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Conserved domains on  [gi|1370457804|ref|XP_024303940|]
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transmembrane protein 180 isoform X3 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
17-277 7.89e-103

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17481:

Pssm-ID: 475125  Cd Length: 429  Bit Score: 307.33  E-value: 7.89e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  17 VVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPrSGAGLSSRAVVL 96
Cdd:cd17481     1 VAYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDPLFGWLSDRKFLSSSS-SGAHISSPAVVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  97 ARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17481    80 KRLRALSINGPLFALSFLAFWVPWAPPGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSAIGSLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 177 VFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLrrrveaarkdpgcsglvvdsglcgeellvgseeadsitlgry 256
Cdd:cd17481   160 VFLSYAVWDKENLGSFRIFCACLAIISAVGFFLSSALL------------------------------------------ 197
                         250       260
                  ....*....|....*....|.
gi 1370457804 257 lrqlarhrNFLWFVSMDLVQV 277
Cdd:cd17481   198 --------NFLWFVVMNLVQV 210
 
Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
17-277 7.89e-103

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


Pssm-ID: 341034  Cd Length: 429  Bit Score: 307.33  E-value: 7.89e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  17 VVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPrSGAGLSSRAVVL 96
Cdd:cd17481     1 VAYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDPLFGWLSDRKFLSSSS-SGAHISSPAVVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  97 ARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17481    80 KRLRALSINGPLFALSFLAFWVPWAPPGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSAIGSLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 177 VFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLrrrveaarkdpgcsglvvdsglcgeellvgseeadsitlgry 256
Cdd:cd17481   160 VFLSYAVWDKENLGSFRIFCACLAIISAVGFFLSSALL------------------------------------------ 197
                         250       260
                  ....*....|....*....|.
gi 1370457804 257 lrqlarhrNFLWFVSMDLVQV 277
Cdd:cd17481   198 --------NFLWFVVMNLVQV 210
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-276 8.07e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.82  E-value: 8.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  11 LGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSVYKINkmAFWVGeTVFL---LWNSLNDPLFGWLSDRqflsSQPRSGA 87
Cdd:COG2211     7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLS--AALVG-LILLvarLWDAITDPLIGALSDR----TRTRWGR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  88 glssravvlaRVQALGWHGPLLALSFLAFWV--PWAPAG--LQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLN 163
Cdd:COG2211    80 ----------RRPWILIGAIPLALSFVLLFTapDLSPTGklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 164 FYCSLFSAAGSLSVFAS----YAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKdpgcsglvvdsglcge 239
Cdd:COG2211   150 SWRFAFAGLGGLLASVLppplVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---------------- 213
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370457804 240 ellvgseeadSITLGRYLRQLARHRNFLWFVSMDLVQ 276
Cdd:COG2211   214 ----------KVSLKESLKALLKNRPFLLLLLAYLLF 240
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
19-276 9.28e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 46.92  E-value: 9.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  19 YGSLA--LFTTILHNVFLLYYVDtfvsVYKINkmAFWVGETVFL--LWNSLNDPLFGWLSDRqflsSQPRSGAGLSsrAV 94
Cdd:pfam13347   4 SGALAagIKYAGLATYLLYFYTD----VLGLS--AAAVGLVLLVarLVDAFTDPIVGHIIDR----TRTRWGRRRP--WL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  95 VLArvqalgwhGPLLALSFLAFWVP--WAPAGLQ--FLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFS 170
Cdd:pfam13347  72 LLS--------AIILAVSFILLFTPpeLGRAPLFiwLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFS 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 171 AAGSLSV----FASYAFWN--KEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPGCSglvvdsglcgeellvg 244
Cdd:pfam13347 144 VGGGLLAaalaFPLVLILGgtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ---------------- 207
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1370457804 245 seeADSITLGRYLRQLARHRNFLWFVSMDLVQ 276
Cdd:pfam13347 208 ---KEAGSLLDMLKEVFRNRAFLILLASFLLA 236
 
Name Accession Description Interval E-value
MFS_MFSD13A cd17481
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ...
17-277 7.89e-103

Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement


Pssm-ID: 341034  Cd Length: 429  Bit Score: 307.33  E-value: 7.89e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  17 VVYGSLALFTTILHNVFLLYYVDTFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFLSSQPrSGAGLSSRAVVL 96
Cdd:cd17481     1 VAYGSLAFFLSILHNVFLLYYVDVFVSVYKIDKASFWIGETIFLIWNSLNDPLFGWLSDRKFLSSSS-SGAHISSPAVVL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  97 ARVQALGWHGPLLALSFLAFWVPWAPAGLQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLS 176
Cdd:cd17481    80 KRLRALSINGPLFALSFLAFWVPWAPPGLQFVVCLCLYDGFLTMVDLNHNALLADLAVSAEDRTRLNSYCSVFSAIGSLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 177 VFASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLrrrveaarkdpgcsglvvdsglcgeellvgseeadsitlgry 256
Cdd:cd17481   160 VFLSYAVWDKENLGSFRIFCACLAIISAVGFFLSSALL------------------------------------------ 197
                         250       260
                  ....*....|....*....|.
gi 1370457804 257 lrqlarhrNFLWFVSMDLVQV 277
Cdd:cd17481   198 --------NFLWFVVMNLVQV 210
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
11-276 8.07e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.82  E-value: 8.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  11 LGLPTAVVYGSLALFTTILHNVFLLYYVDTFVSVYKINkmAFWVGeTVFL---LWNSLNDPLFGWLSDRqflsSQPRSGA 87
Cdd:COG2211     7 LSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLS--AALVG-LILLvarLWDAITDPLIGALSDR----TRTRWGR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  88 glssravvlaRVQALGWHGPLLALSFLAFWV--PWAPAG--LQFLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLN 163
Cdd:COG2211    80 ----------RRPWILIGAIPLALSFVLLFTapDLSPTGklIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLS 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 164 FYCSLFSAAGSLSVFAS----YAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKdpgcsglvvdsglcge 239
Cdd:COG2211   150 SWRFAFAGLGGLLASVLppplVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEE---------------- 213
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1370457804 240 ellvgseeadSITLGRYLRQLARHRNFLWFVSMDLVQ 276
Cdd:COG2211   214 ----------KVSLKESLKALLKNRPFLLLLLAYLLF 240
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
19-276 9.28e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 46.92  E-value: 9.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  19 YGSLA--LFTTILHNVFLLYYVDtfvsVYKINkmAFWVGETVFL--LWNSLNDPLFGWLSDRqflsSQPRSGAGLSsrAV 94
Cdd:pfam13347   4 SGALAagIKYAGLATYLLYFYTD----VLGLS--AAAVGLVLLVarLVDAFTDPIVGHIIDR----TRTRWGRRRP--WL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  95 VLArvqalgwhGPLLALSFLAFWVP--WAPAGLQ--FLLCLCLYDGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFS 170
Cdd:pfam13347  72 LLS--------AIILAVSFILLFTPpeLGRAPLFiwLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFS 143
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804 171 AAGSLSV----FASYAFWN--KEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDPGCSglvvdsglcgeellvg 244
Cdd:pfam13347 144 VGGGLLAaalaFPLVLILGgtGLERKGYRIFALIGAVLMLLGVIITAAGTKERVSMRSKEDTGQ---------------- 207
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1370457804 245 seeADSITLGRYLRQLARHRNFLWFVSMDLVQ 276
Cdd:pfam13347 208 ---KEAGSLLDMLKEVFRNRAFLILLASFLLA 236
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
19-225 8.69e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 37.41  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  19 YGSLALFTTILHNVFLLYYVDtFVSVYKINKMAFWVGETVFLLWNSLNDPLFGWLSDRQFlssqprsgaglssravvlaR 98
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-------------------R 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370457804  99 VQALGWHGPLLALSFLAFWvpWAPAGLQFLLCLCLYdGFLTLVDLHHHALLADLALSAHDRTHLNFYCSLFSAAGSLSVF 178
Cdd:cd06174    61 RPVLLLGLLLFALGALLFA--FAPSFWLLLLGRFLL-GLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGP 137
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1370457804 179 ASYAFWNKEDFSSFRAFCVTLAVSSGLGFLGATQLLRRRVEAARKDP 225
Cdd:cd06174   138 LLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKN 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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