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Conserved domains on  [gi|1370451934|ref|XP_024308953|]
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leucine-rich repeat and IQ domain-containing protein 3 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-119 3.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  33 VKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTkfwNGLKNLKLLYLHDNgfakl 112
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENL---ENLVNLKKLYLGGN----- 78


                  ....*..
gi 1370451934 113 kNICVLS 119
Cdd:cd21340    79 -RISVVE 84
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-119 3.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  33 VKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTkfwNGLKNLKLLYLHDNgfakl 112
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENL---ENLVNLKKLYLGGN----- 78


                  ....*..
gi 1370451934 113 kNICVLS 119
Cdd:cd21340    79 -RISVVE 84
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-127 2.70e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  44 ENLQSCISLRVCIFSNNFITDIH-PLQSCIKLIKLDLHGNQIKSLPntKFWNGLKNLKLLYLHDNGFAKLKNicVLSACP 122
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDLPePLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNNQITDLPE--PLGNLT 205


                  ....*
gi 1370451934 123 TLIAL 127
Cdd:COG4886   206 NLEEL 210
LRR_8 pfam13855
Leucine rich repeat;
51-109 1.70e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370451934  51 SLRVCIFSNNFITDIHP--LQSCIKLIKLDLHGNQIKSLPNTKFWnGLKNLKLLYLHDNGF 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS-GLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 33-119 3.60e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 3.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  33 VKFNGLHLKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTkfwNGLKNLKLLYLHDNgfakl 112
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENL---ENLVNLKKLYLGGN----- 78


                  ....*..
gi 1370451934 113 kNICVLS 119
Cdd:cd21340    79 -RISVVE 84
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-127 2.70e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.86  E-value: 2.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  44 ENLQSCISLRVCIFSNNFITDIH-PLQSCIKLIKLDLHGNQIKSLPntKFWNGLKNLKLLYLHDNGFAKLKNicVLSACP 122
Cdd:COG4886   130 EELANLTNLKELDLSNNQLTDLPePLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNNQITDLPE--PLGNLT 205


                  ....*
gi 1370451934 123 TLIAL 127
Cdd:COG4886   206 NLEEL 210
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-135 3.18e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 3.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  44 ENLQSCISLRVCIFSNNFITDI-HPLQSCIKLIKLDLHGNQIKSLPNtkfWNGLKNLKLLYLHDNgfaKLKNICVLSACP 122
Cdd:COG4886   199 EPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNN---QLTDLPPLANLT 272

                          90
                  ....*....|...
gi 1370451934 123 TLIALTMFDCPVS 135
Cdd:COG4886   273 NLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-113 4.84e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.09  E-value: 4.84e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  44 ENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTKfwnGLKNLKLLYLHDNGFAKLK 113
Cdd:COG4886   222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA---NLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-127 3.22e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 3.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370451934  57 FSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTkfwNGLKNLKLLYLHDNgfaKLKNICVLSACPTLIAL 127
Cdd:cd21340     9 LNDKNITKIDNLSLCKNLKVLYLYDNKITKIENL---EFLTNLTHLYLQNN---QIEKIENLENLVNLKKL 73
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 51-169 9.77e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 9.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  51 SLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSlpntkfwnglknlkllylhdngfakLKNIC-VLSACPTLIALTM 129
Cdd:cd21340   121 SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISD-------------------------LEELLdLLSSWPSLRELDL 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1370451934 130 FDCPVSLKKGYRHVLVNSIWPLKALDHHVISDEEI--IQNWH 169
Cdd:cd21340   176 TGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERqfLKRLK 217
LRR_8 pfam13855
Leucine rich repeat;
51-109 1.70e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370451934  51 SLRVCIFSNNFITDIHP--LQSCIKLIKLDLHGNQIKSLPNTKFWnGLKNLKLLYLHDNGF 109
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFS-GLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-128 2.90e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  40 LKSMENLQSCISLRVCIFSNNFITDIHPLQSCIKLIKLDLHGNQIKSLPNTKFWNGLKNLKLLYLHDNGFAKLKNICVLS 119
Cdd:COG4886   240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319


                  ....*....
gi 1370451934 120 ACPTLIALT 128
Cdd:COG4886   320 LTTLLLLLL 328
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 73-119 1.92e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 1.92e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1370451934  73 KLIKLDLHGNQIKSLPNtkfWNGLKNLKLLYLHDNGfaKLKNICVLS 119
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP---LAKLPNLETLDLSGNN--KITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-135 2.20e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451934  36 NGLHLKSMENLQSCISLRVCIFSNNFitdihPLQSCIKLIKLDLHGNQIKSLPntKFWNGLKNLKLLYLHDNGFAKLKNi 115
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLP--EELANLTNLKELDLSNNQLTDLPE- 153

                          90       100
                  ....*....|....*....|
gi 1370451934 116 cVLSACPTLIALTMFDCPVS 135
Cdd:COG4886   154 -PLGNLTNLKSLDLSNNQLT 172
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-89 5.91e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 5.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370451934  37 GLHLKSMENLQSCISLRVCIFSNNFITDIH----PLQSCIKLIKLDLHGNQIKSLPN 89
Cdd:cd21340   129 GNNIDSLEPLAPLRNLEQLDASNNQISDLEelldLLSSWPSLRELDLTGNPVCKKPK 185
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 51-89 5.96e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1370451934  51 SLRVCIFSNNFITDIHPLQSCIKLIKLDLHGN-QIKSLPN 89
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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