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Conserved domains on  [gi|1622967843|ref|XP_028682812|]
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EEF1A lysine methyltransferase 2 isoform X3 [Macaca mulatta]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 11423066)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Saccharomyces cerevisiae trans-aconitate 3-methyltransferase

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 49-169 7.33e-17

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


:

Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 75.34  E-value: 7.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  49 WMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLSTqlsgfhic 128
Cdd:COG0500    18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP-------- 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622967843 129 IDKGTFDAISLNpdNAI-----EKRKQYVKSLSRVLKVKGFFLITS 169
Cdd:COG0500    90 LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
 
Name Accession Description Interval E-value
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 49-169 7.33e-17

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 75.34  E-value: 7.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  49 WMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLSTqlsgfhic 128
Cdd:COG0500    18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP-------- 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622967843 129 IDKGTFDAISLNpdNAI-----EKRKQYVKSLSRVLKVKGFFLITS 169
Cdd:COG0500    90 LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-192 7.64e-17

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 73.99  E-value: 7.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  58 DASVLDIGTGNGVFLVELAKFGFSD--ITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGT 133
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622967843 134 FDAISlNPDNAIEKrkqyvksLSRVLKVKGFFLITSCNWtKEELLNEFSEGFELFEELP 192
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCV 133
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 61-168 2.71e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 2.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  61 VLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLstqlsgfhICIDKGTFDAISLN 140
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL--------PPEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622967843 141 P--DNAIEKRKQYVKSLSRVLKVKGFFLIT 168
Cdd:cd02440    74 PplHHLVEDLARFLEEARRLLKPGGVLVLT 103
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 43-130 7.29e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 48.29  E-value: 7.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  43 MNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSGSVIEKEGLS-NIKLKVEDflnLSTQ 121
Cdd:PRK07580   49 RDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEARERAPEAGLAgNITFEVGD---LESL 124

                          90
                  ....*....|.
gi 1622967843 122 LSGFH--ICID 130
Cdd:PRK07580  125 LGRFDtvVCLD 135
 
Name Accession Description Interval E-value
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 49-169 7.33e-17

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 75.34  E-value: 7.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  49 WMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLSTqlsgfhic 128
Cdd:COG0500    18 LALLERLPKGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP-------- 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1622967843 129 IDKGTFDAISLNpdNAI-----EKRKQYVKSLSRVLKVKGFFLITS 169
Cdd:COG0500    90 LPAESFDLVVAF--GVLhhlppEEREALLRELARALKPGGVLLLSA 133
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 58-192 7.64e-17

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 73.99  E-value: 7.64e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  58 DASVLDIGTGNGVFLVELAKFGFSD--ITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGT 133
Cdd:pfam13847   4 GMRVLDLGCGTGHLSFELAEELGPNaeVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622967843 134 FDAISlNPDNAIEKrkqyvksLSRVLKVKGFFLITSCNWtKEELLNEFSEGFELFEELP 192
Cdd:pfam13847  84 LNHIP-DPDKVLQE-------ILRVLKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCV 133
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 45-171 6.61e-15

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 68.51  E-value: 6.61e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  45 RLIRWMQKHkIPLDASVLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSGSVIEKEglsNIKLKVEDFLNLStqlsg 124
Cdd:COG2227    13 RLAALLARL-LPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISPEALEIARERAAEL---NVDFVQGDLEDLP----- 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622967843 125 fhicIDKGTFDAISLNpdNAIE---KRKQYVKSLSRVLKVKGFFLITSCN 171
Cdd:COG2227    83 ----LEDGSFDLVICS--EVLEhlpDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 61-160 2.40e-14

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 66.05  E-value: 2.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  61 VLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLsNIKLKVEDFLNLStqlsgfhicIDKGTFDAISLN 140
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLP---------FPDGSFDLVVSS 70

                          90       100
                  ....*....|....*....|....*
gi 1622967843 141 pdNAI-----EKRKQYVKSLSRVLK 160
Cdd:pfam13649  71 --GVLhhlpdPDLEAALREIARVLK 93
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 45-186 1.95e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 65.02  E-value: 1.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  45 RLIRWMQKHKiplDASVLDIGTGNGVFLVELAKFGFSdITGIDYSPSAIQLSGSVIEKEGLsNIKLKVEDFLNLStqlsg 124
Cdd:COG2226    13 ALLAALGLRP---GARVLDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP----- 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622967843 125 fhicIDKGTFDAI-SLNPDNAIEKRKQYVKSLSRVLKVKGFFLITSCNW-TKEELLNEFSE-GFE 186
Cdd:COG2226    83 ----FPDGSFDLViSSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPpDLAELEELLAEaGFE 143
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 39-169 1.59e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 62.64  E-value: 1.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  39 GEESMNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAK-FGFsDITGIDYSPSAIQLSGSVIEKEGLSN-IKLKVEDFL 116
Cdd:COG2230    33 EEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARrYGV-RVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYR 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622967843 117 NLSTQlsgfhicidkGTFDAISLNpdNAIE-----KRKQYVKSLSRVLKVKGFFLITS 169
Cdd:COG2230   112 DLPAD----------GQFDAIVSI--GMFEhvgpeNYPAYFAKVARLLKPGGRLLLHT 157
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 61-168 2.71e-12

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 60.91  E-value: 2.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  61 VLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLstqlsgfhICIDKGTFDAISLN 140
Cdd:cd02440     2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL--------PPEADESFDVIISD 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622967843 141 P--DNAIEKRKQYVKSLSRVLKVKGFFLIT 168
Cdd:cd02440    74 PplHHLVEDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-167 2.09e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 52.67  E-value: 2.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  62 LDIGTGNGVFLVELAKFGfSDITGIDYSPSAIQLSGSVIEKEGLSNIklkVEDFLNLStqlsgfhicIDKGTFDAISLNp 141
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG-ARVTGVDISPEMLELAREKAPREGLTFV---VGDAEDLP---------FPDNSFDLVLSS- 66

                          90       100
                  ....*....|....*....|....*....
gi 1622967843 142 dNAIE---KRKQYVKSLSRVLKVKGFFLI 167
Cdd:pfam08241  67 -EVLHhveDPERALREIARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
48-168 3.60e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 51.15  E-value: 3.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  48 RWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSgsvieKEGLSNIKLKVEDFLNLSTqlsgfhi 127
Cdd:COG4976    37 ELLARLPPGPFGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKA-----REKGVYDRLLVADLADLAE------- 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1622967843 128 ciDKGTFDAI----SLNPDNAIEkrkQYVKSLSRVLKVKGFFLIT 168
Cdd:COG4976   104 --PDGRFDLIvaadVLTYLGDLA---AVFAGVARALKPGGLFIFS 143
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
58-168 7.77e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 48.67  E-value: 7.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  58 DASVLDIGTGNGVFLVELAK-FGFSDITGIDYSPSAIQLSgsvieKEGLSNIKLKVEDFLNLSTQlsgfhicidkGTFDA 136
Cdd:COG4106     2 PRRVLDLGCGTGRLTALLAErFPGARVTGVDLSPEMLARA-----RARLPNVRFVVADLRDLDPP----------EPFDL 66

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1622967843 137 ISLNpdNA---IEKRKQYVKSLSRVLKVKGFFLIT 168
Cdd:COG4106    67 VVSN--AAlhwLPDHAALLARLAAALAPGGVLAVQ 99
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 62-165 1.42e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 47.75  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  62 LDIGTGNGVFLVELAK-FGFSDITGIDYSPSAIqlsgsVIEKEGLSNIKLKVEDFLNLSTQLSGFHiciDKGTFDAISLN 140
Cdd:pfam08242   1 LEIGCGTGTLLRALLEaLPGLEYTGLDISPAAL-----EAARERLAALGLLNAVRVELFQLDLGEL---DPGSFDVVVAS 72

                          90       100
                  ....*....|....*....|....*...
gi 1622967843 141 pdNAIE---KRKQYVKSLSRVLKVKGFF 165
Cdd:pfam08242  73 --NVLHhlaDPRAVLRNIRRLLKPGGVL 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 54-160 1.59e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 49.35  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  54 KIPLDASVLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDflnlstqlsgfhicidkGT 133
Cdd:pfam13489  19 KLPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIERALLNVRFDQFDEQEAAVPA-----------------GK 80

                          90       100
                  ....*....|....*....|....*..
gi 1622967843 134 FDAISLNpdNAIEkrkqYVKSLSRVLK 160
Cdd:pfam13489  81 FDVIVAR--EVLE----HVPDPPALLR 101
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 43-130 7.29e-07

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 48.29  E-value: 7.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  43 MNRLIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSGSVIEKEGLS-NIKLKVEDflnLSTQ 121
Cdd:PRK07580   49 RDTVLSWLPADGDLTGLRILDAGCGVGSLSIPLARRGA-KVVASDISPQMVEEARERAPEAGLAgNITFEVGD---LESL 124

                          90
                  ....*....|.
gi 1622967843 122 LSGFH--ICID 130
Cdd:PRK07580  125 LGRFDtvVCLD 135
PRK11207 PRK11207
tellurite resistance methyltransferase TehB;
59-119 2.53e-06

tellurite resistance methyltransferase TehB;


Pssm-ID: 183040  Cd Length: 197  Bit Score: 46.27  E-value: 2.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622967843  59 ASVLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNLS 119
Cdd:PRK11207   32 GKTLDLGCGNGRNSLYLAANGF-DVTAWDKNPMSIANLERIKAAENLDNLHTAVVDLNNLT 91
TrmB COG0220
tRNA G46 N7-methylase TrmB [Translation, ribosomal structure and biogenesis]; tRNA G46 ...
 36-187 7.61e-06

tRNA G46 N7-methylase TrmB [Translation, ribosomal structure and biogenesis]; tRNA G46 N7-methylase TrmB is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 439990  Cd Length: 204  Bit Score: 44.74  E-value: 7.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  36 KQFGEESMNRLIRWMQKHKIPLDAS---------VLDIGTGNGVFLVELAK----FGFsdItGID-YSPSAIQLSGSvIE 101
Cdd:COG0220     2 TPFQQRVLEELLPLGLDLKGPLDWAelfgndaplVLEIGFGKGEFLVELAAanpdINF--I-GIEvHEPGVAKALKK-AE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843 102 KEGLSNIKL---KVEDFLNlstqlsgfhiCIDKGTFDAISLN-PD----NAIEKR----KQYVKSLSRVLKVKGFFLITS 169
Cdd:COG0220    78 EEGLTNVRLlrgDAVELLE----------LFPDGSLDRIYLNfPDpwpkKRHHKRrlvqPEFLALLARVLKPGGELHLAT 147

                         170       180
                  ....*....|....*....|...
gi 1622967843 170 -----CNWTKEELLNEfsEGFEL 187
Cdd:COG0220   148 dwedyAEEMLEVLSAH--PGFEN 168
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 61-193 7.66e-06

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 44.59  E-value: 7.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  61 VLDIGTGNGVFLVELAKfGFSDIT--GIDYSPSAIQLSGSVIEKEGLSNIKLKvedFLNLSTQLSGFhicIDKGTFDAIS 138
Cdd:pfam02390   5 FLEIGCGMGGFLVAMAK-ANPDKNfiGIEIRVPGVAKALKKIDALGLQNLRIL---CGNALDVLPNY---FPPGSLQKIF 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622967843 139 LN-PDNAIEKRKQ--------YVKSLSRVLKVKGFFLitscnwTKEELLNEFSEGFELFEELPT 193
Cdd:pfam02390  78 INfPDPWPKKRHHkrrllqpeFLKEYARVLKPGGVLH------LATDVEEYAEEMLKHLAEHPL 135
trmB PRK00121
tRNA (guanine-N(7)-)-methyltransferase; Reviewed
 61-191 1.61e-05

tRNA (guanine-N(7)-)-methyltransferase; Reviewed


Pssm-ID: 234649  Cd Length: 202  Bit Score: 44.00  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  61 VLDIGTGNGVFLVELAKfGFSDIT--GID-YSPSAIQLSGSVIEkEGLSNIKL----KVEDFLNlstqlsgfhiCIDKGT 133
Cdd:PRK00121   44 HLEIGFGKGEFLVEMAK-ANPDINfiGIEvHEPGVGKALKKIEE-EGLTNLRLlcgdAVEVLLD----------MFPDGS 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622967843 134 FDAISLN-PD----NAIEKR----KQYVKSLSRVLKVKGFFLITS-----CNWTKEELLNEfsEGFELFEEL 191
Cdd:PRK00121  112 LDRIYLNfPDpwpkKRHHKRrlvqPEFLALYARKLKPGGEIHFATdwegyAEYMLEVLSAE--GGFLVSEAG 181
PRK14968 PRK14968
putative methyltransferase; Provisional
 60-191 2.86e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.96  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  60 SVLDIGTGNGVFLVELAKFGfSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVE--DFLNlstqlsgfhiCIDKGTFDAI 137
Cdd:PRK14968   26 RVLEVGTGSGIVAIVAAKNG-KKVVGVDINPYAVECAKCNAKLNNIRNNGVEVIrsDLFE----------PFRGDKFDVI 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843 138 SLNP-------DNAIEKRKQY---------------VKSLSRVLKVKG--FFLITSCnwTK-EELLNEF-SEGFE----- 186
Cdd:PRK14968   95 LFNPpylpteeEEEWDDWLNYalsggkdgrevidrfLDEVGRYLKPGGriLLLQSSL--TGeDEVLEYLeKLGFEaevva 172


                  ....*....
gi 1622967843 187 ----LFEEL 191
Cdd:PRK14968  173 eekfPFEEL 181
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
58-141 3.44e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.97  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  58 DASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSGSVIEKEGlSNIKLKVEDFLNLStqlsgfhiciDKGTFDAI 137
Cdd:COG2263    46 GKTVLDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRIP----------LGGSVDTV 114


                  ....
gi 1622967843 138 SLNP 141
Cdd:COG2263   115 VMNP 118
PRK12335 PRK12335
tellurite resistance protein TehB; Provisional
 61-114 4.40e-05

tellurite resistance protein TehB; Provisional


Pssm-ID: 183450 [Multi-domain]  Cd Length: 287  Bit Score: 43.39  E-value: 4.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622967843  61 VLDIGTGNGVFLVELAKFGFsDITGIDYSPSAIQLSGSVIEKEGLsNIKLKVED 114
Cdd:PRK12335  124 ALDLGCGQGRNSLYLALLGF-DVTAVDINQQSLENLQEIAEKENL-NIRTGLYD 175
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 60-167 1.40e-04

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 41.67  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  60 SVLDIGTGNGVFLVELA-KFGFSDITGIDYSPSAIQLSGSVIEKEGLSN-IKLKVEDFLNLSTQLSgfhicidKGTFDAI 137
Cdd:COG4123    40 RVLDLGTGTGVIALMLAqRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELP-------PGSFDLV 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622967843 138 SLNP---------DNAIEKRKQ-----------YVKSLSRVLKVKG-FFLI 167
Cdd:COG4123   113 VSNPpyfkagsgrKSPDEARAIarhedaltledLIRAAARLLKPGGrFALI 163
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 59-141 2.92e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 40.53  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  59 ASVLDIGTGNGVFLVELAK-FGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDFLNlstqlsgfhiCIDKGTFDAI 137
Cdd:PRK09328  110 LRVLDLGTGSGAIALALAKeRPDAEVTAVDISPEALAVARRNAKHGLGARVEFLQGDWFE----------PLPGGRFDLI 179


                  ....
gi 1622967843 138 SLNP 141
Cdd:PRK09328  180 VSNP 183
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 47-140 4.96e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 39.94  E-value: 4.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  47 IRWMQKHKIPlDASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQLSgsvieKEglsNIKL-KVEDFLNLSTQLSGF 125
Cdd:pfam06325 152 LEALERLVKP-GESVLDVGCGSGILAIAALKLGAKKVVGVDIDPVAVRAA-----KE---NAELnGVEARLEVYLPGDLP 222

                          90
                  ....*....|....*
gi 1622967843 126 hicidKGTFDAISLN 140
Cdd:pfam06325 223 -----KEKADVVVAN 232
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
47-94 9.29e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 38.98  E-value: 9.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622967843  47 IRWMQKHkIPLDASVLDIGTGNGVflveLA----KFGFSDITGIDYSPSAIQ 94
Cdd:PRK00517  110 LEALEKL-VLPGKTVLDVGCGSGI----LAiaaaKLGAKKVLAVDIDPQAVE 156
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
47-94 1.59e-03

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 38.62  E-value: 1.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622967843  47 IRWMQKHkIPLDASVLDIGTGNGVflveLA----KFGFSDITGIDYSPSAIQ 94
Cdd:COG2264   139 LEALEKL-LKPGKTVLDVGCGSGI----LAiaaaKLGAKRVLAVDIDPVAVE 185
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 55-141 2.31e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 37.48  E-value: 2.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  55 IPLDASVLDIGTGNGVFLVELAK-FGFSDITGIDYSPSAIQLSGSVIEKEGLSNIKLKVEDflnlstQLSGfhicIDKGT 133
Cdd:COG2813    47 EPLGGRVLDLGCGYGVIGLALAKrNPEARVTLVDVNARAVELARANAAANGLENVEVLWSD------GLSG----VPDGS 116


                  ....*...
gi 1622967843 134 FDAISLNP 141
Cdd:COG2813   117 FDLILSNP 124
PRK14967 PRK14967
putative methyltransferase; Provisional
 46-94 4.49e-03

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 36.95  E-value: 4.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622967843  46 LIRWMQKHKIPLDASVLDIGTGNGVFLVELAKFGFSDITGIDYSPSAIQ 94
Cdd:PRK14967   25 LADALAAEGLGPGRRVLDLCTGSGALAVAAAAAGAGSVTAVDISRRAVR 73
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 47-167 5.44e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 36.67  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  47 IRWMQkhkIPLDASVLDIGTGNGVFLVELAKFG--FSDITGIDYSPSaiQLS-GS--VIEKEGLSNIKLKVEDFLNLStq 121
Cdd:PRK00216   44 IKWLG---VRPGDKVLDLACGTGDLAIALAKAVgkTGEVVGLDFSEG--MLAvGRekLRDLGLSGNVEFVQGDAEALP-- 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622967843 122 lsgfhicIDKGTFDAISL-----NpdnaIEKRKQYVKSLSRVLKVKGFFLI 167
Cdd:PRK00216  117 -------FPDNSFDAVTIafglrN----VPDIDKALREMYRVLKPGGRLVI 156
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 47-141 7.40e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 36.67  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622967843  47 IRWMQKHKIPldaSVLDIGTGNGVFLVELAK-FGFSDITGIDYSPSAIQLSgsvieKEglsNI-KLKVEDFLNLsTQLSG 124
Cdd:COG2890   105 LALLPAGAPP---RVLDLGTGSGAIALALAKeRPDARVTAVDISPDALAVA-----RR---NAeRLGLEDRVRF-LQGDL 172

                          90
                  ....*....|....*..
gi 1622967843 125 FHICIDKGTFDAISLNP 141
Cdd:COG2890   173 FEPLPGDGRFDLIVSNP 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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