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Conserved domains on  [gi|1370456590|ref|XP_024303630|]
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phospholipid phosphatase 4 isoform X5 [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 7-104 7.44e-54

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 168.17  E-value: 7.44e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDS 86
Cdd:cd03390    98 CTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF--DPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDV 175

                          90
                  ....*....|....*...
gi 1370456590  87 FVGGVIGLIFAYICYRQH 104
Cdd:cd03390   176 IAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 7-104 7.44e-54

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 168.17  E-value: 7.44e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDS 86
Cdd:cd03390    98 CTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF--DPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDV 175

                          90
                  ....*....|....*...
gi 1370456590  87 FVGGVIGLIFAYICYRQH 104
Cdd:cd03390   176 IAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 3-107 1.04e-35

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 125.42  E-value: 1.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   3 SEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTEsgRGKSWRLCAAILPLYCAMMIALSRMCDYKHH 82
Cdd:PLN02250  145 TDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDR--RGHVAKLCIVFLPLLVAALVGVSRVDDYWHH 222

                          90       100
                  ....*....|....*....|....*
gi 1370456590  83 WQDSFVGGVIGLIFAYICYRQHYPP 107
Cdd:PLN02250  223 WQDVFAGALIGLTVASFCYLQFFPP 247
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 4-105 3.28e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.45  E-value: 3.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   4 EMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGklhcftesgRGKSWRLCAAILPLYCAMMIALSRMCDYKHHW 83
Cdd:pfam01569  31 EGGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRR---------LRKIVRVLLALLLLVLALLVGLSRLYLGVHFP 101

                          90       100
                  ....*....|....*....|..
gi 1370456590  84 QDSFVGGVIGLIFAYICYRQHY 105
Cdd:pfam01569 102 SDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
7-101 1.81e-12

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 60.05  E-value: 1.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590    7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLagklhcfteSGRGKSWRLCAAILPLycAMMIALSRMCDYKHHWQDS 86
Cdd:smart00014  33 CTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGRKLLIFLLLLL--ALVVGFSRVYLGAHWPSDV 101

                           90
                   ....*....|....*
gi 1370456590   87 FVGGVIGLIFAYICY 101
Cdd:smart00014 102 LAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 5-102 8.75e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 46.19  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   5 MHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLhcftesgrgksWRLCAAILplycAMMIALSRMCDYKHHWQ 84
Cdd:COG0671   103 VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRRW-----------LAALLLAL----ALLVGLSRVYLGVHYPS 167

                          90
                  ....*....|....*...
gi 1370456590  85 DSFVGGVIGLIFAYICYR 102
Cdd:COG0671   168 DVLAGALLGLAIALLLLA 185
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 7-104 7.44e-54

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 168.17  E-value: 7.44e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDS 86
Cdd:cd03390    98 CTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF--DPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDV 175

                          90
                  ....*....|....*...
gi 1370456590  87 FVGGVIGLIFAYICYRQH 104
Cdd:cd03390   176 IAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 3-107 1.04e-35

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 125.42  E-value: 1.04e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   3 SEMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTEsgRGKSWRLCAAILPLYCAMMIALSRMCDYKHH 82
Cdd:PLN02250  145 TDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVFDR--RGHVAKLCIVFLPLLVAALVGVSRVDDYWHH 222

                          90       100
                  ....*....|....*....|....*
gi 1370456590  83 WQDSFVGGVIGLIFAYICYRQHYPP 107
Cdd:PLN02250  223 WQDVFAGALIGLTVASFCYLQFFPP 247
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 7-122 7.91e-32

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 115.51  E-value: 7.91e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFteSGRGKSWRLCAAILPLYCAMMIALSRMCDYKHHWQDS 86
Cdd:PLN02731  167 CHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF--DGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDV 244

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1370456590  87 FVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLRV 122
Cdd:PLN02731  245 FAGGLLGLAISTICYLQFFPPPYHTEGWGPYAYFQV 280
PLN02715 PLN02715
lipid phosphate phosphatase
 7-121 1.59e-26

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 101.67  E-value: 1.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHCFTESGRGKswRLCAAILPLYCAMMIALSRMCDYKHHWQDS 86
Cdd:PLN02715  173 CHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVA--KLCLVIFPLLAACLVGISRVDDYWHHWQDV 250

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1370456590  87 FVGGVIGLIFAYICYRQHYPPLANTACHKPYVSLR 121
Cdd:PLN02715  251 FAGALIGILVAAFCYRQFYPNPYHEEGWGPYAYFK 285
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 7-99 1.12e-18

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 76.90  E-value: 1.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLhcftesgRGKSWRLCAAILPLYCAM---MIALSRMCDYKHHW 83
Cdd:cd03384    60 CTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARL-------KLRGSRLLRPLLQFLLLAlalYVGLSRISDYKHHW 132

                          90
                  ....*....|....*.
gi 1370456590  84 QDSFVGGVIGLIFAYI 99
Cdd:cd03384   133 SDVLAGALLGSVIALF 148
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 8-101 2.86e-16

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 70.18  E-value: 2.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   8 TGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLhcftesgrgksWRLCAAILPLYCAMMIALSRMCDYKHHWQDSF 87
Cdd:cd01610    40 DGDPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRL-----------LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVL 108

                          90
                  ....*....|....
gi 1370456590  88 VGGVIGLIFAYICY 101
Cdd:cd01610   109 AGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 4-105 3.28e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 67.45  E-value: 3.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   4 EMHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGklhcftesgRGKSWRLCAAILPLYCAMMIALSRMCDYKHHW 83
Cdd:pfam01569  31 EGGLVPAPSTLPGLGYSFPSGHSATAFALALLLALLLRR---------LRKIVRVLLALLLLVLALLVGLSRLYLGVHFP 101

                          90       100
                  ....*....|....*....|..
gi 1370456590  84 QDSFVGGVIGLIFAYICYRQHY 105
Cdd:pfam01569 102 SDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
7-101 1.81e-12

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 60.05  E-value: 1.81e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590    7 CTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLagklhcfteSGRGKSWRLCAAILPLycAMMIALSRMCDYKHHWQDS 86
Cdd:smart00014  33 CTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGRKLLIFLLLLL--ALVVGFSRVYLGAHWPSDV 101

                           90
                   ....*....|....*
gi 1370456590   87 FVGGVIGLIFAYICY 101
Cdd:smart00014 102 LAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 5-102 8.75e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 46.19  E-value: 8.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590   5 MHCTGDPDLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLhcftesgrgksWRLCAAILplycAMMIALSRMCDYKHHWQ 84
Cdd:COG0671   103 VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLLPRRW-----------LAALLLAL----ALLVGLSRVYLGVHYPS 167

                          90
                  ....*....|....*...
gi 1370456590  85 DSFVGGVIGLIFAYICYR 102
Cdd:COG0671   168 DVLAGALLGLAIALLLLA 185
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 11-101 1.42e-06

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 44.24  E-value: 1.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590  11 PDLVSEGRKSFPSIHSSFAFSGLGFTTFylagklhcftESGRGKSWrlcaaiLPLYC-AMMIALSRMCDYKHHWQDSFVG 89
Cdd:cd03394    31 PDGSNNGYRSFPSGHTASAFAAATFLQY----------RYGWRWYG------IPAYAlASLVGASRVVANRHWLSDVLAG 94

                          90
                  ....*....|..
gi 1370456590  90 GVIGLIFAYICY 101
Cdd:cd03394    95 AAIGILVGYLVT 106
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 12-101 3.35e-04

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 38.74  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370456590  12 DLVSEGRKSFPSIHSSFAFSGLGFTTFYLAGKLHcftesgrGKSWRLCAAILPLYCAMMIALSRMcdYKH-HWQDSFVGG 90
Cdd:cd03392    94 LLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLP-------RRRVRILLLILAAILILLVGLSRL--YLGvHYPSDVLAG 164

                          90
                  ....*....|..
gi 1370456590  91 V-IGLIFAYICY 101
Cdd:cd03392   165 WlLGLAWLALLI 176
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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