Phage_integrase pfam00589
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ...
 152-255 1.43e-03

Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.


Pssm-ID: 395471 [Multi-domain]  Cd Length: 169  Bit Score: 39.61  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 152 GLAALQYL--YLQDNALQALPDDTfrdlgnlthLFL--HGNRISSvpeRAFRglHSLDRLLLHQNRVAHVHPHAFRdlgr 227
Cdd:pfam00589  71 SDAALELLkeWLSKRLLEAPKSDY---------LFAskRGKPLSR---QTVR--KIFKRAGKEAGLELPLHPHMLR---- 132

                          90       100
                  ....*....|....*....|....*...
gi 1622838921 228 lmtlYLFANNLsalpAEALAPLRALQYL 255
Cdd:pfam00589 133 ----HSFATHL----LEAGVDLRVVQKL 152
LRR_8 pfam13855
Leucine rich repeat;
60-115 1.95e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622838921  60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFAGLALLEQLDLSDN 115
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 179-212 6.64e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 6.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622838921 179 NLTHLFLHGNRISSVPerAFRGLHSLDRLLLHQN 212
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRR_9 pfam14580
Leucine-rich repeat;
169-261 7.32e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 37.44  E-value: 7.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622838921 169 LPDDTFRDLGNLTHLflhgNRISSvperafrglhsldrLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSAL-PAEALA 247
Cdd:pfam14580  49 FSDNEIRKLDGFPLL----RRLKT--------------LLLNNNRICRIGEGLGEALPNLTELILTNNNLQELgDLDPLA 110

                          90
                  ....*....|....
gi 1622838921 248 PLRALQYLRLNDNP 261
Cdd:pfam14580 111 SLKKLTFLSLLRNP 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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