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Conserved domains on  [gi|1622837070|ref|XP_028683247|]
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isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X8 [Macaca mulatta]

Protein Classification

isocitrate/isopropylmalate dehydrogenase family protein( domain architecture ID 296)

isocitrate/isopropylmalate dehydrogenase family protein such as isocitrate dehydrogenase that in the Krebs cycle catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2, and isopropylmalate dehydrogenase that in leucine biosynthesis catalyzes the oxidation and decarboxylation of 3-isopropyl-l-malate to 4-methyl-2-oxovalerate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iso_dh super family cl00445
Isocitrate/isopropylmalate dehydrogenase;
47-348 8.14e-166

Isocitrate/isopropylmalate dehydrogenase;


The actual alignment was detected with superfamily member TIGR00175:

Pssm-ID: 444908  Cd Length: 333  Bit Score: 466.47  E-value: 8.14e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIHTPMEyKGELA 126
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 127 SYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYAT 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 207 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622837070 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKA 301
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 47-348 8.14e-166

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 466.47  E-value: 8.14e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIHTPMEyKGELA 126
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 127 SYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYAT 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 207 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622837070 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKA 301
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 50-338 1.18e-117

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 344.93  E-value: 1.18e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIHTPMeyKGELASYD 129
Cdd:PLN00123   32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 130 MRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKG 209
Cdd:PLN00123  106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 210 RSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
Cdd:PLN00123  186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622837070 290 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSASNMLRHLNL 338
Cdd:PLN00123  266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQF 317
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 48-339 4.05e-96

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 289.60  E-value: 4.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIHTP 118
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 119 -MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRH-----NNLDLVIIREQTEGEYSSLEHESARG----VIECLKI 188
Cdd:COG0473    77 kWDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 189 VTRAKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLV 268
Cdd:COG0473   157 YTRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622837070 269 MPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSASNMLRHLNLE 339
Cdd:COG0473   236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEE 306
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
51-348 4.48e-84

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 258.76  E-value: 4.48e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  51 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIHTPMEYKGEL 125
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 126 ASYD--MRLRRKLDLFANVVHVKSLPG------YMTRHNNLDLVIIREQTEGEYSSLEHE---SARGVIECLKIVTRAKS 194
Cdd:pfam00180  82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 195 QRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622837070 275 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSNMIADA 348
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA 316
 
Name Accession Description Interval E-value
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 47-348 8.14e-166

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 466.47  E-value: 8.14e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEkLEQVLSSMKENKVAIIGKIHTPMEyKGELA 126
Cdd:TIGR00175   2 GKYTVTLIPGDGIGPEISGSVKKIFRAANVPIEFEEIDVSPQTDGKTEI-PDEAVESIKRNKVALKGPLETPIG-KGGHR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 127 SYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYAT 206
Cdd:TIGR00175  80 SLNVALRKELDLYANVVHCKSLPGFKTRHEDVDIVIIRENTEGEYSGLEHESVPGVVESLKVITRDKSERIARYAFEYAR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 207 KKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
Cdd:TIGR00175 160 KNGRKKVTAVHKANIMKLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQFDVMVMPNLYGNILSNLGAGLVG 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622837070 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:TIGR00175 240 GPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEHADRIQKA 301
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 50-338 1.18e-117

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 344.93  E-value: 1.18e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  50 PVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHhlsEVQNmASEEKLEQVLSSMKENKVAIIGKIHTPMeyKGELASYD 129
Cdd:PLN00123   32 AVTLIPGDGIGPLVTGAVEQVMEAMHAPVYFERY---EVHG-DMKKVPEEVLESIRRNKVCLKGGLATPV--GGGVSSLN 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 130 MRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKG 209
Cdd:PLN00123  106 VQLRKELDLFASLVNCFNLPGLPTRHENVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITKFCSERIAKYAFEYAYLNN 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 210 RSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
Cdd:PLN00123  186 RKKVTAVHKANIMKLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTG 265

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622837070 290 VVPGESYSAEYAVFETGARH---PFAQAVGRNIANPTAMLLSASNMLRHLNL 338
Cdd:PLN00123  266 VMPGGNVGADHAVFEQGASAgnvGNEKLVEQKKANPVALLLSSAMMLRHLQF 317
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 47-348 5.13e-114

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 336.47  E-value: 5.13e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSE-----VQNMASEEKLEqvlsSMKENKVAIIGKIHTPMEy 121
Cdd:PLN00118   40 TPITATLFPGDGIGPEIAESVKQVFTAAGVPIEWEEHYVGTtvdprTGSFLTWESLE----SVRRNKVGLKGPMATPIG- 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 122 KGElASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFA 201
Cdd:PLN00118  115 KGH-RSLNLTLRKELGLYANVRPCYSLPGYKTRYDDVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYA 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 202 FDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLA 281
Cdd:PLN00118  194 FHYAKTHGRKRVSAIHKANIMKKTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLC 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622837070 282 AGLVGGAGVVP-GESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:PLN00118  274 AGLIGGLGLTPsCNIGENGLALAE--AVHGSAPDIaGKNLANPTALLLSAVMMLRHLKLNEQAEQIHNA 340
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 48-339 4.05e-96

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 289.60  E-value: 4.05e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEH-----HLSEVQNMASEEkleqVLSSMKENKVAIIGKIHTP 118
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAerfgLDFEFEEAdiggaAYDKTGTPLPDE----TLEALRKADAILLGAVGGP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 119 -MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRH-----NNLDLVIIREQTEGEYSSLEHESARG----VIECLKI 188
Cdd:COG0473    77 kWDDGVRPESGLLALRKELDLYANLRPAKLYPGLPSPLkpeivEGIDLVIVRENTEGLYFGIGGRIGTGtgeeVAIDTRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 189 VTRAKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLV 268
Cdd:COG0473   157 YTRKGIERIARYAFELA-RKRRKKVTSVDKANVLKLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIV 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622837070 269 MPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY-AVFEtgARH---PfaQAVGRNIANPTAMLLSASNMLRHLNLE 339
Cdd:COG0473   236 TENLFGDILSDLAAGLTGSLGLAPSANIGDEGkALFE--PVHgsaP--DIAGKGIANPIATILSAAMMLRHLGEE 306
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 51-348 1.09e-91

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 277.76  E-value: 1.09e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQehhLSEVQNMASEEKLE----QVLSSMKENKVAIIGKIHTPMeykGE-L 125
Cdd:PRK08997    5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYE---FADAGLTALEKHGEllpqRTLDLIEKNKIALKGPLTTPV---GEgF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 126 ASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHE-SARG-VIECLKIVTRAKSQRIAKFAFD 203
Cdd:PRK08997   79 TSINVTLRKKFDLYANVRPVLSFPGTKARYDNIDIITVRENTEGMYSGEGQTvSEDGeTAEATSIITRKGAERIVRFAYE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 204 YATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAG 283
Cdd:PRK08997  159 LARKEGRKKVTAVHKANIMKSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIVTTNLFGDILSDLCAG 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622837070 284 LVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:PRK08997  239 LVGGLGMAPGANIGRDAAIFE--AVHGSAPDIaGKNLANPTSVILAAIQMLEYLGMPDKAERIRKA 302
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
47-348 4.06e-86

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 268.30  E-value: 4.06e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  47 GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVE----------FQEHHLSEVqnmaSEEKLEqvlsSMKENKVAIIGKIH 116
Cdd:PRK09222    3 EKTPITVAYGDGIGPEIMEAVLKILEAAGAPLEietieigekvYKKGWTSGI----SPSAWE----SIRRTKVLLKAPIT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 117 TPME--YKgelaSYDMRLRRKLDLFANVVHVKSL-PGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAK 193
Cdd:PRK09222   75 TPQGggYK----SLNVTLRKTLGLYANVRPCVSYhPFVETKHPNLDVVIIRENEEDLYAGIEHRQTPDVYQCLKLISRPG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 194 SQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLY 273
Cdd:PRK09222  151 SEKIIRYAFEYARANGRKKVTCLTKDNIMKLTDGLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLY 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622837070 274 GNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:PRK09222  231 GDILSDIAAEISGSVGLAGSANIGEEYAMFE--AVHGSAPDIaGKNIANPSGLLNAAVMMLVHIGQFDIAELIENA 304
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
51-348 4.48e-84

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 258.76  E-value: 4.48e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  51 VTMLPGDGVGPELMHAVKEVFKAAAVPV----EFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIHTPMEYKGEL 125
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAplefEFEERDVGGAAIDETGEPLpDETLEACKKADAVLLGAVGGPKWDPAGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 126 ASYD--MRLRRKLDLFANVVHVKSLPG------YMTRHNNLDLVIIREQTEGEYSSLEHE---SARGVIECLKIVTRAKS 194
Cdd:pfam00180  82 RPENglLALRKELGLFANLRPAKVFPPlgdaspLKNEVEGVDIVIVRELTGGIYFGIEKGikgSGNEVAVDTKLYSRDEI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 195 QRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYG 274
Cdd:pfam00180 162 ERIARVAFELARKRGRKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVTPNLFG 241

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622837070 275 NIIDNLAAGLVGGAGVVPGESYSA-EYAVFEtgARHPFAQAV-GRNIANPTAMLLSASNMLRH-LNLEYHSNMIADA 348
Cdd:pfam00180 242 DILSDEASMLTGSLGLLPSASLGAnGFGIFE--PVHGSAPDIaGKGIANPIATILSAAMMLRYsLGLEDAADKIEAA 316
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 51-348 2.37e-76

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 238.49  E-value: 2.37e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFqehhlseVQNMASEEKLEQVLSSMKENKVAIIGKIH-TPMEYKGELA-SY 128
Cdd:PRK14025    4 ICVIEGDGIGKEVVPAALHVLEATGLPFEF-------VYAEAGDEVFEKTGKALPEETIEAAKEADaVLFGAAGETAaDV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 129 DMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKK 208
Cdd:PRK14025   77 IVKLRRILDTYANVRPVKSYKGVKCLYPDIDYVIVRENTEGLYKGIEAEIADGVTVATRVITRKASERIFRFAFEMAKRR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 209 ----GRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGL 284
Cdd:PRK14025  157 kkmgKEGKVTCAHKANVLKKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTFDVVVTSNLFGDILSDGAAGL 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622837070 285 VGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:PRK14025  237 VGGLGLAPSANIGDKYGLFE--PVHGSApDIAGKGIANPTATILTAVLMLRHLGENEEADKVEKA 299
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 51-348 2.64e-52

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 177.22  E-value: 2.64e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  51 VTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLS-----EVQNMASEEKLEQVLSSMkenkvAII-GKIHTPme 120
Cdd:PRK00772    5 IAVLPGDGIGPEVMAEAVKVLDAVAekfgFDFEFEEALVGgaaidAHGVPLPEETLEACRAAD-----AVLlGAVGGP-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 121 yKGELASYDMR-------LRRKLDLFANVVHVKSLPGYMT-------RHNNLDLVIIREQTEGEYS------SLEHESAR 180
Cdd:PRK00772   78 -KWDNLPPDVRpergllaLRKELGLFANLRPAKLYPGLADasplkpeIVAGLDILIVRELTGGIYFgeprgrEGLGGEER 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 181 GVIEClkIVTRAKSQRIAKFAFDYAtKKGRSKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 260
Cdd:PRK00772  157 AFDTM--VYTREEIERIARVAFELA-RKRRKKVTSVDKANVLE-SSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRN 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 261 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFETGarHPFA-QAVGRNIANPTAMLLSASNMLRH-LN 337
Cdd:PRK00772  233 PKQFDVIVTENLFGDILSDEAAMLTGSLGMLPSASLGESgPGLYEPI--HGSApDIAGKGIANPIATILSAAMMLRYsLG 310

                         330
                  ....*....|.
gi 1622837070 338 LEYHSNMIADA 348
Cdd:PRK00772  311 LEEAADAIEAA 321
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 51-348 9.54e-46

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 159.49  E-value: 9.54e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  51 VTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKI------HTPM 119
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAerfgLKFEFEEHLIGGAAIDATGQPLpEETLKGCKEADAVLLGAVggpkwdNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 120 EYKGELASydMRLRRKLDLFANVVHVKSLPGYMTRH-------NNLDLVIIREQTEGEY--SSLEHESARGVIECLKiVT 190
Cdd:TIGR00169  82 DQRPEQGL--LKLRKSLDLFANLRPAKVFPGLEDLSplkeeiaKGVDFVVVRELTGGIYfgEPKGREGEGEAWDTEV-YT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 191 RAKSQRIAKFAFDYATKKgRSKVTAVHKANIMKLGDgLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270
Cdd:TIGR00169 159 VPEIERIARVAFEMARKR-RKKVTSVDKANVLESSR-LWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFE-TGARHPfaQAVGRNIANPTAMLLSASNMLRH-LNLEYHSNMIAD 347
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDgFGLFEpVHGSAP--DIAGKGIANPIAQILSAAMLLRYsFNLEEAADAIEA 314


                  .
gi 1622837070 348 A 348
Cdd:TIGR00169 315 A 315
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 53-339 8.04e-42

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 149.31  E-value: 8.04e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  53 MLPGDGVGPELMH-AVKeVFKAAA---VPVEFQEHHLSEVQNMASEEKL-EQVLSSMKENKVAIIGKIHTP------MEy 121
Cdd:PRK03437    9 VIPGDGIGPEVVAeALK-VLDAVAaggPGVETTEYDLGARRYLRTGETLpDSVLAELRQHDAILLGAIGDPsvpsgvLE- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 122 KGELasydMRLRRKLDLFANVVHVKSLPGYMTRHNN---LDLVIIREQTEGEYSS--------LEHESARGVieclKIVT 190
Cdd:PRK03437   87 RGLL----LKLRFALDHYVNLRPSKLYPGVTSPLAGpgdIDFVVVREGTEGPYTGnggalrvgTPHEVATEV----SVNT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 191 RAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMP 270
Cdd:PRK03437  159 AFGVERVVRDAFERAQKRPRKHLTLVHKTNVLTFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPSRFDVIVTD 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622837070 271 NLYGNIIDNLAAGLVGGAGVVPGESYSAEYA---VFE-TGARHPfaQAVGRNIANPTAMLLSASNMLRHLNLE 339
Cdd:PRK03437  239 NLFGDIITDLAAAVTGGIGLAASGNINPTGTnpsMFEpVHGSAP--DIAGQGIADPTAAILSVALLLDHLGEE 309
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
56-348 1.24e-38

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 142.28  E-value: 1.24e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  56 GDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASE--EKL------EQVLSSMKENKVAIIGKIHTPMEyKGeLAS 127
Cdd:PRK06451   31 GDGIGPEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDkaEKLtgnrfpKESEELIEKYRVLLKGPLETPIG-KG-WKS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 128 YDMRLRRKLDLFANVVHVKSLPGY---MTRHNNLDLVIIREQTEGEYSSLEH----ESARGVIECL-------------- 186
Cdd:PRK06451  109 INVAIRLMLDLYANIRPVKYIPGIespLKNPEKIDLIIFRENTDDLYRGIEYpydsEEAKKIRDFLrkelgveveddtgi 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 187 --KIVTRAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCC---------------EEVAELYP------KI 243
Cdd:PRK06451  189 giKLISKFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWAyevalkefrdyvvteEEVTKNYNgvppsgKV 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 244 KFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANP 322
Cdd:PRK06451  269 IINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFE--AIHGTApKYAGKNVANP 346

                         330       340
                  ....*....|....*....|....*.
gi 1622837070 323 TAMLLSASNMLRHLNLEYHSNMIADA 348
Cdd:PRK06451  347 TGIIKGGELMLRFMGWDKAADLIDKA 372
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 56-336 1.18e-35

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 134.08  E-value: 1.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  56 GDGVGPELMHAVKEVFKAA-------AVPVEFQEHHLSEvqnMASEEKLEQV----LSSMKENKVAIIGKIHTPMEykGE 124
Cdd:COG0538    26 GDGIGPEITRAIWKVIDAAvekayggKRDIEWKEVDAGE---KARDETGDWLpdetAEAIKEYGVGIKGPLTTPVG--GG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 125 LASYDMRLRRKLDLFAN---VVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHES----ARGVIECL----------- 186
Cdd:COG0538   101 WRSLNVTIRQILDLYVCrrpVRYFKGVPSPVKHPEKVDIVIFRENTEDIYAGIEWKAgspeALKLIFFLedemgvtvirf 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 187 --------KIVTRAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAE--------------LYP--- 241
Cdd:COG0538   181 pedsgigiKPVSDEGTERLVRAAIQYALDNKRKSVTLVHKGNIMKFTEGAFKDWGYEVAEeefgdkfitegpweKYKgpk 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 242 ---KIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGE--SYSAeYAVFE----TGARHpfa 312
Cdd:COG0538   261 pagKIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGAniGDDG-GAEFEathgTAPKY--- 336

                         330       340
                  ....*....|....*....|....
gi 1622837070 313 qaVGRNIANPTAMLLSASNMLRHL 336
Cdd:COG0538   337 --AGKDSTNPGSLILSGTMMLRHR 358
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 49-336 3.18e-35

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 131.77  E-value: 3.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  49 FPVTMLPGDGVGPELMHAVKEVFKAAA-----VPVEFQEHHLS-----EVQNMASEEKLEQvlssMKENKVAIIGKIHTP 118
Cdd:PRK08194    4 FKIAVIPGDGVGKEVVPAAVRVLKAVAevhggLKFEFTEFPWSceyylEHGEMMPEDGLEQ----LKQFDAIFLGAVGNP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 119 MEYKGELASYDM--RLRRKLDLFANVVHVKSLPGY---MTRHNNLDLVIIREQTEGEYSSLEHESARGVIECL---KIVT 190
Cdd:PRK08194   80 KLVPDHISLWGLliKIRREFEQVINIRPAKQLRGIkspLANPKDFDLLVVRENSEGEYSEVGGRIHRGEDEIAiqnAVFT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 191 RAKSQRIAKFAFDYATKKgRSKVTAVHKAN----IMKLGDGLFlqccEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDV 266
Cdd:PRK08194  160 RKGTERAMRYAFELAAKR-RKHVTSATKSNgivhSMPFWDEVF----QEVGKDYPEIETDSQHIDALAAFFVTRPEEFDV 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622837070 267 LVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE--Y-AVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHL 336
Cdd:PRK08194  235 IVASNLFGDILTDIGAAIMGSIGIAPAANINVNgkYpSMFE--PVHGSApDIAGKGIANPIGQIWTAKLMLDHF 306
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 56-337 9.87e-35

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 131.72  E-value: 9.87e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  56 GDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL----------EQVLSSMKENKVAIIGKIHTPMeyKGEL 125
Cdd:PRK07006   27 GDGIGPDITPAMLKVVDAAVEKAYKGERKISWMEIYAGEKATkvygedvwlpEETLDLIREYRVAIKGPLTTPV--GGGI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 126 ASYDMRLRRKLDLFA---NVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHES----ARGVIECL------------ 186
Cdd:PRK07006  105 RSLNVALRQELDLYVclrPVRYFKGVPSPVKRPEDTDMVIFRENSEDIYAGIEWKAgsaeAKKVIKFLqeemgvkkirfp 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 187 -------KIVTRAKSQRIAKFAFDYATKKGRSKVTAVHKANIMKLGDGLFLQCCEEVAEL-----------YPKIK---- 244
Cdd:PRK07006  185 etsgigiKPVSEEGTERLVRAAIEYAIDNDRKSVTLVHKGNIMKFTEGAFKDWGYQLAEEefgdelidggpWDKIKnpet 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 245 -----FETMIIDNCCMQLVQNPYQFDVLVMPNLYGNII-DNLAAGlVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGR 317
Cdd:PRK07006  265 gkeiiVKDSIADAFLQQILLRPAEYDVIATMNLNGDYIsDALAAQ-VGGIGIAPGANINDGHAIFE--ATHGTApKYAGL 341

                         330       340
                  ....*....|....*....|
gi 1622837070 318 NIANPTAMLLSASNMLRHLN 337
Cdd:PRK07006  342 DKVNPGSVILSAEMMLRHMG 361
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 45-348 1.73e-27

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 111.70  E-value: 1.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  45 VEGSFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQ-NMASEEKLEQVLSSMKENKVAIIGKIHTpm 119
Cdd:PLN02329   43 GKKRYNIALLPGDGIGPEVISVAKNVLQKAGslegLEFDFQEMPVGGAAlDLVGVPLPEETFTAAKQSDAILLGAIGG-- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 120 eYKGELASYDMR-------LRRKLDLFANVVHVKSLPGYMTRHN-------NLDLVIIREQTEGEYSSLE-----HESAR 180
Cdd:PLN02329  121 -YKWDKNEKHLRpemalfyLRRDLKVFANLRPATVLPQLVDASTlkkevaeGVDMMIVRELTGGIYFGEPrgitiNENGE 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 181 GVIECLKIVTRAKSQRIAKFAFDYATKKgRSKVTAVHKANIMKlGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQN 260
Cdd:PLN02329  200 EVGVSTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRD 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 261 PYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRH-LNLE 339
Cdd:PLN02329  278 PKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEE 357


                  ....*....
gi 1622837070 340 YHSNMIADA 348
Cdd:PLN02329  358 KAAKRIEDA 366
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
56-345 6.80e-18

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 84.76  E-value: 6.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070  56 GDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL----------EQVLSSMKENKVAIIGKIHTPMeyKGEL 125
Cdd:PRK07362   36 GDGTGVDIWPATQKVLDAAVAKAYGGERKINWFKVYAGDEACdlygtyqylpEDTLEAIREYGVAIKGPLTTPI--GGGI 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 126 ASYDMRLRRKLDLFANVVHVKSLPGYMTRHNN---LDLVIIREQTEGEYSSLEHES----ARGVIECL------------ 186
Cdd:PRK07362  114 RSLNVALRQIFDLYSCVRPCRYYAGTPSPHKNpekLDVIVYRENTEDIYMGIEWEAgdeiGDKLIKHLneevipaspelg 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 187 ------------KIVTRAKSQRIAKFAFDYATK--KGRSKVTAVHKANIMKLGDGLF----------------------- 229
Cdd:PRK07362  194 krqiplgsgigiKPVSKTGSQRHIRRAIEHALRlpGDKRHVTLVHKGNIMKYTEGAFrdwgyelattefrdecvteresw 273

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 230 --------------------------------LQCCEEVAELYPKI-------KFETMII------DNCCMQLVQNPYQF 264
Cdd:PRK07362  274 ilsnkeknpnisiednarmiepgydsltpekkAAICAEVKEVLDSIwsshgngKWKEKVLvddriaDSIFQQIQTRPQEY 353

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622837070 265 DVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFEtgARHPFA-QAVGRNIANPTAMLLSASNMLRHLNLEYHSN 343
Cdd:PRK07362  354 SILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAAIFE--ATHGTApKHAGLDRINPGSVILSGVMMLEYLGWQEAAD 431


                  ..
gi 1622837070 344 MI 345
Cdd:PRK07362  432 LI 433
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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