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Conserved domains on  [gi|1207195300|ref|XP_021330217|]
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eukaryotic translation initiation factor 4 gamma 3 isoform X1 [Danio rerio]

Protein Classification

eukaryotic translation initiation factor 4 gamma 3( domain architecture ID 10501431)

eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome

CATH:  1.25.40.180
Gene Ontology:  GO:0003743|GO:0003743|GO:0000339|GO:0003723|GO:0003729|GO:0006446
PubMed:  10872469|12867079|9019810|27694156
SCOP:  4000569

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 902-1130 3.47e-60

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


:

Pssm-ID: 397130  Cd Length: 203  Bit Score: 205.29  E-value: 3.47e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  902 FRKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLATLkvpmtdkpnSTVNFR 981
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  982 KLLLNRCQKEFEKDKMdddafekKHREleaatassererlqeeleeaKDKARRRSIGNIKFIGELFKLRMLTEAIMHDCV 1061
Cdd:pfam02854   72 IHLLNRLQEEFEKRFE-------LEEN--------------------EQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195300 1062 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLHN 1130
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1568-1703 2.47e-48

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


:

Pssm-ID: 211397  Cd Length: 134  Bit Score: 168.62  E-value: 2.47e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1568 LSPEELNKQLEKLLLEDMVGDEqIFDWVEANLDESEMSSAPFVRALMTAVCKAAVkTEGSSCKVDLSIIQTRLPVLHKYL 1647
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAI-EEKSLPEKEKALLEKYAPLLQKYL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195300 1648 NSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPA 1703
Cdd:cd11559     79 DDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1370-1481 1.65e-33

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


:

Pssm-ID: 397128  Cd Length: 113  Bit Score: 125.47  E-value: 1.65e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1370 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1449
Cdd:pfam02847    2 KRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1207195300 1450 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1481
Cdd:pfam02847   82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 59-631 4.57e-14

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 4.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   59 PPPLDERIFSTQPVSAVYSVQ---RPPGPPFTAHEINKGHPNLAATP--PG--HASSPGLSQVSVSTVSTahlygHPKGW 131
Cdd:PHA03247  2552 PPPLPPAAPPAAPDRSVPPPRpapRPSEPAVTSRARRPDAPPQSARPraPVddRGDPRGPAPPSPLPPDT-----HAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  132 EPGGGSPYTTgQNAGTTPLVYSPPTQPMNAQPQSRpfAPGPRPTHHQG-GFRSIQFFQRTQMQTARPTIPSNTPPIRPTS 210
Cdd:PHA03247  2627 PPPSPSPAAN-EPDPHPPPTVPPPERPRDDPAPGR--VSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  211 QTPTAAvyspnqhimmtmahmPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPStfyAAASPGEfPAPYAGPPYYP 290
Cdd:PHA03247  2704 PPPTPE---------------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA---GPATPGG-PARPARPPTTA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  291 GQPVYT-PSPPIIVPTPQQPPPAKREKKTIRIRDPNQggKDVTDEilSGVGLSRNPT-PPVGRPSST-PTPPQFLCPHPH 367
Cdd:PHA03247  2765 GPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSP--WDPADP--PAAVLAPAAAlPPAASPAGPlPPPTSAQPTAPP 2840

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  368 YPHIFYLKSQQLNSQVADHGHIMYNVDSSPHLPAPfnlKADDKPKLEF----SLQRTASPGLRQPDTPLERRDPSSPVQ- 442
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKP---AAPARPPVRRlarpAVSRSTESFALPPDQPERPPQPQAPPPp 2917

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  443 --TPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLT 520
Cdd:PHA03247  2918 qpQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  521 QHekAVNGLTDVdAAPLSEELETQPREASpLLPTSSVP-QSEPRPVTPVLEEESDPINMDS--PLPPVEDD--AGCPDNV 595
Cdd:PHA03247  2998 GH--SLSRVSSW-ASSLALHEETDPPPVS-LKQTLWPPdDTEDSDADSLFDSDSERSDLEAldPLPPEPHDpfAHEPDPA 3073

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1207195300  596 SPSLSTSTTAAISTTPPapppglshPSQVSAALDRR 631
Cdd:PHA03247  3074 TPEAGARESPSSQFGPP--------PLSANAALSRR 3101
W2 super family cl17013
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1682-1728 1.46e-06

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


The actual alignment was detected with superfamily member cd11560:

Pssm-ID: 473053 [Multi-domain]  Cd Length: 194  Bit Score: 50.67  E-value: 1.46e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207195300 1682 LYDEDVISEDAFYKWevSKDPAEQQGKGVALKSVTAFFTWLREAEEE 1728
Cdd:cd11560    150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 1093-1370 4.44e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.96  E-value: 4.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1093 KPRMDQYFNQMEKIVKERKTSSRIrfmlqDVIDLrlhnWVsRRADQGPKTIEQIHKDAKLEEQEEQRKVHQQLLSKDNKR 1172
Cdd:PTZ00108  1101 KEKVEKLNAELEKKEKELEKLKNT-----TPKDM----WL-EDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLR 1170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1173 RPVVQREETWSTVPMTKNSRTIDPAKIPKFSKSAIDEKIQLGPRAQVNWMKGSSGGAGAKASESDASRPSaslNRYSPLQ 1252
Cdd:PTZ00108  1171 KPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSV---KRLKSKK 1247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1253 PSALQTSSLPSTSPDFDSRRVLGSRG--SSGRERNDKPLSAGPARTGPISLSSSNKETPEELVQ---EVSRRDSNASDTP 1327
Cdd:PTZ00108  1248 NNSSKSSEDNDEFSSDDLSKEGKPKNapKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrlEGSLAALKKKKKS 1327

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1207195300 1328 KLLVSTADKS--RLENSQPRESAVKLEALSGPSPDKPALSEEEME 1370
Cdd:PTZ00108  1328 EKKTARKKKSktRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 902-1130 3.47e-60

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 205.29  E-value: 3.47e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  902 FRKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLATLkvpmtdkpnSTVNFR 981
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  982 KLLLNRCQKEFEKDKMdddafekKHREleaatassererlqeeleeaKDKARRRSIGNIKFIGELFKLRMLTEAIMHDCV 1061
Cdd:pfam02854   72 IHLLNRLQEEFEKRFE-------LEEN--------------------EQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195300 1062 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLHN 1130
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 903-1127 1.95e-50

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 177.55  E-value: 1.95e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   903 RKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLAtLKVPmtdkpnstvNFRK 982
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   983 LLLNRCQKEFEKDKMDDDAfekkhreleaatassererlqeeleeakdKARRRSIGNIKFIGELFKLRMLTEAIMHDCVV 1062
Cdd:smart00543   72 LLLERLQEEFEKGLESEEE-----------------------------SDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195300  1063 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1127
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1568-1703 2.47e-48

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 168.62  E-value: 2.47e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1568 LSPEELNKQLEKLLLEDMVGDEqIFDWVEANLDESEMSSAPFVRALMTAVCKAAVkTEGSSCKVDLSIIQTRLPVLHKYL 1647
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAI-EEKSLPEKEKALLEKYAPLLQKYL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195300 1648 NSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPA 1703
Cdd:cd11559     79 DDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1370-1481 1.65e-33

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 125.47  E-value: 1.65e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1370 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1449
Cdd:pfam02847    2 KRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1207195300 1450 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1481
Cdd:pfam02847   82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1370-1481 1.06e-31

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 120.43  E-value: 1.06e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  1370 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1449
Cdd:smart00544    2 KKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWRL 81

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207195300  1450 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1481
Cdd:smart00544   82 LEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1641-1725 1.35e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.35e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  1641 PVLHKYLNSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPAEqqGKGVALKSVTAFFT 1720
Cdd:smart00515    1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78


                    ....*
gi 1207195300  1721 WLREA 1725
Cdd:smart00515   79 WLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1654-1730 1.03e-25

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 101.84  E-value: 1.03e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195300 1654 QLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEvSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1730
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWW-EDVSSAEKGMKKVRKQAKPFVEWLEEAEEESD 76
PHA03247 PHA03247
large tegument protein UL36; Provisional
 59-631 4.57e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 4.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   59 PPPLDERIFSTQPVSAVYSVQ---RPPGPPFTAHEINKGHPNLAATP--PG--HASSPGLSQVSVSTVSTahlygHPKGW 131
Cdd:PHA03247  2552 PPPLPPAAPPAAPDRSVPPPRpapRPSEPAVTSRARRPDAPPQSARPraPVddRGDPRGPAPPSPLPPDT-----HAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  132 EPGGGSPYTTgQNAGTTPLVYSPPTQPMNAQPQSRpfAPGPRPTHHQG-GFRSIQFFQRTQMQTARPTIPSNTPPIRPTS 210
Cdd:PHA03247  2627 PPPSPSPAAN-EPDPHPPPTVPPPERPRDDPAPGR--VSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  211 QTPTAAvyspnqhimmtmahmPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPStfyAAASPGEfPAPYAGPPYYP 290
Cdd:PHA03247  2704 PPPTPE---------------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA---GPATPGG-PARPARPPTTA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  291 GQPVYT-PSPPIIVPTPQQPPPAKREKKTIRIRDPNQggKDVTDEilSGVGLSRNPT-PPVGRPSST-PTPPQFLCPHPH 367
Cdd:PHA03247  2765 GPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSP--WDPADP--PAAVLAPAAAlPPAASPAGPlPPPTSAQPTAPP 2840

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  368 YPHIFYLKSQQLNSQVADHGHIMYNVDSSPHLPAPfnlKADDKPKLEF----SLQRTASPGLRQPDTPLERRDPSSPVQ- 442
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKP---AAPARPPVRRlarpAVSRSTESFALPPDQPERPPQPQAPPPp 2917

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  443 --TPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLT 520
Cdd:PHA03247  2918 qpQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  521 QHekAVNGLTDVdAAPLSEELETQPREASpLLPTSSVP-QSEPRPVTPVLEEESDPINMDS--PLPPVEDD--AGCPDNV 595
Cdd:PHA03247  2998 GH--SLSRVSSW-ASSLALHEETDPPPVS-LKQTLWPPdDTEDSDADSLFDSDSERSDLEAldPLPPEPHDpfAHEPDPA 3073

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1207195300  596 SPSLSTSTTAAISTTPPapppglshPSQVSAALDRR 631
Cdd:PHA03247  3074 TPEAGARESPSSQFGPP--------PLSANAALSRR 3101
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1682-1728 1.46e-06

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 50.67  E-value: 1.46e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207195300 1682 LYDEDVISEDAFYKWevSKDPAEQQGKGVALKSVTAFFTWLREAEEE 1728
Cdd:cd11560    150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 25-264 2.44e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 49.26  E-value: 2.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   25 QLSASQLRTTLTtVPLQSVAQQVFLNFPSRYPRVPPPLDERIFSTQPVSAVYSVQRPPGPpftaheINKGHPNLA----- 99
Cdd:pfam09770   94 AIEEEQVRFNRQ-QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEP------IPDLQVDASlwgva 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  100 ---ATPPGHASSPGLSQVSVSTVS---------TAHLYGHPKGWEPGGGSPYTTGQNAGTTPLVYSPPTQPMNAQPQSRP 167
Cdd:pfam09770  167 pkkAAAPAPAPQPAAQPASLPAPSrkmmsleevEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  168 FAPGPRPTHHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHI------MMTMAHMPFHSPQTAQY 241
Cdd:pfam09770  247 QQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQP 326

                          250       260
                   ....*....|....*....|...
gi 1207195300  242 YIPQYRHSAPQYVGPPQQYPVQP 264
Cdd:pfam09770  327 APAHQAHRQQGSFGRQAPIITHP 349
Amelogenin smart00818
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem ...
 176-315 2.37e-03

Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem to regulate formation of crystallites during the secretory stage of tooth enamel development and are thought to play a major role in the structural organisation and mineralisation of developing enamel. The extracellular matrix of the developing enamel comprises two major classes of protein: the hydrophobic amelogenins and the acidic enamelins. Circular dichroism studies of porcine amelogenin have shown that the protein consists of 3 discrete folding units: the N-terminal region appears to contain beta-strand structures, while the C-terminal region displays characteristics of a random coil conformation. Subsequent studies on the bovine protein have indicated the amelogenin structure to contain a repetitive beta-turn segment and a "beta-spiral" between Gln112 and Leu138, which sequester a (Pro, Leu, Gln) rich region. The beta-spiral offers a probable site for interactions with Ca2+ ions. Muatations in the human amelogenin gene (AMGX) cause X-linked hypoplastic amelogenesis imperfecta, a disease characterised by defective enamel. A 9bp deletion in exon 2 of AMGX results in the loss of codons for Ile5, Leu6, Phe7 and Ala8, and replacement by a new threonine codon, disrupting the 16-residue (Met1-Ala16) amelogenin signal peptide.


Pssm-ID: 197891 [Multi-domain]  Cd Length: 165  Bit Score: 40.54  E-value: 2.37e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   176 HHQGGFRSIQF--FQRTQMQTARPTIPSNTPPIRPTSQTPTaavysPNQHIMMTMAHMPFHSPQTAQYYIPqyrhsaPQY 253
Cdd:smart00818   36 HHQIIPVSQQHppTHTLQPHHHIPVLPAQQPVVPQQPLMPV-----PGQHSMTPTQHHQPNLPQPAQQPFQ------PQP 104

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195300   254 VGPPQ-QYPVQPTGPstfyaAASPGEFPAPYAGPPYYPGQPVytpsPPIIVPTPQQPPPA----KRE 315
Cdd:smart00818  105 LQPPQpQQPMQPQPP-----VHPIPPLPPQPPLPPMFPMQPL----PPLLPDLPLEAWPAtdktKRE 162
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1093-1370 4.44e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.96  E-value: 4.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1093 KPRMDQYFNQMEKIVKERKTSSRIrfmlqDVIDLrlhnWVsRRADQGPKTIEQIHKDAKLEEQEEQRKVHQQLLSKDNKR 1172
Cdd:PTZ00108  1101 KEKVEKLNAELEKKEKELEKLKNT-----TPKDM----WL-EDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLR 1170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1173 RPVVQREETWSTVPMTKNSRTIDPAKIPKFSKSAIDEKIQLGPRAQVNWMKGSSGGAGAKASESDASRPSaslNRYSPLQ 1252
Cdd:PTZ00108  1171 KPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSV---KRLKSKK 1247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1253 PSALQTSSLPSTSPDFDSRRVLGSRG--SSGRERNDKPLSAGPARTGPISLSSSNKETPEELVQ---EVSRRDSNASDTP 1327
Cdd:PTZ00108  1248 NNSSKSSEDNDEFSSDDLSKEGKPKNapKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrlEGSLAALKKKKKS 1327

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1207195300 1328 KLLVSTADKS--RLENSQPRESAVKLEALSGPSPDKPALSEEEME 1370
Cdd:PTZ00108  1328 EKKTARKKKSktRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372
 
Name Accession Description Interval E-value
MIF4G pfam02854
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ...
 902-1130 3.47e-60

MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.


Pssm-ID: 397130  Cd Length: 203  Bit Score: 205.29  E-value: 3.47e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  902 FRKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLATLkvpmtdkpnSTVNFR 981
Cdd:pfam02854    1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  982 KLLLNRCQKEFEKDKMdddafekKHREleaatassererlqeeleeaKDKARRRSIGNIKFIGELFKLRMLTEAIMHDCV 1061
Cdd:pfam02854   72 IHLLNRLQEEFEKRFE-------LEEN--------------------EQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195300 1062 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLHN 1130
Cdd:pfam02854  125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
MIF4G smart00543
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ...
 903-1127 1.95e-50

Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)


Pssm-ID: 214713  Cd Length: 200  Bit Score: 177.55  E-value: 1.95e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   903 RKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLAtLKVPmtdkpnstvNFRK 982
Cdd:smart00543    2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   983 LLLNRCQKEFEKDKMDDDAfekkhreleaatassererlqeeleeakdKARRRSIGNIKFIGELFKLRMLTEAIMHDCVV 1062
Cdd:smart00543   72 LLLERLQEEFEKGLESEEE-----------------------------SDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122

                           170       180       190       200       210       220       230
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195300  1063 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1127
Cdd:smart00543  123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
W2_eIF4G1_like cd11559
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ...
 1568-1703 2.47e-48

C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.


Pssm-ID: 211397  Cd Length: 134  Bit Score: 168.62  E-value: 2.47e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1568 LSPEELNKQLEKLLLEDMVGDEqIFDWVEANLDESEMSSAPFVRALMTAVCKAAVkTEGSSCKVDLSIIQTRLPVLHKYL 1647
Cdd:cd11559      1 LPLLRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAI-EEKSLPEKEKALLEKYAPLLQKYL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195300 1648 NSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPA 1703
Cdd:cd11559     79 DDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
MA3 pfam02847
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ...
 1370-1481 1.65e-33

MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.


Pssm-ID: 397128  Cd Length: 113  Bit Score: 125.47  E-value: 1.65e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1370 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1449
Cdd:pfam02847    2 KRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1207195300 1450 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1481
Cdd:pfam02847   82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
MA3 smart00544
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ...
 1370-1481 1.06e-31

Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press


Pssm-ID: 214714  Cd Length: 113  Bit Score: 120.43  E-value: 1.06e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  1370 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1449
Cdd:smart00544    2 KKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWRL 81

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207195300  1450 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1481
Cdd:smart00544   82 LEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
1641-1725 1.35e-26

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 104.68  E-value: 1.35e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  1641 PVLHKYLNSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPAEqqGKGVALKSVTAFFT 1720
Cdd:smart00515    1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78


                    ....*
gi 1207195300  1721 WLREA 1725
Cdd:smart00515   79 WLQEA 83
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 1654-1730 1.03e-25

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 101.84  E-value: 1.03e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195300 1654 QLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEvSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1730
Cdd:pfam02020    1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWW-EDVSSAEKGMKKVRKQAKPFVEWLEEAEEESD 76
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 1571-1697 2.54e-21

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 91.38  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1571 EELNKQLEKLLLEDMVGDEQIFDWVEANLDESEMSSAPFVRALMTAVCKAAVKTEGSS---CKVDLSIIQTRLPVLHKYL 1647
Cdd:cd11473      4 KKLRDSLLKELEEDKSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADSISltqKEQLVLVLKKYGPVLRELL 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207195300 1648 NSDTERQLQALYALQAL--IVKLDQPANLLRMFFDCLYDEDVISEDAFYKWE 1697
Cdd:cd11473     84 KLIKKDQLYLLLKIEKLclQLKLSELISLLEKILDLLYDADVLSEEAILSWF 135
W2_eIF2B_epsilon cd11558
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ...
 1611-1730 4.61e-16

C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211396  Cd Length: 169  Bit Score: 77.68  E-value: 4.61e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1611 RALMTAVCKAAVKTEGSSCKVDLSIIQTRL----PVLHKYLNSDTErQLQALYALQALIVKLDQPANLLRMFFDCLYDED 1686
Cdd:cd11558     47 RAVVKALLELILEVSSTSTAELLEALKKLLskwgPLLENYVKSQDD-QVELLLALEEFCLESEEGGPLFAKLLHALYDLD 125

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1207195300 1687 VISEDAFYKWEVSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1730
Cdd:cd11558    126 ILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
PHA03247 PHA03247
large tegument protein UL36; Provisional
 59-631 4.57e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.44  E-value: 4.57e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   59 PPPLDERIFSTQPVSAVYSVQ---RPPGPPFTAHEINKGHPNLAATP--PG--HASSPGLSQVSVSTVSTahlygHPKGW 131
Cdd:PHA03247  2552 PPPLPPAAPPAAPDRSVPPPRpapRPSEPAVTSRARRPDAPPQSARPraPVddRGDPRGPAPPSPLPPDT-----HAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  132 EPGGGSPYTTgQNAGTTPLVYSPPTQPMNAQPQSRpfAPGPRPTHHQG-GFRSIQFFQRTQMQTARPTIPSNTPPIRPTS 210
Cdd:PHA03247  2627 PPPSPSPAAN-EPDPHPPPTVPPPERPRDDPAPGR--VSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  211 QTPTAAvyspnqhimmtmahmPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPStfyAAASPGEfPAPYAGPPYYP 290
Cdd:PHA03247  2704 PPPTPE---------------PAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPA---GPATPGG-PARPARPPTTA 2764

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  291 GQPVYT-PSPPIIVPTPQQPPPAKREKKTIRIRDPNQggKDVTDEilSGVGLSRNPT-PPVGRPSST-PTPPQFLCPHPH 367
Cdd:PHA03247  2765 GPPAPApPAAPAAGPPRRLTRPAVASLSESRESLPSP--WDPADP--PAAVLAPAAAlPPAASPAGPlPPPTSAQPTAPP 2840

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  368 YPHIFYLKSQQLNSQVADHGHIMYNVDSSPHLPAPfnlKADDKPKLEF----SLQRTASPGLRQPDTPLERRDPSSPVQ- 442
Cdd:PHA03247  2841 PPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKP---AAPARPPVRRlarpAVSRSTESFALPPDQPERPPQPQAPPPp 2917

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  443 --TPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLT 520
Cdd:PHA03247  2918 qpQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  521 QHekAVNGLTDVdAAPLSEELETQPREASpLLPTSSVP-QSEPRPVTPVLEEESDPINMDS--PLPPVEDD--AGCPDNV 595
Cdd:PHA03247  2998 GH--SLSRVSSW-ASSLALHEETDPPPVS-LKQTLWPPdDTEDSDADSLFDSDSERSDLEAldPLPPEPHDpfAHEPDPA 3073

                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1207195300  596 SPSLSTSTTAAISTTPPapppglshPSQVSAALDRR 631
Cdd:PHA03247  3074 TPEAGARESPSSQFGPP--------PLSANAALSRR 3101
PHA03247 PHA03247
large tegument protein UL36; Provisional
 57-683 5.78e-14

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 78.06  E-value: 5.78e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   57 RVPPPLDERIFSTQPVSAVYSVQRPPGPP---FTAHE-------INKGHPNLAATP----PGHASSPGLSQVSVSTVSTA 122
Cdd:PHA03247  2393 RSPPCLVLVDISMAPLFVLWEQPDPPGPPdvrFVGSEeieelpfVSPGGDVLAGLAadgdPFFARTILGAPFSLSLLLGE 2472

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  123 HLYGHPKGWEPG--------GGSPyttGQNAGTTPLVYSPPTqPMNAQPQSRPFAPGPRPTHHQ--GGFRSIQFFQRTQM 192
Cdd:PHA03247  2473 LFPGAPVYRRPAearfpfaaGAAP---DPGGGGPPDPDAPPA-PSRLAPAILPDEPVGEPVHPRmlTWIRGLEELASDDA 2548

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  193 QTARPTIPSNTPPIRPTSQTPTA-AVYSPNQHIMMTMAHMPFHSPQTAQYYIP-----QYRHSAPQYVGPPQQYPVQPTG 266
Cdd:PHA03247  2549 GDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARPRAPvddrgDPRGPAPPSPLPPDTHAPDPPP 2628

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  267 PSTFYAAASPGEfPAPYAGPPyyPGQPVYTPSPPIIVPtpqqPPPAKREKKTIRIRDPNQGGKD--VTDEILSGVGLSRN 344
Cdd:PHA03247  2629 PSPSPAANEPDP-HPPPTVPP--PERPRDDPAPGRVSR----PRRARRLGRAAQASSPPQRPRRraARPTVGSLTSLADP 2701

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  345 PTPPvgrpsSTPTPPqflcPHPHYPHIFYLKSQQLNSQvadhghimynvdSSPHLP-APFNLKADDKPKLEFSLQRTASP 423
Cdd:PHA03247  2702 PPPP-----PTPEPA----PHALVSATPLPPGPAAARQ------------ASPALPaAPAPPAVPAGPATPGGPARPARP 2760

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  424 GLrqPDTPLERRDPSSPVQTPssPPHKPelPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSE 503
Cdd:PHA03247  2761 PT--TAGPPAPAPPAAPAAGP--PRRLT--RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSA 2834

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  504 PEKSSSPPPQSLSGSLTQHEKAVNGltdvdaAPLSEELETQPREASPLLPTSSVPQSEPRPVTPvLEEESDPINMDSPLP 583
Cdd:PHA03247  2835 QPTAPPPPPGPPPPSLPLGGSVAPG------GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVS-RSTESFALPPDQPER 2907

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  584 PVEDDAGCPdnvsPSLSTSTTAAISTTPPAPPPGLShPSQVSAALDRRPSNGAEIKETGKENEALPDKRgEPFLQSRKSS 663
Cdd:PHA03247  2908 PPQPQAPPP----PQPQPQPPPPPQPQPPPPPPPRP-QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR-VAVPRFRVPQ 2981

                          650       660
                   ....*....|....*....|
gi 1207195300  664 NQATSSAPKTWKKPKEDMPV 683
Cdd:PHA03247  2982 PAPSREAPASSTPPLTGHSL 3001
W2_eIF5 cd11561
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ...
 1589-1730 6.06e-11

C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211399  Cd Length: 157  Bit Score: 62.63  E-value: 6.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1589 EQIFDWVEANLDESEMS-------SAPFVRALMTAVCKAAVKTEGSSCKVDLsiIQTRLPVLHKYLNSDtERQLQALYAL 1661
Cdd:cd11561      9 DELGEFLKKNKDESGLSelkeilkEAERLDVVKDKAVLVLAEVLFDENIVKE--IKKRKALLLKLVTDE-KAQKALLGGI 85

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195300 1662 QALIVK-----LDQPANLLRmffdCLYDEDVISEDAFYKW--EVSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1730
Cdd:cd11561     86 ERFCGKhspelLKKVPLILK----ALYDNDILEEEVILKWyeKVSKKYVSKEKSKKVRKAAEPFVEWLEEAEEEEE 157
PHA03247 PHA03247
large tegument protein UL36; Provisional
 52-470 6.52e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 68.04  E-value: 6.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   52 PSRYPRVPPPLDERIFSTQPVSAVYSVQRPPGPPFTAHEINKGHPNLAATPPG---HASSPGLSQVSVSTVSTAHLYGHP 128
Cdd:PHA03247  2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGparPARPPTTAGPPAPAPPAAPAAGPP 2780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  129 KGWEPGGGSPYTTGQNAGTTPLVYSPPTQPMNAQ-----PQSRPFAPGPRPThhqggfrsiqffqrtqmqTARPTIPSNT 203
Cdd:PHA03247  2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPaaalpPAASPAGPLPPPT------------------SAQPTAPPPP 2842

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  204 PPIRPTSQTPTAAVySPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPstfyAAASPGEFPAPY 283
Cdd:PHA03247  2843 PGPPPPSLPLGGSV-APGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP----ERPPQPQAPPPP 2917

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  284 AGPPYYPGQPVYTPSPPiivPTPQQPPPAKREKKTIRIRDPNQGgkdVTDEILSGVGLSRNPTPPVGRPSSTPTPPqflC 363
Cdd:PHA03247  2918 QPQPQPPPPPQPQPPPP---PPPRPQPPLAPTTDPAGAGEPSGA---VPQPWLGALVPGRVAVPRFRVPQPAPSRE---A 2988

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  364 PHPHYPHIFYLKSQQLNSQVADhghIMYNVDSSPH-------LPAPFNLKADDKPKLEFSLQRTASPGLRQPDTPlerrD 436
Cdd:PHA03247  2989 PASSTPPLTGHSLSRVSSWASS---LALHEETDPPpvslkqtLWPPDDTEDSDADSLFDSDSERSDLEALDPLPP----E 3061

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1207195300  437 PSSPVQTPSSPPhkpeLPPSDSETASSVATAPTP 470
Cdd:PHA03247  3062 PHDPFAHEPDPA----TPEAGARESPSSQFGPPP 3091
dnaA PRK14086
chromosomal replication initiator protein DnaA;
154-360 2.90e-07

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 55.22  E-value: 2.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  154 PPTQPMNAQPQSRpfAPGPRP----THHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMA 229
Cdd:PRK14086    99 PPHARRTSEPELP--RPGRRPyegyGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPP 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  230 HMPFHSPqtAQYYIPQYRHSAPQYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAGPPYYPGQPVYTPSPPIIVPTPQQP 309
Cdd:PRK14086   177 RAPYASP--ASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHVHRGGPGPPERDDAPVV 254

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207195300  310 PPAkrekktirirdpnqggkdvtdeilsgvglSRNPTPPVGRPSSTPTPPQ 360
Cdd:PRK14086   255 PIR-----------------------------PSAPGPLAAQPAPAPGPGE 276
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 1682-1728 1.46e-06

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 50.67  E-value: 1.46e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207195300 1682 LYDEDVISEDAFYKWevSKDPAEQQGKGVALKSVTAFFTWLREAEEE 1728
Cdd:cd11560    150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 266-684 1.97e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 1.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  266 GPSTFYAAASPGEFPAPYAGPPYYPGQPvyTPSPPIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDeilsgvglSRNP 345
Cdd:PHA03307    44 VSDSAELAAVTVVAGAAACDRFEPPTGP--PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPP--------GPSS 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  346 TPPVGRPSSTPTPPqflcPHPHYPHIFYLKSQQLNSQVADHghimynvdSSPHLPAPFNLKADDKPklefslqRTASPGL 425
Cdd:PHA03307   114 PDPPPPTPPPASPP----PSPAPDLSEMLRPVGSPGPPPAA--------SPPAAGASPAAVASDAA-------SSRQAAL 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  426 RQPDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADapSPLAEPSLTKAITPEPESSEPE 505
Cdd:PHA03307   175 PLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAAD--DAGASSSDSSSSESSGCGWGPE 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  506 KSSSPPPQSLSGSLTQHEKAVNG-LTDVDAAPLSEELETQPREASPLLPTSSVPQSEPRPVTPVLEEESDPINMDSPLPP 584
Cdd:PHA03307   253 NECPLPRPAPITLPTRIWEASGWnGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSS 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  585 VEDDAGCPDNVSPSLSTSTTAAISTTPPAPPPGLSHPSQVSAALDRRPSNG-AEIKETGKENEALPDKRGEPFLQ----S 659
Cdd:PHA03307   333 SESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGrPTRRRARAAVAGRARRRDATGRFpagrP 412

                          410       420
                   ....*....|....*....|....*
gi 1207195300  660 RKSSNQATSSAPKTWKKPKEDMPVG 684
Cdd:PHA03307   413 RPSPLDAGAASGAFYARYPLLTPSG 437
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 25-264 2.44e-05

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 49.26  E-value: 2.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   25 QLSASQLRTTLTtVPLQSVAQQVFLNFPSRYPRVPPPLDERIFSTQPVSAVYSVQRPPGPpftaheINKGHPNLA----- 99
Cdd:pfam09770   94 AIEEEQVRFNRQ-QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEP------IPDLQVDASlwgva 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  100 ---ATPPGHASSPGLSQVSVSTVS---------TAHLYGHPKGWEPGGGSPYTTGQNAGTTPLVYSPPTQPMNAQPQSRP 167
Cdd:pfam09770  167 pkkAAAPAPAPQPAAQPASLPAPSrkmmsleevEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  168 FAPGPRPTHHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHI------MMTMAHMPFHSPQTAQY 241
Cdd:pfam09770  247 QQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQP 326

                          250       260
                   ....*....|....*....|...
gi 1207195300  242 YIPQYRHSAPQYVGPPQQYPVQP 264
Cdd:pfam09770  327 APAHQAHRQQGSFGRQAPIITHP 349
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 53-494 4.80e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 48.22  E-value: 4.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   53 SRYPRVPPPLDERIFSTQPVSAVYSVQRPPGppftaheINKGHPNLAATPPGhasSPGLSQVSVSTVSTAHLYGHPKGWE 132
Cdd:pfam03154  143 STSPSIPSPQDNESDSDSSAQQQILQTQPPV-------LQAQSGAASPPSPP---PPGTTQAATAGPTPSAPSVPPQGSP 212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  133 PGGGSPYTTGQNAGTTPLVYS-------------PPTQPMN--AQPQSRPFAPGPRPTHHQggfrsiqffQRTQMQTARP 197
Cdd:pfam03154  213 ATSQPPNQTQSTAAPHTLIQQtptlhpqrlpsphPPLQPMTqpPPPSQVSPQPLPQPSLHG---------QMPPMPHSLQ 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  198 TIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQyvgPPQQYPVqPTGPSTFYAAASPG 277
Cdd:pfam03154  284 TGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ---PPREQPL-PPAPLSMPHIKPPP 359

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  278 EFPAPYAGPPYYPGQPVYTPSP-PIIVPTPQQPPPAKREKKTIRIRDPNqggkdvtdeilsgvglSRNPTPPVGRPSSTP 356
Cdd:pfam03154  360 TTPIPQLPNPQSHKHPPHLSGPsPFQMNSNLPPPPALKPLSSLSTHHPP----------------SAHPPPLQLMPQSQQ 423

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  357 TPPQflcphPHYPHIFyLKSQQLNSQVADHGHIMYNVDSSPHLPAPfnlkaddkpklEFSLQRTASPGLRQPDTPLERRD 436
Cdd:pfam03154  424 LPPP-----PAQPPVL-TQSQSLPPPAASHPPTSGLHQVPSQSPFP-----------QHPFVPGGPPPITPPSGPPTSTS 486

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195300  437 PSSP-VQTPSSpphkpeLPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKA 494
Cdd:pfam03154  487 SAMPgIQPPSS------ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
PHA03378 PHA03378
EBNA-3B; Provisional
 68-469 7.21e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 47.75  E-value: 7.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   68 STQPVSAVYSVQRPPGPPFTAHEINKGHPNLAATPPGHASSPGLsqvsvstvsTAHLYGHPKGWEPGGGSPYTTGQNAGT 147
Cdd:PHA03378   555 STEPVHDQLLPAPGLGPLQIQPLTSPTTSQLASSAPSYAQTPWP---------VPHPSQTPEPPTTQSHIPETSAPRQWP 625

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  148 TPLvYSPPTQPMNAQPQsrPFAPGPRPTHHQGGFRSIQFFQRTQMQTarPTIPSNTPPIRPTSQTPTAAvySPNQhiMMT 227
Cdd:PHA03378   626 MPL-RPIPMRPLRMQPI--TFNVLVFPTPHQPPQVEITPYKPTWTQI--GHIPYQPSPTGANTMLPIQW--APGT--MQP 696

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  228 MAHMPFHSPQTAQYYIPQYR-HSAPQYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAGPPYYPGQPVYTPSPPIIVPTP 306
Cdd:PHA03378   697 PPRAPTPMRPPAAPPGRAQRpAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTP 776

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  307 QQPPPAkrekktirirdpnqggkdvtdeilsgvglsrnPTPPVGRPSSTPTPPQflcPHPHYPHIFYLKSQQLNSQVADH 386
Cdd:PHA03378   777 QPPPQA--------------------------------PPAPQQRPRGAPTPQP---PPQAGPTSMQLMPRAAPGQQGPT 821

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  387 GHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDTPLERRDPSSPVQTPSSPPHKpeLPPSDSETASSVAT 466
Cdd:PHA03378   822 KQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQ--LGSVRAAAASTVTQ 899


                   ...
gi 1207195300  467 APT 469
Cdd:PHA03378   900 APT 902
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 101-310 7.25e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.77  E-value: 7.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  101 TPPGHASSPGLSQVSVStvstahlyghpkgWEPGGGsPYTTGQNAGTTPLVYSPptQPMNAQPQSRPFAPGPRPTHHQGG 180
Cdd:PRK10263   343 TPPVASVDVPPAQPTVA-------------WQPVPG-PQTGEPVIAPAPEGYPQ--QSQYAQPAVQYNEPLQQPVQPQQP 406

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  181 FRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHImmtmahmpfhspqtaqyyiPQYRHSAPQYVGPPQQY 260
Cdd:PRK10263   407 YYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-------------------EQQSTFAPQSTYQTEQT 467

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207195300  261 PVQPTGPstfyaaaspgefPAPYAGPPYYPGQPVYTPSPPIIVPTPQQPP 310
Cdd:PRK10263   468 YQQPAAQ------------EPLYQQPQPVEQQPVVEPEPVVEETKPARPP 505
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 210-490 1.34e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.83  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  210 SQTPTAAVYSPnqhimmTMAHMPFHSPQTAQYyIPQYRH-----SAPQYVGPPQQYP--VQPTGPSTFYAAASPGEFPAP 282
Cdd:pfam05109  422 SKAPESTTTSP------TLNTTGFAAPNTTTG-LPSSTHvptnlTAPASTGPTVSTAdvTSPTPAGTTSGASPVTPSPSP 494

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  283 YAGPPYYPGQPVYTPSPPIIVPTPQ--QPPPAKrEKKTIRIRDPNQGGKDVTDEILSGVGLSRNPTPPVGRPSSTPTPPQ 360
Cdd:pfam05109  495 RDNGTESKAPDMTSPTSAVTTPTPNatSPTPAV-TTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPT 573

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  361 FLCPHPH------YPHIFYLKSQQLNSQVADHGHIMYNVDSSPHLPAPFN--LKADDKPKLEFSLQRTASPGLRqPDTPL 432
Cdd:pfam05109  574 LGKTSPTsavttpTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKnaTSAVTTGQHNITSSSTSSMSLR-PSSIS 652

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207195300  433 ERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPS 490
Cdd:pfam05109  653 ETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQAS 710
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 133-312 3.35e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  133 PGGGSPYTTGQNAGTTPLVYSPPTQPMNAQPQSRPFAPGPRPTHHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQT 212
Cdd:PRK07764   590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  213 PTAAVYSPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPSTfyAAASPGEFPAPYAGPPYYPGQ 292
Cdd:PRK07764   670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQ--GASAPSPAADDPVPLPPEPDD 747

                          170       180
                   ....*....|....*....|
gi 1207195300  293 PVYTPSPPIIVPTPQQPPPA 312
Cdd:PRK07764   748 PPDPAGAPAQPPPPPAPAPA 767
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 79-482 3.86e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 3.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   79 QRPPGPP-FTAHEINKGHPNLAATPPGHASSPglsqVSVSTvSTAHLYGHPKGWEPGGGSPYTTGQNAGTTPLVYSPPTQ 157
Cdd:PHA03307    22 PRPPATPgDAADDLLSGSQGQLVSDSAELAAV----TVVAG-AAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLA 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  158 PMNAQPQSRPFAPGPRPThhqggfrsiqffqRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQ 237
Cdd:PHA03307    97 PASPAREGSPTPPGPSSP-------------DPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  238 TAQyyipqyrhsapqyVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAGPPYYPGQPvYTPSPPIIVPTPQ-QPPPAKREK 316
Cdd:PHA03307   164 SDA-------------ASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRP-PRRSSPISASASSpAPAPGRSAA 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  317 ktiriRDPNQGGKDVTDEILSGVGLSRNPTPPVGRPSSTPTPPQFLCPHPHyphifylksqqlNSQVADHGHIMYNVDSS 396
Cdd:PHA03307   230 -----DDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGW------------NGPSSRPGPASSSSSPR 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  397 PHLPAPFNLKADDKPK-------LEFSLQRTASPGLRQPDTPLERRDPSSPVQTPSSPPHKPelPPSDSETASSVATAPT 469
Cdd:PHA03307   293 ERSPSPSPSSPGSGPApssprasSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS--RPPPPADPSSPRKRPR 370

                          410
                   ....*....|...
gi 1207195300  470 PSIPASTEESADA 482
Cdd:PHA03307   371 PSRAPSSPAASAG 383
PRK10905 PRK10905
cell division protein DamX; Validated
 420-494 4.78e-04

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 44.16  E-value: 4.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  420 TASPGLRQPDTPLERR----DPSSPVQTPSSPPHKPELPPSDSETASSVATAPTP---SIPASTEESADAPSPLAEPSLT 492
Cdd:PRK10905   144 KTQTAERPATTRPARKqaviEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPaatSTPAPKETATTAPVQTASPAQT 223


                   ..
gi 1207195300  493 KA 494
Cdd:PRK10905   224 TA 225
PHA03247 PHA03247
large tegument protein UL36; Provisional
 107-366 1.01e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  107 SSPGLSQVSVSTVSTAHLYG-------------------HP-KGWEPGGGSPYTTGQNAGttplvySPPTQPMNAQPQSr 166
Cdd:PHA03247   207 SGPGPAAPADLTAAALHLYGasetylqdepfverrvvisHPlRGDIAAPAPPPVVGEGAD------RAPETARGATGPP- 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  167 pfaPGPRPTHHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAA-------------VYSPNQHIMMTMA--HM 231
Cdd:PHA03247   280 ---PPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPAPAGDAEEeddedgamevvspLPRPRQHYPLGFPkrRR 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  232 PFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAGPPYYPGQPVYTPSPPIIVPTPQQP-- 309
Cdd:PHA03247   357 PTWTPPSSLEDLSAGRHHPKRASLPTRKRRSARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPlp 436

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207195300  310 -----------PPAKREKKTIRIRDPNQGGKDVTDEILSGVGLSRNPTPPVGRPSstptppQFLCPHP 366
Cdd:PHA03247   437 saepgsddgpaPPPERQPPAPATEPAPDDPDDATRKALDALRERRPPEPPGADLA------ELLGRHP 498
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 290-568 1.08e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 43.76  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  290 PGQPVYT--PSPPIIVPTPQQPPPAKREKktirirDPNQGgKDVTDEILSGVGLSRNPTPPVgrpSSTPTPPQflcphph 367
Cdd:PLN03209   330 PKESDAAdgPKPVPTKPVTPEAPSPPIEE------EPPQP-KAVVPRPLSPYTAYEDLKPPT---SPIPTPPS------- 392

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  368 yphifylkSQQLNSQVADHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDtplerrdpsspVQTPSSP 447
Cdd:PLN03209   393 --------SSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYED-----------LKPPTSP 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  448 PHKPELPPSDSETASSVATA-PTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLTQHEKAV 526
Cdd:PLN03209   454 SPTAPTGVSPSVSSTSSVPAvPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVG 533

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1207195300  527 NGLTDVDAAPLSEELETQPREASPLLPTSSV-PQSEPRPVTPV 568
Cdd:PLN03209   534 NSAPPTALADEQHHAQPKPRPLSPYTMYEDLkPPTSPTPSPVL 576
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
428-593 1.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.71  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  428 PDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPA----------------STEESADAPSPLAEPSL 491
Cdd:PRK12323   383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApealaaarqasargpgGAPAPAPAPAAAPAAAA 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  492 TKAITPEPESSEPEKSSSPPPQSLSGSLTQHEK-----------AVNGLTDVDAAPLSEELETQPREASPLLPTSSVPQS 560
Cdd:PRK12323   463 RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppweelppefASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA 542

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1207195300  561 EPRPVTPVLEEESDPINMDSPLPPVEDDAGCPD 593
Cdd:PRK12323   543 PAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
Amelogenin smart00818
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem ...
 176-315 2.37e-03

Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem to regulate formation of crystallites during the secretory stage of tooth enamel development and are thought to play a major role in the structural organisation and mineralisation of developing enamel. The extracellular matrix of the developing enamel comprises two major classes of protein: the hydrophobic amelogenins and the acidic enamelins. Circular dichroism studies of porcine amelogenin have shown that the protein consists of 3 discrete folding units: the N-terminal region appears to contain beta-strand structures, while the C-terminal region displays characteristics of a random coil conformation. Subsequent studies on the bovine protein have indicated the amelogenin structure to contain a repetitive beta-turn segment and a "beta-spiral" between Gln112 and Leu138, which sequester a (Pro, Leu, Gln) rich region. The beta-spiral offers a probable site for interactions with Ca2+ ions. Muatations in the human amelogenin gene (AMGX) cause X-linked hypoplastic amelogenesis imperfecta, a disease characterised by defective enamel. A 9bp deletion in exon 2 of AMGX results in the loss of codons for Ile5, Leu6, Phe7 and Ala8, and replacement by a new threonine codon, disrupting the 16-residue (Met1-Ala16) amelogenin signal peptide.


Pssm-ID: 197891 [Multi-domain]  Cd Length: 165  Bit Score: 40.54  E-value: 2.37e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300   176 HHQGGFRSIQF--FQRTQMQTARPTIPSNTPPIRPTSQTPTaavysPNQHIMMTMAHMPFHSPQTAQYYIPqyrhsaPQY 253
Cdd:smart00818   36 HHQIIPVSQQHppTHTLQPHHHIPVLPAQQPVVPQQPLMPV-----PGQHSMTPTQHHQPNLPQPAQQPFQ------PQP 104

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195300   254 VGPPQ-QYPVQPTGPstfyaAASPGEFPAPYAGPPYYPGQPVytpsPPIIVPTPQQPPPA----KRE 315
Cdd:smart00818  105 LQPPQpQQPMQPQPP-----VHPIPPLPPQPPLPPMFPMQPL----PPLLPDLPLEAWPAtdktKRE 162
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 199-371 4.28e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 4.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  199 IPSNTPPIRPTSQTPTAAVYSPNQHI--MMTM----AHMPFHSPQTAQYYIPQYRHSaPQYVGPPQQYPVQPTGPSTFYA 272
Cdd:pfam09770  165 VAPKKAAAPAPAPQPAAQPASLPAPSrkMMSLeeveAAMRAQAKKPAQQPAPAPAQP-PAAPPAQQAQQQQQFPPQIQQQ 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  273 AASPGEfpAPYAGPPYYPGQPVYT----PSPPIIVPTP----------QQPPPAKREKKTIrIRDPNQGGKdvtdeilSG 338
Cdd:pfam09770  244 QQPQQQ--PQQPQQHPGQGHPVTIlqrpQSPQPDPAQPsiqpqaqqfhQQPPPVPVQPTQI-LQNPNRLSA-------AR 313

                          170       180       190
                   ....*....|....*....|....*....|...
gi 1207195300  339 VGLSRNPTPPVGRPSSTPTPPQfLCPHPHYPHI 371
Cdd:pfam09770  314 VGYPQNPQPGVQPAPAHQAHRQ-QGSFGRQAPI 345
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 1093-1370 4.44e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.96  E-value: 4.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1093 KPRMDQYFNQMEKIVKERKTSSRIrfmlqDVIDLrlhnWVsRRADQGPKTIEQIHKDAKLEEQEEQRKVHQQLLSKDNKR 1172
Cdd:PTZ00108  1101 KEKVEKLNAELEKKEKELEKLKNT-----TPKDM----WL-EDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLR 1170

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1173 RPVVQREETWSTVPMTKNSRTIDPAKIPKFSKSAIDEKIQLGPRAQVNWMKGSSGGAGAKASESDASRPSaslNRYSPLQ 1252
Cdd:PTZ00108  1171 KPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSV---KRLKSKK 1247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300 1253 PSALQTSSLPSTSPDFDSRRVLGSRG--SSGRERNDKPLSAGPARTGPISLSSSNKETPEELVQ---EVSRRDSNASDTP 1327
Cdd:PTZ00108  1248 NNSSKSSEDNDEFSSDDLSKEGKPKNapKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrlEGSLAALKKKKKS 1327

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 1207195300 1328 KLLVSTADKS--RLENSQPRESAVKLEALSGPSPDKPALSEEEME 1370
Cdd:PTZ00108  1328 EKKTARKKKSktRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 294-495 5.89e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 40.61  E-value: 5.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  294 VYTPSPPIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLSRNPTppvGRPSSTPTPPqflCPHPhyphify 373
Cdd:PHA02682    25 LFTKCPQATIPAPAAPCPPDADVDPLDKYSVKEAGRYYQSRLKANSACMQRPS---GQSPLAPSPA---CAAP------- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  374 lkSQQLNSqvadhghimynvdSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDTPleRRDPSSPVQTPSSPPHKPEL 453
Cdd:PHA02682    92 --APACPA-------------CAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPA--RPAPACPPSTRQCPPAPPLP 154

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1207195300  454 PPSDSETASSV---ATAPTPSIPAS---TEESADAPSPLAEPSLTKAI 495
Cdd:PHA02682   155 TPKPAPAAKPIflhNQLPPPDYPAAscpTIETAPAASPVLEPRIPDKI 202
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 437-620 7.26e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 7.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  437 PSSPVQTPSSPPhkPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLtkaitpepessepekssspppqsls 516
Cdd:PRK07994   361 PAAPLPEPEVPP--QSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAV------------------------- 413

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  517 gsltQHEKAVNGLTDVDAAPLSEELETQPREASPllptssVPQSEPRPVTPVLEE--ESDPINMDSPLPPVEDDAGCPDN 594
Cdd:PRK07994   414 ----PLPETTSQLLAARQQLQRAQGATKAKKSEP------AAASRARPVNSALERlaSVRPAPSALEKAPAKKEAYRWKA 483

                          170       180
                   ....*....|....*....|....*.
gi 1207195300  595 VSPSLstsTTAAISTTPPAPPPGLSH 620
Cdd:PRK07994   484 TNPVE---VKKEPVATPKALKKALEH 506
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 411-485 8.10e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 40.71  E-value: 8.10e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195300  411 PKLEFSLQRTASPGLRQPDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSP 485
Cdd:PHA03291   188 PALPLSAPRLGPADVFVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEGTPAPPTP 262
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 197-315 8.28e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 8.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195300  197 PTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQ---QYPVQPTGPSTFYA- 272
Cdd:PRK10263   740 PHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQpqyQQPQQPVAPQPQYQq 819

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207195300  273 ----AASPGEFPAPYAGPPYYP--------------GQPVYTPSPPIIVPTPQQPPPAKRE 315
Cdd:PRK10263   820 pqqpVAPQPQYQQPQQPVAPQPqdtllhpllmrngdSRPLHKPTTPLPSLDLLTPPPSEVE 880
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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