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Conserved domains on  [gi|1390642043|ref|XP_025018668|]
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uncharacterized protein LOC112540003 [Tetranychus urticae]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 68-240 1.12e-19

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17386:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 360  Bit Score: 87.33  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  68 LISTILVGIIANIG-YSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPLFINVMNLHDTSLAIIGIVSIM 146
Cdd:cd17386   180 LLILLLLAAFLTIFvLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLLKMSDSTLAMLGLASHI 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 147 TAYLTKGFILSPIAYFFT-IFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATLDYNPG 225
Cdd:cd17386   260 LSSLLFAFATNTWMMYLAaVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKATLTTFPG 339

                         170
                  ....*....|....*
gi 1390642043 226 LVYIIAGLLFTIPLA 240
Cdd:cd17386   340 FFFLLSAGLLLIPVI 354
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 68-240 1.12e-19

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 87.33  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  68 LISTILVGIIANIG-YSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPLFINVMNLHDTSLAIIGIVSIM 146
Cdd:cd17386   180 LLILLLLAAFLTIFvLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLLKMSDSTLAMLGLASHI 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 147 TAYLTKGFILSPIAYFFT-IFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATLDYNPG 225
Cdd:cd17386   260 LSSLLFAFATNTWMMYLAaVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKATLTTFPG 339

                         170
                  ....*....|....*
gi 1390642043 226 LVYIIAGLLFTIPLA 240
Cdd:cd17386   340 FFFLLSAGLLLIPVI 354
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
50-251 2.24e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.42  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  50 LHSSRTVFKRRPNnahWYLISTILVGIIANIGYSGdqhIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPL--FI 127
Cdd:COG2223   195 LRDQLEALRDPRF---WLLSLLYFGTFGSFIGFSS---WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLsdRI 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 128 NVMNLHDTSLAIIGIVSIMTAYLTKGFILSPIAyfFTIFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTI 207
Cdd:COG2223   269 GGRRVLLIVFALMALGLLLLALALGSLWLFLVL--FLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1390642043 208 ASVFYSKVFTATLDYNPGLVYIIAGLLFTIPLANAILLNIKKQK 251
Cdd:COG2223   347 GPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
 
Name Accession Description Interval E-value
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 68-240 1.12e-19

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 87.33  E-value: 1.12e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  68 LISTILVGIIANIG-YSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPLFINVMNLHDTSLAIIGIVSIM 146
Cdd:cd17386   180 LLILLLLAAFLTIFvLSGESDVLYLFVLEKFAWNVKDFSYFSTLGSLIYLTGMLGGVLLLRCLLKMSDSTLAMLGLASHI 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 147 TAYLTKGFILSPIAYFFT-IFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATLDYNPG 225
Cdd:cd17386   260 LSSLLFAFATNTWMMYLAaVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESLSPLVASPIYNNIYKATLTTFPG 339

                         170
                  ....*....|....*
gi 1390642043 226 LVYIIAGLLFTIPLA 240
Cdd:cd17386   340 FFFLLSAGLLLIPVI 354
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 66-239 4.73e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 53.35  E-value: 4.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  66 WYLISTILVGIIANIGYSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPLFinVMNLHDTSLAIIGIVSI 145
Cdd:cd17330   174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRL--AKRLGERKLLRLGLLLA 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 146 MTAYLTKGFILSPI--AYFFTIFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTAtldYN 223
Cdd:cd17330   252 IIGLLLLPFASSVPllVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSF---LG 328

                         170
                  ....*....|....*.
gi 1390642043 224 PGLVYIIAGLLFTIPL 239
Cdd:cd17330   329 PGVPFLLAAGLLLIAL 344
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
50-251 2.24e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.42  E-value: 2.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  50 LHSSRTVFKRRPNnahWYLISTILVGIIANIGYSGdqhIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPL--FI 127
Cdd:COG2223   195 LRDQLEALRDPRF---WLLSLLYFGTFGSFIGFSS---WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLsdRI 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 128 NVMNLHDTSLAIIGIVSIMTAYLTKGFILSPIAyfFTIFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTI 207
Cdd:COG2223   269 GGRRVLLIVFALMALGLLLLALALGSLWLFLVL--FLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1390642043 208 ASVFYSKVFTATLDYNPGLVYIIAGLLFTIPLANAILLNIKKQK 251
Cdd:COG2223   347 GPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 91-235 7.21e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 49.49  E-value: 7.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  91 QFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPLFINVMNLHDTSLAIIG----IVSIMTAYLTKGFILSPIAYFFTIF 166
Cdd:cd17319   204 TYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGlllaAVGLLLAYLTTSPVVAVILLSLAGF 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1390642043 167 GSFAAVISLAdrSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATLDYNPGLVYIIAGLLF 235
Cdd:cd17319   284 GIGAASPVFW--SLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALL 350
MFS_SLC46A2_TSCOT cd17450
Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the ...
 101-239 7.45e-07

Solute carrier family 46 member 2, also called Thymic stromal cotransporter protein, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 2 (SLC46A2) is also called thymic stromal cotransporter protein (TSCOT). It is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. Polymorphisms in TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. TSCOT belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341008  Cd Length: 383  Bit Score: 49.75  E-value: 7.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 101 AEQIGY---YGSIVVIFPTLGtligppLFINVMNLHDTSLAIIGIVSIMTAYLTKGFILSPIAYFFTIFGSFAAVISLAD 177
Cdd:cd17450   240 AVEVGYgnaAGYMIFITSFLG------VFVFSRCLRDTTMIMIGMVSFSSGILIMAFVKWTFMFYIARAVMLFALIPLPT 313

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1390642043 178 -RSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATLDYNPGLVYI---IAGLLFTIPL 239
Cdd:cd17450   314 iRSLISKQVQGSSYGKVFVMLQLSLKLTGVATSTIYNKIYQATLDWFPGFCFIlssILGFLSIIPI 379
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
94-240 1.07e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.10  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  94 QKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPL---FINVMNLHDTSLAIIGIVSIMTAYLTKGFILSPIAYFFTIFGSFA 170
Cdd:COG2271   208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLsdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGG 287

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 171 AVISLAdrSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATlDYNPGLVYIIAGLLFTIPLA 240
Cdd:COG2271   288 AFGLLW--ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLA 354
MFS_SLC46A3 cd17448
Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 107-240 1.60e-06

Solute carrier family 46 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 3 (SLC46A3) is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. SLC46A3 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341006  Cd Length: 396  Bit Score: 48.57  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 107 YGSIVVIFPTLGTLIGPPLFINVMNlhDTSLAIIGIVSIMTAYLTKGFILSPIAYFFTIFGS-FAAVISLADRSIISRMI 185
Cdd:cd17448   258 YGSAASTAIFLTSFVGVALFSRCLP--DIYIVFIGIFSVAGGMIMTAFAKTTLLMFLVRLPLlFAIMPFPVLRSMMSKVV 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1390642043 186 HKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTATLDYNPGLVYIIAGLLFTIPLA 240
Cdd:cd17448   336 LPSEQGALFACVAFLETLSGVLSVTIFNSIYAATVAWFPGFSFLLSAGLCLIPAS 390
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 49-240 1.06e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.27  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  49 FLHSSRTVFKRRPnnahwyLISTILVGIIANIGYSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPPL--- 125
Cdd:cd06174   192 VLKLLKRVLKNPG------LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLsdr 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 126 FINVMNLHDTSLAIIGIVSIMTAYLTKGFILSPIAYFFTIFGSFAAVISLAdrsIISRMIHKDEIGQVYAFSSAIGGFSP 205
Cdd:cd06174   266 LIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA---LIAELFPPEIRGTAFGLLNTFGFLGG 342

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1390642043 206 TIASVFYSKVFTATLDYNPGLVYIIAGLLFTIPLA 240
Cdd:cd06174   343 AIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 65-245 5.47e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.06  E-value: 5.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  65 HWYLISTILVGIIANIGYSGDQHIGYQFSQKVYHFSAEQIGyygsIVVIFPTLGTLIGPpLFINVMNLHDTSLAIIGIVS 144
Cdd:cd06173   207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG----LLLAAFGVGALLGA-LLLGRLSKRRRRGRLLLIGA 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 145 IMTAYLTKGFILSPIAY----FFTIFGSFAAVISLADRSIISRMIHKDEIGQVYAFSSAIGGFSPTIASVFYSKVFTAtl 220
Cdd:cd06173   282 LLLGLALLVLGLSPSLWlllaALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA-- 359

                         170       180
                  ....*....|....*....|....*
gi 1390642043 221 dYNPGLVYIIAGLLfTIPLANAILL 245
Cdd:cd06173   360 -LGLSAVFLLAGAL-LLLAALLLLL 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
45-203 7.18e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 7.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  45 KPDNFLHSSRTVFKRRPnnahwyLISTILVGIIANIGYSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIFPTLGTLIGPP 124
Cdd:COG2814   192 ARARLRGSLRELLRRPR------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 125 LF--INVMNLHDTSLAIIGIVSIMTAYLTkGFILSPIAYFFTIFGSFAAVISLAdrSIISRMIHKDEIGQVYAFSSAIGG 202
Cdd:COG2814   266 LAdrFGRRRLLLIGLLLLALGLLLLALAG-SLWLLLLALFLLGFGFGLLFPLLQ--ALVAELAPPEARGRASGLYNSAFF 342


                  .
gi 1390642043 203 F 203
Cdd:COG2814   343 L 343
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
35-244 2.58e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043  35 TVKQIIYDIIKPDNFLHSSRTVFKRRPnnahwyLISTILVGIIANIGYSGDQHIGYQFSQKVYHFSAEQIGYYGSIVVIF 114
Cdd:COG2211   203 GTKERPVPEEEKVSLKESLKALLKNRP------FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390642043 115 PTLGTLIGPPL--FINVMNLHDTSLAIIGIVSIMTAYLTKGFILSPIAYFFtIFGSFAAVISLADRSIISRMIHKDEIGQ 192
Cdd:COG2211   277 ALLGAPLWPRLakRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA-LAGIGLGAILVLPWAMLADVVDYDEWKT 355

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390642043 193 ----------VYAFSSAIG-GFSPTIASVFYSKV-FTATLDYNPGLVYIIAGLLFTIPLANAIL 244
Cdd:COG2211   356 grrreglyfgIFTFAIKLGqALAGALAGLLLALFgYVAGAAQSPSALTGIRLLFFLLPAVLLLL 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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