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Conserved domains on  [gi|1387267338|ref|XP_024847265|]
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integrin alpha-7 isoform X3 [Bos taurus]

Protein Classification

integrin alpha( domain architecture ID 12192668)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.60.40.1530|2.60.40.1510|2.60.40.1460|2.130.10.130
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4007553|4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 498-988 1.18e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 455.63  E-value: 1.18e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  498 RPVLHVSHEVSILPRAIDLEQPNCANG--HLVCMDLRVCFSYIASPSsYSPTVALDYMLDGDTDRRlRGQVPRVTFLsrg 575
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTgtPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFL--- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  576 pDDPKHQSSGTVWLKHQHDRVCGDTMLQLQENVKDKLRAIVVTLSYGLQtprlRRQAPGQGLPPVAPILNAHQPSTQRTE 655
Cdd:pfam08441   76 -DSQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  656 IHFLKQgCGEDKICQSNLQLvQARFCARVSDTEFqplpmdadgttalfALSGQPVIGLELKVTNlpsdpaqpqaDGDDAH 735
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  736 EAQLLVTLPAALHYSGVRGLDPVEKPLCLSDENAS--HVECELGNPMKRGAQVTFYLILSTSGITIETTELEVELLLATI 813
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  814 SEQELH--PVLARARVFIELPLSITGVAIPQQLFFsGVVRGESAM--RSERDVGSKVKYEVTVSNQGQSlnTLGSAFLNI 889
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMkpRSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  890 MWPHEIANGKWLLYPMRVElegGQGPGQrglCSPRPNILQLDVDSRDRRRRELGPPESQEPREQPEPSTSWWPVSSAEKk 969
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 1387267338  970 kniTLDCARGtANCVVFSC 988
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 404-455 3.30e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 70.87  E-value: 3.30e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387267338   404 DSMFGISLAVLGDLNQDGFPDLAVGAPFDGD----GKVFIYHGSSLGVVTKPSQVL 455
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 344-397 1.13e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.16  E-value: 1.13e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387267338   344 SGFGYSLA-VADLNNDGWTDLVVGAPYFFERQEelGGAVYVYMNE--GGHWAGVAPL 397
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSsgGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-109 4.83e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.76  E-value: 4.83e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387267338    48 PGSLFGFSVALHRQLQPRPQSWLLVGAPQAlalpgQQANRTGGLFACPLSLEETDCYRVDID 109
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 465-504 3.48e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.48e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387267338   465 FGYSLSGGLDADGNHYPDLLVGS-LDDTAVLFRARPVLHVS 504
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 315-365 1.06e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


:

Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1387267338  315 NHKGAVVILRKDSASRLVPEVTLSgerlTSGFGYSLAVADLNNDGWTDLVV 365
Cdd:pfam13517   15 DGGLRLYLNNGDGTFTFITSVSLG----GGGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 286-327 2.47e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 2.47e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1387267338   286 NSYLGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 327
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 498-988 1.18e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 455.63  E-value: 1.18e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  498 RPVLHVSHEVSILPRAIDLEQPNCANG--HLVCMDLRVCFSYIASPSsYSPTVALDYMLDGDTDRRlRGQVPRVTFLsrg 575
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTgtPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFL--- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  576 pDDPKHQSSGTVWLKHQHDRVCGDTMLQLQENVKDKLRAIVVTLSYGLQtprlRRQAPGQGLPPVAPILNAHQPSTQRTE 655
Cdd:pfam08441   76 -DSQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  656 IHFLKQgCGEDKICQSNLQLvQARFCARVSDTEFqplpmdadgttalfALSGQPVIGLELKVTNlpsdpaqpqaDGDDAH 735
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  736 EAQLLVTLPAALHYSGVRGLDPVEKPLCLSDENAS--HVECELGNPMKRGAQVTFYLILSTSGITIETTELEVELLLATI 813
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  814 SEQELH--PVLARARVFIELPLSITGVAIPQQLFFsGVVRGESAM--RSERDVGSKVKYEVTVSNQGQSlnTLGSAFLNI 889
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMkpRSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  890 MWPHEIANGKWLLYPMRVElegGQGPGQrglCSPRPNILQLDVDSRDRRRRELGPPESQEPREQPEPSTSWWPVSSAEKk 969
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 1387267338  970 kniTLDCARGtANCVVFSC 988
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 404-455 3.30e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 70.87  E-value: 3.30e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387267338   404 DSMFGISLAVLGDLNQDGFPDLAVGAPFDGD----GKVFIYHGSSLGVVTKPSQVL 455
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 344-397 1.13e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.16  E-value: 1.13e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387267338   344 SGFGYSLA-VADLNNDGWTDLVVGAPYFFERQEelGGAVYVYMNE--GGHWAGVAPL 397
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSsgGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 346-384 2.27e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 56.36  E-value: 2.27e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1387267338  346 FGYSLAVADLNNDGWTDLVVGAPYFFERQeelGGAVYVY 384
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 407-440 2.14e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.89  E-value: 2.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387267338  407 FGISLAVlGDLNQDGFPDLAVGAPF---DGDGKVFIY 440
Cdd:pfam01839    1 FGYSVAV-GDLNGDGYADLAVGAPGeggAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-109 4.83e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.76  E-value: 4.83e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387267338    48 PGSLFGFSVALHRQLQPRPQSWLLVGAPQAlalpgQQANRTGGLFACPLSLEETDCYRVDID 109
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 465-504 3.48e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.48e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387267338   465 FGYSLSGGLDADGNHYPDLLVGS-LDDTAVLFRARPVLHVS 504
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 315-365 1.06e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1387267338  315 NHKGAVVILRKDSASRLVPEVTLSgerlTSGFGYSLAVADLNNDGWTDLVV 365
Cdd:pfam13517   15 DGGLRLYLNNGDGTFTFITSVSLG----GGGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 286-327 2.47e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 2.47e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1387267338   286 NSYLGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 327
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 498-988 1.18e-149

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 455.63  E-value: 1.18e-149
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  498 RPVLHVSHEVSILPRAIDLEQPNCANG--HLVCMDLRVCFSYIASPSsYSPTVALDYMLDGDTDRRlRGQVPRVTFLsrg 575
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTgtPVSCFTVRACFSYTGKPI-PNPSLVLNYELELDRQKK-KGLPPRVLFL--- 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  576 pDDPKHQSSGTVWLKHQHDRVCGDTMLQLQENVKDKLRAIVVTLSYGLQtprlRRQAPGQGLPPVAPILNAHQPSTQRTE 655
Cdd:pfam08441   76 -DSQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLR----VDPRAPSDLPGLKPILDQNQPSTVQEQ 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  656 IHFLKQgCGEDKICQSNLQLvQARFCARVSDTEFqplpmdadgttalfALSGQPVIGLELKVTNlpsdpaqpqaDGDDAH 735
Cdd:pfam08441  151 ANFLKD-CGEDNVCVPDLQL-SAKFDSRESDEPL--------------LLGDDNDLALEITVTN----------LGEDAY 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  736 EAQLLVTLPAALHYSGVRGLDPVEKPLCLSDENAS--HVECELGNPMKRGAQVTFYLILSTSGITIETTELEVELLLATI 813
Cdd:pfam08441  205 EAELYVTLPPGLDYSGVRREGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRST 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  814 SEQELH--PVLARARVFIELPLSITGVAIPQQLFFsGVVRGESAM--RSERDVGSKVKYEVTVSNQGQSlnTLGSAFLNI 889
Cdd:pfam08441  285 NEQNSNsnPVSLKVPVVAEAQLSLSGVSKPDQVVG-GSVKGESAMkpRSEEDIGPLVEHTYEVINNGPS--TVSGASLEI 361

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  890 MWPHEIANGKWLLYPMRVElegGQGPGQrglCSPRPNILQLDVDSRDRRRRELGPPESQEPREQPEPSTSWWPVSSAEKk 969
Cdd:pfam08441  362 SWPYELSNGKWLLYLLDVQ---GQGKGE---CSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASV- 434

                          490
                   ....*....|....*....
gi 1387267338  970 kniTLDCARGtANCVVFSC 988
Cdd:pfam08441  435 ---LLSCDSG-ARCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 404-455 3.30e-15

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 70.87  E-value: 3.30e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387267338   404 DSMFGISLAVLGDLNQDGFPDLAVGAPFDGD----GKVFIYHGSSLGVVTKPSQVL 455
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 344-397 1.13e-10

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 58.16  E-value: 1.13e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387267338   344 SGFGYSLA-VADLNNDGWTDLVVGAPYFFERQEelGGAVYVYMNE--GGHWAGVAPL 397
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRANDAGE--TGAVYVYFGSsgGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 346-384 2.27e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 56.36  E-value: 2.27e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1387267338  346 FGYSLAVADLNNDGWTDLVVGAPYFFERQeelGGAVYVY 384
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 354-427 2.59e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 51.46  E-value: 2.59e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387267338  354 DLNNDGWTDLVVGAPyfferqeelgGAVYVYMNEG-GHWAGVAPLRLCGSLDSMfgiSLAVlGDLNQDGFPDLAV 427
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNGdGTFTFITSVSLGGGGGGL---SVAV-GDLDGDGRLDLLV 61
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 407-440 2.14e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.89  E-value: 2.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387267338  407 FGISLAVlGDLNQDGFPDLAVGAPF---DGDGKVFIY 440
Cdd:pfam01839    1 FGYSVAV-GDLNGDGYADLAVGAPGeggAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-109 4.83e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 47.76  E-value: 4.83e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387267338    48 PGSLFGFSVALHRQLQPRPQSWLLVGAPQAlalpgQQANRTGGLFACPLSLEETDCYRVDID 109
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRA-----NDAGETGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 416-485 3.77e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.60  E-value: 3.77e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387267338  416 DLNQDGFPDLAVGapfdGDGKVFIYHGSSLGVVTKPSQVlegeAVGIKSFGYSLSGGlDADGNHYPDLLV 485
Cdd:pfam13517    1 DLDGDGKLDLVVA----NDGGLRLYLNNGDGTFTFITSV----SLGGGGGGLSVAVG-DLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 465-504 3.48e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 39.67  E-value: 3.48e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387267338   465 FGYSLSGGLDADGNHYPDLLVGS-LDDTAVLFRARPVLHVS 504
Cdd:smart00191    5 FGYSVAGVGDVNGDGYPDLLVGApRANDAGETGAVYVYFGS 45
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 315-365 1.06e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 38.36  E-value: 1.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1387267338  315 NHKGAVVILRKDSASRLVPEVTLSgerlTSGFGYSLAVADLNNDGWTDLVV 365
Cdd:pfam13517   15 DGGLRLYLNNGDGTFTFITSVSLG----GGGGGLSVAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 286-327 2.47e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.35  E-value: 2.47e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1387267338   286 NSYLGFSIDSGKGLVRAEELSFVAGAPRANHK---GAVVILRKDS 327
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAgetGAVYVYFGSS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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