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Conserved domains on  [gi|1297716008|ref|XP_023044662|]
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natural cytotoxicity triggering receptor 3 isoform X3 [Piliocolobus tephrosceles]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 18-104 1.59e-59

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20926:

Pssm-ID: 472250  Cd Length: 112  Bit Score: 180.17  E-value: 1.59e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKE-------------------------AELHIWD 72
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEvrngtpefrgrlaplassrflrdhqAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1297716008  73 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 104
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-104 1.59e-59

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 180.17  E-value: 1.59e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKE-------------------------AELHIWD 72
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEvrngtpefrgrlaplassrflrdhqAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1297716008  73 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 104
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-102 2.94e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 2.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008   24 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVAP------------GKEAELHIWDVRGHDASIYVCRVEVlGLG 91
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKLlaesgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATN-SSG 75

                           90
                   ....*....|.
gi 1297716008   92 VGTGnGTRLVV 102
Cdd:smart00410  76 SASS-GTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
21-86 1.02e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008  21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDE-----------VAPGKEAELHIWDVRGHDASIYVCRV 85
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCT--------VTGtpdpEVSWFKDGqplrssdrfkvTYEGGTYTLTISNVQPDDSGKYTCVA 75


                  .
gi 1297716008  86 E 86
Cdd:pfam07679  76 T 76
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-104 1.59e-59

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 180.17  E-value: 1.59e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKE-------------------------AELHIWD 72
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEvrngtpefrgrlaplassrflrdhqAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1297716008  73 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 104
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-102 2.94e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.57  E-value: 2.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008   24 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVAP------------GKEAELHIWDVRGHDASIYVCRVEVlGLG 91
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKLlaesgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATN-SSG 75

                           90
                   ....*....|.
gi 1297716008   92 VGTGnGTRLVV 102
Cdd:smart00410  76 SASS-GTTLTV 85
I-set pfam07679
Immunoglobulin I-set domain;
21-86 1.02e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.16  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008  21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDE-----------VAPGKEAELHIWDVRGHDASIYVCRV 85
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCT--------VTGtpdpEVSWFKDGqplrssdrfkvTYEGGTYTLTISNVQPDDSGKYTCVA 75


                  .
gi 1297716008  86 E 86
Cdd:pfam07679  76 T 76
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 21-86 1.08e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 1.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1297716008  21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDEVAP-----------GKEAELHIWDVRGHDASIYVCRV 85
Cdd:pfam13927   5 TVSPSSVTVREGETVTLTCE--------ATGspppTITWYKNGEPIssgstrsrslsGSNSTLTISNVTRSDAGTYTCVA 76


                  .
gi 1297716008  86 E 86
Cdd:pfam13927  77 S 77
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 24-85 5.04e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 34.48  E-value: 5.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1297716008  24 PPEIRTLEGSSAFLPCSfnASQGRLAIgSVTWFRD-----EVAPGKE-------AELHIWDVRGHDASIYVCRV 85
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGP-DVTWSKEggtliESLKVKHdngrttqSSLLISNVTKEDAGTYTCVV 73
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 35-86 7.31e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 33.46  E-value: 7.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1297716008  35 AFLPCSFNASQGrlaiGSVTWFRDE-----------VAPGKEAELHIWDVRGHDASIYVCRVE 86
Cdd:cd00096     1 VTLTCSASGNPP----PTITWYKNGkplppssrdsrRSELGNGTLTISNVTLEDSGTYTCVAS 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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