|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
169-353 |
2.95e-29 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 121.19 E-value: 2.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 169 EALDGLGSLRRLELEGNALEELrPGTFGALGALATLNLAHNALVYLPAmAFQGLLRVRWLRLSHNALSVLaPEALAGLPA 248
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 249 LRRLSLHHNELQALPGPaLSQARGLARLELGHNPLTYAGEEdgLA-LPGLRELLLDGGALQALgpRAFAHCPRLHTLDLR 327
Cdd:COG4886 184 LKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP--LAnLTNLETLDLSNNQLTDL--PELGNLTNLEELDLS 258
|
170 180
....*....|....*....|....*.
gi 1622837890 328 GNQLDTLPPLQGPGQLRRLRLQGNPL 353
Cdd:COG4886 259 NNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
484-714 |
1.86e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 112.72 E-value: 1.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 484 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLsaaalagVPRLGYLYLERNRFLQVPgAALRALPSLFSL 563
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN-------LTNLESLDLSGNQLTDLP-EELANLTNLKEL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 564 HLQDNAVDRLaPGDLGGTRALRWLYLSGNRITEVPPgALGPARELEKLHLDRNQLREVPTgALEGLPALLELQLSGNPLR 643
Cdd:COG4886 142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622837890 644 ALHDgafqPVSR--SLQHLFLNSSGLEQISpgAFSGLgPGLQSLHLQKNQLQALPALPSLSQLELIDLSSNPF 714
Cdd:COG4886 219 DLPE----PLANltNLETLDLSNNQLTDLP--ELGNL-TNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
535-714 |
1.93e-17 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 81.76 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 535 RLGYLYLERNRFLQVPGaaLRALPSLFSLHLQDNAVDRLApgDLGGTRALRWLYLSGNRITEVPPgaLGPARELEKLHLD 614
Cdd:cd21340 3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 615 RNQLREVpTGaLEGLPALLELQLS------GNPLralhdgAFQP-----VSRSLQHLFLNSSGLEQISPgaFSGLGpGLQ 683
Cdd:cd21340 77 GNRISVV-EG-LENLTNLEELHIEnqrlppGEKL------TFDPrslaaLSNSLRVLNISGNNIDSLEP--LAPLR-NLE 145
|
170 180 190
....*....|....*....|....*....|....*
gi 1622837890 684 SLHLQKNQLQAL----PALPSLSQLELIDLSSNPF 714
Cdd:cd21340 146 QLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
201-259 |
5.97e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.39 E-value: 5.97e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1622837890 201 LATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNEL 259
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
582-642 |
2.22e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.76 E-value: 2.22e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 582 RALRWLYLSGNRITEVPPGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPL 642
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
86-263 |
2.92e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 60.96 E-value: 2.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 86 HVACRHQNLTEVPDAI--PELTQrLNLQGNLLKVIPAaaFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHL 163
Cdd:cd21340 6 HLYLNDKNITKIDNLSlcKNLKV-LYLYDNKITKIEN--LEFLTNLTHLYLQN------------------------NQI 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 164 RELpqEALDGLGSLRRLELEGN------------ALEELR---------------PGTFGALGA-LATLNLAHNALVYLp 215
Cdd:cd21340 59 EKI--ENLENLVNLKKLYLGGNrisvveglenltNLEELHienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSL- 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1622837890 216 aMAFQGLLRVRWLRLSHNALSVLAP--EALAGLPALRRLSLHHNELQALP 263
Cdd:cd21340 136 -EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
106-187 |
8.74e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.22 E-value: 8.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 106 QRLNLQGNLLKVIPAAAFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHLRELPQEALDGLGSLRRLELEGN 185
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN------------------------NLLTTLSPGAFSGLPSLRYLDLSGN 59
|
..
gi 1622837890 186 AL 187
Cdd:pfam13855 60 RL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
65-336 |
2.44e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 60.87 E-value: 2.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 65 PARQAAAQRCpQACIcDNSRWHVACRHQNLTEVPDAIPELTQRLNLQGNLLKvipaaafqGLPHLTHLDLRHCQVElvae 144
Cdd:PRK15370 163 ANREEAVQRM-RDCL-KNNKTELRLKILGLTTIPACIPEQITTLILDNNELK--------SLPENLQGNIKTLYAN---- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 145 gafrglgrllllnlaSNHLRELPQEALDglgSLRRLELEGNALEELRPgtfgalgalatlnlahnalvYLPAmAFQGLLr 224
Cdd:PRK15370 229 ---------------SNQLTSIPATLPD---TIQEMELSINRITELPE--------------------RLPS-ALQSLD- 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 225 vrwlrLSHNALSVLaPEALAglPALRRLSLHHNELQALPGPALSqarGLARLELGHNPLTYAGEedglALP-GLRELLLD 303
Cdd:PRK15370 269 -----LFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHLPS---GITHLNVQSNSLTALPE----TLPpGLKTLEAG 333
|
250 260 270
....*....|....*....|....*....|....*..
gi 1622837890 304 GGALQALgPRAFAhcPRLHTLDLRGNQL----DTLPP 336
Cdd:PRK15370 334 ENALTSL-PASLP--PELQVLDVSKNQItvlpETLPP 367
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
467-712 |
3.24e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.00 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 467 LDLRRNHFP-LVPRAAFPGLGHLVSLHLQHCGIAELEAGALAglgRLIYLYLSDNQLAGLSAAALAGVPRLGYLYLERNR 545
Cdd:PLN00113 123 LNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQ 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 546 FL-QVPgAALRALPSLFSLHLQDNAVDRLAPGDLGGTRALRWLYLSGNRITEVPPGALGPARELEKLHLDRNQLREVPTG 624
Cdd:PLN00113 200 LVgQIP-RELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 625 ALEGLPALLELQLSGNPLRA-LHDGAFQPVSRSLQHLFLNSsgLEQISPGAFSGLgPGLQSLHLQKNQLQA-LPA-LPSL 701
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNN--FTGKIPVALTSL-PRLQVLQLWSNKFSGeIPKnLGKH 355
|
250
....*....|.
gi 1622837890 702 SQLELIDLSSN 712
Cdd:PLN00113 356 NNLTVLDLSTN 366
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
712-760 |
4.42e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 4.42e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1622837890 712 NPFHCDCQLLPLHRWLTG---LNLRVGATCATPPSACGQRVKAAAAVFeACP 760
Cdd:smart00082 1 NPFICDCELRWLLRWLQAnehLQDPVDLRCASPSSLRGPLLELLHSEF-KCP 51
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
701-747 |
4.59e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 50.47 E-value: 4.59e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 701 LSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRV----GATCATPPSACGQ 747
Cdd:TIGR00864 18 LCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpeAALCAGPGALAGQ 68
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
74-106 |
3.42e-03 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 35.76 E-value: 3.42e-03
10 20 30
....*....|....*....|....*....|...
gi 1622837890 74 CPQACICDNSrwHVACRHQNLTEVPDAIPELTQ 106
Cdd:smart00013 2 CPAPCNCSGT--AVDCSGRGLTEVPLDLPPDTT 32
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
169-353 |
2.95e-29 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 121.19 E-value: 2.95e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 169 EALDGLGSLRRLELEGNALEELrPGTFGALGALATLNLAHNALVYLPAmAFQGLLRVRWLRLSHNALSVLaPEALAGLPA 248
Cdd:COG4886 107 EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 249 LRRLSLHHNELQALPGPaLSQARGLARLELGHNPLTYAGEEdgLA-LPGLRELLLDGGALQALgpRAFAHCPRLHTLDLR 327
Cdd:COG4886 184 LKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEP--LAnLTNLETLDLSNNQLTDL--PELGNLTNLEELDLS 258
|
170 180
....*....|....*....|....*.
gi 1622837890 328 GNQLDTLPPLQGPGQLRRLRLQGNPL 353
Cdd:COG4886 259 NNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
166-353 |
6.32e-27 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 114.26 E-value: 6.32e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 166 LPQEALDGLGSLRRLELEGNAleelrpgTFGALGALATLNLAHNALVYLPAmAFQGLLRVRWLRLSHNALSVLaPEALAG 245
Cdd:COG4886 87 LGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGN 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 246 LPALRRLSLHHNELQALPGPaLSQARGLARLELGHNPLTYAGEEdgLA-LPGLRELLLDGGALQALgPRAFAHCPRLHTL 324
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEP--LGnLTNLEELDLSGNQLTDL-PEPLANLTNLETL 233
|
170 180
....*....|....*....|....*....
gi 1622837890 325 DLRGNQLDTLPPLQGPGQLRRLRLQGNPL 353
Cdd:COG4886 234 DLSNNQLTDLPELGNLTNLEELDLSNNQL 262
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
484-714 |
1.86e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 112.72 E-value: 1.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 484 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLsaaalagVPRLGYLYLERNRFLQVPgAALRALPSLFSL 563
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSN-------LTNLESLDLSGNQLTDLP-EELANLTNLKEL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 564 HLQDNAVDRLaPGDLGGTRALRWLYLSGNRITEVPPgALGPARELEKLHLDRNQLREVPTgALEGLPALLELQLSGNPLR 643
Cdd:COG4886 142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT 218
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622837890 644 ALHDgafqPVSR--SLQHLFLNSSGLEQISpgAFSGLgPGLQSLHLQKNQLQALPALPSLSQLELIDLSSNPF 714
Cdd:COG4886 219 DLPE----PLANltNLETLDLSNNQLTDLP--ELGNL-TNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
90-312 |
3.83e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 111.95 E-value: 3.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 90 RHQNLTEVPDAIPELT--QRLNLQGNLLKVIPAAaFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHLRELP 167
Cdd:COG4886 121 SGNQLTDLPEELANLTnlKELDLSNNQLTDLPEP-LGNLTNLKSLDLSN------------------------NQLTDLP 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 168 qEALDGLGSLRRLELEGNALEELrPGTFGALGALATLNLAHNALVYLPAmAFQGLLRVRWLRLSHNALSVLapEALAGLP 247
Cdd:COG4886 176 -EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLT 250
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622837890 248 ALRRLSLHHNELQALPgpALSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGP 312
Cdd:COG4886 251 NLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL 313
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
98-334 |
5.29e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 111.56 E-value: 5.29e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 98 PDAIPELT--QRLNLQGNLLKVIPAAaFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHLRELPqEALDGLG 175
Cdd:COG4886 106 NEELSNLTnlESLDLSGNQLTDLPEE-LANLTNLKELDLSN------------------------NQLTDLP-EPLGNLT 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 176 SLRRLELEGNALEELrPGTFGALGALATLNLAHNALVYLPAmAFQGLLRVRWLRLSHNALSVLaPEALAGLPALRRLSLH 255
Cdd:COG4886 160 NLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLS 236
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622837890 256 HNELQALPgpALSQARGLARLELGHNPLTyageedglALPGLRELlldggalqalgprafahcPRLHTLDLRGNQLDTL 334
Cdd:COG4886 237 NNQLTDLP--ELGNLTNLEELDLSNNQLT--------DLPPLANL------------------TNLKTLDLSNNQLTDL 287
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
498-714 |
2.02e-25 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 109.64 E-value: 2.02e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 498 IAELEAGALAGLGRLIYLYLSDNQLAGLSAAALAGVPRLGYLYLERNRFLQvpgaalrALPSLFSLHLQDNAVDRLaPGD 577
Cdd:COG4886 60 LLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDL-PEE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 578 LGGTRALRWLYLSGNRITEVPPgALGPARELEKLHLDRNQLREVPTgALEGLPALLELQLSGNPLRALHDgafqPVSR-- 655
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE----PLGNlt 205
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1622837890 656 SLQHLFLNSSGLEQIsPGAFSGLgPGLQSLHLQKNQLQALPALPSLSQLELIDLSSNPF 714
Cdd:COG4886 206 NLEELDLSGNQLTDL-PEPLANL-TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
467-712 |
2.48e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 100.39 E-value: 2.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 467 LDLRRNHFPLVPrAAFPGLGHLVSLHLQHCGIAELEAgALAGLGRLIYLYLSDNQLAGLSAAALAGvPRLGYLYLERNRF 546
Cdd:COG4886 118 LDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 547 LQVPgAALRALPSLFSLHLQDNAVDRLaPGDLGGTRALRWLYLSGNRITEVPpgALGPARELEKLHLDRNQLREVPTgaL 626
Cdd:COG4886 195 TDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--L 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 627 EGLPALLELQLSGNPLRALHDGAFQPVSRSLQHLFLNSSGLEQISPGAFSGLGPGLQSLHLQKNQLQALPALPSLSQLEL 706
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLA 348
|
....*.
gi 1622837890 707 IDLSSN 712
Cdd:COG4886 349 LLTLLL 354
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
89-303 |
3.91e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 100.01 E-value: 3.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 89 CRHQNLTEVPDAIPELT--QRLNLQGNLLKVIPAAaFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHLREL 166
Cdd:COG4886 143 LSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLPEE-LGNLTNLKELDLSN------------------------NQITDL 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 167 PqEALDGLGSLRRLELEGNALEELrPGTFGALGALATLNLAHNALVYLPAMAfqGLLRVRWLRLSHNALSVLAPeaLAGL 246
Cdd:COG4886 198 P-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPP--LANL 271
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1622837890 247 PALRRLSLHHNELQALPGPALSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 303
Cdd:COG4886 272 TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLL 328
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
535-714 |
1.93e-17 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 81.76 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 535 RLGYLYLERNRFLQVPGaaLRALPSLFSLHLQDNAVDRLApgDLGGTRALRWLYLSGNRITEVPPgaLGPARELEKLHLD 614
Cdd:cd21340 3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 615 RNQLREVpTGaLEGLPALLELQLS------GNPLralhdgAFQP-----VSRSLQHLFLNSSGLEQISPgaFSGLGpGLQ 683
Cdd:cd21340 77 GNRISVV-EG-LENLTNLEELHIEnqrlppGEKL------TFDPrslaaLSNSLRVLNISGNNIDSLEP--LAPLR-NLE 145
|
170 180 190
....*....|....*....|....*....|....*
gi 1622837890 684 SLHLQKNQLQAL----PALPSLSQLELIDLSSNPF 714
Cdd:cd21340 146 QLDASNNQISDLeellDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
170-521 |
9.68e-13 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 71.12 E-value: 9.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 170 ALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAlvylpamAFQGLLRVRWLRLSHNALSVLaPEALAGLPAL 249
Cdd:COG4886 67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 250 RRLSLHHNELQALPgPALSQARGLARLELGHNPLTyageedglalpglrELlldggalqalgPRAFAHCPRLHTLDLRGN 329
Cdd:COG4886 139 KELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLT--------------DL-----------PEELGNLTNLKELDLSNN 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 330 QLDTLP-PLQGPGQLRRLRLQGNPLwcgcqaRPLLEWLARarvrsdgacrgprrlrgeaLDALRpwdlrcpgdaaqeeee 408
Cdd:COG4886 193 QITDLPePLGNLTNLEELDLSGNQL------TDLPEPLAN-------------------LTNLE---------------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 409 qeeragsgprapprgpgeeravapcpracvcapesrhsscegcglqavprgfpndtlLLDLRRNHFPLVPraAFPGLGHL 488
Cdd:COG4886 232 ---------------------------------------------------------TLDLSNNQLTDLP--ELGNLTNL 252
|
330 340 350
....*....|....*....|....*....|...
gi 1622837890 489 VSLHLQHCGIAELeaGALAGLGRLIYLYLSDNQ 521
Cdd:COG4886 253 EELDLSNNQLTDL--PPLANLTNLKTLDLSNNQ 283
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
201-259 |
5.97e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.39 E-value: 5.97e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1622837890 201 LATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNEL 259
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
176-235 |
4.56e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.69 E-value: 4.56e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 176 SLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNAL 235
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
482-642 |
1.84e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 61.34 E-value: 1.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 482 FPGLGHLVSLHLQHCGIAELEagalaGLGRLiylylsdnqlaglsaaalagvPRLGYLYLERNRFLQVPGaaLRALPSLF 561
Cdd:cd21340 42 LEFLTNLTHLYLQNNQIEKIE-----NLENL---------------------VNLKKLYLGGNRISVVEG--LENLTNLE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 562 SLHLQDNavdRLAPGD-----------LGGTraLRWLYLSGNRITEVPPgaLGPARELEKLHLDRNQLREVP--TGALEG 628
Cdd:cd21340 94 ELHIENQ---RLPPGEkltfdprslaaLSNS--LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSS 166
|
170
....*....|....
gi 1622837890 629 LPALLELQLSGNPL 642
Cdd:cd21340 167 WPSLRELDLTGNPV 180
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
582-642 |
2.22e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.76 E-value: 2.22e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 582 RALRWLYLSGNRITEVPPGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPL 642
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
86-263 |
2.92e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 60.96 E-value: 2.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 86 HVACRHQNLTEVPDAI--PELTQrLNLQGNLLKVIPAaaFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHL 163
Cdd:cd21340 6 HLYLNDKNITKIDNLSlcKNLKV-LYLYDNKITKIEN--LEFLTNLTHLYLQN------------------------NQI 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 164 RELpqEALDGLGSLRRLELEGN------------ALEELR---------------PGTFGALGA-LATLNLAHNALVYLp 215
Cdd:cd21340 59 EKI--ENLENLVNLKKLYLGGNrisvveglenltNLEELHienqrlppgekltfdPRSLAALSNsLRVLNISGNNIDSL- 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1622837890 216 aMAFQGLLRVRWLRLSHNALSVLAP--EALAGLPALRRLSLHHNELQALP 263
Cdd:cd21340 136 -EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
93-304 |
5.22e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 62.26 E-value: 5.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 93 NLTEVPDAIPELT--QRLNLQGNLLKVIPAAaFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHLRELPQea 170
Cdd:COG4886 193 QITDLPEPLGNLTnlEELDLSGNQLTDLPEP-LANLTNLETLDLSN------------------------NQLTDLPE-- 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 171 LDGLGSLRRLELEGNALEELRPgtFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALR 250
Cdd:COG4886 246 LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1622837890 251 RLSLHHNELQALPGPALSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDG 304
Cdd:COG4886 324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEA 377
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
106-187 |
8.74e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.22 E-value: 8.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 106 QRLNLQGNLLKVIPAAAFQGLPHLTHLDLRHcqvelvaegafrglgrllllnlasNHLRELPQEALDGLGSLRRLELEGN 185
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSN------------------------NLLTTLSPGAFSGLPSLRYLDLSGN 59
|
..
gi 1622837890 186 AL 187
Cdd:pfam13855 60 RL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
534-594 |
2.07e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.07e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 534 PRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGGTRALRWLYLSGNRI 594
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
606-667 |
2.19e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 2.19e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622837890 606 RELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALHDGAFQPVsRSLQHLFLNSSGL 667
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
295-353 |
2.44e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.68 E-value: 2.44e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 295 PGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPL 353
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
65-336 |
2.44e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 60.87 E-value: 2.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 65 PARQAAAQRCpQACIcDNSRWHVACRHQNLTEVPDAIPELTQRLNLQGNLLKvipaaafqGLPHLTHLDLRHCQVElvae 144
Cdd:PRK15370 163 ANREEAVQRM-RDCL-KNNKTELRLKILGLTTIPACIPEQITTLILDNNELK--------SLPENLQGNIKTLYAN---- 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 145 gafrglgrllllnlaSNHLRELPQEALDglgSLRRLELEGNALEELRPgtfgalgalatlnlahnalvYLPAmAFQGLLr 224
Cdd:PRK15370 229 ---------------SNQLTSIPATLPD---TIQEMELSINRITELPE--------------------RLPS-ALQSLD- 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 225 vrwlrLSHNALSVLaPEALAglPALRRLSLHHNELQALPGPALSqarGLARLELGHNPLTYAGEedglALP-GLRELLLD 303
Cdd:PRK15370 269 -----LFHNKISCL-PENLP--EELRYLSVYDNSIRTLPAHLPS---GITHLNVQSNSLTALPE----TLPpGLKTLEAG 333
|
250 260 270
....*....|....*....|....*....|....*..
gi 1622837890 304 GGALQALgPRAFAhcPRLHTLDLRGNQL----DTLPP 336
Cdd:PRK15370 334 ENALTSL-PASLP--PELQVLDVSKNQItvlpETLPP 367
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
224-283 |
3.68e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 53.30 E-value: 3.68e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 224 RVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPALSQARGLARLELGHNPL 283
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
630-692 |
7.82e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.53 E-value: 7.82e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622837890 630 PALLELQLSGNPLRALHDGAFQPVSrSLQHLFLNSSGLEQISPGAFSGLgPGLQSLHLQKNQL 692
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
655-714 |
7.01e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.83 E-value: 7.01e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622837890 655 RSLQHLFLNSSGLEQISPGAFSGLgPGLQSLHLQKNQLQALP--ALPSLSQLELIDLSSNPF 714
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTLSpgAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
160-211 |
7.81e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.45 E-value: 7.81e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1622837890 160 SNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAL 211
Cdd:pfam13855 10 NNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
558-618 |
1.05e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.05e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 558 PSLFSLHLQDNAVDRLAPGDLGGTRALRWLYLSGNRITEVPPGALGPARELEKLHLDRNQL 618
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
159-331 |
3.54e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 54.08 E-value: 3.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 159 ASNHLR-ELPqEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSV 237
Cdd:PLN00113 364 STNNLTgEIP-EGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 238 LAPEALAGLPALRRLSLHHNELQAlPGPALSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAH 317
Cdd:PLN00113 443 RINSRKWDMPSLQMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSS 521
|
170
....*....|....
gi 1622837890 318 CPRLHTLDLRGNQL 331
Cdd:PLN00113 522 CKKLVSLDLSHNQL 535
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
90-353 |
7.04e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 52.78 E-value: 7.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 90 RHQNLTEVPDAIPELTQRLNLQGNLLKVIPaaafQGLPH-LTHLDLRHcqvelvaegafrglgrllllnlasNHLRELPQ 168
Cdd:PRK15370 228 NSNQLTSIPATLPDTIQEMELSINRITELP----ERLPSaLQSLDLFH------------------------NKISCLPE 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 169 EALDGLGSLRRLELEGNALEELRPgtfgalGALATLNLAHNALVYLPAMAFQGLlrvRWLRLSHNALSVLaPEALAglPA 248
Cdd:PRK15370 280 NLPEELRYLSVYDNSIRTLPAHLP------SGITHLNVQSNSLTALPETLPPGL---KTLEAGENALTSL-PASLP--PE 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 249 LRRLSLHHNELQALPG---PALSQarglarLELGHNPLTYAGEEdglaLPglrellldgGALQalgprafahcprlhTLD 325
Cdd:PRK15370 348 LQVLDVSKNQITVLPEtlpPTITT------LDVSRNALTNLPEN----LP---------AALQ--------------IMQ 394
|
250 260 270
....*....|....*....|....*....|...
gi 1622837890 326 LRGNQL----DTLPPLQGPG-QLRRLRLQGNPL 353
Cdd:PRK15370 395 ASRNNLvrlpESLPHFRGEGpQPTRIIVEYNPF 427
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
233-353 |
7.65e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 50.94 E-value: 7.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 233 NALSVLapEALAGLPALRRLSLHHNELQALPGpaLSQARGLARLELGHNPLTyagEEDGLA-LPGLRELLLDGgalQALG 311
Cdd:cd21340 34 NKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS---VVEGLEnLTNLEELHIEN---QRLP 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 312 PR---------AFAHCPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPL 353
Cdd:cd21340 104 PGekltfdprsLAALSNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQI 154
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
165-642 |
2.07e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.39 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 165 ELPQEaLDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALA 244
Cdd:PLN00113 155 EIPND-IGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIG 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 245 GLPALRRLSLHHNELQALPGPALSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTL 324
Cdd:PLN00113 234 GLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEIL 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 325 DLRGNQLDTlpplQGPGQLRRL-RLQGNPLWcgcqarpllewlararvrsdgacrgPRRLRGEAldalrPWDLrcpgdaa 403
Cdd:PLN00113 314 HLFSNNFTG----KIPVALTSLpRLQVLQLW-------------------------SNKFSGEI-----PKNL------- 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 404 qeeeeqeeragsgprapprgpgeeravapcpracvcapesrhsscegcglqavprGFPNDTLLLDLRRNHFPLVPRAAFP 483
Cdd:PLN00113 353 -------------------------------------------------------GKHNNLTVLDLSTNNLTGEIPEGLC 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 484 GLGHLVSL-------------HLQHCGIAE---LEAGALAG--------LGRLIYLYLSDNQLAGLSAAALAGVPRLGYL 539
Cdd:PLN00113 378 SSGNLFKLilfsnslegeipkSLGACRSLRrvrLQDNSFSGelpseftkLPLVYFLDISNNNLQGRINSRKWDMPSLQML 457
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 540 YLERNRFLQvpgaalrALPSLF------SLHLQDNAVDRLAPGDLGGTRALRWLYLSGNRITEVPPGALGPARELEKLHL 613
Cdd:PLN00113 458 SLARNKFFG-------GLPDSFgskrleNLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDL 530
|
490 500 510
....*....|....*....|....*....|
gi 1622837890 614 DRNQLR-EVPTGALEgLPALLELQLSGNPL 642
Cdd:PLN00113 531 SHNQLSgQIPASFSE-MPVLSQLDLSQNQL 559
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
467-712 |
3.24e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.00 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 467 LDLRRNHFP-LVPRAAFPGLGHLVSLHLQHCGIAELEAGALAglgRLIYLYLSDNQLAGLSAAALAGVPRLGYLYLERNR 545
Cdd:PLN00113 123 LNLSNNNFTgSIPRGSIPNLETLDLSNNMLSGEIPNDIGSFS---SLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQ 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 546 FL-QVPgAALRALPSLFSLHLQDNAVDRLAPGDLGGTRALRWLYLSGNRITEVPPGALGPARELEKLHLDRNQLREVPTG 624
Cdd:PLN00113 200 LVgQIP-RELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 625 ALEGLPALLELQLSGNPLRA-LHDGAFQPVSRSLQHLFLNSsgLEQISPGAFSGLgPGLQSLHLQKNQLQA-LPA-LPSL 701
Cdd:PLN00113 279 SIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNN--FTGKIPVALTSL-PRLQVLQLWSNKFSGeIPKnLGKH 355
|
250
....*....|.
gi 1622837890 702 SQLELIDLSSN 712
Cdd:PLN00113 356 NNLTVLDLSTN 366
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
712-760 |
4.42e-06 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 44.34 E-value: 4.42e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1622837890 712 NPFHCDCQLLPLHRWLTG---LNLRVGATCATPPSACGQRVKAAAAVFeACP 760
Cdd:smart00082 1 NPFICDCELRWLLRWLQAnehLQDPVDLRCASPSSLRGPLLELLHSEF-KCP 51
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
701-747 |
4.59e-06 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 50.47 E-value: 4.59e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 701 LSQLELIDLSSNPFHCDCQLLPLHRWLTGLNLRV----GATCATPPSACGQ 747
Cdd:TIGR00864 18 LCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpeAALCAGPGALAGQ 68
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
165-283 |
8.94e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.46 E-value: 8.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 165 ELPQeaLDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALA 244
Cdd:PLN00113 467 GLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFS 544
|
90 100 110
....*....|....*....|....*....|....*....
gi 1622837890 245 GLPALRRLSLHHNELQALPGPALSQARGLARLELGHNPL 283
Cdd:PLN00113 545 EMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
508-714 |
1.10e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.08 E-value: 1.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 508 GLGRLIYLYLSDNQLAGLSAAALAGVPRLGYLYLERNRFL-QVPGaALRALPSLFSLHLQDNAVDRLAPGDLGGTRALRW 586
Cdd:PLN00113 282 SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPV-ALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTV 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 587 LYLSGNRITEVPPGALGPARELEKLHLDRNQLR-EVPTgALEGLPALLELQLSGNPLRAlhdgafqPVSRSLQHL----F 661
Cdd:PLN00113 361 LDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPK-SLGACRSLRRVRLQDNSFSG-------ELPSEFTKLplvyF 432
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622837890 662 LNssgleqISPGAFSGL-------GPGLQSLHLQKNQ-LQALPALPSLSQLELIDLSSNPF 714
Cdd:PLN00113 433 LD------ISNNNLQGRinsrkwdMPSLQMLSLARNKfFGGLPDSFGSKRLENLDLSRNQF 487
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
160-331 |
1.12e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 49.08 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 160 SNHLR-ELPQeALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAL----------------VYLPAMAFQGL 222
Cdd:PLN00113 389 SNSLEgEIPK-SLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLqgrinsrkwdmpslqmLSLARNKFFGG 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 223 L-------RVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPALSQARGLARLELGHNPLTyaGEEdglalp 295
Cdd:PLN00113 468 LpdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS--GQI------ 539
|
170 180 190
....*....|....*....|....*....|....*.
gi 1622837890 296 glrellldggalqalgPRAFAHCPRLHTLDLRGNQL 331
Cdd:PLN00113 540 ----------------PASFSEMPVLSQLDLSQNQL 559
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
467-521 |
2.89e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 2.89e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 1622837890 467 LDLRRNHFPLVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQ 521
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
587-700 |
5.09e-05 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 47.08 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 587 LYLSGNRITEVPpgALGParELEKLHLDRNQLREVPTGAleglPALLELQLSGNPLRALhdgafQPVSRSLQHLFLNSSG 666
Cdd:PRK15387 227 LVIPDNNLTSLP--ALPP--ELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHL-----PALPSGLCKLWIFGNQ 293
|
90 100 110
....*....|....*....|....*....|....
gi 1622837890 667 LEQISPgafsgLGPGLQSLHLQKNQLQALPALPS 700
Cdd:PRK15387 294 LTSLPV-----LPPGLQELSVSDNQLASLPALPS 322
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
452-640 |
7.46e-05 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 45.42 E-value: 7.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 452 GLQAVPRGFPNDTLL--LDLRRNHFPLVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLiylyLSDNQlaglsaaa 529
Cdd:cd00116 69 GLQSLLQGLTKGCGLqeLDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKG----LKDLP-------- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 530 lagvPRLGYLYLERNRfLQVPGA-----ALRALPSLFSLHLQDNAVD-----RLAPGdLGGTRALRWLYLSGNRITEVPP 599
Cdd:cd00116 137 ----PALEKLVLGRNR-LEGASCealakALRANRDLKELNLANNGIGdagirALAEG-LKANCNLEVLDLNNNGLTDEGA 210
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1622837890 600 GALGPA----RELEKLHLDRNQLREVPTGAL-----EGLPALLELQLSGN 640
Cdd:cd00116 211 SALAETlaslKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCN 260
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
169-360 |
8.52e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 45.94 E-value: 8.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 169 EALDGLGSLRRLELEGNALEElrpgtfGALGALATlNLAHNAlvylpamafqgllRVRWLRLSHNALSV-----LApEAL 243
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGD------EGVIALAE-ALKNNT-------------TVETLYLSGNQIGAegaiaLA-KAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 244 AGLPALRRLSLHHNEL-----QALpGPALSQARGLARLELGHNPLTYAGEEdGLA-----LPGLRELLLDGGALQALGPR 313
Cdd:COG5238 289 QGNTTLTSLDLSVNRIgdegaIAL-AEGLQGNKTLHTLNLAYNGIGAQGAI-ALAkalqeNTTLHSLDLSDNQIGDEGAI 366
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1622837890 314 AFAH----CPRLHTLDLRGNQL------DTLPPLQGpGQLRRLRLQGNPLWCGCQAR 360
Cdd:COG5238 367 ALAKylegNTTLRELNLGKNNIgkqgaeALIDALQT-NRLHTLILDGNLIGAEAQQR 422
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
487-546 |
1.78e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.20 E-value: 1.78e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 487 HLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALAGVPRLGYLYLERNRF 546
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
680-713 |
2.39e-04 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 39.15 E-value: 2.39e-04
10 20 30
....*....|....*....|....*....|....
gi 1622837890 680 PGLQSLHLQKNQLQALPALPSLSQLELIDLSSNP 713
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
102-331 |
6.40e-04 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 42.73 E-value: 6.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 102 PELTQRLNLQGNLLKVIPAA------AFQGLPHLTHLDLRHCQVELVAEGAFRGLGRllllnlaSNHLRELP--QEALDG 173
Cdd:cd00116 50 QPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLR-------SSSLQELKlnNNGLGD 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 174 LG-------------SLRRLELEGNALE----ELRPGTFGALGALATLNLAHNALvylpamafqgllrvrwlrlSHNALS 236
Cdd:cd00116 123 RGlrllakglkdlppALEKLVLGRNRLEgascEALAKALRANRDLKELNLANNGI-------------------GDAGIR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 237 VLApEALAGLPALRRLSLHHNEL-----QALPGpALSQARGLARLELGHNPLTYAG-----EEDGLALPGLRELLLDGGA 306
Cdd:cd00116 184 ALA-EGLKANCNLEVLDLNNNGLtdegaSALAE-TLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 1622837890 307 LQALGPRAFAHC----PRLHTLDLRGNQL 331
Cdd:cd00116 262 ITDDGAKDLAEVlaekESLLELDLRGNKF 290
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
171-299 |
1.20e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 42.50 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 171 LDGLGslrrleLEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALR 250
Cdd:PLN03150 420 IDGLG------LDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLR 493
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1622837890 251 RLSLHHNELQALPgPALSQARGL--ARLELGHNPltyageedGL-ALPGLRE 299
Cdd:PLN03150 494 ILNLNGNSLSGRV-PAALGGRLLhrASFNFTDNA--------GLcGIPGLRA 536
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
174-709 |
1.41e-03 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 42.55 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 174 LGSLRRLELEGNALeelrpgtFGALGALAT--LNLAHNAL--------VYLPAMAFQ---GLLRVRWLRLSHNALSVLAP 240
Cdd:COG3321 820 LPSLRRGEDELAQL-------LTALAQLWVagVPVDWSALypgrgrrrVPLPTYPFQredAAAALLAAALAAALAAAAAL 892
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 241 EALAGLPALRRLSLHHNELQALPGPALSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPR 320
Cdd:COG3321 893 GALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAA 972
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 321 LHTLDLRGNQ----------LDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGACRGPRRLRGEALDA 390
Cdd:COG3321 973 AAAAAAAAAAaaaaaaaaaaAAALAAAAALALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALA 1052
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 391 LRPWDLRCPGDAAQEEEEQEERAGSGPRAPPRGPGEERAVAPCPRACVCAPESRHSSCEGCGLQAVPRGFPNDTLLLDLR 470
Cdd:COG3321 1053 AAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLA 1132
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 471 RNHFPLVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALAGVPRLGYLYLERNRFLQVP 550
Cdd:COG3321 1133 AAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALA 1212
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 551 GAALRALPSLFS-LHLQDNAVDRLAPGDLGGTRALRWLYLSGNRITEVPPGALGPARELEKLHLDRNQLREVPTGALEGL 629
Cdd:COG3321 1213 LAALAAAAAALLaAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAA 1292
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 630 PALLELQ--LSGNPLRALHDGAFQPVSRSLQHLFLNSSGLEQISPGAFSGLGPGLQSLHLQKNQLQALPALPSLSQLELI 707
Cdd:COG3321 1293 AAAAALAalLAAAAAAAAAAAAAAAAAALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAAA 1372
|
..
gi 1622837890 708 DL 709
Cdd:COG3321 1373 AA 1374
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
120-347 |
3.11e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 40.93 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 120 AAAFQGLPHLTHLDLRHCQVElvAEGAfrglgrllllnlasnhlrELPQEALDGLGSLRRLELEGNaleelrpgtfgalg 199
Cdd:COG5238 229 AEALKGNKSLTTLDLSNNQIG--DEGV------------------IALAEALKNNTTVETLYLSGN-------------- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 200 alatlNLAHNALVYLpAMAFQGLLRVRWLRLSHNALS-----VLApEALAGLPALRRLSLHHNELQALPGPALSQA---- 270
Cdd:COG5238 275 -----QIGAEGAIAL-AKALQGNTTLTSLDLSVNRIGdegaiALA-EGLQGNKTLHTLNLAYNGIGAQGAIALAKAlqen 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 271 RGLARLELGHNPLTYAGEEdGLA-----LPGLRELLLDGGALQALGPRAFA---HCPRLHTLDLRGNQLDTLPPLQGPGQ 342
Cdd:COG5238 348 TTLHSLDLSDNQIGDEGAI-ALAkylegNTTLRELNLGKNNIGKQGAEALIdalQTNRLHTLILDGNLIGAEAQQRLEQL 426
|
....*
gi 1622837890 343 LRRLR 347
Cdd:COG5238 427 LERIK 431
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
74-106 |
3.42e-03 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 35.76 E-value: 3.42e-03
10 20 30
....*....|....*....|....*....|...
gi 1622837890 74 CPQACICDNSrwHVACRHQNLTEVPDAIPELTQ 106
Cdd:smart00013 2 CPAPCNCSGT--AVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
93-294 |
3.62e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 40.69 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 93 NLTEVPDAIPELT--QRLNLQGNLLKVIPAaaFQGLPHLTHLDLRHCQVELVAEGAfrGLGRLLLLNLASNHLRELPQEA 170
Cdd:COG4886 216 QLTDLPEPLANLTnlETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKE 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 171 LDGLGSLRRLELEGNALEELRPgtFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALR 250
Cdd:COG4886 292 LELLLGLNSLLLLLLLLNLLEL--LILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1622837890 251 RLSLHHNELQALPGPALSQARGLARLELGHNPLTYAGEEDGLAL 294
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
177-353 |
3.87e-03 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 40.92 E-value: 3.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 177 LRRLELEGNALEELR---PGtfgalgaLATLNLAHNALVYLPAMAfQGLLRVRWLRLSHNALSVLAPealaglpALRRLS 253
Cdd:PRK15387 244 LRTLEVSGNQLTSLPvlpPG-------LLELSIFSNPLTHLPALP-SGLCKLWIFGNQLTSLPVLPP-------GLQELS 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 254 LHHNELQALpgPALSQArgLARLELGHNPLTyageedglALP----GLRELLLDGGALQALGP------RAFAHCPRLHT 323
Cdd:PRK15387 309 VSDNQLASL--PALPSE--LCKLWAYNNQLT--------SLPtlpsGLQELSVSDNQLASLPTlpselyKLWAYNNRLTS 376
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1622837890 324 LD----------LRGNQLDTLPPLqgPGQLRRLRLQGNPL 353
Cdd:PRK15387 377 LPalpsglkeliVSGNRLTSLPVL--PSELKELMVSGNRL 414
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
319-353 |
5.01e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 5.01e-03
10 20 30
....*....|....*....|....*....|....*
gi 1622837890 319 PRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPL 353
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK 35
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
601-733 |
5.03e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.03 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 601 ALGPARELEKLHLDRNQLREVPTG------ALEGLPALLELQLSGNPLRALHDGAFQPVSRS--LQHLFLNSSGLEqISP 672
Cdd:cd00116 46 ALRPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLRSssLQELKLNNNGLG-DRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 673 GAFSGLGPG---------------------------------LQSLHLQKNQLQA------LPALPSLSQLELIDLSSNP 713
Cdd:cd00116 125 LRLLAKGLKdlppaleklvlgrnrlegascealakalranrdLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNG 204
|
170 180
....*....|....*....|....*
gi 1622837890 714 FHCD-----CQLLPLHRWLTGLNLR 733
Cdd:cd00116 205 LTDEgasalAETLASLKSLEVLNLG 229
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
545-713 |
7.40e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 39.26 E-value: 7.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 545 RFLQVPGAALRALPSLFSLHLQDNAVDRLAPG---DLGGTRALRWLYLS----GNRITEVPPGALGPARE-LEKLHLDRN 616
Cdd:cd00116 68 RGLQSLLQGLTKGCGLQELDLSDNALGPDGCGvleSLLRSSSLQELKLNnnglGDRGLRLLAKGLKDLPPaLEKLVLGRN 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837890 617 QLREVPT----GALEGLPALLELQLSGNPLRalHDGA---FQ--PVSRSLQHLFLNSSGLEQISPGAFSGlgpglqslhl 687
Cdd:cd00116 148 RLEGASCealaKALRANRDLKELNLANNGIG--DAGIralAEglKANCNLEVLDLNNNGLTDEGASALAE---------- 215
|
170 180
....*....|....*....|....*.
gi 1622837890 688 qknqlqalpALPSLSQLELIDLSSNP 713
Cdd:cd00116 216 ---------TLASLKSLEVLNLGDNN 232
|
|
| |
