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Conserved domains on  [gi|1622966961|ref|XP_028682590|]
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protein transport protein Sec31B isoform X7 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-336 1.45e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   84 SSGVIAGGGDNGMLILYNVThilssGKEPVIAQKQkHTGAVRALDFNPFqGNLLASGASDSEVFIWDLNNLNVPMTLGSK 163
Cdd:cd00200     20 DGKLLATGSGDGTIKVWDLE-----TGELLRTLKG-HTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  164 SQYseppedVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRLpvI 243
Cdd:cd00200     93 TSY------VSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT--I 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  244 QLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSA 323
Cdd:cd00200    160 KLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLAS 236

                          250
                   ....*....|...
gi 1622966961  324 ASFDGWISLYSVM 336
Cdd:cd00200    237 GSEDGTIRVWDLR 249
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 771-1078 1.05e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  771 PPVQQLRDRLFHAQGSAVLGQQSPPFPYPRIVVGAIPHSKETSyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPS 850
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  851 PYQgprmqnisdyrasgsqaiqPLPLGPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSLLLMACPdiTQPGSTSLS 930
Cdd:PHA03247  2705 PPT-------------------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  931 ETPRlfpllplrppgpshmvshAPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE 1010
Cdd:PHA03247  2764 AGPP------------------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622966961 1011 TFMAPAPITAPVMSLTPE--LQGILPLQ---PPVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPPEHQSL 1078
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPgpPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
WD40 super family cl43672
WD40 repeat [General function prediction only];
13-153 1.22e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHkliwgsfgsgllESSGVIAGGG 92
Cdd:COG2319    295 AFSPDGKL---LASG----------SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------------PDGKTLASGS 349

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622966961   93 DNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNN 153
Cdd:COG2319    350 DDGTVRLWD----LATGEL--LRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
ACE1-Sec16-like super family cl14807
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 571-691 1.34e-04

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


The actual alignment was detected with superfamily member cd09233:

Pssm-ID: 449359 [Multi-domain]  Cd Length: 314  Bit Score: 45.33  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  571 LLLGELGPAVELYLKEERFADAIILAQAGGADLLKQTQERYlAKKKTKISSLLACVVQ---KNWKDVVCTCS-------- 639
Cdd:cd09233     73 LLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGNSPEAITELAdnpaeaew 151

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622966961  640 -LKNWREALALLLTYSSTEKfpelcDM-----LGTRMEQEGgraLTSEARLCYVCSGS 691
Cdd:cd09233    152 aLGNWREHLAIILSNRTSNL-----DLealveLGDLLAQRG---LVEAAHICYLLAGV 201
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-336 1.45e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   84 SSGVIAGGGDNGMLILYNVThilssGKEPVIAQKQkHTGAVRALDFNPFqGNLLASGASDSEVFIWDLNNLNVPMTLGSK 163
Cdd:cd00200     20 DGKLLATGSGDGTIKVWDLE-----TGELLRTLKG-HTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  164 SQYseppedVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRLpvI 243
Cdd:cd00200     93 TSY------VSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT--I 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  244 QLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSA 323
Cdd:cd00200    160 KLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLAS 236

                          250
                   ....*....|...
gi 1622966961  324 ASFDGWISLYSVM 336
Cdd:cd00200    237 GSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
6-335 1.56e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.56e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961    6 LERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHklIWGSFGSGLLESS 85
Cdd:COG2319     13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH--TAAVLSVAFSPDG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   86 GVIAGGGDNGMLILYNVthilSSGKEPviAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNNLNVPMTLgsksq 165
Cdd:COG2319     91 RLLASASADGTVRLWDL----ATGLLL--RTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTL----- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  166 ySEPPEDVKALSWNRQAQhILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDRlpvIQL 245
Cdd:COG2319    159 -TGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPD-GKLLASGSADGT---VRL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  246 WDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSAAS 325
Cdd:COG2319    231 WDLA-TGKLLRTLTGHSGSVRSVAFS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGS 307

                          330
                   ....*....|
gi 1622966961  326 FDGWISLYSV 335
Cdd:COG2319    308 DDGTVRLWDL 317
PHA03247 PHA03247
large tegument protein UL36; Provisional
 771-1078 1.05e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  771 PPVQQLRDRLFHAQGSAVLGQQSPPFPYPRIVVGAIPHSKETSyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPS 850
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  851 PYQgprmqnisdyrasgsqaiqPLPLGPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSLLLMACPdiTQPGSTSLS 930
Cdd:PHA03247  2705 PPT-------------------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  931 ETPRlfpllplrppgpshmvshAPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE 1010
Cdd:PHA03247  2764 AGPP------------------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622966961 1011 TFMAPAPITAPVMSLTPE--LQGILPLQ---PPVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPPEHQSL 1078
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPgpPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 825-1063 4.50e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 4.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  825 PTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPR--MQNISDYRA----SGSQAIQPLPLGPgvRPASSQPQLLGGQRVQAP 898
Cdd:pfam03154  197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtlIQQTPTLHPqrlpSPHPPLQPMTQPP--PPSQVSPQPLPQPSLHGQ 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  899 NPvgfPGTWPLPGSLLLMACPDITQP-GSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPVSFLVPYPPGgpvapcSSVL 977
Cdd:pfam03154  275 MP---PMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPR------EQPL 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  978 PTTGILTPH--PGPQDSWKEAPAPggnlQRNKLPETFMAPAPITAPVmSLTPElqgilPLQPPVSGVS-HAPPGA-PGEL 1053
Cdd:pfam03154  346 PPAPLSMPHikPPPTTPIPQLPNP----QSHKHPPHLSGPSPFQMNS-NLPPP-----PALKPLSSLStHHPPSAhPPPL 415

                          250
                   ....*....|.
gi 1622966961 1054 SLQ-QLQHLPP 1063
Cdd:pfam03154  416 QLMpQSQQLPP 426
PTZ00420 PTZ00420
coronin; Provisional
 80-204 7.27e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 7.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   80 GLLESSGVIA------GGGDNGMLILYNVTHilssgKEPVIAQKqKHTGAVRALDFNPFQGNLLASGASDSEVFIWDL-- 151
Cdd:PTZ00420    33 GIACSSGFVAvpweveGGGLIGAIRLENQMR-----KPPVIKLK-GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIph 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622966961  152 NNLNVPMTLGSKSQYSEPPEDVKALSWNRQAQHILSSAHPSGKAVVWDLrKNE 204
Cdd:PTZ00420   107 NDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDI-ENE 158
WD40 COG2319
WD40 repeat [General function prediction only];
13-153 1.22e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHkliwgsfgsgllESSGVIAGGG 92
Cdd:COG2319    295 AFSPDGKL---LASG----------SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------------PDGKTLASGS 349

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622966961   93 DNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNN 153
Cdd:COG2319    350 DDGTVRLWD----LATGEL--LRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-150 3.00e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 3.00e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1622966961   120 HTGAVRALDFNPfQGNLLASGASDSEVFIWD 150
Cdd:smart00320   11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 571-691 1.34e-04

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 45.33  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  571 LLLGELGPAVELYLKEERFADAIILAQAGGADLLKQTQERYlAKKKTKISSLLACVVQ---KNWKDVVCTCS-------- 639
Cdd:cd09233     73 LLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGNSPEAITELAdnpaeaew 151

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622966961  640 -LKNWREALALLLTYSSTEKfpelcDM-----LGTRMEQEGgraLTSEARLCYVCSGS 691
Cdd:cd09233    152 aLGNWREHLAIILSNRTSNL-----DLealveLGDLLAQRG---LVEAAHICYLLAGV 201
WD40 pfam00400
WD domain, G-beta repeat;
120-150 2.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.13e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622966961  120 HTGAVRALDFNPfQGNLLASGASDSEVFIWD 150
Cdd:pfam00400   10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-336 1.45e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.83  E-value: 1.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   84 SSGVIAGGGDNGMLILYNVThilssGKEPVIAQKQkHTGAVRALDFNPFqGNLLASGASDSEVFIWDLNNLNVPMTLGSK 163
Cdd:cd00200     20 DGKLLATGSGDGTIKVWDLE-----TGELLRTLKG-HTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETGECVRTLTGH 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  164 SQYseppedVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiaTQLVLCSEDDRLpvI 243
Cdd:cd00200     93 TSY------VSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS--VAFSPD--GTFVASSSQDGT--I 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  244 QLWDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSA 323
Cdd:cd00200    160 KLWDLR-TGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLAS 236

                          250
                   ....*....|...
gi 1622966961  324 ASFDGWISLYSVM 336
Cdd:cd00200    237 GSEDGTIRVWDLR 249
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-334 1.95e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 122.44  E-value: 1.95e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLK-HKGVLSassrfhKLIWGSFGSgllessgVIAGG 91
Cdd:cd00200     16 AFSPDGKL---LATG----------SGDGTIKVWDLETGELLRTLKgHTGPVR------DVAASADGT-------YLASG 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   92 GDNGMLILYNVthilsSGKEPVIAQKQkHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNNLNVPMTLGSKSQyseppe 171
Cdd:cd00200     70 SSDKTIRLWDL-----ETGECVRTLTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD------ 136

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  172 DVKALSWNrQAQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDrlpVIQLWDLRfA 251
Cdd:cd00200    137 WVNSVAFS-PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS--VAFSPD-GEKLLSSSSDG---TIKLWDLS-T 208

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  252 SSPLKVLESHSRGILSVSWSQaDAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPRDPSVFSaASFDGWIS 331
Cdd:cd00200    209 GKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS-GSADGTIR 286


                   ...
gi 1622966961  332 LYS 334
Cdd:cd00200    287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-335 1.56e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.56e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961    6 LERPAVQAWSPASQYPLYLATGTSAQQLDSSFSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHklIWGSFGSGLLESS 85
Cdd:COG2319     13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGH--TAAVLSVAFSPDG 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   86 GVIAGGGDNGMLILYNVthilSSGKEPviAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNNLNVPMTLgsksq 165
Cdd:COG2319     91 RLLASASADGTVRLWDL----ATGLLL--RTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTL----- 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  166 ySEPPEDVKALSWNRQAQhILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDRlpvIQL 245
Cdd:COG2319    159 -TGHSGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS--VAFSPD-GKLLASGSADGT---VRL 230

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  246 WDLRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSAAS 325
Cdd:COG2319    231 WDLA-TGKLLRTLTGHSGSVRSVAFS-PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGS 307

                          330
                   ....*....|
gi 1622966961  326 FDGWISLYSV 335
Cdd:COG2319    308 DDGTVRLWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
88-335 4.07e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 4.07e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   88 IAGGGDNGMLILYNVThilsSGKEpvIAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNNLNVPMTLGSKSQYs 167
Cdd:COG2319    177 LASGSDDGTVRLWDLA----TGKL--LRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS- 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  168 eppedVKALSWNRQAQHILsSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHcsGLAWHPDiATQLVLCSEDDRlpvIQLWD 247
Cdd:COG2319    249 -----VRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD-GKLLASGSDDGT---VRLWD 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  248 LRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPrDPSVFSAASFD 327
Cdd:COG2319    317 LA-TGKLLRTLTGHTGAVRSVAFS-PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSAD 393


                   ....*...
gi 1622966961  328 GWISLYSV 335
Cdd:COG2319    394 GTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
88-335 9.91e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 9.91e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   88 IAGGGDNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNNLNVPMTLgsksqyS 167
Cdd:COG2319    135 LASGSADGTVRLWD----LATGKL--LRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL------T 201

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  168 EPPEDVKALSWNRQAQhILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCsgLAWHPDiATQLVLCSEDDRlpvIQLWD 247
Cdd:COG2319    202 GHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS--VAFSPD-GRLLASGSADGT---VRLWD 274

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  248 LRfASSPLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPRDPSVFSaASFD 327
Cdd:COG2319    275 LA-TGELLRTLTGHSGGVNSVAFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS-GSDD 351


                   ....*...
gi 1622966961  328 GWISLYSV 335
Cdd:COG2319    352 GTVRLWDL 359
PHA03247 PHA03247
large tegument protein UL36; Provisional
 771-1078 1.05e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.95  E-value: 1.05e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  771 PPVQQLRDRLFHAQGSAVLGQQSPPFPYPRIVVGAIPHSKETSyRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPS 850
Cdd:PHA03247  2626 PPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRAR-RLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP 2704

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  851 PYQgprmqnisdyrasgsqaiqPLPLGPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSLLLMACPdiTQPGSTSLS 930
Cdd:PHA03247  2705 PPT-------------------PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP--ARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  931 ETPRlfpllplrppgpshmvshAPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE 1010
Cdd:PHA03247  2764 AGPP------------------APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA 2825

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622966961 1011 TFMAPAPITAPVMSLTPE--LQGILPLQ---PPVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPPEHQSL 1078
Cdd:PHA03247  2826 GPLPPPTSAQPTAPPPPPgpPPPSLPLGgsvAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESF 2898
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 825-1063 4.50e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 4.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  825 PTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPR--MQNISDYRA----SGSQAIQPLPLGPgvRPASSQPQLLGGQRVQAP 898
Cdd:pfam03154  197 AGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtlIQQTPTLHPqrlpSPHPPLQPMTQPP--PPSQVSPQPLPQPSLHGQ 274

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  899 NPvgfPGTWPLPGSLLLMACPDITQP-GSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPVSFLVPYPPGgpvapcSSVL 977
Cdd:pfam03154  275 MP---PMPHSLQTGPSHMQHPVPPQPfPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPR------EQPL 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  978 PTTGILTPH--PGPQDSWKEAPAPggnlQRNKLPETFMAPAPITAPVmSLTPElqgilPLQPPVSGVS-HAPPGA-PGEL 1053
Cdd:pfam03154  346 PPAPLSMPHikPPPTTPIPQLPNP----QSHKHPPHLSGPSPFQMNS-NLPPP-----PALKPLSSLStHHPPSAhPPPL 415

                          250
                   ....*....|.
gi 1622966961 1054 SLQ-QLQHLPP 1063
Cdd:pfam03154  416 QLMpQSQQLPP 426
PHA03247 PHA03247
large tegument protein UL36; Provisional
 791-1073 6.00e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 6.00e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  791 QQSPPFPYPRIVVGAiphsketsyrlgsqpshqvpTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPrmqnisdyrasgsqA 870
Cdd:PHA03247  2704 PPPTPEPAPHALVSA--------------------TPLPPGPAAARQASPALPAAPAPPAVPAGP--------------A 2749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  871 IQPLPLGPGVRPASSQPqllggqrvQAPNPVGFPGTWPLPGslllmacpdITQPGSTSLSETPRLFPLLPLRPPGPSHMV 950
Cdd:PHA03247  2750 TPGGPARPARPPTTAGP--------PAPAPPAAPAAGPPRR---------LTRPAVASLSESRESLPSPWDPADPPAAVL 2812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  951 SHAPAPPVSflvpYPPGGPVAPCSSVLPTTGILTPHP-GPQDSWKEAPAPGGNLQRnKLPETFMAPAPIT---------- 1019
Cdd:PHA03247  2813 APAAALPPA----ASPAGPLPPPTSAQPTAPPPPPGPpPPSLPLGGSVAPGGDVRR-RPPSRSPAAKPAAparppvrrla 2887

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622966961 1020 APVMSLTPELQGILPLQP--PVSGVSHAPPGAPGELSLQQLQHLPPEKMERKELPP 1073
Cdd:PHA03247  2888 RPAVSRSTESFALPPDQPerPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPL 2943
PHA03247 PHA03247
large tegument protein UL36; Provisional
 820-1050 1.17e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  820 PSHQVPTPSPRPRVFTP--QSSPAMPLAPSHPSPYQGPRmqnisDYRASGSQAIQPLPLGPGVRPASSQPQllggQRVQA 897
Cdd:PHA03247  2564 PDRSVPPPRPAPRPSEPavTSRARRPDAPPQSARPRAPV-----DDRGDPRGPAPPSPLPPDTHAPDPPPP----SPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  898 PNPVGFPGTWPLPGSLLLMACPditQPGSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPVSFLVPY--PPGGPVAPCSS 975
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDP---APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLadPPPPPPTPEPA 2711

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622966961  976 VLPTTGILTPHPGPQDSWKEAPAPggnlqrnklPETFMAPAPITAPVMSLTPELQGI--LPLQPPVSGVSHAPPGAP 1050
Cdd:PHA03247  2712 PHALVSATPLPPGPAAARQASPAL---------PAAPAPPAVPAGPATPGGPARPARppTTAGPPAPAPPAAPAAGP 2779
PHA03247 PHA03247
large tegument protein UL36; Provisional
 794-1051 2.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.71  E-value: 2.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  794 PPFPYPRIVVGAIpHSKETSYRLGSQPSH-QVPT--PSPRPRVFTPQSSPAMPLAPSHPSPYQGPRmqniSDYRASGSQA 870
Cdd:PHA03247  2570 PPRPAPRPSEPAV-TSRARRPDAPPQSARpRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPA----ANEPDPHPPP 2644

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  871 IQPLPLGPGVRPASSQPQLLGGQRVQ--APNPVGFPGTW------PLPGSLLLMACPdiTQPGSTSLSETPRLFPLLPLR 942
Cdd:PHA03247  2645 TVPPPERPRDDPAPGRVSRPRRARRLgrAAQASSPPQRPrrraarPTVGSLTSLADP--PPPPPTPEPAPHALVSATPLP 2722

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  943 PPGPSHMVShAPAPPVSFLVPYPPGGPVAPCSSVLP-----TTGILTPHP------GPQDSWKEAPAPGGNLQRNKLP-- 1009
Cdd:PHA03247  2723 PGPAAARQA-SPALPAAPAPPAVPAGPATPGGPARParpptTAGPPAPAPpaapaaGPPRRLTRPAVASLSESRESLPsp 2801

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1622966961 1010 -ETFMAPAPITAPVMSLTPELQGILPLQPPVSGVSHAPPGAPG 1051
Cdd:PHA03247  2802 wDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 731-1095 3.25e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.86  E-value: 3.25e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  731 PHGVSPGPATTYRVTQYANLLAAQGSLATAMSfLPHDCAQPPVqqlrdrlfhAQGSAVLGQQSPPfpyPRIVVGAIPHSK 810
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPA-LPAAPAPPAV---------PAGPATPGGPARP---ARPPTTAGPPAP 2769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  811 ETSYRLGSQPSHQVPTPSPRPRVFTPQSSPAMPLAPSHPSPYQGPRMQNISDYRASGSQA--IQPLPLGPGVRPASSQPQ 888
Cdd:PHA03247  2770 APPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPppTSAQPTAPPPPPGPPPPS 2849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  889 L-LGG---------QRVQAPNPVGFPGTWPLPgSLLLMACPDITQPGSTSLSETPRLFPLLPLRPPGPSHMVSHAPAPPV 958
Cdd:PHA03247  2850 LpLGGsvapggdvrRRPPSRSPAAKPAAPARP-PVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  959 SFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGG-NLQRNKLPEtfmaPAPITAPVMSLTPELQGIlplqp 1037
Cdd:PHA03247  2929 PQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRvAVPRFRVPQ----PAPSREAPASSTPPLTGH----- 2999

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622966961 1038 PVSGVS--------HAPPgAPGELSLQQLQHLPPEKmerkelppEHQSLKSSFEALLQRCSLSATD 1095
Cdd:PHA03247  3000 SLSRVSswasslalHEET-DPPPVSLKQTLWPPDDT--------EDSDADSLFDSDSERSDLEALD 3056
PTZ00420 PTZ00420
coronin; Provisional
 80-204 7.27e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 7.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   80 GLLESSGVIA------GGGDNGMLILYNVTHilssgKEPVIAQKqKHTGAVRALDFNPFQGNLLASGASDSEVFIWDL-- 151
Cdd:PTZ00420    33 GIACSSGFVAvpweveGGGLIGAIRLENQMR-----KPPVIKLK-GHTSSILDLQFNPCFSEILASGSEDLTIRVWEIph 106

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622966961  152 NNLNVPMTLGSKSQYSEPPEDVKALSWNRQAQHILSSAHPSGKAVVWDLrKNE 204
Cdd:PTZ00420   107 NDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDI-ENE 158
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 728-1076 9.48e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 9.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  728 LRGPHGVSPGPATTYRVTQYANLLAAQGSLATAMSFLPHDCAQPPVQQLRDRLFHA--QGSAVLGQQSPPFPYPRIV-VG 804
Cdd:pfam03154  174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTliQQTPTLHPQRLPSPHPPLQpMT 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  805 AIPHSKETSYRLGSQPSHQVPTP-----------------SPRPRVFTPQSSPA-MPLAPSHPSPYQGPRMQNISDYRAS 866
Cdd:pfam03154  254 QPPPPSQVSPQPLPQPSLHGQMPpmphslqtgpshmqhpvPPQPFPLTPQSSQSqVPPGPSPAAPGQSQQRIHTPPSQSQ 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  867 GSQAI----QPLPLGPGVRP------ASSQPQLLGGQ------RVQAPNPVGFPGTWPLPGSLLLMAC-----PDITQPG 925
Cdd:pfam03154  334 LQSQQppreQPLPPAPLSMPhikpppTTPIPQLPNPQshkhppHLSGPSPFQMNSNLPPPPALKPLSSlsthhPPSAHPP 413

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  926 STSLSETPRLFPLLPLRPPGPSHMVSHAP----APPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSwkeAPAPGG 1001
Cdd:pfam03154  414 PLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaasHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTS---TSSAMP 490

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622966961 1002 NLQrnklpetfmapapitaPVMSLTPELQGILPLQPPVSgvshAPPgapgelslQQLQHLPPEKMERKELPPEHQ 1076
Cdd:pfam03154  491 GIQ----------------PPSSASVSSSGPVPAAVSCP----LPP--------VQIKEEALDEAEEPESPPPPP 537
WD40 COG2319
WD40 repeat [General function prediction only];
13-153 1.22e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 1.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961   13 AWSPASQYplyLATGtsaqqldssfSTNGTLEIFEVDFRDPSLDLKHKGVLSASSRFHkliwgsfgsgllESSGVIAGGG 92
Cdd:COG2319    295 AFSPDGKL---LASG----------SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------------PDGKTLASGS 349

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622966961   93 DNGMLILYNvthiLSSGKEpvIAQKQKHTGAVRALDFNPfQGNLLASGASDSEVFIWDLNN 153
Cdd:COG2319    350 DDGTVRLWD----LATGEL--LRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 845-1078 2.33e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.61  E-value: 2.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  845 APSHPSPyqgprMQNISDYRASGSQAI---QPLPLgPGVRPASSQPQLLGGQRVQAPNPVGFPGTWPLPGSlllmACPDI 921
Cdd:pfam03154  145 SPSIPSP-----QDNESDSDSSAQQQIlqtQPPVL-QAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQ----GSPAT 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  922 TQPGSTSLSetprlfpllplrppgpshmvshaPAPPVSFLVPYPPGGPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGG 1001
Cdd:pfam03154  215 SQPPNQTQS-----------------------TAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSL 271

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961 1002 NLQrnklpetfMAPAPitAPVMSLTPELQGILPLQP----PVSGVSHAPPGAPGELS--LQQLQHLPPEKME-RKELPPE 1074
Cdd:pfam03154  272 HGQ--------MPPMP--HSLQTGPSHMQHPVPPQPfpltPQSSQSQVPPGPSPAAPgqSQQRIHTPPSQSQlQSQQPPR 341


                   ....
gi 1622966961 1075 HQSL 1078
Cdd:pfam03154  342 EQPL 345
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-150 3.00e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 3.00e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1622966961   120 HTGAVRALDFNPfQGNLLASGASDSEVFIWD 150
Cdd:smart00320   11 HTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 254-337 4.21e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 4.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  254 PLKVLESHSRGILSVSWSqADAELLLTSAKDSQILCLNLESSEVVYKLPTQSSWCFEVQWCPRDPSVFSaASFDGWISLY 333
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLAS-GSSDKTIRLW 78


                   ....
gi 1622966961  334 SVMG 337
Cdd:cd00200     79 DLET 82
ACE1-Sec16-like cd09233
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ...
 571-691 1.34e-04

Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.


Pssm-ID: 187750 [Multi-domain]  Cd Length: 314  Bit Score: 45.33  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  571 LLLGELGPAVELYLKEERFADAIILAQAGGADLLKQTQERYlAKKKTKISSLLACVVQ---KNWKDVVCTCS-------- 639
Cdd:cd09233     73 LLTGNRKEALELALDNGLWAHALLLASSLGKETWAEVVSRF-ARSESKLNDPLQTLYQlfsGNSPEAITELAdnpaeaew 151

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622966961  640 -LKNWREALALLLTYSSTEKfpelcDM-----LGTRMEQEGgraLTSEARLCYVCSGS 691
Cdd:cd09233    152 aLGNWREHLAIILSNRTSNL-----DLealveLGDLLAQRG---LVEAAHICYLLAGV 201
WD40 pfam00400
WD domain, G-beta repeat;
120-150 2.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 2.13e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1622966961  120 HTGAVRALDFNPfQGNLLASGASDSEVFIWD 150
Cdd:pfam00400   10 HTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 114-299 3.71e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 3.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  114 IAQKQKHTGAVRALDFNPFQGNLLASGASDSEVFIWDLNNLNVPMTLGSKSQYseppedVKALSWNRQAQhILSSAHPSG 193
Cdd:PTZ00421   118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ------ITSLEWNLDGS-LLCTTSKDK 190

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  194 KAVVWDLRKNEPIIKVSDH-SNRMHCSGLAWHPDIATQLVLCSEDDRLpvIQLWDLRFASSPLKVLESHSRGILSVSWSQ 272
Cdd:PTZ00421   191 KLNIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSQQRQ--IMLWDTRKMASPYSTVDLDQSSALFIPFFD 268

                          170       180
                   ....*....|....*....|....*...
gi 1622966961  273 ADAELLLTSAK-DSQILCLNLESSEVVY 299
Cdd:PTZ00421   269 EDTNLLYIGSKgEGNIRCFELMNERLTF 296
PHA03378 PHA03378
EBNA-3B; Provisional
 809-1110 2.32e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  809 SKETSYRLGSQPSH-QVPTPSPRPRVfTPQSSPAMPLAPSHPSPYQGPRMQNISDYRasgSQAIQPLPLGPGVRPASSQP 887
Cdd:PHA03378   579 SPTTSQLASSAPSYaQTPWPVPHPSQ-TPEPPTTQSHIPETSAPRQWPMPLRPIPMR---PLRMQPITFNVLVFPTPHQP 654

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  888 QllggqrvqAPNPVGFPGTWPLPGSLllMACPDITQPGSTSLSETPRLFPLLPLRPPGPSHMVSHAPA---PPVSFLVPY 964
Cdd:PHA03378   655 P--------QVEITPYKPTWTQIGHI--PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGraqRPAAATGRA 724

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  965 PPggPVAPCSSVLPTTGILTPHPGPQDSWKEAPAPGGNLQRNKLPE-TFMAPAPITAPVMsltpelqGILPLQPPVSGVS 1043
Cdd:PHA03378   725 RP--PAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAaAPGAPTPQPPPQA-------PPAPQQRPRGAPT 795

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961 1044 HAPP----GAPGELSLQQL--QHLPPEKMERKELPPEHQSLKSS--FEALLQRcsLSATDLVLALGAGVGIH------FF 1109
Cdd:PHA03378   796 PQPPpqagPTSMQLMPRAApgQQGPTKQILRQLLTGGVKRGRPSlkKPAALER--QAAAGPTPSPGSGTSDKivqapvFY 873


                   .
gi 1622966961 1110 P 1110
Cdd:PHA03378   874 P 874
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 792-1051 5.32e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  792 QSPPFPyprivvGAIPHSKETSYRLGSQPSHQVPTPS--PRPRVFTPQSSPAMPLAPsHPSPYQGPRMQNISDYRASGSQ 869
Cdd:PRK10263   342 QTPPVA------SVDVPPAQPTVAWQPVPGPQTGEPViaPAPEGYPQQSQYAQPAVQ-YNEPLQQPVQPQQPYYAPAAEQ 414

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  870 AIQPLPLGPGVRPASSQPQLlggqrVQAPNPVGFPGTWPLPGSLLLMACPDITQPGSTslsetprlfpllplrppgpshM 949
Cdd:PRK10263   415 PAQQPYYAPAPEQPAQQPYY-----APAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQT---------------------Y 468

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622966961  950 VSHAPAPPvsflvPYPPGGPVAPCSSVLPTTGILTPHPG-PQDSWKEAPAPGGNLQRNKL-------PETFMAPAPITAP 1021
Cdd:PRK10263   469 QQPAAQEP-----LYQQPQPVEQQPVVEPEPVVEETKPArPPLYYFEEVEEKRAREREQLaawyqpiPEPVKEPEPIKSS 543

                          250       260       270
                   ....*....|....*....|....*....|
gi 1622966961 1022 VMSLTPelqgilPLQPPVSGVSHAPPGAPG 1051
Cdd:PRK10263   544 LKAPSV------AAVPPVEAAAAVSPLASG 567
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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