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Conserved domains on  [gi|1207186055|ref|XP_021334691|]
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protein ITPRID2 [Danio rerio]

Protein Classification

KRAP_IP3R_bind and SSFA2_C domain-containing protein( domain architecture ID 10631615)

KRAP_IP3R_bind and SSFA2_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAP_IP3R_bind super family cl20655
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 128-275 1.03e-54

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


The actual alignment was detected with superfamily member pfam14722:

Pssm-ID: 464280  Cd Length: 145  Bit Score: 187.15  E-value: 1.03e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  128 KQKGRSMNSTGSGKSSAtvSSVSELLDLYEEDPEEILYNLGFGREEPDIASKIPSRFFNASSNAKGIDIKVYLGAQIQRM 207
Cdd:pfam14722    1 LSRGTSFNSSHSTASTP--QSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207186055  208 EIENPNyaLTSRFRQTEVLATVANVLSDIYSHVSGKPT-DKIGNGDMETNVPNPLKKRSSAGNFAKILK 275
Cdd:pfam14722   79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVqAEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C super family cl20656
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 905-1071 7.69e-44

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


The actual alignment was detected with superfamily member pfam14723:

Pssm-ID: 464281  Cd Length: 171  Bit Score: 157.00  E-value: 7.69e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  905 SHSAP-YSSGYNGSPHHPAAVYSHPYYPSPAYPFSFGTPPAptpamgSTEMQLRRVLHDIRGTMQNLGQSSSVHGGDTPM 983
Cdd:pfam14723    4 THSVPnLSGAPCGAFYSPFSCPYSPRHQGPPHRGHSRNPPS------TTEMQLRRVLHDIRNSVQNLSQYPVLRGPDLST 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  984 DRI-GTPR-SVQPLYE----ELQMRRRSLNVFRTQMMDLELALMRQQSLVYQHLSPEERREAEQLQTLRTAVRQELQELE 1057
Cdd:pfam14723   78 ASGyNTQRsSVLPLYEntfqELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELE 157

                          170
                   ....*....|....
gi 1207186055 1058 LQLEDRLLSINEQM 1071
Cdd:pfam14723  158 LQLEDRLLALEEQL 171
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 825-950 8.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  825 SRLPFPQYQNSP----CPPPLQSNTFVPPQGAhFTPQNNMHYAHPHSApYNPfyPSNNIPQGTPYDPSlnmqgNPYPNHV 900
Cdd:pfam03154  364 PQLPNPQSHKHPphlsGPSPFQMNSNLPPPPA-LKPLSSLSTHHPPSA-HPP--PLQLMPQSQQLPPP-----PAQPPVL 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207186055  901 PLAQSHSAPYSSGYNGSPHHPAAvyshPYYPSPAYPFSFGTPPAPTPAMG 950
Cdd:pfam03154  435 TQSQSLPPPAASHPPTSGLHQVP----SQSPFPQHPFVPGGPPPITPPSG 480
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 128-275 1.03e-54

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 187.15  E-value: 1.03e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  128 KQKGRSMNSTGSGKSSAtvSSVSELLDLYEEDPEEILYNLGFGREEPDIASKIPSRFFNASSNAKGIDIKVYLGAQIQRM 207
Cdd:pfam14722    1 LSRGTSFNSSHSTASTP--QSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207186055  208 EIENPNyaLTSRFRQTEVLATVANVLSDIYSHVSGKPT-DKIGNGDMETNVPNPLKKRSSAGNFAKILK 275
Cdd:pfam14722   79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVqAEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 905-1071 7.69e-44

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 157.00  E-value: 7.69e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  905 SHSAP-YSSGYNGSPHHPAAVYSHPYYPSPAYPFSFGTPPAptpamgSTEMQLRRVLHDIRGTMQNLGQSSSVHGGDTPM 983
Cdd:pfam14723    4 THSVPnLSGAPCGAFYSPFSCPYSPRHQGPPHRGHSRNPPS------TTEMQLRRVLHDIRNSVQNLSQYPVLRGPDLST 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  984 DRI-GTPR-SVQPLYE----ELQMRRRSLNVFRTQMMDLELALMRQQSLVYQHLSPEERREAEQLQTLRTAVRQELQELE 1057
Cdd:pfam14723   78 ASGyNTQRsSVLPLYEntfqELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELE 157

                          170
                   ....*....|....
gi 1207186055 1058 LQLEDRLLSINEQM 1071
Cdd:pfam14723  158 LQLEDRLLALEEQL 171
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 825-950 8.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  825 SRLPFPQYQNSP----CPPPLQSNTFVPPQGAhFTPQNNMHYAHPHSApYNPfyPSNNIPQGTPYDPSlnmqgNPYPNHV 900
Cdd:pfam03154  364 PQLPNPQSHKHPphlsGPSPFQMNSNLPPPPA-LKPLSSLSTHHPPSA-HPP--PLQLMPQSQQLPPP-----PAQPPVL 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207186055  901 PLAQSHSAPYSSGYNGSPHHPAAvyshPYYPSPAYPFSFGTPPAPTPAMG 950
Cdd:pfam03154  435 TQSQSLPPPAASHPPTSGLHQVP----SQSPFPQHPFVPGGPPPITPPSG 480
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 128-275 1.03e-54

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 187.15  E-value: 1.03e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  128 KQKGRSMNSTGSGKSSAtvSSVSELLDLYEEDPEEILYNLGFGREEPDIASKIPSRFFNASSNAKGIDIKVYLGAQIQRM 207
Cdd:pfam14722    1 LSRGTSFNSSHSTASTP--QSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207186055  208 EIENPNyaLTSRFRQTEVLATVANVLSDIYSHVSGKPT-DKIGNGDMETNVPNPLKKRSSAGNFAKILK 275
Cdd:pfam14722   79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVqAEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 905-1071 7.69e-44

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 157.00  E-value: 7.69e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  905 SHSAP-YSSGYNGSPHHPAAVYSHPYYPSPAYPFSFGTPPAptpamgSTEMQLRRVLHDIRGTMQNLGQSSSVHGGDTPM 983
Cdd:pfam14723    4 THSVPnLSGAPCGAFYSPFSCPYSPRHQGPPHRGHSRNPPS------TTEMQLRRVLHDIRNSVQNLSQYPVLRGPDLST 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  984 DRI-GTPR-SVQPLYE----ELQMRRRSLNVFRTQMMDLELALMRQQSLVYQHLSPEERREAEQLQTLRTAVRQELQELE 1057
Cdd:pfam14723   78 ASGyNTQRsSVLPLYEntfqELQVMRRSLNLFRTQMMDLELSMLRQQTMVYQHLTEEERYEADQLQSLRNSVRMELQELE 157

                          170
                   ....*....|....
gi 1207186055 1058 LQLEDRLLSINEQM 1071
Cdd:pfam14723  158 LQLEDRLLALEEQL 171
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 825-950 8.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186055  825 SRLPFPQYQNSP----CPPPLQSNTFVPPQGAhFTPQNNMHYAHPHSApYNPfyPSNNIPQGTPYDPSlnmqgNPYPNHV 900
Cdd:pfam03154  364 PQLPNPQSHKHPphlsGPSPFQMNSNLPPPPA-LKPLSSLSTHHPPSA-HPP--PLQLMPQSQQLPPP-----PAQPPVL 434

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207186055  901 PLAQSHSAPYSSGYNGSPHHPAAvyshPYYPSPAYPFSFGTPPAPTPAMG 950
Cdd:pfam03154  435 TQSQSLPPPAASHPPTSGLHQVP----SQSPFPQHPFVPGGPPPITPPSG 480
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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