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Conserved domains on  [gi|1516094401|ref|XP_026961629|]
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programmed cell death 1 ligand 2 isoform X3 [Lagenorhynchus obliquidens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_PD-L2 cd20983
Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here ...
 20-119 3.01e-69

Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 2 (PD-L2; also known as B7-DC or CD273). Receptor-binding domain of PD-L2 is a cell-surface ligand that competes with PD-L1 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the CD28/B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. PD-L2 has a higher affinity for PD-1 but is expressed at lower levels. PD-L2 interaction with PD-1 suppresses T cell proliferation, cytokine production and cytotoxic activity. PD-L2 is expressed on tumor cells, antigen-presenting cells or APCs (such as macrophages, B cells and dendritic cells), and a variety of other immune and nonimmune cells. Tumor expression of PD-L2 may contribute to tumor evasion of immune destruction by inactivating T cells. Thus, PD-L2 is a negative predictor for prognosis among solid cancer patients.


:

Pssm-ID: 409575  Cd Length: 100  Bit Score: 210.50  E-value: 3.01e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401  20 LFTVTVPKEMYTVDYGGNVTLECDFDTGGHVELGDLKASLQKVENDTTLLSERAILLEEQLPLGKALFHIPQVQVRDAGQ 99
Cdd:cd20983     1 LFTVTVPKELYTVDHGSNVTLECDFDTGEHVELGAIRASLQKVENDTSLHSERATLLEEQLPLGKALFHIPSVQVRDAGQ 80

                          90       100
                  ....*....|....*....|
gi 1516094401 100 YRCLIIYGIAWDYKYLTLKV 119
Cdd:cd20983    81 YRCLIIYGVAWDYKYLTLKV 100
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 127-208 2.58e-58

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20986:

Pssm-ID: 472250  Cd Length: 82  Bit Score: 181.77  E-value: 2.58e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401 127 NTRNLKVPGTDEVELTCQAVGYPLAEVSWPNISVPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANMKELTSAI 206
Cdd:cd20986     1 DTHILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHTRTPEGLYQVTSVLRLKPQPGRNFSCMFWNAHMKELTSAI 80


                  ..
gi 1516094401 207 ID 208
Cdd:cd20986    81 ID 82
 
Name Accession Description Interval E-value
IgV_PD-L2 cd20983
Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here ...
 20-119 3.01e-69

Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 2 (PD-L2; also known as B7-DC or CD273). Receptor-binding domain of PD-L2 is a cell-surface ligand that competes with PD-L1 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the CD28/B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. PD-L2 has a higher affinity for PD-1 but is expressed at lower levels. PD-L2 interaction with PD-1 suppresses T cell proliferation, cytokine production and cytotoxic activity. PD-L2 is expressed on tumor cells, antigen-presenting cells or APCs (such as macrophages, B cells and dendritic cells), and a variety of other immune and nonimmune cells. Tumor expression of PD-L2 may contribute to tumor evasion of immune destruction by inactivating T cells. Thus, PD-L2 is a negative predictor for prognosis among solid cancer patients.


Pssm-ID: 409575  Cd Length: 100  Bit Score: 210.50  E-value: 3.01e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401  20 LFTVTVPKEMYTVDYGGNVTLECDFDTGGHVELGDLKASLQKVENDTTLLSERAILLEEQLPLGKALFHIPQVQVRDAGQ 99
Cdd:cd20983     1 LFTVTVPKELYTVDHGSNVTLECDFDTGEHVELGAIRASLQKVENDTSLHSERATLLEEQLPLGKALFHIPSVQVRDAGQ 80

                          90       100
                  ....*....|....*....|
gi 1516094401 100 YRCLIIYGIAWDYKYLTLKV 119
Cdd:cd20983    81 YRCLIIYGVAWDYKYLTLKV 100
IgC1_PD-L2 cd20986
Immunoglobulin Constant 1 (IgC1) domain of Programmed death ligand 2 (PD-L2); The members here ...
 127-208 2.58e-58

Immunoglobulin Constant 1 (IgC1) domain of Programmed death ligand 2 (PD-L2); The members here are composed of the immunoglobulin Constant 1 (IgC1) domain of Programmed death ligand 2 (PD-L2; also known as B7-DC or CD273). PD-L2 is a cell-surface ligand that competes with PD-L1 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the CD28/B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. PD-L2 has a higher affinity for PD-1 but is expressed at lower levels. PD-L2 interaction with PD-1 suppresses T cell proliferation, cytokine production and cytotoxic activity. PD-L2 is expressed on tumor cells, antigen-presenting cells or APCs (such as macrophages, B cells and dendritic cells), and a variety of other immune and nonimmune cells. Tumor expression of PD-L2 may contribute to tumor evasion of immune destruction by inactivating T cells. Thus, PD-L2 is a negative predictor for prognosis among solid cancer patients.


Pssm-ID: 409578  Cd Length: 82  Bit Score: 181.77  E-value: 2.58e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401 127 NTRNLKVPGTDEVELTCQAVGYPLAEVSWPNISVPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANMKELTSAI 206
Cdd:cd20986     1 DTHILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHTRTPEGLYQVTSVLRLKPQPGRNFSCMFWNAHMKELTSAI 80


                  ..
gi 1516094401 207 ID 208
Cdd:cd20986    81 ID 82
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 138-194 7.55e-05

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 40.86  E-value: 7.55e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1516094401 138 EVELTC-QAVGYPLAEVSW----PNISVPTNTSHTKTSEGLYQVTSVLRLKPHP---GRNFSCVF 194
Cdd:pfam08205  16 EVVATCsSAGGKPAPRITWyldgKPLEAAETSSEQDPESGLVTVTSELKLVPSRsdhGQSLTCQV 80
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 22-102 1.05e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401  22 TVTVPKEMYTVDYGGNVTLECDFDTGGHVELgdlkaSLQKveNDTTLLSERAILLEEQLplGKALFHIPQVQVRDAGQYR 101
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPTI-----TWYK--NGEPISSGSTRSRSLSG--SNSTLTISNVTRSDAGTYT 73


                  .
gi 1516094401 102 C 102
Cdd:pfam13927  74 C 74
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-119 1.51e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401   30 YTVDYGGNVTLECDFDTGGHVELGDLKASLQKVendttLLSERAILLEEQlplGKALFHIPQVQVRDAGQYRCLIIYGIA 109
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPEVTWYKQGGKLL-----AESGRFSVSRSG---STSTLTISNVTPEDSGTYTCAATNSSG 75

                           90
                   ....*....|
gi 1516094401  110 WDYKYLTLKV 119
Cdd:smart00410  76 SASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_PD-L2 cd20983
Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here ...
 20-119 3.01e-69

Immunoglobulin Variable (IgV) domain of Programmed death ligand 2 (PD-L2); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 2 (PD-L2; also known as B7-DC or CD273). Receptor-binding domain of PD-L2 is a cell-surface ligand that competes with PD-L1 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the CD28/B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. PD-L2 has a higher affinity for PD-1 but is expressed at lower levels. PD-L2 interaction with PD-1 suppresses T cell proliferation, cytokine production and cytotoxic activity. PD-L2 is expressed on tumor cells, antigen-presenting cells or APCs (such as macrophages, B cells and dendritic cells), and a variety of other immune and nonimmune cells. Tumor expression of PD-L2 may contribute to tumor evasion of immune destruction by inactivating T cells. Thus, PD-L2 is a negative predictor for prognosis among solid cancer patients.


Pssm-ID: 409575  Cd Length: 100  Bit Score: 210.50  E-value: 3.01e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401  20 LFTVTVPKEMYTVDYGGNVTLECDFDTGGHVELGDLKASLQKVENDTTLLSERAILLEEQLPLGKALFHIPQVQVRDAGQ 99
Cdd:cd20983     1 LFTVTVPKELYTVDHGSNVTLECDFDTGEHVELGAIRASLQKVENDTSLHSERATLLEEQLPLGKALFHIPSVQVRDAGQ 80

                          90       100
                  ....*....|....*....|
gi 1516094401 100 YRCLIIYGIAWDYKYLTLKV 119
Cdd:cd20983    81 YRCLIIYGVAWDYKYLTLKV 100
IgC1_PD-L2 cd20986
Immunoglobulin Constant 1 (IgC1) domain of Programmed death ligand 2 (PD-L2); The members here ...
 127-208 2.58e-58

Immunoglobulin Constant 1 (IgC1) domain of Programmed death ligand 2 (PD-L2); The members here are composed of the immunoglobulin Constant 1 (IgC1) domain of Programmed death ligand 2 (PD-L2; also known as B7-DC or CD273). PD-L2 is a cell-surface ligand that competes with PD-L1 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the CD28/B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. PD-L2 has a higher affinity for PD-1 but is expressed at lower levels. PD-L2 interaction with PD-1 suppresses T cell proliferation, cytokine production and cytotoxic activity. PD-L2 is expressed on tumor cells, antigen-presenting cells or APCs (such as macrophages, B cells and dendritic cells), and a variety of other immune and nonimmune cells. Tumor expression of PD-L2 may contribute to tumor evasion of immune destruction by inactivating T cells. Thus, PD-L2 is a negative predictor for prognosis among solid cancer patients.


Pssm-ID: 409578  Cd Length: 82  Bit Score: 181.77  E-value: 2.58e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401 127 NTRNLKVPGTDEVELTCQAVGYPLAEVSWPNISVPTNTSHTKTSEGLYQVTSVLRLKPHPGRNFSCVFWNANMKELTSAI 206
Cdd:cd20986     1 DTHILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHTRTPEGLYQVTSVLRLKPQPGRNFSCMFWNAHMKELTSAI 80


                  ..
gi 1516094401 207 ID 208
Cdd:cd20986    81 ID 82
IgV_PDl1 cd20947
Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here ...
 23-119 7.33e-22

Immunoglobulin Variable (IgV) domain of Programmed death ligand 1 (PD-L1); The members here are composed of the immunoglobulin variable (IgV) domain of Programmed death ligand 1 (PD-L1; also known as Cluster of Differentiation 274 (CD274)). PD-L1 is a cell-surface ligand that competes with PD-L2 for binding to the immunosuppressive receptor programmed death-1 (PD-1). PD-1 is a member of the B7 family that plays an important role in negatively regulating immune responses upon interaction with its two ligands, PD-L1 or PD-L2. Like PD-L2, PD-L1 interacts with PD-1 and suppresses T cell proliferation and cytokine production. The PD-1 receptor is expressed on the surface of activated T cells, while PD-L1 is expressed on cancer cells. When PD-1 and PD-L1 bind together, they form a molecular shield protecting tumor cells from being destroyed by the immune system. Thus, inhibiting the binding of PD-L1 to PD-1 with an antibody leads to killing of tumor cells by T cells. PD-1 inhibitors (such as Pembrolizumab, Nivolumab, and Cemiplimab) and PD-L1 inhibitors (such as Atezolizumab, Avelumab, and Durvalumab ) are an emerging class of immunotherapy that stimulate lymphocytes against tumor cells.


Pssm-ID: 409539  Cd Length: 110  Bit Score: 88.45  E-value: 7.33e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401  23 VTVPKEMYTVDYGGNVTLECDFDTGGHVELGDL--------KASLQKVENDTTL------LSERAILLEEQLPLGKALFH 88
Cdd:cd20947     1 VTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALivywemedKNIIQFVHGEEDLkvqhssYRQRARLLKDQLSLGNAALQ 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1516094401  89 IPQVQVRDAGQYRCLIIYGIAwDYKYLTLKV 119
Cdd:cd20947    81 ITDVKLQDAGVYRCMISYGGA-DYKRITVKV 110
IgC1_2_Nectin-2_Necl-5_like cd07703
Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; ...
 133-193 4.46e-05

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; member of the C1-set of the Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409500  Cd Length: 97  Bit Score: 41.62  E-value: 4.46e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1516094401 133 VPGTDEVEL-TCQAV-GYPLAEVSWPNiSVPTNTSHTKTSE---GLYQVTSVLRLKPHP---GRNFSCV 193
Cdd:cd07703    11 QAGGIPVPVaRCVSAnGRPPARISWSS-TLNGNANTTQVPGpdsGTVTVTSEYSLVPTPeanGKEVTCK 78
IgC1_Tapasin_R cd05771
Tapasin-R immunoglobulin-like domain; member of the C1-set of Ig superfamily (IgSF) domains; ...
 126-193 5.52e-05

Tapasin-R immunoglobulin-like domain; member of the C1-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin-like domain on Tapasin-R. Tapasin is a V-C1 (variable-constant) immunoglobulin superfamily molecule present in the endoplasmic reticulum (ER), where it links MHC class I molecules to the transporter associated with antigen processing (TAP). Tapasin-R is a tapasin-related protein that contains similar structural motifs to Tapasin, with some marked differences, especially in the V domain, transmembrane and cytoplasmic regions. The majority of Tapasin-R is located within the ER; however, there may be some expression of Tapasin-R at the cell surface. Tapasin-R lacks an obvious ER retention signal.


Pssm-ID: 409428  Cd Length: 100  Bit Score: 41.33  E-value: 5.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401 126 INTRNLKVPGTDEVeLTCQAVG-YPL-AEVSW--------PNISVPTNT---SHTKTSEGLYQVTSVLRLKP---HPGRN 189
Cdd:cd05771     5 LSPKNLVKPDLPQT-LSCHIAGyYPLdVDVEWlreepggsESQVSRDGVslsSHRQSVDGTYSISSYLTLEPgteNRGAT 83


                  ....
gi 1516094401 190 FSCV 193
Cdd:cd05771    84 YTCR 87
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 138-194 7.55e-05

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 40.86  E-value: 7.55e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1516094401 138 EVELTC-QAVGYPLAEVSW----PNISVPTNTSHTKTSEGLYQVTSVLRLKPHP---GRNFSCVF 194
Cdd:pfam08205  16 EVVATCsSAGGKPAPRITWyldgKPLEAAETSSEQDPESGLVTVTSELKLVPSRsdhGQSLTCQV 80
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 126-196 4.60e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 38.32  E-value: 4.60e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1516094401 126 INTRNLKVPGTDEVELTCQAVGYPLAEVSW-----PNISVPTNTSHTKTSEGLYQVTSVlrlKPHPGRNFSCVFWN 196
Cdd:pfam13927   6 VSPSSVTVREGETVTLTCEATGSPPPTITWykngePISSGSTRSRSLSGSNSTLTISNV---TRSDAGTYTCVASN 78
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 22-102 1.05e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.16  E-value: 1.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401  22 TVTVPKEMYTVDYGGNVTLECDFDTGGHVELgdlkaSLQKveNDTTLLSERAILLEEQLplGKALFHIPQVQVRDAGQYR 101
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPTI-----TWYK--NGEPISSGSTRSRSLSG--SNSTLTISNVTRSDAGTYT 73


                  .
gi 1516094401 102 C 102
Cdd:pfam13927  74 C 74
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 30-119 1.51e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 37.10  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1516094401   30 YTVDYGGNVTLECDFDTGGHVELGDLKASLQKVendttLLSERAILLEEQlplGKALFHIPQVQVRDAGQYRCLIIYGIA 109
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPEVTWYKQGGKLL-----AESGRFSVSRSG---STSTLTISNVTPEDSGTYTCAATNSSG 75

                           90
                   ....*....|
gi 1516094401  110 WDYKYLTLKV 119
Cdd:smart00410  76 SASSGTTLTV 85
IgC2_D1_D2_LILR_KIR_like cd16843
Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer ...
 35-110 5.47e-03

Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains; The members here are composed of the first and second immunoglobulin (Ig)-like domains found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs, also known as also known as cluster of differentiation (CD) 158), and similar proteins. This group includes LILRB1 (also known as LIR-1), LILRA5 (also known as LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (also known as cluster of differentiation (CD) 89). LILRs are a family of immunoreceptors expressed on expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3, and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1, LILRB2 (also known as LIR-2), and LILRB3 (also known as LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs), it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LILRB1, and LILRB2, show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1, and LILRB2, and two in the case of LILRB4 (also known as LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils, and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst. Killer cell immunoglobulin-like receptors (KIRs; also known as CD158 for human KIR) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. KIRs are a family of highly polymorphic activating and inhibitory receptors that serve as key regulators of human NK cell function. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The major ligands for KIR are MHC class I (HLA-A, -B or -C) molecules.


Pssm-ID: 409518 [Multi-domain]  Cd Length: 90  Bit Score: 35.43  E-value: 5.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1516094401  35 GGNVTLECdfdtggHVELGDLKASLQKVENdttLLSERAILLEEqlPLGKALFHIPQVQVRDAGQYRCliIYGIAW 110
Cdd:cd16843    15 GENVTIRC------QGPPEAVLFQLYKEGN---SLSQGTVREKE--PQNKAEFYIPHMDRNHAGRYRC--RYRSGT 77
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 139-206 8.70e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.61  E-value: 8.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1516094401 139 VELTCQAVGYPLAEVSW--PNISVPTNTSHTKTSEglyQVTSVLRLKP----HPGrNFSCVFWNANMKELTSAI 206
Cdd:cd00096     1 VTLTCSASGNPPPTITWykNGKPLPPSSRDSRRSE---LGNGTLTISNvtleDSG-TYTCVASNSAGGSASASV 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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