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Conserved domains on  [gi|1622837977|ref|XP_028683529|]
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voltage-dependent T-type calcium channel subunit alpha-1I isoform X2 [Macaca mulatta]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
642-869 3.01e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.47  E-value: 3.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  642 SKYFNRGIMMAILVNTVSMGIEHHEQPEE-LTNILEICNVVFTSMFALEMILKLAAFGLFD-YLRNPYN---IFDSIIVI 716
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNildFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  717 ISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSlrtD 796
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622837977  797 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSP-WASLYFVALMTFGNYVLFNLLVAILVEGFQ 869
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1175-1447 2.08e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.08  E-value: 2.08e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1175 HKLFDYVVLAFIFLNCITIALERPQIEAGSTErIFLTVSNYIFTAIFVGEMTLKVVSLGLYFgeqAYLRSSWNVLDGFLV 1254
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1255 FVSIIDIVVSLASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLKPIGNIVLICCA 1321
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1322 FFIIFGILGVQLFKGKFYHCLGVDTRNitnrsdcmaanyrwvhhkYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAvav 1401
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG--- 197
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1622837977 1402 dqqpvtNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1447
Cdd:pfam00520  198 ------KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1492-1747 1.70e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.39  E-value: 1.70e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1492 SHYLDIFITFIICLNVVTMSLEHYNQP-TSLETALKYCNYMFTTVFVLEAVLKLVAFGL-RRFFKDRWNQLDLAIVLLSV 1569
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1570 MGITLEEIEinaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK 1649
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1650 LVCNDENPCEGMSrhaTFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCThdersclsslQFVSPLYFVSFVLTAQFVLIN 1729
Cdd:pfam00520  154 KLKTWENPDNGRT---NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILGGFLLLN 220
                          250
                   ....*....|....*...
gi 1622837977 1730 VVVAVLMKHLDDSNKEAQ 1747
Cdd:pfam00520  221 LFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
116-447 1.62e-39

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 147.80  E-value: 1.62e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  116 NPWFECVSMLVILLNCVTLGMYQPCDDMDCLsdrCKILQVFDDFIFIFFAMEMVLKMVALGIfgKKCYLGDTWNRLDFFI 195
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL---TTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  196 VMAGMVEYSLDLQNI--NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFfvffifgiigvqlwagll 273
Cdd:pfam00520   76 VLPSLISLVLSSVGSlsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  274 rnrCFLeenftiqgdvalppyyqpeeddempFICSLSGDNgimgcheipplkeqgrecclskddvydfgagrqdlnasgl 353
Cdd:pfam00520  138 ---LFL-------------------------FIFAIIGYQ---------------------------------------- 149
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  354 cvnwnrYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 432
Cdd:pfam00520  150 ------LFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223
                          330
                   ....*....|....*
gi 1622837977  433 VVIATQFSETKQREH 447
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
642-869 3.01e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.47  E-value: 3.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  642 SKYFNRGIMMAILVNTVSMGIEHHEQPEE-LTNILEICNVVFTSMFALEMILKLAAFGLFD-YLRNPYN---IFDSIIVI 716
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNildFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  717 ISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSlrtD 796
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622837977  797 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSP-WASLYFVALMTFGNYVLFNLLVAILVEGFQ 869
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1175-1447 2.08e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.08  E-value: 2.08e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1175 HKLFDYVVLAFIFLNCITIALERPQIEAGSTErIFLTVSNYIFTAIFVGEMTLKVVSLGLYFgeqAYLRSSWNVLDGFLV 1254
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1255 FVSIIDIVVSLASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLKPIGNIVLICCA 1321
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1322 FFIIFGILGVQLFKGKFYHCLGVDTRNitnrsdcmaanyrwvhhkYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAvav 1401
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG--- 197
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1622837977 1402 dqqpvtNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1447
Cdd:pfam00520  198 ------KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1492-1747 1.70e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.39  E-value: 1.70e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1492 SHYLDIFITFIICLNVVTMSLEHYNQP-TSLETALKYCNYMFTTVFVLEAVLKLVAFGL-RRFFKDRWNQLDLAIVLLSV 1569
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1570 MGITLEEIEinaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK 1649
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1650 LVCNDENPCEGMSrhaTFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCThdersclsslQFVSPLYFVSFVLTAQFVLIN 1729
Cdd:pfam00520  154 KLKTWENPDNGRT---NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILGGFLLLN 220
                          250
                   ....*....|....*...
gi 1622837977 1730 VVVAVLMKHLDDSNKEAQ 1747
Cdd:pfam00520  221 LFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
116-447 1.62e-39

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 147.80  E-value: 1.62e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  116 NPWFECVSMLVILLNCVTLGMYQPCDDMDCLsdrCKILQVFDDFIFIFFAMEMVLKMVALGIfgKKCYLGDTWNRLDFFI 195
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL---TTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  196 VMAGMVEYSLDLQNI--NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFfvffifgiigvqlwagll 273
Cdd:pfam00520   76 VLPSLISLVLSSVGSlsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  274 rnrCFLeenftiqgdvalppyyqpeeddempFICSLSGDNgimgcheipplkeqgrecclskddvydfgagrqdlnasgl 353
Cdd:pfam00520  138 ---LFL-------------------------FIFAIIGYQ---------------------------------------- 149
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  354 cvnwnrYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 432
Cdd:pfam00520  150 ------LFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223
                          330
                   ....*....|....*
gi 1622837977  433 VVIATQFSETKQREH 447
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
642-869 3.01e-53

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 187.47  E-value: 3.01e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  642 SKYFNRGIMMAILVNTVSMGIEHHEQPEE-LTNILEICNVVFTSMFALEMILKLAAFGLFD-YLRNPYN---IFDSIIVI 716
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNildFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  717 ISIWEIVGQADGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSlrtD 796
Cdd:pfam00520   81 ISLVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622837977  797 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSP-WASLYFVALMTFGNYVLFNLLVAILVEGFQ 869
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1175-1447 2.08e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 182.08  E-value: 2.08e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1175 HKLFDYVVLAFIFLNCITIALERPQIEAGSTErIFLTVSNYIFTAIFVGEMTLKVVSLGLYFgeqAYLRSSWNVLDGFLV 1254
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1255 FVSIIDIVVSLASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLKPIGNIVLICCA 1321
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1322 FFIIFGILGVQLFKGKFYHCLGVDTRNitnrsdcmaanyrwvhhkYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAvav 1401
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG--- 197
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 1622837977 1402 dqqpvtNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1447
Cdd:pfam00520  198 ------KGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1492-1747 1.70e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 179.39  E-value: 1.70e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1492 SHYLDIFITFIICLNVVTMSLEHYNQP-TSLETALKYCNYMFTTVFVLEAVLKLVAFGL-RRFFKDRWNQLDLAIVLLSV 1569
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1570 MGITLEEIEinaalpiNPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK 1649
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1650 LVCNDENPCEGMSrhaTFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCThdersclsslQFVSPLYFVSFVLTAQFVLIN 1729
Cdd:pfam00520  154 KLKTWENPDNGRT---NFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----------EFWAYIYFVSFIILGGFLLLN 220
                          250
                   ....*....|....*...
gi 1622837977 1730 VVVAVLMKHLDDSNKEAQ 1747
Cdd:pfam00520  221 LFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
116-447 1.62e-39

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 147.80  E-value: 1.62e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  116 NPWFECVSMLVILLNCVTLGMYQPCDDMDCLsdrCKILQVFDDFIFIFFAMEMVLKMVALGIfgKKCYLGDTWNRLDFFI 195
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPL---TTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  196 VMAGMVEYSLDLQNI--NLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFfvffifgiigvqlwagll 273
Cdd:pfam00520   76 VLPSLISLVLSSVGSlsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  274 rnrCFLeenftiqgdvalppyyqpeeddempFICSLSGDNgimgcheipplkeqgrecclskddvydfgagrqdlnasgl 353
Cdd:pfam00520  138 ---LFL-------------------------FIFAIIGYQ---------------------------------------- 149
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977  354 cvnwnrYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 432
Cdd:pfam00520  150 ------LFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223
                          330
                   ....*....|....*
gi 1622837977  433 VVIATQFSETKQREH 447
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
1523-1736 4.13e-06

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 49.97  E-value: 4.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1523 TALKYCNYMFTTVFVLEAVLKLVAFGLR------RFFKDRWNQLDLAIVLLSV----------------MGITLEEIE-- 1578
Cdd:pfam08016    4 TNRSLFILLCEIVFVVFFLYFVVEEILKirkhrpSYLRSVWNLLDLAIVILSVvlivlniyrdfladrlIKSVEASPVtf 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1579 --------------INAALPINPTIIRIMRVLRIARVLKLLKmatgmrallDTVVQALPQVGNLGLLFMLLFFIYAALGV 1644
Cdd:pfam08016   84 idfdrvaqldnlyrIILAFLVFLTWLKLFKVLRFNKTMSLFT---------KTLSRAWKDLAGFALMFVIFFFAYAQFGY 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837977 1645 ELFGklvcndenpcegmSRHATFENFGMAFLTLFQVSTGD-NWNGIMkdtlrdcthdersclSSLQFVSPLYFVSFVLTA 1723
Cdd:pfam08016  155 LLFG-------------TQAPNFSNFVKSILTLFRTILGDfGYNEIF---------------SGNRVLGPLLFLTFVFLV 206
                          250
                   ....*....|...
gi 1622837977 1724 QFVLINVVVAVLM 1736
Cdd:pfam08016  207 IFILLNLFLAIIN 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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