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Conserved domains on  [gi|1370465588|ref|XP_024305483|]
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dynein axonemal light chain 1 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-142 3.10e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 3.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   5 LSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLE-----------------------------AVGDT 55
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEnltnleelhienqrlppgekltfdprslaALSNS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588  56 LEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK-LAELPCLEDLVFVGNPLeekhSAENNWIEEATKRVPKL 134
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPV----CKKPKYRDKIILASKSL 197


                  ....*...
gi 1370465588 135 KKLDGTPV 142
Cdd:cd21340   198 EVLDGKEI 205
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-142 3.10e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 3.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   5 LSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLE-----------------------------AVGDT 55
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEnltnleelhienqrlppgekltfdprslaALSNS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588  56 LEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK-LAELPCLEDLVFVGNPLeekhSAENNWIEEATKRVPKL 134
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPV----CKKPKYRDKIILASKSL 197


                  ....*...
gi 1370465588 135 KKLDGTPV 142
Cdd:cd21340   198 EVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-115 3.13e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   2 DASLSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHIMKKLK 79
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLE 231

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1370465588  80 ILYMSNNLVKDWAEfvkLAELPCLEDLVFVGNPLEE 115
Cdd:COG4886   232 TLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTD 264
LRR_9 pfam14580
Leucine-rich repeat;
34-115 3.14e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588  34 RILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAeLPCLEDLVFVGNPL 113
Cdd:pfam14580  22 RELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEA-LPNLTELILTNNNL 100


                  ..
gi 1370465588 114 EE 115
Cdd:pfam14580 101 QE 102
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-142 3.10e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 3.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   5 LSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLE-----------------------------AVGDT 55
Cdd:cd21340    42 LEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLEnltnleelhienqrlppgekltfdprslaALSNS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588  56 LEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVK-LAELPCLEDLVFVGNPLeekhSAENNWIEEATKRVPKL 134
Cdd:cd21340   122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELDLTGNPV----CKKPKYRDKIILASKSL 197


                  ....*...
gi 1370465588 135 KKLDGTPV 142
Cdd:cd21340   198 EVLDGKEI 205
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-115 3.13e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 3.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   2 DASLSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHIMKKLK 79
Cdd:COG4886   152 PEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLE 231

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1370465588  80 ILYMSNNLVKDWAEfvkLAELPCLEDLVFVGNPLEE 115
Cdd:COG4886   232 TLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTD 264
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 14-86 1.16e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 1.16e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370465588  14 LSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAvGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNN 86
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEF-LTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGN 78
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-138 8.51e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 8.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   5 LSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNglEAVGD--TLEELWISYNFIEKL-KGIHIMKKLKI 80
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLP--EPLGNltNLKSLDLSNNQLTDLpEELGNLTNLKE 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370465588  81 LYMSNNLVKDWAEFvkLAELPCLEDLVFVGNPLEEkhsaennwIEEATKRVPKLKKLD 138
Cdd:COG4886   187 LDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTD--------LPEPLANLTNLETLD 234
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-115 5.43e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   1 MDASLSMLANCEKLSLSTNCIEKI-ANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHIMKKL 78
Cdd:COG4886   128 LPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLpEPLGNLTNL 207

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1370465588  79 KILYMSNNLVKDWAEFvkLAELPCLEDLVFVGNPLEE 115
Cdd:COG4886   208 EELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-115 2.29e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   2 DASLSMLANCEKLSLSTNciekiANLNGLKNLRILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKL-KGIHIMKKLKI 80
Cdd:COG4886    89 LTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKS 163

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1370465588  81 LYMSNNLVKDWAEFvkLAELPCLEDLVFVGNPLEE 115
Cdd:COG4886   164 LDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITD 196
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1-106 3.07e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.53  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588   1 MDASLSMLANCEKLSLSTNCIEKIANLNGLKNLRILSLGRNNIKNLNGLEAVgDTLEELWISYNFIEKLKGIHIMKKLKI 80
Cdd:COG4886   220 LPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKLKELELLLGL 298

                          90       100
                  ....*....|....*....|....*.
gi 1370465588  81 LYMSNNLVKDWAEFVKLAELPCLEDL 106
Cdd:COG4886   299 NSLLLLLLLLNLLELLILLLLLTTLL 324
LRR_9 pfam14580
Leucine-rich repeat;
34-115 3.14e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465588  34 RILSLGRNNIKNLNGLEAVGDTLEELWISYNFIEKLKGIHIMKKLKILYMSNNLVKDWAEFVKLAeLPCLEDLVFVGNPL 113
Cdd:pfam14580  22 RELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEA-LPNLTELILTNNNL 100


                  ..
gi 1370465588 114 EE 115
Cdd:pfam14580 101 QE 102
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 10-50 5.46e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 5.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370465588  10 NCEKLSLSTNCIEKIANLNGLKNLRILSLGRNN-IKNLNGLE 50
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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