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Conserved domains on  [gi|1207190887|ref|XP_021328418|]
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nidogen-1 isoform X2 [Danio rerio]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 9.20e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 9.20e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207190887   24 QLIKSDIGSPEGIAIDHLGRNMFWTDSMKDRIEVSSLDGTQR 65
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2-143 9.44e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.40  E-value: 9.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPAISRANLQGGEPVQLIKSDiGSPEGIAIDHLGRNMFWTDSMKDRIEVssLDGTQRRVLVNTDL-VNPRAIL 80
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVgAGPHGIA 158

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190887  81 TDSTNGYIYWADWNreSPKIEM--AYMDGTNRRVLAK-DDLSLPNGLTYDPQTSLLCWADAGTHKV 143
Cdd:COG3391   159 VDPDGKRLYVANSG--SNTVSVivSVIDTATGKVVATiPVGGGPVGVAVSPDGRRLYVANRGSNTS 222
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 222-246 4.15e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 4.15e-09
                          10        20
                  ....*....|....*....|....*
gi 1207190887 222 CSSNNGGCTHLCLATPAGRSCRCPD 246
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 9.20e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 9.20e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207190887   24 QLIKSDIGSPEGIAIDHLGRNMFWTDSMKDRIEVSSLDGTQR 65
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2-143 9.44e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.40  E-value: 9.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPAISRANLQGGEPVQLIKSDiGSPEGIAIDHLGRNMFWTDSMKDRIEVssLDGTQRRVLVNTDL-VNPRAIL 80
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVgAGPHGIA 158

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190887  81 TDSTNGYIYWADWNreSPKIEM--AYMDGTNRRVLAK-DDLSLPNGLTYDPQTSLLCWADAGTHKV 143
Cdd:COG3391   159 VDPDGKRLYVANSG--SNTVSVivSVIDTATGKVVATiPVGGGPVGVAVSPDGRRLYVANRGSNTS 222
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-110 1.13e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 1.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1207190887   66 RVLVNTDLVNPRAILTDSTNGYIYWADWNResPKIEMAYMDGTNR 110
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2-40 3.26e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 3.26e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPA-ISRANLQGGEPVQLIKSDIGSPEGIAIDH 40
Cdd:pfam00058   3 LYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 222-246 4.15e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 4.15e-09
                          10        20
                  ....*....|....*....|....*
gi 1207190887 222 CSSNNGGCTHLCLATPAGRSCRCPD 246
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 27-192 1.22e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  27 KSDIGSPEGIAIDHLGrNMFWTDSMKDRIEVSSLDGTQRRVL-----VNTDLVNPRAILTDStNGYIYWADWNrespkie 101
Cdd:cd05819    98 DGEFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTG------- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887 102 maymdgtNRRVL-----------------AKDDLSLPNGLTYDPQTSLLCwADAGTHKVECMNP------QQGRRTQLME 158
Cdd:cd05819   169 -------NHRIQvfdpdgnflttfgstgtGPGQFNYPTGIAVDSDGNIYV-ADSGNNRVQVFDPdgagfgGNGNFLGSDG 240

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1207190887 159 EIQYPFGLTTDGKNfyytdwtrvSVVVVDRHLRR 192
Cdd:cd05819   241 QFNRPSGLAVDSDG---------NLYVADTGNNR 265
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 43-82 1.58e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 1.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1207190887  43 RNMFWTD-SMKDRIEVSSLDGTQRRVLVNTDLVNPRAILTD 82
Cdd:pfam00058   1 GRLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 31-94 6.69e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 37.25  E-value: 6.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190887  31 GSPEGIAIDHLGrNMFWTDSMKDRIEVSSLDGTqrrvLVNT---------DLVNPRAILTDStNGYIYWAD-WN 94
Cdd:cd14957   159 NGPQGIAVDSDG-NIYVADTGNHRIQVFTSSGT----FQYTfgssgsgpgQFSDPYGIAVDS-DGNIYVADtGN 226
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 24-65 9.20e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.38  E-value: 9.20e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207190887   24 QLIKSDIGSPEGIAIDHLGRNMFWTDSMKDRIEVSSLDGTQR 65
Cdd:smart00135   2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
2-143 9.44e-10

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.40  E-value: 9.44e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPAISRANLQGGEPVQLIKSDiGSPEGIAIDHLGRNMFWTDSMKDRIEVssLDGTQRRVLVNTDL-VNPRAIL 80
Cdd:COG3391    82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVATIPVgAGPHGIA 158

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190887  81 TDSTNGYIYWADWNreSPKIEM--AYMDGTNRRVLAK-DDLSLPNGLTYDPQTSLLCWADAGTHKV 143
Cdd:COG3391   159 VDPDGKRLYVANSG--SNTVSVivSVIDTATGKVVATiPVGGGPVGVAVSPDGRRLYVANRGSNTS 222
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 66-110 1.13e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.60  E-value: 1.13e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1207190887   66 RVLVNTDLVNPRAILTDSTNGYIYWADWNResPKIEMAYMDGTNR 110
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL--DVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 2-40 3.26e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.39  E-value: 3.26e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPA-ISRANLQGGEPVQLIKSDIGSPEGIAIDH 40
Cdd:pfam00058   3 LYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 222-246 4.15e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 51.09  E-value: 4.15e-09
                          10        20
                  ....*....|....*....|....*
gi 1207190887 222 CSSNNGGCTHLCLATPAGRSCRCPD 246
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 86-128 5.72e-09

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 50.62  E-value: 5.72e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1207190887  86 GYIYWADWNrESPKIEMAYMDGTNRRVLAKDDLSLPNGLTYDP 128
Cdd:pfam00058   1 GRLYWTDSS-LRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 27-192 1.22e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 1.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  27 KSDIGSPEGIAIDHLGrNMFWTDSMKDRIEVSSLDGTQRRVL-----VNTDLVNPRAILTDStNGYIYWADWNrespkie 101
Cdd:cd05819    98 DGEFNGPRGIAVDSSG-NIYVADTGNHRIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVDS-DGNIYVADTG------- 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887 102 maymdgtNRRVL-----------------AKDDLSLPNGLTYDPQTSLLCwADAGTHKVECMNP------QQGRRTQLME 158
Cdd:cd05819   169 -------NHRIQvfdpdgnflttfgstgtGPGQFNYPTGIAVDSDGNIYV-ADSGNNRVQVFDPdgagfgGNGNFLGSDG 240

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1207190887 159 EIQYPFGLTTDGKNfyytdwtrvSVVVVDRHLRR 192
Cdd:cd05819   241 QFNRPSGLAVDSDG---------NLYVADTGNNR 265
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 2-219 2.32e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 53.36  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPAISRANLQGGEpVQLIKSDIGSPEGIAIDHLGRnmFWTDSMKDRIEVSSLDGTQRRVLVNT---------D 72
Cdd:COG3386    21 LYWVDIPGGRIHRYDPDGGA-VEVFAEPSGRPNGLAFDPDGR--LLVADHGRGLVRFDPADGEVTVLADEygkplnrpnD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  73 L-VNP--RAILTDST----NGYIYWADWnrespkiemaymDGTNRRVLakDDLSLPNGLTYDPQTSLLCWADAGTHKVEC 145
Cdd:COG3386    98 GvVDPdgRLYFTDMGeylpTGALYRVDP------------DGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGAGRIYR 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887 146 MNPQQ-----GRRT--QLMEEIQYPFGLTTDGK-NFYYTDWTRVSVVVVD---RHLRR-EVDEFQP-------QKRTRLY 206
Cdd:COG3386   164 FDLDAdgtlgNRRVfaDLPDGPGGPDGLAVDADgNLWVALWGGGGVVRFDpdgELLGRiELPERRPtnvafggPDLRTLY 243

                         250
                  ....*....|...
gi 1207190887 207 gITTAHARCPAGQ 219
Cdd:COG3386   244 -VTTARSLPLAGA 255
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1-210 8.54e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 48.86  E-value: 8.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   1 MIYWTDISTPAISRANLQGGEPVQLIKSDIGSPEGIAIDHLGrNMFWTDSMKDRI-EVSSLDGTQRRVLVNTDLVNPRAI 79
Cdd:COG4257    29 AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDG-NLWFTDNGNNRIgRIDPKTGEITTFALPGGGSNPHGI 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  80 LTDStNGYIYWADwnRESPKIemAYMDGTNRRVL---AKDDLSLPNGLTYDPQTSLLcWADAGTHKVECMNPQQGRRTQ- 155
Cdd:COG4257   108 AFDP-DGNLWFTD--QGGNRI--GRLDPATGEVTefpLPTGGAGPYGIAVDPDGNLW-VTDFGANAIGRIDPDTGTLTEy 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190887 156 -LMEEIQYPFGLTTDGK-NFYYTDWTRVSVVVVDRHLrREVDEFQ-PQKRTRLYGITT 210
Cdd:COG4257   182 aLPTPGAGPRGLAVDPDgNLWVADTGSGRIGRFDPKT-GTVTEYPlPGGGARPYGVAV 238
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 111-147 2.71e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 43.36  E-value: 2.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207190887  111 RVLAKDDLSLPNGLTYDPQTSLLCWADAGTHKVECMN 147
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVAN 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 43-82 1.58e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.99  E-value: 1.58e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1207190887  43 RNMFWTD-SMKDRIEVSSLDGTQRRVLVNTDLVNPRAILTD 82
Cdd:pfam00058   1 GRLYWTDsSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 18-129 2.10e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 44.59  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  18 QGGEPVQLIksdigSPEGIAIDHLGrNMFWTDSMKDRIEVSSLDGTQRRVLVNTD-----LVNPRAILTDStNGYIYWAD 92
Cdd:cd14963   140 PGSEPGELS-----YPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKELNGSPdgksgFVNPRGIAVDP-DGNLYVVD 212

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1207190887  93 wnRESPKIEMAYMDGTNRRVLA---KDD--LSLPNGLTYDPQ 129
Cdd:cd14963   213 --NLSHRVYVFDEQGKELFTFGgrgKDDgqFNLPNGLFIDDD 252
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 2-128 1.82e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.80  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   2 IYWTDISTPAISRANLQGGEpVQLIKSD----IGSPEGIAIDHLGrNMFWTDSMKDRIEVSSLDGTQRRVLVNTDLVN-P 76
Cdd:cd14962    25 IYVADTGRGAVFVFDLPNGK-VFVIGNAgpnrFVSPIGVAIDANG-NLYVSDAELGKVFVFDRDGKFLRAIGAGALFKrP 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190887  77 RAILTDSTNGYIYWADwnRESPKIEMAYMDGTNRRVLAKDD-----LSLPNGLTYDP 128
Cdd:cd14962   103 TGIAVDPAGKRLYVVD--TLAHKVKVFDLDGRLLFDIGKRGsgpgeFNLPTDLAVDR 157
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 18-183 2.82e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 41.12  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  18 QGGEPVQLiksdiGSPEGIAIDHlGRNMFWTDSMKDRIEVSSLDGTQRRVLVNTD----LVNPRAILTDSTN-------- 85
Cdd:cd14963    48 PGTGPGEF-----KYPYGIAVDS-DGNIYVADLYNGRIQVFDPDGKFLKYFPEKKdrvkLISPAGLAIDDGKlyvsdvkk 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  86 -------------------------------------GYIYWADWNRESPKI---EMAYMDGTNRRVLAKDDLSLPNGLT 125
Cdd:cd14963   122 hkvivfdlegklllefgkpgsepgelsypngiavdedGNIYVADSGNGRIQVfdkNGKFIKELNGSPDGKSGFVNPRGIA 201

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190887 126 YDPQTSLLCwADAGTHKVECMNPQQ------GRRTQLMEEIQYPFGLTTDGKNFYY-TDW--TRVSV 183
Cdd:cd14963   202 VDPDGNLYV-VDNLSHRVYVFDEQGkelftfGGRGKDDGQFNLPNGLFIDDDGRLYvTDRenNRVAV 267
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 5-94 1.83e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 38.78  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   5 TDISTPAISRANLQGGepVQLIKSDIGSPEGIAIDHLGRNMFWTDSMKDRIEVSSLDG-----TQRRVLVNT--DLVNPR 77
Cdd:pfam08450 110 PGGDPGALYRLDPDGK--LTRVLDGLTISNGLAWSPDGRTLYFADSPARKIWAYDYDLdggliSNRRVFADFkpGLGRPD 187

                          90
                  ....*....|....*..
gi 1207190887  78 AILTDStNGYIYWADWN 94
Cdd:pfam08450 188 GMAVDA-EGNVWVARWG 203
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 31-94 6.69e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 37.25  E-value: 6.69e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190887  31 GSPEGIAIDHLGrNMFWTDSMKDRIEVSSLDGTqrrvLVNT---------DLVNPRAILTDStNGYIYWAD-WN 94
Cdd:cd14957   159 NGPQGIAVDSDG-NIYVADTGNHRIQVFTSSGT----FQYTfgssgsgpgQFSDPYGIAVDS-DGNIYVADtGN 226
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 29-92 7.32e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 36.86  E-value: 7.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190887  29 DIGSPEGIAIDHLGrNMFWTDSMKDRIEV-SSLDGTQRRVLVNT----DLVNPRAILTDStNGYIYWAD 92
Cdd:cd14957    63 QFNSPYGIAVDSNG-NIYVADTDNNRIQVfNSSGVYQYSIGTGGsgdgQFNGPYGIAVDS-NGNIYVAD 129
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 3-212 7.34e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 36.86  E-value: 7.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887   3 YWTDISTPAISRANLQGGEPVQLiksDIGSPEGIAIDHLGRNMFWTdsMKDRIEVSSLDGTQRRVLVntDLVNPRAILTD 82
Cdd:pfam08450  15 YWVDILGGRIHRLDPATGKETVW---DTPGPVGAIAPRDDGGLIVA--LKDGVALLDLATGELTPLA--DPEDDDWPLNR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887  83 STNGYI-----YWAD--WNRESPKIEMA---YMDGTNRRVLAKDDLSLPNGLTYDPQTSLLCWADAGTHKV------ECM 146
Cdd:pfam08450  88 FNDGKVdpdgrFWFGtmGDDEAPGGDPGalyRLDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKIwaydydLDG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190887 147 NPQQGRRT--QLMEEIQYPFGLTTDGKNFYYTDWTRVS-VVVVDRH--LRREVD---------EFQPQKRTRLYgITTAH 212
Cdd:pfam08450 168 GLISNRRVfaDFKPGLGRPDGMAVDAEGNVWVARWGGGkVVRFDPDgkLLREIElpakrptscAFGGPDLRTLY-VTSAR 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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