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Conserved domains on  [gi|1573738607|ref|XP_028033161|]
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protein spaetzle-like [Bombyx mandarina]

Protein Classification

spaetzle family protein( domain architecture ID 11240682)

spaetzle family protein similar to Drosophila melanogaster protein spaetzle, component of the extracellular signaling pathway that establishes dorsal-ventral polarity in the embryo; it binds to the Toll receptor and activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spaetzle pfam16077
Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway ...
 179-271 9.21e-33

Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway that establishes the dorsal-ventral pattern of the embryo. They form a cystine knot structure.


:

Pssm-ID: 465007  Cd Length: 93  Bit Score: 115.49  E-value: 9.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573738607 179 ELCDFRVKIMTPLAAQSDDLKWYHVLNfNENPLQGFRVEICNTTSTGCAKFVTMENNYNPKCVQKFIFRKMKILSESGEM 258
Cdd:pfam16077   1 YLCPSRERYIRPKRAKNTDGEWRVIVN-TDEYTQGVRIETCSNPGQPCSFLDGFPPGYSSKCKQKYVYRRLLAIDDNGEG 79

                          90
                  ....*....|....
gi 1573738607 259 IE-RSMKVPSCCSC 271
Cdd:pfam16077  80 IFtDSFKFPSCCSC 93
 
Name Accession Description Interval E-value
Spaetzle pfam16077
Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway ...
 179-271 9.21e-33

Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway that establishes the dorsal-ventral pattern of the embryo. They form a cystine knot structure.


Pssm-ID: 465007  Cd Length: 93  Bit Score: 115.49  E-value: 9.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573738607 179 ELCDFRVKIMTPLAAQSDDLKWYHVLNfNENPLQGFRVEICNTTSTGCAKFVTMENNYNPKCVQKFIFRKMKILSESGEM 258
Cdd:pfam16077   1 YLCPSRERYIRPKRAKNTDGEWRVIVN-TDEYTQGVRIETCSNPGQPCSFLDGFPPGYSSKCKQKYVYRRLLAIDDNGEG 79

                          90
                  ....*....|....
gi 1573738607 259 IE-RSMKVPSCCSC 271
Cdd:pfam16077  80 IFtDSFKFPSCCSC 93
 
Name Accession Description Interval E-value
Spaetzle pfam16077
Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway ...
 179-271 9.21e-33

Spaetzle; This family of proteins are nerve growth factor-like ligands required in the pathway that establishes the dorsal-ventral pattern of the embryo. They form a cystine knot structure.


Pssm-ID: 465007  Cd Length: 93  Bit Score: 115.49  E-value: 9.21e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1573738607 179 ELCDFRVKIMTPLAAQSDDLKWYHVLNfNENPLQGFRVEICNTTSTGCAKFVTMENNYNPKCVQKFIFRKMKILSESGEM 258
Cdd:pfam16077   1 YLCPSRERYIRPKRAKNTDGEWRVIVN-TDEYTQGVRIETCSNPGQPCSFLDGFPPGYSSKCKQKYVYRRLLAIDDNGEG 79

                          90
                  ....*....|....
gi 1573738607 259 IE-RSMKVPSCCSC 271
Cdd:pfam16077  80 IFtDSFKFPSCCSC 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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