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Conserved domains on  [gi|1381517241|ref|XP_024648091|]
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protein bassoon [Macaca nemestrina]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 95-158 5.76e-45

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


:

Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 157.55  E-value: 5.76e-45
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1381517241   95 PSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGM 158
Cdd:cd15773      1 PSSTLCPICNTTELTSFPSQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 64
FYVE_like_SF super family cl28890
FYVE domain like superfamily; FYVE domain is a 60-80 residue double zinc finger ...
 392-456 4.10e-41

FYVE domain like superfamily; FYVE domain is a 60-80 residue double zinc finger motif-containing module named after the four proteins, Fab1, YOTB, Vac1, and EEA1. The canonical FYVE domains are distinguished from other zinc fingers by three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif, which form a compact phosphatidylinositol 3-phosphate (PtdIns3P, also termed PI3P)-binding site. They are found in many membrane trafficking regulators, including EEA1, Hrs, Vac1p, Vps27p, and FENS-1, which locate to early endosomes, specifically bind PtdIns3P, and play important roles in vesicular traffic and in signal transduction. Some proteins, such as rabphilin-3A and alpha-Rab3-interacting molecules (RIMs), are also involved in membrane trafficking and bind to members of the Rab subfamily of GTP hydrolases. However, they contain FYVE-related domains that are structurally similar to the canonical FYVE domains but lack the three signature sequences. At this point, they may not bind to phosphoinositides. In addition, this superfamily also contains the third group of proteins, caspase-associated ring proteins CARP1 and CARP2. They do not localize to membranes in the cell and are involved in the negative regulation of apoptosis, specifically targeting two initiator caspases, caspase 8 and caspase 10, which are distinguished from other FYVE-type proteins. Moreover, these proteins have an altered sequence in the basic ligand binding patch and lack the WxxD motif that is conserved only in phosphoinositide binding FYVE domains. Thus they constitute a family of unique FYVE-type domains called FYVE-like domains. The FYVE domain is structurally similar to the RING domain and the PHD finger. This superfamily also includes ADDz zinc finger domain, which is a PHD-like zinc finger motif that contains two parts, a C2-C2 and a PHD-like zinc finger.


The actual alignment was detected with superfamily member cd15775:

Pssm-ID: 333710 [Multi-domain]  Cd Length: 65  Bit Score: 146.60  E-value: 4.10e-41
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1381517241  392 RATCPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLG 456
Cdd:cd15775      1 RVTCPLCKTELNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLLEGSLG 65
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 3733-3854 1.58e-08

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 60.77  E-value: 1.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3733 GLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGkPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTPG 3812
Cdd:PRK07764   391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1381517241 3813 PGPAGVKAGARPGGTPGAPASQPGADGESVFSKILPGGAAEQ 3854
Cdd:PRK07764   470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 3415-3837 2.97e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 2.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3415 PKPSSLSMAHSRARPPMRSQASEEESPVSPLGRPRPAGGPLPPSGDTCPqfcsshsmPDVQehvKDGPRAHAYKREEGyi 3494
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA--------PDPP---PPSPSPAANEPDPH-- 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3495 lddshcvvsdSEAYHLGQEETDWFDKPRDARSDRFRHHGGHAVSSSSQKRGPARH-------SYHDYDEPPEEGLWPhdE 3567
Cdd:PHA03247  2642 ----------PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaarptvgSLTSLADPPPPPPTP--E 2709

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3568 GGPGRHASAKEHRHHGDHGRHSGRHTGEEPGRRAAkPHARDLGRHEARPHSQPssAPAMPKKGQPgyPSSAEYSQPSRAP 3647
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-PAGPATPGGPARPARPP--TTAGPPAPAP--PAAPAAGPPRRLT 2784

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3648 SAYHHASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQ 3727
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR 2864

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3728 QQQSLGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQtngSKGTAKAPQQGRAPQA 3807
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP---PPQPQPPPPPPPRPQP 2941

                          410       420       430
                   ....*....|....*....|....*....|
gi 1381517241 3808 QPTPGPGPAGVkagarPGGTPGAPASQPGA 3837
Cdd:PHA03247  2942 PLAPTTDPAGA-----GEPSGAVPQPWLGA 2966
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1238-1592 3.25e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1238 PLTPGTSPTQLTAPVSFSTPT----SSDSSGGRVIPDVRVTQ-----HFAKETQDPLKLHSSPASASLTSKEVGMPFSQG 1308
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPperpRDDPAPGRVSRPRRARRlgraaQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1309 PG---TPATTAVAPCPAGLPRGYMTPASPAGSERSPSPSSTAHSYGHSPTTANYGSQTEDLPQAPIGLAAAGQAAREKPL 1385
Cdd:PHA03247  2708 PEpapHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1386 SASDGEGGTPQPSRAYSYVASSSPPLSPSSPSESPTFSPGKLGPRATAEFSTQTPSPAPASDMPR----SPGAPI----P 1457
Cdd:PHA03247  2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVrrrpP 2867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1458 SPMVAQGTQTPHRPSTPRLVWQESSQEAPfmviTLASDASSQTRMVHASASTSPLCSPTEIQPtthgySQTTPPSVSQLP 1537
Cdd:PHA03247  2868 SRSPAAKPAAPARPPVRRLARPAVSRSTE----SFALPPDQPERPPQPQAPPPPQPQPQPPPP-----PQPQPPPPPPPR 2938

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1381517241 1538 PEPPGPPGFPRAPSAGADGPLALYGWGALPAENISLCRI-SSVPGTSRVEPGPRPP 1592
Cdd:PHA03247  2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrVPQPAPSREAPASSTP 2994
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
126-279 1.37e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14971:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 614  Bit Score: 44.77  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  126 KVCNQCGFN----PNPHLtQVKEWLCLNCQmqraLGMDMTTAPRSKSQQQLHSPALS-PAhsPAKQPLGKPEQERSRGPG 200
Cdd:PRK14971   333 KLCNQCDLNyrasKNKRL-LVELTLIQLAQ----LTQKGDDASGGRGPKQHIKPVFTqPA--AAPQPSAAAAASPSPSQS 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  201 GLQPGSHQGEIARATSVPEPAQAAAPPEVGRVSPQ---PPQPTKPSTAEPRPPageAPAKSATAVPTGLGATEQTQEGLT 277
Cdd:PRK14971   406 SAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPstaPQAVRPAQFKEEKKI---PVSKVSSLGPSTLRPIQEKAEQAT 482


                   ..
gi 1381517241  278 GK 279
Cdd:PRK14971   483 GN 484
DUF4659 super family cl37893
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 2287-2360 8.38e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


The actual alignment was detected with superfamily member pfam15558:

Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.56  E-value: 8.38e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381517241 2287 LEK-EEASQEERQRKQ-QEQLLQL-ERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRE-LQELqtIKHHVL 2360
Cdd:pfam15558  108 QEKlERARQEAEQRKQcQEQRLKEkEEELQALREQNSLQLQERLEEACHKRQLKEREEQKKVQENnLSEL--LNHQAR 183
 
Name Accession Description Interval E-value
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 95-158 5.76e-45

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 157.55  E-value: 5.76e-45
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1381517241   95 PSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGM 158
Cdd:cd15773      1 PSSTLCPICNTTELTSFPSQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 64
FYVE2_BSN cd15775
FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 392-456 4.10e-41

FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277314 [Multi-domain]  Cd Length: 65  Bit Score: 146.60  E-value: 4.10e-41
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1381517241  392 RATCPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLG 456
Cdd:cd15775      1 RVTCPLCKTELNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLLEGSLG 65
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 98-156 8.48e-36

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 131.00  E-value: 8.48e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241   98 TLCPICKTSDLTS-TPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRAL 156
Cdd:pfam05715    1 TLCPLCKTTELNVgSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 393-451 1.76e-35

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 130.23  E-value: 1.76e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  393 ATCPLCQ-AELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLL 451
Cdd:pfam05715    1 TLCPLCKtTELNVGSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3733-3854 1.58e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 60.77  E-value: 1.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3733 GLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGkPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTPG 3812
Cdd:PRK07764   391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1381517241 3813 PGPAGVKAGARPGGTPGAPASQPGADGESVFSKILPGGAAEQ 3854
Cdd:PRK07764   470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3415-3837 2.97e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 2.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3415 PKPSSLSMAHSRARPPMRSQASEEESPVSPLGRPRPAGGPLPPSGDTCPqfcsshsmPDVQehvKDGPRAHAYKREEGyi 3494
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA--------PDPP---PPSPSPAANEPDPH-- 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3495 lddshcvvsdSEAYHLGQEETDWFDKPRDARSDRFRHHGGHAVSSSSQKRGPARH-------SYHDYDEPPEEGLWPhdE 3567
Cdd:PHA03247  2642 ----------PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaarptvgSLTSLADPPPPPPTP--E 2709

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3568 GGPGRHASAKEHRHHGDHGRHSGRHTGEEPGRRAAkPHARDLGRHEARPHSQPssAPAMPKKGQPgyPSSAEYSQPSRAP 3647
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-PAGPATPGGPARPARPP--TTAGPPAPAP--PAAPAAGPPRRLT 2784

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3648 SAYHHASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQ 3727
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR 2864

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3728 QQQSLGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQtngSKGTAKAPQQGRAPQA 3807
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP---PPQPQPPPPPPPRPQP 2941

                          410       420       430
                   ....*....|....*....|....*....|
gi 1381517241 3808 QPTPGPGPAGVkagarPGGTPGAPASQPGA 3837
Cdd:PHA03247  2942 PLAPTTDPAGA-----GEPSGAVPQPWLGA 2966
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1238-1592 3.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1238 PLTPGTSPTQLTAPVSFSTPT----SSDSSGGRVIPDVRVTQ-----HFAKETQDPLKLHSSPASASLTSKEVGMPFSQG 1308
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPperpRDDPAPGRVSRPRRARRlgraaQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1309 PG---TPATTAVAPCPAGLPRGYMTPASPAGSERSPSPSSTAHSYGHSPTTANYGSQTEDLPQAPIGLAAAGQAAREKPL 1385
Cdd:PHA03247  2708 PEpapHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1386 SASDGEGGTPQPSRAYSYVASSSPPLSPSSPSESPTFSPGKLGPRATAEFSTQTPSPAPASDMPR----SPGAPI----P 1457
Cdd:PHA03247  2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVrrrpP 2867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1458 SPMVAQGTQTPHRPSTPRLVWQESSQEAPfmviTLASDASSQTRMVHASASTSPLCSPTEIQPtthgySQTTPPSVSQLP 1537
Cdd:PHA03247  2868 SRSPAAKPAAPARPPVRRLARPAVSRSTE----SFALPPDQPERPPQPQAPPPPQPQPQPPPP-----PQPQPPPPPPPR 2938

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1381517241 1538 PEPPGPPGFPRAPSAGADGPLALYGWGALPAENISLCRI-SSVPGTSRVEPGPRPP 1592
Cdd:PHA03247  2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrVPQPAPSREAPASSTP 2994
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1202-1532 6.67e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.72  E-value: 6.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1202 RQASSRDLAFAEDKKKEKQFLNAESAYMDPMKQNGGPLTPGTSPTQLTA-----PVSFSTPTSSDSSGGRVIPDVRVTQh 1276
Cdd:pfam17823   40 QNASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEVTAehtphGTDLSEPATREGAADGAASRALAAA- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1277 fAKETQDPLKLHSSPASASLTSKEVGMPFSQGPGTPATTAVAPCPAGLPRGYMTPASPAGSERSPSPSSTAHSYGHSPTT 1356
Cdd:pfam17823  119 -ASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTT 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1357 ANYGSQTEDLPQAPIGLAA-------AGQAAREKPLSAS-----DGEGGTPQPSRAYSYVASSSPPLSPSSPSESPTFSP 1424
Cdd:pfam17823  198 AASSAPATLTPARGISTAAtatghpaAGTALAAVGNSSPaagtvTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHA 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1425 GKLGPRATAEFSTQTPSPAPAS-------------DMPRSPGAPIPSPmvaQGTQTPHRPSTPRLVWQESSQeapfmVIT 1491
Cdd:pfam17823  278 RRLSPAKHMPSDTMARNPAAPMgaqaqgpiiqvstDQPVHNTAGEPTP---SPSNTTLEPNTPKSVASTNLA-----VVT 349

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1381517241 1492 lasdaSSQTRMVHASASTSPLcSPTEIQPTTHGYSQTTPPS 1532
Cdd:pfam17823  350 -----TTKAQAKEPSASPVPV-LHTSMIPEVEATSPTTQPS 384
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
126-279 1.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.77  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  126 KVCNQCGFN----PNPHLtQVKEWLCLNCQmqraLGMDMTTAPRSKSQQQLHSPALS-PAhsPAKQPLGKPEQERSRGPG 200
Cdd:PRK14971   333 KLCNQCDLNyrasKNKRL-LVELTLIQLAQ----LTQKGDDASGGRGPKQHIKPVFTqPA--AAPQPSAAAAASPSPSQS 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  201 GLQPGSHQGEIARATSVPEPAQAAAPPEVGRVSPQ---PPQPTKPSTAEPRPPageAPAKSATAVPTGLGATEQTQEGLT 277
Cdd:PRK14971   406 SAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPstaPQAVRPAQFKEEKKI---PVSKVSSLGPSTLRPIQEKAEQAT 482


                   ..
gi 1381517241  278 GK 279
Cdd:PRK14971   483 GN 484
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 2287-2360 8.38e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.56  E-value: 8.38e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381517241 2287 LEK-EEASQEERQRKQ-QEQLLQL-ERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRE-LQELqtIKHHVL 2360
Cdd:pfam15558  108 QEKlERARQEAEQRKQcQEQRLKEkEEELQALREQNSLQLQERLEEACHKRQLKEREEQKKVQENnLSEL--LNHQAR 183
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2276-2353 9.84e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 9.84e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381517241 2276 GGGSGALSRSGLEKEEASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRELQELQ 2353
Cdd:COG1196    656 GSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAE 733
 
Name Accession Description Interval E-value
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 95-158 5.76e-45

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 157.55  E-value: 5.76e-45
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1381517241   95 PSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGM 158
Cdd:cd15773      1 PSSTLCPICNTTELTSFPSQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 64
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 98-158 1.93e-42

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 150.15  E-value: 1.93e-42
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1381517241   98 TLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGM 158
Cdd:cd15771      1 TLCPLCNTTELTLHVPKPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
FYVE2_BSN cd15775
FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 392-456 4.10e-41

FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277314 [Multi-domain]  Cd Length: 65  Bit Score: 146.60  E-value: 4.10e-41
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1381517241  392 RATCPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLG 456
Cdd:cd15775      1 RVTCPLCKTELNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLLEGSLG 65
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 393-456 6.59e-41

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 145.94  E-value: 6.59e-41
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1381517241  393 ATCPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLG 456
Cdd:cd15772      1 VTCPLCKTELNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLMSGGLG 64
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 98-156 8.48e-36

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 131.00  E-value: 8.48e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241   98 TLCPICKTSDLTS-TPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRAL 156
Cdd:pfam05715    1 TLCPLCKTTELNVgSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
zf-piccolo pfam05715
Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. ...
 393-451 1.76e-35

Piccolo Zn-finger; This (predicted) Zinc finger is found in the bassoon and piccolo proteins. There are eight conserved cysteines, suggesting that it coordinates two zinc ligands.


Pssm-ID: 461722 [Multi-domain]  Cd Length: 60  Bit Score: 130.23  E-value: 1.76e-35
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  393 ATCPLCQ-AELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLL 451
Cdd:pfam05715    1 TLCPLCKtTELNVGSKEPPNYNTCTECKSQVCNLCGFNPTPHLTEKKEWLCLNCQTQRAL 60
FYVE1_PCLO cd15774
FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 98-158 2.75e-31

FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277313 [Multi-domain]  Cd Length: 62  Bit Score: 118.21  E-value: 2.75e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1381517241   98 TLCPICKTSDL-TSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGM 158
Cdd:cd15774      1 TICPLCKTTELlLHTPEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
FYVE2_PCLO cd15776
FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 394-456 6.05e-31

FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277315 [Multi-domain]  Cd Length: 64  Bit Score: 117.48  E-value: 6.05e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1381517241  394 TCPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLG 456
Cdd:cd15776      2 LCPLCKTELNIGSKDPPNFNTCTECKKTVCNLCGFNPTPHLTEVKEWLCLNCQTQRAMSGQLG 64
FYVE_BSN_PCLO cd15751
FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon ...
 98-158 4.68e-29

FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277290 [Multi-domain]  Cd Length: 62  Bit Score: 111.77  E-value: 4.68e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1381517241   98 TLCPICKTSDL-TSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGM 158
Cdd:cd15751      1 SACPLCGTSELpLGSKSPPNYNTCTDCKNRVCNQCGFNSTPPVTKVKEWLCLNCQKKRALGA 62
FYVE_BSN_PCLO cd15751
FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon ...
 394-452 3.42e-26

FYVE-related domain found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277290 [Multi-domain]  Cd Length: 62  Bit Score: 103.68  E-value: 3.42e-26
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  394 TCPLC-QAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLE 452
Cdd:cd15751      2 ACPLCgTSELPLGSKSPPNYNTCTDCKNRVCNQCGFNSTPPVTKVKEWLCLNCQKKRALG 61
FYVE2_BSN_PCLO cd15772
FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein ...
 100-156 2.38e-25

FYVE-related domain 2 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the second FYVE-related domain.


Pssm-ID: 277311 [Multi-domain]  Cd Length: 64  Bit Score: 101.65  E-value: 2.38e-25
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381517241  100 CPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRAL 156
Cdd:cd15772      3 CPLCKTELNVGSKEPPNYNTCTQCHTQVCNLCGFNPTPHLVEKKEWLCLNCQTQRLM 59
FYVE1_PCLO cd15774
FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 395-453 3.26e-24

FYVE-related domain 1 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277313 [Multi-domain]  Cd Length: 62  Bit Score: 98.18  E-value: 3.26e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  395 CPLCQA-ELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEG 453
Cdd:cd15774      3 CPLCKTtELLLHTPEKANYNTCTQCQTTVCSLCGFNPNPHITEKKEWLCLNCQMQRALGG 62
FYVE2_PCLO cd15776
FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a ...
 98-156 4.04e-24

FYVE-related domain 2 found in protein piccolo; Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Piccolo is a multi-domain protein containing two N-terminal FYVE zinc fingers, a polyproline tract, and a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277315 [Multi-domain]  Cd Length: 64  Bit Score: 97.83  E-value: 4.04e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1381517241   98 TLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRAL 156
Cdd:cd15776      1 LLCPLCKTELNIGSKDPPNFNTCTECKKTVCNLCGFNPTPHLTEVKEWLCLNCQTQRAM 59
FYVE2_BSN cd15775
FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 99-156 1.51e-23

FYVE-related domain 2 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the second FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277314 [Multi-domain]  Cd Length: 65  Bit Score: 96.52  E-value: 1.51e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1381517241   99 LCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRAL 156
Cdd:cd15775      3 TCPLCKTELNVGSTEPPNYNTCTSCRTQVCNLCGFNPTPHLVEKNEWLCLNCQTQRLL 60
FYVE1_BSN_PCLO cd15771
FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein ...
 395-453 3.12e-21

FYVE-related domain 1 found in protein bassoon and piccolo; This family includes protein bassoon and piccolo. Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Protein piccolo, also termed aczonin, is a neuron-specific presynaptic active zone scaffolding protein that mainly interacts with a detergent-resistant cytoskeletal-like subcellular fraction and is involved in the organization of the interplay between neurotransmitter vesicles, the cytoskeleton, and the plasma membrane at synaptic active zones. It binds profilin, an actin-binding protein implicated in actin cytoskeletal dynamics. It also functions as a presynaptic low-affinity Ca2+ sensor and has been implicated in Ca2+ regulation of neurotransmitter release. Both bassoon and piccolo contain two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. Their FYVE domain resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. This model corresponds to the first FYVE-related domain.


Pssm-ID: 277310 [Multi-domain]  Cd Length: 61  Bit Score: 89.68  E-value: 3.12e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1381517241  395 CPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEG 453
Cdd:cd15771      3 CPLCNTTELTLHVPKPNFNTCTQCHTTVCNQCGFNPNPHLTEVKEWLCLNCQMQRALGM 61
FYVE1_BSN cd15773
FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger ...
 395-451 4.23e-19

FYVE-related domain 1 found in protein bassoon; Protein bassoon, also termed zinc finger protein 231, is a core component of the presynaptic cytomatrix. It is a vertebrate-specific active zone scaffolding protein that plays a key role in structural organization and functional regulation of presynaptic release sites. Bassoon may modulate synaptic transmission efficiency by binding to presynaptic P/Q-type voltage-dependent calcium channel (VDCC) complexes and modify the channel function. As one of the most highly phosphorylated synaptic proteins, bassoon can interact with the small ubiquitous adaptor protein 14-3-3 in a phosphorylation-dependent manner, which modulates its anchoring to the presynaptic cytomatrix. Bassoon contains two N-terminal FYVE zinc fingers, a PDZ domain and two C-terminal C2 domains. This family corresponds to the first FYVE domain, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif.


Pssm-ID: 277312 [Multi-domain]  Cd Length: 64  Bit Score: 83.59  E-value: 4.23e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1381517241  395 CPLCQAELNVGSKSPANYNTCTTCRLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLL 451
Cdd:cd15773      6 CPICNTTELTSFPSQPNFNTCTQCHNKVCNQCGFNPNPHLTEVKEWLCLNCQMQRAL 62
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3733-3854 1.58e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 60.77  E-value: 1.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3733 GLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGkPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTPG 3812
Cdd:PRK07764   391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1381517241 3813 PGPAGVKAGARPGGTPGAPASQPGADGESVFSKILPGGAAEQ 3854
Cdd:PRK07764   470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAAT 511
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3415-3837 2.97e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 60.34  E-value: 2.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3415 PKPSSLSMAHSRARPPMRSQASEEESPVSPLGRPRPAGGPLPPSGDTCPqfcsshsmPDVQehvKDGPRAHAYKREEGyi 3494
Cdd:PHA03247  2575 PRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHA--------PDPP---PPSPSPAANEPDPH-- 2641

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3495 lddshcvvsdSEAYHLGQEETDWFDKPRDARSDRFRHHGGHAVSSSSQKRGPARH-------SYHDYDEPPEEGLWPhdE 3567
Cdd:PHA03247  2642 ----------PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaarptvgSLTSLADPPPPPPTP--E 2709

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3568 GGPGRHASAKEHRHHGDHGRHSGRHTGEEPGRRAAkPHARDLGRHEARPHSQPssAPAMPKKGQPgyPSSAEYSQPSRAP 3647
Cdd:PHA03247  2710 PAPHALVSATPLPPGPAAARQASPALPAAPAPPAV-PAGPATPGGPARPARPP--TTAGPPAPAP--PAAPAAGPPRRLT 2784

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3648 SAYHHASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQ 3727
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR 2864

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3728 QQQSLGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQtngSKGTAKAPQQGRAPQA 3807
Cdd:PHA03247  2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP---PPQPQPPPPPPPRPQP 2941

                          410       420       430
                   ....*....|....*....|....*....|
gi 1381517241 3808 QPTPGPGPAGVkagarPGGTPGAPASQPGA 3837
Cdd:PHA03247  2942 PLAPTTDPAGA-----GEPSGAVPQPWLGA 2966
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3601-3864 2.06e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 2.06e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3601 AAKPHARDLGRHEARPHSQPSSAPAMPKKGQPGYPSsaeysQPSRaPSAYHHASDSKKGSRQAHSGPAALQSKAEPQAQP 3680
Cdd:PHA03247  2558 AAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPP-----QSAR-PRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3681 QLQGRQAAPGPQQSQSPSSRQMPSGAASRqpqpqqqqqqqqqqqqqqqqqslgLQPPQQAPTQARLQQQSQPTARGSAPA 3760
Cdd:PHA03247  2632 SPAANEPDPHPPPTVPPPERPRDDPAPGR------------------------VSRPRRARRLGRAAQASSPPQRPRRRA 2687

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3761 ASQPAGK-------PQPGPTTATGPQPAGP--PRAEQTNGSKGTAKAPQQGRAPQAQPTPGPGPAGVKAGARPGGTPGAP 3831
Cdd:PHA03247  2688 ARPTVGSltsladpPPPPPTPEPAPHALVSatPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP 2767

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1381517241 3832 ASQPGADGESVFSKILPGGAAEQAGKLTEAVSA 3864
Cdd:PHA03247  2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3653-3842 2.31e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 53.84  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3653 ASDSKKGSRQAHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRqmPSGAASRQPQPQQQQQQQQQQQQQQQQQSL 3732
Cdd:PRK07764   588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAA--PAEASAAPAPGVAAPEHHPKHVAVPDASDG 665

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3733 GLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQG-RAPQAQPTP 3811
Cdd:PRK07764   666 GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAAdDPVPLPPEP 745

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1381517241 3812 GPGPAGVKAGARPGGTPGAPASQPGADGESV 3842
Cdd:PRK07764   746 DDPPDPAGAPAQPPPPPAPAPAAAPAAAPPP 776
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3735-3842 8.22e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 8.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3735 QPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTPGPg 3814
Cdd:PRK07764   406 PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAP- 484

                           90       100
                   ....*....|....*....|....*...
gi 1381517241 3815 PAGVKAGARPGGTPGAPASQPGADGESV 3842
Cdd:PRK07764   485 PAAPAPAAAPAAPAAPAAPAGADDAATL 512
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3656-3842 9.49e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 9.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3656 SKKGSRQAHSGPAAlQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQ 3735
Cdd:PRK07764   604 ASSGPPEEAARPAA-PAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPP 682

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3736 PPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEqtnGSKGTAKAPQQGRAPQAQPTPGPGP 3815
Cdd:PRK07764   683 PAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPA---ADDPVPLPPEPDDPPDPAGAPAQPP 759

                          170       180
                   ....*....|....*....|....*..
gi 1381517241 3816 AGVKAGARPGGTPGAPASQPGADGESV 3842
Cdd:PRK07764   760 PPPAPAPAAAPAAAPPPSPPSEEEEMA 786
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3732-3840 1.10e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.53  E-value: 1.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3732 LGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTP 3811
Cdd:PRK07764   385 LGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSA 464

                           90       100
                   ....*....|....*....|....*....
gi 1381517241 3812 GPGPAGVKAGARPGGTPGAPASQPGADGE 3840
Cdd:PRK07764   465 QPAPAPAAAPEPTAAPAPAPPAAPAPAAA 493
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3594-3823 5.84e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.21  E-value: 5.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3594 GEEPGRRAAKPHARDLGRHEARPHSQPSSAPAmpkkgqPGYPSSAEYSQPSRAPSAYHHASDSKKGSRQAHSGPAALQSK 3673
Cdd:PRK07764   589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAA------PAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3674 AEpqaqpqlqGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPT 3753
Cdd:PRK07764   663 SD--------GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPA 734

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3754 ARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPqAQPTPGPGPAGVKAGAR 3823
Cdd:PRK07764   735 ADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA-EDDAPSMDDEDRRDAEE 803
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3591-3866 6.68e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 6.68e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3591 RHTGEEPGRRAAKPHA-------RDLGRHEARPHSQPSSAPAMPKKGQPGYPSSAEYSQPSRAPSAYHHASDSKKGSRQA 3663
Cdd:PHA03247  2576 RPSEPAVTSRARRPDAppqsarpRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD 2655

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3664 HSGPaalqsKAEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQ 3743
Cdd:PHA03247  2656 PAPG-----RVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQ 2730

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3744 ARLQQQSQPTARGSAPAASQPAGKPQPG-PTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTPGPGPAGVKAGA 3822
Cdd:PHA03247  2731 ASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1381517241 3823 RPGGTPGAPASQPGADGESVFSKILPGGAAEQAGKLTEAVSAFG 3866
Cdd:PHA03247  2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 3751-3852 7.75e-05

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 49.12  E-value: 7.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3751 QPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAeqtngskgtakAPQQGRAPQAQPTPGPGPAGVKAGARPggTPGA 3830
Cdd:PRK12270    37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAP-----------APPAAAAPAAPPKPAAAAAAAAAPAAP--PAAA 103

                           90       100
                   ....*....|....*....|..
gi 1381517241 3831 PASQPGADGESVFSKILPGGAA 3852
Cdd:PRK12270   104 AAAAPAAAAVEDEVTPLRGAAA 125
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3556-3838 1.43e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 1.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3556 EPPEEGLWPHDEGGPGRHASAKEHRHHGDHGRHSGRHTG-----EEPGRRAAKPHARDLGrHEARPHSQ---PSSAPAMP 3627
Cdd:PHA03247  2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQassppQRPRRRAARPTVGSLT-SLADPPPPpptPEPAPHAL 2715

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3628 KKGQPGYPSSAEYSQPSRAPSAYH-----------HASDSKKGSRQAHSGPAALQSKAEPQAQPQlqgRQAAPGPQQSQS 3696
Cdd:PHA03247  2716 VSATPLPPGPAAARQASPALPAAPappavpagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPP---RRLTRPAVASLS 2792

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3697 PSSRQMPSgaaSRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKP--QPGPTT 3774
Cdd:PHA03247  2793 ESRESLPS---PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDvrRRPPSR 2869

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1381517241 3775 ATGPQPAGPPR-----------AEQTNGSKGTAKAPQQGRAPQA--QPTPGPGPAGVKAGARPGGTPGAPASQPGAD 3838
Cdd:PHA03247  2870 SPAAKPAAPARppvrrlarpavSRSTESFALPPDQPERPPQPQAppPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 3750-3835 2.48e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 47.19  E-value: 2.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3750 SQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTngskgTAKAPQQGRAPQAQPTPGPGPAGVKAgarPGGTPG 3829
Cdd:PRK12270    42 AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPA-----APPKPAAAAAAAAAPAAPPAAAAAAA---PAAAAV 113


                   ....*.
gi 1381517241 3830 APASQP 3835
Cdd:PRK12270   114 EDEVTP 119
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1238-1592 3.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1238 PLTPGTSPTQLTAPVSFSTPT----SSDSSGGRVIPDVRVTQ-----HFAKETQDPLKLHSSPASASLTSKEVGMPFSQG 1308
Cdd:PHA03247  2628 PPSPSPAANEPDPHPPPTVPPperpRDDPAPGRVSRPRRARRlgraaQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1309 PG---TPATTAVAPCPAGLPRGYMTPASPAGSERSPSPSSTAHSYGHSPTTANYGSQTEDLPQAPIGLAAAGQAAREKPL 1385
Cdd:PHA03247  2708 PEpapHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1386 SASDGEGGTPQPSRAYSYVASSSPPLSPSSPSESPTFSPGKLGPRATAEFSTQTPSPAPASDMPR----SPGAPI----P 1457
Cdd:PHA03247  2788 VASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvAPGGDVrrrpP 2867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1458 SPMVAQGTQTPHRPSTPRLVWQESSQEAPfmviTLASDASSQTRMVHASASTSPLCSPTEIQPtthgySQTTPPSVSQLP 1537
Cdd:PHA03247  2868 SRSPAAKPAAPARPPVRRLARPAVSRSTE----SFALPPDQPERPPQPQAPPPPQPQPQPPPP-----PQPQPPPPPPPR 2938

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1381517241 1538 PEPPGPPGFPRAPSAGADGPLALYGWGALPAENISLCRI-SSVPGTSRVEPGPRPP 1592
Cdd:PHA03247  2939 PQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrVPQPAPSREAPASSTP 2994
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 3735-3840 3.95e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.25  E-value: 3.95e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3735 QPPQQAPTQARLQQQSQPTARG-------SAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQA 3807
Cdd:PRK14951   383 RPEAAAPAAAPVAQAAAAPAPAaapaaaaSAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAI 462

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1381517241 3808 QPTPGPGPAGVKAGARPGGTPGAPASQPGADGE 3840
Cdd:PRK14951   463 PVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
3594-3839 6.49e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 46.00  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3594 GEEPGRRAAKPHARDLGRHEARPHSQPSSAPAMPKKGQPGYPSSAEYSQPSrAPSAYHHASDSKKGSRQAHSGPAALQSK 3673
Cdd:PRK07003   365 GGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA-AAAAATRAEAPPAAPAPPATADRGDDAA 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3674 AEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPt 3753
Cdd:PRK07003   444 DGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAP- 522

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3754 argsAPAASQPAGKPQPGPTTATGPQPAGPPRAE-----------QTNGSKGTAKAPQQGRAPQAQPTPGPGPAGVkaga 3822
Cdd:PRK07003   523 ----AAAAPPAPEARPPTPAAAAPAARAGGAAAAldvlrnagmrvSSDRGARAAAAAKPAAAPAAAPKPAAPRVAV---- 594

                          250
                   ....*....|....*..
gi 1381517241 3823 rPGGTPGAPASQPGADG 3839
Cdd:PRK07003   595 -QVPTPRARAATGDAPP 610
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 1202-1532 6.67e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.72  E-value: 6.67e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1202 RQASSRDLAFAEDKKKEKQFLNAESAYMDPMKQNGGPLTPGTSPTQLTA-----PVSFSTPTSSDSSGGRVIPDVRVTQh 1276
Cdd:pfam17823   40 QNASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEVTAehtphGTDLSEPATREGAADGAASRALAAA- 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1277 fAKETQDPLKLHSSPASASLTSKEVGMPFSQGPGTPATTAVAPCPAGLPRGYMTPASPAGSERSPSPSSTAHSYGHSPTT 1356
Cdd:pfam17823  119 -ASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTT 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1357 ANYGSQTEDLPQAPIGLAA-------AGQAAREKPLSAS-----DGEGGTPQPSRAYSYVASSSPPLSPSSPSESPTFSP 1424
Cdd:pfam17823  198 AASSAPATLTPARGISTAAtatghpaAGTALAAVGNSSPaagtvTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHA 277

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 1425 GKLGPRATAEFSTQTPSPAPAS-------------DMPRSPGAPIPSPmvaQGTQTPHRPSTPRLVWQESSQeapfmVIT 1491
Cdd:pfam17823  278 RRLSPAKHMPSDTMARNPAAPMgaqaqgpiiqvstDQPVHNTAGEPTP---SPSNTTLEPNTPKSVASTNLA-----VVT 349

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1381517241 1492 lasdaSSQTRMVHASASTSPLcSPTEIQPTTHGYSQTTPPS 1532
Cdd:pfam17823  350 -----TTKAQAKEPSASPVPV-LHTSMIPEVEATSPTTQPS 384
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3679-3864 8.28e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 8.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3679 QPQLQGRQAAPgpqQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPTARGSA 3758
Cdd:PRK12323   364 RPGQSGGGAGP---ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3759 PAAsqPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTP---GPGPAGVKAGARPggTPGAPASQP 3835
Cdd:PRK12323   441 ARG--PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPaddDPPPWEELPPEFA--SPAPAQPDA 516

                          170       180
                   ....*....|....*....|....*....
gi 1381517241 3836 GADGESVFSKILPGGAAEQAGKLTEAVSA 3864
Cdd:PRK12323   517 APAGWVAESIPDPATADPDDAFETLAPAP 545
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
3623-3830 1.29e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.84  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3623 APAMPKKGQPGYPSSAEYSQPSRAPSAYHHASDSKKGSRQAHSGPAALQSKAEPQAqpqlqgrQAAPGPQQSQSPSSRQM 3702
Cdd:PRK07003   359 EPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKA-------AAAAAATRAEAPPAAPA 431

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3703 PSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPtQARLQQQSQPTARGSAPAASQPAGKP-QPGPTTATGPQPA 3781
Cdd:PRK07003   432 PPATADRGDDAADGDAPVPAKANARASADSRCDERDAQP-PADSGSASAPASDAPPDAAFEPAPRAaAPSAATPAAVPDA 510

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1381517241 3782 GPPRAEQTNgskgTAKAPQQGRAPQAQPtpgPGPAGVKAGARPGGTPGA 3830
Cdd:PRK07003   511 RAPAAASRE----DAPAAAAPPAPEARP---PTPAAAAPAARAGGAAAA 552
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
126-279 1.37e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 44.77  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  126 KVCNQCGFN----PNPHLtQVKEWLCLNCQmqraLGMDMTTAPRSKSQQQLHSPALS-PAhsPAKQPLGKPEQERSRGPG 200
Cdd:PRK14971   333 KLCNQCDLNyrasKNKRL-LVELTLIQLAQ----LTQKGDDASGGRGPKQHIKPVFTqPA--AAPQPSAAAAASPSPSQS 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241  201 GLQPGSHQGEIARATSVPEPAQAAAPPEVGRVSPQ---PPQPTKPSTAEPRPPageAPAKSATAVPTGLGATEQTQEGLT 277
Cdd:PRK14971   406 SAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPstaPQAVRPAQFKEEKKI---PVSKVSSLGPSTLRPIQEKAEQAT 482


                   ..
gi 1381517241  278 GK 279
Cdd:PRK14971   483 GN 484
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 3759-3834 1.58e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 44.18  E-value: 1.58e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1381517241 3759 PAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGRAPQAQPTPGPGPAGVKAGARPGGTPGAPASQ 3834
Cdd:PHA03291   205 PATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEGTPAPPTPGGGEAPPANATPAPEASR 280
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3614-3858 2.00e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3614 ARPHSQPSSAPAMPKkgqpgYPSSAEYSQPSRAPSAYHHASDSKKGSRQAHSGPAALQSKAEPQAqPQLQGRQAAPGPQQ 3693
Cdd:PRK12323   375 ATAAAAPVAQPAPAA-----AAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALA-AARQASARGPGGAP 448

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3694 SQSPSSRQMPSGAAsrqpqpqqqqqqqqqqqqqqqqqslglqPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPgPT 3773
Cdd:PRK12323   449 APAPAPAAAPAAAA----------------------------RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-PW 499

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3774 TATGPQPAGPPRAEQTNGSKGTAKA----PQQGRAPQAQPTPGPGPAGVKAGARPGGTPGAPASQPGADGESVFSKILPG 3849
Cdd:PRK12323   500 EELPPEFASPAPAQPDAAPAGWVAEsipdPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDG 579


                   ....*....
gi 1381517241 3850 GAAEQAGKL 3858
Cdd:PRK12323   580 DWPALAARL 588
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3703-3844 2.12e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3703 PSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAG 3782
Cdd:PRK07764   591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1381517241 3783 PPRAEQTNGSKGTAKAPQQGRAPQAQPTPGPGPAG-VKAGARPGGTPGAPASQPGADGESVFS 3844
Cdd:PRK07764   671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPaATPPAGQADDPAAQPPQAAQGASAPSP 733
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3663-3856 2.35e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3663 AHSGPAALQSKAEPQAQPQLQGRQAAPGPQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPT 3742
Cdd:PRK07764   589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3743 QARLQQQSQPTARGSAPAASqpagkPQPGPTTATGPQPAGPPRAEqtngskgTAKAPQQGRAPQAQPTPGPGPAGVKAGA 3822
Cdd:PRK07764   669 WPAKAGGAAPAAPPPAPAPA-----APAAPAGAAPAQPAPAPAAT-------PPAGQADDPAAQPPQAAQGASAPSPAAD 736

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1381517241 3823 RPGGTPGAPASQPGADGESVFSKILPGGAAEQAG 3856
Cdd:PRK07764   737 DPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAP 770
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 3741-3864 2.98e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3741 PTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAgPPRAEQTNGSKGTAKAPqqgrAPQAQPTPGPGPAGVKA 3820
Cdd:PRK14951   366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAA-PAAAASAPAAPPAAAPP----APVAAPAAAAPAAAPAA 440

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1381517241 3821 GARPGGTPGAPASQPGADGESVFSKILPGGAAEQAGKLTEAVSA 3864
Cdd:PRK14951   441 APAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPA 484
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
3732-3841 3.26e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 43.23  E-value: 3.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3732 LGLQPPQQAPTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTakAPQQGRAPQAQPTP 3811
Cdd:PRK14971   384 TQPAAAPQPSAAAAASPSPSQSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVNPPSTAPQAV--RPAQFKEEKKIPVS 461

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1381517241 3812 GPGPAG--VKAGARP---GGTPGAPASQPGADGES 3841
Cdd:PRK14971   462 KVSSLGpsTLRPIQEkaeQATGNIKEAPTGTQKEI 496
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3601-3786 4.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 4.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3601 AAKPHARDLGRHEARPHSQPSSAPAMPKKGQPGYPSSAEYSQPSRAPSAYHHASDSKKGSRQAHSGPAalqskAEPQAQP 3680
Cdd:PRK12323   384 QPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-----PAPAAAP 458

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3681 QLQGRQAAPGpQQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPTARGSAPA 3760
Cdd:PRK12323   459 AAAARPAAAG-PRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1381517241 3761 ----ASQPAGKPQPGPTTATGPQ-PAGPPRA 3786
Cdd:PRK12323   538 fetlAPAPAAAPAPRAAAATEPVvAPRPPRA 568
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 3740-3864 4.58e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3740 APTQARLQQQSQPTARGSAPAASQPAGKPQPGPTTAtgPQPAGPPRA----EQTNGSKGTAKAPQQGRAPQAQPTPGPGP 3815
Cdd:PRK07764   591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAA--PAPAGAAAApaeaSAAPAPGVAAPEHHPKHVAVPDASDGGDG 668

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1381517241 3816 AGVKAGARPGGTPGAPASQPGADGESVfskilPGGAAEQAGKLTEAVSA 3864
Cdd:PRK07764   669 WPAKAGGAAPAAPPPAPAPAAPAAPAG-----AAPAQPAPAPAATPPAG 712
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 3752-3832 7.49e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 41.91  E-value: 7.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3752 PTARGSAPAasqPAGKPQPGPTTATGPQPAGPPRAEQTNGSKGTAKAPQQGrAPQAQPTPGPGPAGVKAgARPGGTPGAP 3831
Cdd:PHA03264   268 PAPSGGSPA---PPGDDRPEAKPEPGPVEDGAPGRETGGEGEGPEPAGRDG-AAGGEPKPGPPRPAPDA-DRPEGWPSLE 342


                   .
gi 1381517241 3832 A 3832
Cdd:PHA03264   343 A 343
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 2287-2360 8.38e-03

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 41.56  E-value: 8.38e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381517241 2287 LEK-EEASQEERQRKQ-QEQLLQL-ERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRE-LQELqtIKHHVL 2360
Cdd:pfam15558  108 QEKlERARQEAEQRKQcQEQRLKEkEEELQALREQNSLQLQERLEEACHKRQLKEREEQKKVQENnLSEL--LNHQAR 183
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 3524-3857 9.35e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.08  E-value: 9.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3524 ARSDRFRHHGGHAVSSSSQKRGPARHSYHDYDEPPEEGLWPHDEGGPGRHASAKEHRHHGDHGRHSgrhTGEEPGRRAAK 3603
Cdd:PHA03307    60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPAS---PPPSPAPDLSE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3604 PhARDLGRHEARPHSQPSSAPAMPKKGQPGYPSSAEYSQPSRAPSAYHHASDSKKGSRQAHSGPAALQSKAEPQAQPQLQ 3683
Cdd:PHA03307   137 M-LRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISA 215

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3684 GRqaapgpqQSQSPSSRQMPSGAASRQPQPQQQQQQQQQQQQQQQQQSLGLQPPQQAPTQARLQQQSQPTARGSAPAASQ 3763
Cdd:PHA03307   216 SA-------SSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSS 288

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1381517241 3764 PAGK---PQPGPTTATGPQPAGPPRA------------------EQTNGSKGTAKAPQQGRAPQAQPTPGPGPAGVKAGA 3822
Cdd:PHA03307   289 SSPRersPSPSPSSPGSGPAPSSPRAsssssssressssstsssSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKR 368

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1381517241 3823 RPGGTPGAPASQPGADGESVFSKILPGGAAEQAGK 3857
Cdd:PHA03307   369 PRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDA 403
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2276-2353 9.84e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 9.84e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1381517241 2276 GGGSGALSRSGLEKEEASQEERQRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRELQELQ 2353
Cdd:COG1196    656 GSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAE 733
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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