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Conserved domains on  [gi|1387223166|ref|XP_024835587|]
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nuclear receptor corepressor 1 isoform X4 [Bos taurus]

Protein Classification

nuclear receptor corepressor 1( domain architecture ID 15502538)

nuclear receptor corepressor 1 (NCOR1) is a transcriptional coregulatory protein which assists nuclear receptors in the down regulation of gene expression

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580|20084085
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GPS2_interact super family cl24372
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 151-240 3.47e-26

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


The actual alignment was detected with superfamily member pfam15784:

Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 104.17  E-value: 3.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  151 FGVKHEAPSSPISGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 230
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1387223166  231 EQKHRSVVQI 240
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 630-673 6.33e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.33e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1387223166  630 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 673
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 442-484 1.31e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1387223166  442 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 484
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
MDN1 super family cl34967
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 708-912 6.66e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5271:

Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 45.39  E-value: 6.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  708 TVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPGEDSTENAPPRGTAEAAAELEATPDAVPRPSPSPA 787
Cdd:COG5271    266 GTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAED 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  788 AASTkvAEDDSVEAPANDSITVDTAEPMEVEHEEHGAEGTSALDLPSAAKADAVDVEM--RVPESSPSRVEGDPKDRDLQ 865
Cdd:COG5271    346 AAEE--AATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEAsaDGGTSPTSDTDEEEEEADED 423

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1387223166  866 RSGEKPEPGEDDlgvaqqlsAPRPEPLSDHDSSATCSADEDVDGEPE 912
Cdd:COG5271    424 ASAGETEDESTD--------VTSAEDDIATDEEADSLADEEEEAEAE 462
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 151-240 3.47e-26

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 104.17  E-value: 3.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  151 FGVKHEAPSSPISGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 230
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1387223166  231 EQKHRSVVQI 240
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 630-673 6.33e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.33e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1387223166  630 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 673
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 630-673 1.37e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1387223166  630 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 673
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
630-675 2.18e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.18e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1387223166   630 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 675
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 442-484 1.31e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1387223166  442 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 484
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
440-485 4.03e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.03e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1387223166   440 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 485
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 442-481 5.36e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1387223166  442 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 481
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 708-912 6.66e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 45.39  E-value: 6.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  708 TVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPGEDSTENAPPRGTAEAAAELEATPDAVPRPSPSPA 787
Cdd:COG5271    266 GTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAED 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  788 AASTkvAEDDSVEAPANDSITVDTAEPMEVEHEEHGAEGTSALDLPSAAKADAVDVEM--RVPESSPSRVEGDPKDRDLQ 865
Cdd:COG5271    346 AAEE--AATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEAsaDGGTSPTSDTDEEEEEADED 423

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1387223166  866 RSGEKPEPGEDDlgvaqqlsAPRPEPLSDHDSSATCSADEDVDGEPE 912
Cdd:COG5271    424 ASAGETEDESTD--------VTSAEDDIATDEEADSLADEEEEAEAE 462
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 699-1075 1.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  699 VSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPGEDSTENAPPRGTAEAAAELEATPDA 778
Cdd:PHA03307    45 SDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  779 VPRPSPSPAAASTKVAEDDSVEAPANDSITVDTAEPMEVEHEEHGAEGTSALDLPSAAKADAVDV-EMRVPESSPSRVEG 857
Cdd:PHA03307   125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPpAEPPPSTPPAAASP 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  858 DPKDRDLQRSGEKPEPGEDDlgvAQQLSAPRPEPLSDHDSSATCSADEDVDGEPERQRMFPMDSKPSLLNPAGSILVSSP 937
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAP---GRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  938 IKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIgtpvsgyalyqrhikamheSALLEEQRQRQEQLDLECRSSTSPCSAARS 1017
Cdd:PHA03307   282 PGPASSSSSPRERSPSPSPSSPGSGPAPSSP-------------------RASSSSSSSRESSSSSTSSSSESSRGAAVS 342

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387223166 1018 PGR-------DWEGKSVAYMPYAEATRALEQEAQMHSTAARSASPCRLSPQPGVGAVRSSGPPVL 1075
Cdd:PHA03307   343 PGPspsrspsPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRF 407
 
Name Accession Description Interval E-value
GPS2_interact pfam15784
G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain ...
 151-240 3.47e-26

G-protein pathway suppressor 2-interacting domain; GPS2_interact is the more N-terminal domain of two co-repressor protein-families found in vertebrates. The domain is found in NCoR and SMRT proteins; N-CoR (nuclear receptor co-repressor) and SMRT (silencing mediator for retinoid and thyroid receptors) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways.


Pssm-ID: 464868 [Multi-domain]  Cd Length: 89  Bit Score: 104.17  E-value: 3.47e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  151 FGVKHEAPSSPISGqPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPV 230
Cdd:pfam15784    1 YYPQVEAISPTLPS-PEGQDQELSPFRSSKDELLQNIDKVDREIAKVEQQISKLKKKQQQLEEEAAKPPEPEEPVSPPPS 79

                           90
                   ....*....|
gi 1387223166  231 EQKHRSVVQI 240
Cdd:pfam15784   80 ESKHRSLAQI 89
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 630-673 6.33e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.14  E-value: 6.33e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1387223166  630 RWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYK 673
Cdd:pfam00249    3 PWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 630-673 1.37e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.36  E-value: 1.37e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1387223166  630 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYK 673
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
630-675 2.18e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.00  E-value: 2.18e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1387223166   630 RWTEEEMEVAKKGLVEHG-RNWAAIAKMVGTKSEAQCKNFYFNYKRR 675
Cdd:smart00717    3 EWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 442-484 1.31e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.41  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1387223166  442 WTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTK 484
Cdd:cd00167      2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
440-485 4.03e-04

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 40.28  E-value: 4.03e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 1387223166   440 NVWTDHEKEIFKDKFIQHP-KNFGLIASYLERKSVPDCVLYYYLTKK 485
Cdd:smart00717    2 GEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLK 48
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 442-481 5.36e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 39.79  E-value: 5.36e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1387223166  442 WTDHEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYY 481
Cdd:pfam00249    4 WTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQ 43
MDN1 COG5271
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ...
 708-912 6.66e-04

Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444083 [Multi-domain]  Cd Length: 1028  Bit Score: 45.39  E-value: 6.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  708 TVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPGEDSTENAPPRGTAEAAAELEATPDAVPRPSPSPA 787
Cdd:COG5271    266 GTPDTDDEATDDADGLEAAEDDALDAELTAAQAADPESDDDADDSTLAALEGAAEDTEIATADELAAADDEDDDDSAAED 345

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  788 AASTkvAEDDSVEAPANDSITVDTAEPMEVEHEEHGAEGTSALDLPSAAKADAVDVEM--RVPESSPSRVEGDPKDRDLQ 865
Cdd:COG5271    346 AAEE--AATAEDSAAEDTQDAEDEAAGEAADESEGADTDAAADEADAAADDSADDEEAsaDGGTSPTSDTDEEEEEADED 423

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1387223166  866 RSGEKPEPGEDDlgvaqqlsAPRPEPLSDHDSSATCSADEDVDGEPE 912
Cdd:COG5271    424 ASAGETEDESTD--------VTSAEDDIATDEEADSLADEEEEAEAE 462
SANT_MTA3_like cd11661
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ...
 442-485 9.88e-04

Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.


Pssm-ID: 212559 [Multi-domain]  Cd Length: 46  Bit Score: 39.13  E-value: 9.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1387223166  442 WTDHEKEIFKDKFIQHPKNFGLI-ASYLERKSVPDCVLYYYLTKK 485
Cdd:cd11661      2 WSESEAKLFEEGLRKYGKDFHDIrQDFLPWKSVGELVEFYYMWKK 46
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 699-1075 1.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  699 VSQCESVASTVSAQEDEDIEASNEEENPEDSEGAENSSDTESAPSPSPVEAVKPGEDSTENAPPRGTAEAAAELEATPDA 778
Cdd:PHA03307    45 SDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPA 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  779 VPRPSPSPAAASTKVAEDDSVEAPANDSITVDTAEPMEVEHEEHGAEGTSALDLPSAAKADAVDV-EMRVPESSPSRVEG 857
Cdd:PHA03307   125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPpAEPPPSTPPAAASP 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  858 DPKDRDLQRSGEKPEPGEDDlgvAQQLSAPRPEPLSDHDSSATCSADEDVDGEPERQRMFPMDSKPSLLNPAGSILVSSP 937
Cdd:PHA03307   205 RPPRRSSPISASASSPAPAP---GRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR 281

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  938 IKPNPLDLPQLQHRAAVIPPMVSCTPCNIPIgtpvsgyalyqrhikamheSALLEEQRQRQEQLDLECRSSTSPCSAARS 1017
Cdd:PHA03307   282 PGPASSSSSPRERSPSPSPSSPGSGPAPSSP-------------------RASSSSSSSRESSSSSTSSSSESSRGAAVS 342

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387223166 1018 PGR-------DWEGKSVAYMPYAEATRALEQEAQMHSTAARSASPCRLSPQPGVGAVRSSGPPVL 1075
Cdd:PHA03307   343 PGPspsrspsPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRF 407
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 631-678 2.77e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.06  E-value: 2.77e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1387223166  631 WTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKnFYFNYKRRHNL 678
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCF-DRWRRKLNPKI 47
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
731-904 6.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 41.76  E-value: 6.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  731 GAENSSDTESAPSPSPVEAVKPG-EDSTENAPPRGTAEAAAELEATPDAVPRPSPSPAAASTKVAEDDSVEAPANDSITV 809
Cdd:PRK07003   370 GGVPARVAGAVPAPGARAAAAVGaSAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPV 449

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  810 DTAEPMEVEHEEHGAEGTSALDLPSAAKADAVDvemrvPESSPSRVEGDPKDRDLQRSGEKPEPGEDDLGVAQQLSAP-R 888
Cdd:PRK07003   450 PAKANARASADSRCDERDAQPPADSGSASAPAS-----DAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPaA 524

                          170
                   ....*....|....*.
gi 1387223166  889 PEPLSDHDSSATCSAD 904
Cdd:PRK07003   525 AAPPAPEARPPTPAAA 540
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 717-882 7.01e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 41.50  E-value: 7.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  717 IEASNEEENPEDSEGAENSSDTESAPSPSPVEA---------VKPGEDSTENAPPRGTAEAAAELEATPDAVPRPSPSPA 787
Cdd:PRK13108   273 ILAPKGREAPGALRGSEYVVDEALEREPAELAAaavasaasaVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAAESVVQV 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387223166  788 A---ASTKVAEDDSVEA----PANDSITVDTAEPMEVEHEEHGAEGTSALDLPSAAKADAvdvEMRVPESSPSRVEGDpK 860
Cdd:PRK13108   353 AdrdGESTPAVEETSEAdierEQPGDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDET---EPEVPEKAAPIPDPA-K 428

                          170       180
                   ....*....|....*....|..
gi 1387223166  861 DRDLQRSGEKPEPGEDDLGVAQ 882
Cdd:PRK13108   429 PDELAVAGPGDDPAEPDGIRRQ 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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