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Conserved domains on  [gi|1370514980|ref|XP_024303420|]
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zinc-regulated GTPase metalloprotein activator 1F isoform X14 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YejR super family cl33931
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 18-205 4.48e-35

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


The actual alignment was detected with superfamily member COG0523:

Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 126.44  E-value: 4.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980  18 LINEATRQVALADIILINKTDLVPEEDVKKLRTTLRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQhvPG 97
Cdd:COG0523   139 LHELLVDQIAFADVIVLNKTDLVDEEELAALEARLRALNPGAPIVRTSHGEVDPALLLDLGLFDLEAALARPGWLE--EL 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980  98 TQPHLDQSIVTITFDVPGNAKEEHLNMFIqnllweknvrnkDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELCDLEETPv 177
Cdd:COG0523   217 RDHEHDDGIRSFVFRSDRPFDPERLADFL------------EELGPGVLRAKGFLWLAGRPRRLVFQGVGGRLSLEPLG- 283

                         170       180
                  ....*....|....*....|....*...
gi 1370514980 178 SWKDDtERTNRLVLIGRNLDKDILKQLF 205
Cdd:COG0523   284 PWPAD-DRRSRLVFIGRDLDEAALEAAL 310
 
Name Accession Description Interval E-value
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 18-205 4.48e-35

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 126.44  E-value: 4.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980  18 LINEATRQVALADIILINKTDLVPEEDVKKLRTTLRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQhvPG 97
Cdd:COG0523   139 LHELLVDQIAFADVIVLNKTDLVDEEELAALEARLRALNPGAPIVRTSHGEVDPALLLDLGLFDLEAALARPGWLE--EL 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980  98 TQPHLDQSIVTITFDVPGNAKEEHLNMFIqnllweknvrnkDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELCDLEETPv 177
Cdd:COG0523   217 RDHEHDDGIRSFVFRSDRPFDPERLADFL------------EELGPGVLRAKGFLWLAGRPRRLVFQGVGGRLSLEPLG- 283

                         170       180
                  ....*....|....*....|....*...
gi 1370514980 178 SWKDDtERTNRLVLIGRNLDKDILKQLF 205
Cdd:COG0523   284 PWPAD-DRRSRLVFIGRDLDEAALEAAL 310
CobW-like cd03112
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ...
 8-78 5.89e-20

cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.


Pssm-ID: 349766  Cd Length: 198  Bit Score: 83.72  E-value: 5.89e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514980   8 QHLTEEKpdgLINEATRQVALADIILINKTDLVPEEDVKKLRTTLRSINGLGQILETQRSRVDLSNVLDLH 78
Cdd:cd03112   131 KQLDEED---VSDLAVDQIAFADVIVLNKTDLVDEEELEALRARIRALNPGAKIVETTYGRVDLEELLGTG 198
CobW_C pfam07683
Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of ...
 106-205 4.56e-19

Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.


Pssm-ID: 462228 [Multi-domain]  Cd Length: 93  Bit Score: 78.43  E-value: 4.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980 106 IVTITFDVPGNAKEEHLNMFIQNLLWEKNVrnkdnhcmevIRLKGLVSIKDKSQQVIVQGVHELCDLEETPVSWKDDtER 185
Cdd:pfam07683   1 ISSFVFRADRPFDPERLEAWLEDLLLPEGI----------LRAKGILWLAGRPRPLVFQGVGGRLSLEPAGRWWPDE-DR 69

                          90       100
                  ....*....|....*....|
gi 1370514980 186 TNRLVLIGRNLDKDILKQLF 205
Cdd:pfam07683  70 RSRLVFIGRDLDREALRAAL 89
CobW_C smart00833
Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal ...
 145-205 5.19e-08

Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression.


Pssm-ID: 214844 [Multi-domain]  Cd Length: 92  Bit Score: 49.13  E-value: 5.19e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514980  145 VIRLKGLVSIKDKSQQVIV-QGVHELCDLEETPVsWKDDTERTNRLVLIGRNLDKDILKQLF 205
Cdd:smart00833  28 VLRAKGFFWLASRPDLPGVlSQAGGRLRIEPAGA-WPAAGDRRTRLVFIGRDLDEEAIRAAL 88
 
Name Accession Description Interval E-value
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 18-205 4.48e-35

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 126.44  E-value: 4.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980  18 LINEATRQVALADIILINKTDLVPEEDVKKLRTTLRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQhvPG 97
Cdd:COG0523   139 LHELLVDQIAFADVIVLNKTDLVDEEELAALEARLRALNPGAPIVRTSHGEVDPALLLDLGLFDLEAALARPGWLE--EL 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980  98 TQPHLDQSIVTITFDVPGNAKEEHLNMFIqnllweknvrnkDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELCDLEETPv 177
Cdd:COG0523   217 RDHEHDDGIRSFVFRSDRPFDPERLADFL------------EELGPGVLRAKGFLWLAGRPRRLVFQGVGGRLSLEPLG- 283

                         170       180
                  ....*....|....*....|....*...
gi 1370514980 178 SWKDDtERTNRLVLIGRNLDKDILKQLF 205
Cdd:COG0523   284 PWPAD-DRRSRLVFIGRDLDEAALEAAL 310
CobW-like cd03112
cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino ...
 8-78 5.89e-20

cobalamin synthesis protein CobW; The function of this protein family is unknown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage caused by mitomycin. YijA gene is a homologue of the CobW gene which encodes the cobalamin synthesis protein/P47K.


Pssm-ID: 349766  Cd Length: 198  Bit Score: 83.72  E-value: 5.89e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514980   8 QHLTEEKpdgLINEATRQVALADIILINKTDLVPEEDVKKLRTTLRSINGLGQILETQRSRVDLSNVLDLH 78
Cdd:cd03112   131 KQLDEED---VSDLAVDQIAFADVIVLNKTDLVDEEELEALRARIRALNPGAKIVETTYGRVDLEELLGTG 198
CobW_C pfam07683
Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of ...
 106-205 4.56e-19

Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.


Pssm-ID: 462228 [Multi-domain]  Cd Length: 93  Bit Score: 78.43  E-value: 4.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514980 106 IVTITFDVPGNAKEEHLNMFIQNLLWEKNVrnkdnhcmevIRLKGLVSIKDKSQQVIVQGVHELCDLEETPVSWKDDtER 185
Cdd:pfam07683   1 ISSFVFRADRPFDPERLEAWLEDLLLPEGI----------LRAKGILWLAGRPRPLVFQGVGGRLSLEPAGRWWPDE-DR 69

                          90       100
                  ....*....|....*....|
gi 1370514980 186 TNRLVLIGRNLDKDILKQLF 205
Cdd:pfam07683  70 RSRLVFIGRDLDREALRAAL 89
CobW_C smart00833
Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal ...
 145-205 5.19e-08

Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression.


Pssm-ID: 214844 [Multi-domain]  Cd Length: 92  Bit Score: 49.13  E-value: 5.19e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514980  145 VIRLKGLVSIKDKSQQVIV-QGVHELCDLEETPVsWKDDTERTNRLVLIGRNLDKDILKQLF 205
Cdd:smart00833  28 VLRAKGFFWLASRPDLPGVlSQAGGRLRIEPAGA-WPAAGDRRTRLVFIGRDLDEEAIRAAL 88
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
 20-63 2.27e-07

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 49.17  E-value: 2.27e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1370514980  20 NEATRQVALADIILINKTDLVPEE-DVKKLRTTLRSINGLGQILE 63
Cdd:pfam02492 135 RKAGDQIAFADLIVLNKTDLAPEVaLLEVLEEDLRRLNPGAPVVP 179
YjiA COG2403
Zn/Ni/Co-binding GTPase YjiA, predicted metallochaperone, CobW/Nha3/YciC family [Inorganic ion ...
 28-64 5.46e-04

Zn/Ni/Co-binding GTPase YjiA, predicted metallochaperone, CobW/Nha3/YciC family [Inorganic ion transport and metabolism];


Pssm-ID: 441959  Cd Length: 441  Bit Score: 40.21  E-value: 5.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370514980  28 LADIILINKTDLVPEEDVKKLRTTLRSINGLGQILET 64
Cdd:COG2403   261 MADVVVINKVDTADPEDIETVRENIRKVNPKAEIIEA 297
HypB COG0378
Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, ...
 26-64 2.50e-03

Hydrogenase/urease maturation factor HypB, Ni2+-binding GTPase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440147 [Multi-domain]  Cd Length: 200  Bit Score: 37.73  E-value: 2.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1370514980  26 VALADIILINKTDLVP--EEDVKKLRTTLRSINGLGQILET 64
Cdd:COG0378   138 FTAADLLVINKIDLAPyvGFDLEVMEEDARRVNPGAPIFEV 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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