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Conserved domains on  [gi|1443734043|ref|XP_025909048|]
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major facilitator superfamily domain-containing protein 4A isoform X1 [Nothoprocta perdicaria]

Protein Classification

major facilitator superfamily domain-containing protein 4A( domain architecture ID 13024591)

major facilitator superfamily domain-containing protein 4A (MFSD4A) acts as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MFSD4A cd17453
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily ...
 18-476 0e+00

Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4A (MFSD4A) belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 341011  Cd Length: 415  Bit Score: 728.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  18 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVFKRTLAQSLFALFASSLAISLVFA 97
Cdd:cd17453     1 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLQQITWVFFSQQFCLLLGSTLGGVFKRTLAQSLFALFVSSLAISVVFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  98 IIPLCHNVVVLAVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIADPFLSDTNCilsnstan 177
Cdd:cd17453    81 IIPFCRNVGVLAFVMAVAGLAMGCIDTISNMQLVKIYQKDSAVFLQALHFFVGFGALLSPLIADPFLSDTNC-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 178 asrnlphirksllphhpgnlsrydlpmkgmvvthVSYAFWIMALINLPVPIAVFFLLYKERMVPCCNGSSHPLLSADELA 257
Cdd:cd17453   153 ----------------------------------VSYAFWIMAIINLPVPIAVFVLLYKERMVPCCSDPSRPLLSADELA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 258 MEARPGDKDELSTAvqRPQAARGHEDLFSCCQSKNFRGASYAYFAVHITGALVLFMTDGIVGEYSGFIYSYAVEEPLSVV 337
Cdd:cd17453   199 MEARPEEKLDESTG--KAHTSNGHADLFSCCQSKNFRGAPFSFFAIHVTGALVLFMTDGIVGEYSGFVYSYAVEPPLNLP 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 338 HKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLLLIFSSSVVFLFVGTASLGLFLSSTFPSMLAY 417
Cdd:cd17453   277 HKVAGYLPSLFWGFITLGRLISIPISYRMKPATMVFINLVGVIVTFLLLLIFSNSTVFLFVGTASLGLFLSSTFPSMLAY 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1443734043 418 TEDILQYKGCATTVLVTGAGIGEMVLQLLVGSIIHEQGSYSFLVCGMIFGGLAFTFYAF 476
Cdd:cd17453   357 TEDILQYKGCATTVLVTGAGMGEMVLQMLVGSIMHSQGSYSFLVCGMIFGCLAFTFYTF 415
 
Name Accession Description Interval E-value
MFS_MFSD4A cd17453
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily ...
 18-476 0e+00

Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4A (MFSD4A) belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341011  Cd Length: 415  Bit Score: 728.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  18 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVFKRTLAQSLFALFASSLAISLVFA 97
Cdd:cd17453     1 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLQQITWVFFSQQFCLLLGSTLGGVFKRTLAQSLFALFVSSLAISVVFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  98 IIPLCHNVVVLAVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIADPFLSDTNCilsnstan 177
Cdd:cd17453    81 IIPFCRNVGVLAFVMAVAGLAMGCIDTISNMQLVKIYQKDSAVFLQALHFFVGFGALLSPLIADPFLSDTNC-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 178 asrnlphirksllphhpgnlsrydlpmkgmvvthVSYAFWIMALINLPVPIAVFFLLYKERMVPCCNGSSHPLLSADELA 257
Cdd:cd17453   153 ----------------------------------VSYAFWIMAIINLPVPIAVFVLLYKERMVPCCSDPSRPLLSADELA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 258 MEARPGDKDELSTAvqRPQAARGHEDLFSCCQSKNFRGASYAYFAVHITGALVLFMTDGIVGEYSGFIYSYAVEEPLSVV 337
Cdd:cd17453   199 MEARPEEKLDESTG--KAHTSNGHADLFSCCQSKNFRGAPFSFFAIHVTGALVLFMTDGIVGEYSGFVYSYAVEPPLNLP 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 338 HKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLLLIFSSSVVFLFVGTASLGLFLSSTFPSMLAY 417
Cdd:cd17453   277 HKVAGYLPSLFWGFITLGRLISIPISYRMKPATMVFINLVGVIVTFLLLLIFSNSTVFLFVGTASLGLFLSSTFPSMLAY 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1443734043 418 TEDILQYKGCATTVLVTGAGIGEMVLQLLVGSIIHEQGSYSFLVCGMIFGGLAFTFYAF 476
Cdd:cd17453   357 TEDILQYKGCATTVLVTGAGMGEMVLQMLVGSIMHSQGSYSFLVCGMIFGCLAFTFYTF 415
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-487 1.79e-19

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 90.30  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  12 RRNLQPTLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVF------KRTLAQSLFAL 85
Cdd:COG0738     4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLidrfgyKRGLLLGLLLM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  86 FASSLAISLVFAIIPLChnvvvlaVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIAdpfls 165
Cdd:COG0738    84 ALGLLLFALAPSYPLLL-------LALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLG----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 166 dTNCILSNSTAnasrnlphirksllphhpgnlsrydlpmkgmvvtHVSYAFWIMALInlPVPIAVFFLLYKermvpccng 245
Cdd:COG0738   152 -GLLILLGLSL----------------------------------SWHLPYLILAVL--LLLLALLFLRSK--------- 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 246 sshplLSADELAMEARPGDKDELSTAVQRPQAarghedlfsccqsknfrgasyayfavhITGALVLFMTDGIVGEYSGFI 325
Cdd:COG0738   186 -----LPEIEEEEEEAAGSAASLKSLLKNPRL---------------------------LLGGLAIFLYVGAEGAIGDWL 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 326 YSYAVEEpLSVVHKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVtFLLLLIFSSSVVFLFVGTASLGL 405
Cdd:COG0738   234 PLYLKDV-LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAV-GLLLALLAPGPWLALIGLALVGL 311

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 406 FLSSTFPSMLAYTEDILQYKGCATT-VLVTGAGIGEMVLQLLVGSIIHEQG-SYSFLVcgmifgglAFTFYAFLLFFHRM 483
Cdd:COG0738   312 GLSLMFPTIFSLALDGLGKRTAAAVsAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLV--------PLVCYLLILLLALA 383


                  ....
gi 1443734043 484 YPKP 487
Cdd:COG0738   384 LKRK 387
MFS_1 pfam07690
Major Facilitator Superfamily;
323-502 1.22e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.25  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 323 GFIYSYAVEEPLSVVHKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVtFLLLLIFSSSVVFLFVGTAS 402
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL-GLLLLLFASSLWLLLVLRVL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 403 LGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGEMVLQLLVGSIIHeqgSYSFLVCGMIFGGLAFtFYAFLLFF 480
Cdd:pfam07690  95 QGLGAGALFPAALALIADWFppEERGRALGLVSAGFGLGAALGPLLGGLLAS---LFGWRAAFLILAILSL-LAAVLLLL 170

                         170       180
                  ....*....|....*....|..
gi 1443734043 481 HRMYPKPSSDLDATSPDKPAVT 502
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIV 192
 
Name Accession Description Interval E-value
MFS_MFSD4A cd17453
Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily ...
 18-476 0e+00

Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4A (MFSD4A) belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341011  Cd Length: 415  Bit Score: 728.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  18 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVFKRTLAQSLFALFASSLAISLVFA 97
Cdd:cd17453     1 TLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLQQITWVFFSQQFCLLLGSTLGGVFKRTLAQSLFALFVSSLAISVVFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  98 IIPLCHNVVVLAVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIADPFLSDTNCilsnstan 177
Cdd:cd17453    81 IIPFCRNVGVLAFVMAVAGLAMGCIDTISNMQLVKIYQKDSAVFLQALHFFVGFGALLSPLIADPFLSDTNC-------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 178 asrnlphirksllphhpgnlsrydlpmkgmvvthVSYAFWIMALINLPVPIAVFFLLYKERMVPCCNGSSHPLLSADELA 257
Cdd:cd17453   153 ----------------------------------VSYAFWIMAIINLPVPIAVFVLLYKERMVPCCSDPSRPLLSADELA 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 258 MEARPGDKDELSTAvqRPQAARGHEDLFSCCQSKNFRGASYAYFAVHITGALVLFMTDGIVGEYSGFIYSYAVEEPLSVV 337
Cdd:cd17453   199 MEARPEEKLDESTG--KAHTSNGHADLFSCCQSKNFRGAPFSFFAIHVTGALVLFMTDGIVGEYSGFVYSYAVEPPLNLP 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 338 HKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLLLIFSSSVVFLFVGTASLGLFLSSTFPSMLAY 417
Cdd:cd17453   277 HKVAGYLPSLFWGFITLGRLISIPISYRMKPATMVFINLVGVIVTFLLLLIFSNSTVFLFVGTASLGLFLSSTFPSMLAY 356

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1443734043 418 TEDILQYKGCATTVLVTGAGIGEMVLQLLVGSIIHEQGSYSFLVCGMIFGGLAFTFYAF 476
Cdd:cd17453   357 TEDILQYKGCATTVLVTGAGMGEMVLQMLVGSIMHSQGSYSFLVCGMIFGCLAFTFYTF 415
MFS_MFSD4 cd17395
Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily ...
 20-474 1.90e-129

Major facilitator superfamily domain-containing protein 4; The Major facilitator superfamily domain-containing protein 4 (MFSD4) subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The MFSD4 subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340953 [Multi-domain]  Cd Length: 367  Bit Score: 381.10  E-value: 1.90e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  20 TYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVFKRTLAqSLFALFASSLAISLVFAII 99
Cdd:cd17395     1 TYWSVFFSFGLSIAFLGPTLLDLACNTNSSLPQISWVFFSRQLGYLLGSALGGVFKRTLN-SLWALFTSSLLIALVLAVI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 100 PLCHNVVVLAVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIADPFLSdtncilsnstanas 179
Cdd:cd17395    80 PFCKDVKVLASVMAIAGLAMGCLDTGANMQIVRMWQKDSAPFLQVLHFSFGFGAFLAPLIADPFLS-------------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 180 rnlphirksllphhpgnlsrydlpmkgmvvthvsYAFWIMALINLPVPIAVFFLLYKERMVPCCngsshpllsadelame 259
Cdd:cd17395   146 ----------------------------------YAYWIMALINLPVPMAVLMLLSKERLLTCC---------------- 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 260 arpgdkdelstavqrpqaarghedlfSCCQSKNFRGASYAYFAVHITGALVLFMTDGIVGEYSGFIYSYAVEEPLsVVHK 339
Cdd:cd17395   176 --------------------------SQRRRKNLRRAPYSFFAIHITGALFLFMYVGLEGAYGAFVYSYAVEKPG-VGHK 228

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 340 VAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLLLIFSSSVVFLFVGTASLGLFLSSTFPSMLAYTE 419
Cdd:cd17395   229 VAAYLPSLFWGTFTLGRLLSIPISSRMKPATMVVLNVVGVVVTSLVLLLFSKSVVFLWIGTASLGLFLASTFPSMLSYTE 308

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1443734043 420 DILQYKGCATTVLVTGAGIGEMVLQLLVGSIIHE--QGSYSFLVCGMIFGGLAFTFY 474
Cdd:cd17395   309 DSLQYTGCSTTVLVTGAGLGEMVLPMLVGSIQPFqaQGSYSFLVCGVLFGCLAFTFY 365
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 21-476 5.78e-70

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 227.97  E-value: 5.78e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  21 YWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVFKRTLaQSLFALFASSLAISLVFAIIP 100
Cdd:cd17333     1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRL-GRRRTLILGLLLISLALALIF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 101 LCHNVVVLAVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIADPFLSdtncilsnstanasr 180
Cdd:cd17333    80 ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLT--------------- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 181 nlphirksllphhpgnlsrydlpmkgmVVTHVSYAFWIMALINLPVPIAVFFLLYKErmvpcCNGSSHPLLSAdelamea 260
Cdd:cd17333   145 ---------------------------SELSWSWAYLIIGLIYLLLAILILLTLFPE-----LPSARNPQQSV------- 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 261 rpgdkdelstavqrpqaarghedlfsccQSKNFRGASYAYFAVHITGALVLFMTDGIVGEYSGFIYSYAVEEPlSVVHKV 340
Cdd:cd17333   186 ----------------------------GAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKK-HVSDGL 236

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 341 AGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLLLIFsSSVVFLFVGTASLGLFLSSTFPSMLAYTED 420
Cdd:cd17333   237 AGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLA-PTLVVGLVATALLGLFMAALFPTILSLGIS 315

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1443734043 421 ILQY-KGCATTVLVTGAGIGEMVLQLLVGSIIHEQGSYSFLVCGMIFGGLAFTFYAF 476
Cdd:cd17333   316 NLPYaKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
MFS_NaGLT1_MFSD4B cd17454
Sodium-dependent glucose transporter 1, also called Major facilitator superfamily ...
 23-448 6.94e-24

Sodium-dependent glucose transporter 1, also called Major facilitator superfamily domain-containing protein 4B; Sodium-dependent glucose transporter 1 (NaGLT1) is also called major facilitator superfamily domain-containing protein 4B (MFSD4B). NaGLT1 is a primary fructose transporter in rat renal brush-border membranes. It also facilitates sodium-independent urea uptake in assays performed on Xenopus oocytes. NaGLT1/MFSD4B belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341012  Cd Length: 369  Bit Score: 102.90  E-value: 6.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  23 SVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVFKRTLAQSLFaLFASSLAISLVFAIIPLC 102
Cdd:cd17454     4 ASFLGLGMSIAVLGPTFQDLATNVNKNISNISYIFVGRSLGYLGGSVLGGILFDCMNHHLL-LGFSMLITAAGLFAIPWC 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 103 HNVVVLAVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIADPFLsdtncilsnstanasrnl 182
Cdd:cd17454    83 KKALLLTALMSLIGVSMGVLDTGGNVLILNTWGDQAGPHMQALHFSFALGAFVAPILAKLAF------------------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 183 phirksllphhpgnlsrydlpmkgmvvthvSYAFWIMALINLPVPIAVFFLLYKERMVpccngsshpllsadelamearp 262
Cdd:cd17454   145 ------------------------------LWAYIVIGTYVLLVSLFFFILYSKSSSN---------------------- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 263 gdKDELSTAVQRPQAARGHEdlfsccqsknfrgasyayfAVHITGALVLFMTDGIVGEYSGFIYSYAVEEPLSVVHKVAG 342
Cdd:cd17454   173 --REKSKASAQKTRFAKYHN-------------------ALIILLFLFFFFYVGAEVTYGSYIFTYAKTYVHMEESEAAG 231

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 343 yLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLLLIFSSSVVFLFVGTASLGLFLSSTFPSMLAYTEDIL 422
Cdd:cd17454   232 -LNSLFWGTFAACRGLAIFFAACLYPGTMILLSLIGSTVSSLFLVLFSKNPISLWVGTAVYGASMATTFPSGISWIEQYT 310

                         410       420
                  ....*....|....*....|....*.
gi 1443734043 423 QYKGCATTVLVTGAGIGEMVLQLLVG 448
Cdd:cd17454   311 TITGKSAALFVVGAALGEMVIPAVVG 336
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
12-487 1.79e-19

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 90.30  E-value: 1.79e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  12 RRNLQPTLTYWSVFFSFGLCIAFLGPTLLDLRCQTQSSLSQITWVFFSQQFCLLLGSCLGGVF------KRTLAQSLFAL 85
Cdd:COG0738     4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLidrfgyKRGLLLGLLLM 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043  86 FASSLAISLVFAIIPLChnvvvlaVVMAVAGLAMGCIDTISNMQLVKIYQKDSAIFLQALHFFVGFGALLSPLIAdpfls 165
Cdd:COG0738    84 ALGLLLFALAPSYPLLL-------LALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLG----- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 166 dTNCILSNSTAnasrnlphirksllphhpgnlsrydlpmkgmvvtHVSYAFWIMALInlPVPIAVFFLLYKermvpccng 245
Cdd:COG0738   152 -GLLILLGLSL----------------------------------SWHLPYLILAVL--LLLLALLFLRSK--------- 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 246 sshplLSADELAMEARPGDKDELSTAVQRPQAarghedlfsccqsknfrgasyayfavhITGALVLFMTDGIVGEYSGFI 325
Cdd:COG0738   186 -----LPEIEEEEEEAAGSAASLKSLLKNPRL---------------------------LLGGLAIFLYVGAEGAIGDWL 233

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 326 YSYAVEEpLSVVHKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVtFLLLLIFSSSVVFLFVGTASLGL 405
Cdd:COG0738   234 PLYLKDV-LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAV-GLLLALLAPGPWLALIGLALVGL 311

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 406 FLSSTFPSMLAYTEDILQYKGCATT-VLVTGAGIGEMVLQLLVGSIIHEQG-SYSFLVcgmifgglAFTFYAFLLFFHRM 483
Cdd:COG0738   312 GLSLMFPTIFSLALDGLGKRTAAAVsAVLIMGIVGGAIGPPLIGFLADAFGlRAAFLV--------PLVCYLLILLLALA 383


                  ....
gi 1443734043 484 YPKP 487
Cdd:COG0738   384 LKRK 387
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
308-488 9.34e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.03  E-value: 9.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 308 ALVLFMTDGIVGEYSGFIYSYAVEE-PLSVVHkvAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVTFLLL 386
Cdd:COG2223   211 SLLYFGTFGSFIGFSSWLPPYLVDQfGLSAAT--AGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 387 LIFSSSVVFLFVGTASLGLFLSSTFPSMLAYTEDI--LQYKGCATTVLVTGAGIGEMVLQLLVGSIIHEQGSYSflVCGM 464
Cdd:COG2223   289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIfpTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT--AAFL 366

                         170       180
                  ....*....|....*....|....
gi 1443734043 465 IFGGLAFTFYAFLLFFHRMYPKPS 488
Cdd:COG2223   367 VFAVLALVALVLTLLLYRRPRRAA 390
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 322-476 2.42e-05

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 46.45  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 322 SGFIYSYAVEEPLSVVHKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVtFLLLLIFSSSVVFLFVgTA 401
Cdd:cd17394   247 WSFLINYLMEYIAGLTETSAATFVSYYWGGFMVGRFLGTALLKKISPKKLLAVFALLGLL-LLLGAIFTGGMVALYA-LV 324

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1443734043 402 SLGLFLSSTFPSMLAYTEDIL-QYKGCATTVLVTGAgIGEMVLQLLVGSIIHEQGSYSFLVCGMIFGGLAFTFYAF 476
Cdd:cd17394   325 LVGFFNSIMFPTIFSLALKGLgKHTKTGSGLLVMAI-VGGAVVPLIQGAVADDAAGLRIAFLVPLLCFAYILFYGL 399
MFS_1 pfam07690
Major Facilitator Superfamily;
323-502 1.22e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.25  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 323 GFIYSYAVEEPLSVVHKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVtFLLLLIFSSSVVFLFVGTAS 402
Cdd:pfam07690  16 GPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFAL-GLLLLLFASSLWLLLVLRVL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 403 LGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGEMVLQLLVGSIIHeqgSYSFLVCGMIFGGLAFtFYAFLLFF 480
Cdd:pfam07690  95 QGLGAGALFPAALALIADWFppEERGRALGLVSAGFGLGAALGPLLGGLLAS---LFGWRAAFLILAILSL-LAAVLLLL 170

                         170       180
                  ....*....|....*....|..
gi 1443734043 481 HRMYPKPSSDLDATSPDKPAVT 502
Cdd:pfam07690 171 PRPPPESKRPKPAEEARLSLIV 192
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
308-478 1.44e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 1.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 308 ALVLFMTDGIVGEYSGFIYSYAVEEpLSVVHKVAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVGVLVT-FLLL 386
Cdd:COG2271   186 ALAYFLVYFALYGFLTWLPTYLVEV-RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAlALLL 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 387 LIFSSSVVFLFVGTASLGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGEMVLQLLVGSIIHEQGSYSFLVCGM 464
Cdd:COG2271   265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFpkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344

                         170
                  ....*....|....
gi 1443734043 465 IFGGLAFTFYAFLL 478
Cdd:COG2271   345 ALALLAALLALLLL 358
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 340-422 5.11e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 340 VAGYLPSLFWGFITLGRLISIPVSYRMKPATMVFINVVgvLVTFLLLLIFSSSVVFLFVGTASLGLFLSSTFPSMLAYTE 419
Cdd:cd17478   231 FAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLL--LAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQ 308


                  ...
gi 1443734043 420 DIL 422
Cdd:cd17478   309 ELL 311
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 308-482 8.49e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 8.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 308 ALVLFMTDGIVGEYSGFIYSYAVEEPLSvvHKVAGYLPSLFWGFITLGRLISIPVSYRMkPATMVFINVVGVLVTFLLLL 387
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLS--ASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1443734043 388 IFSSSVVFLFVGTASLGLFLSSTFPSMLAYTEDIL--QYKGCATTVLVTGAGIGEMVLQLLVGSIIhEQGSYSFLVCGMI 465
Cdd:cd06174    79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFpeRERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAVFLI 157

                         170
                  ....*....|....*..
gi 1443734043 466 FGGLAFTFYAFLLFFHR 482
Cdd:cd06174   158 AAALALLAAILLLLVVP 174
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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