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Conserved domains on  [gi|1207189765|ref|XP_021327977|]
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E3 ubiquitin-protein ligase CBL-B isoform X2 [Danio rerio]

Protein Classification

E3 ubiquitin-protein ligase CBL; E3 ubiquitin-protein ligase CBL-B( domain architecture ID 10706126)

E3 ubiquitin-protein ligase CBL is an adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors| E3 ubiquitin-protein ligase CBL-B accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cbl_N pfam02262
CBL proto-oncogene N-terminal domain 1; Cbl is an adaptor protein that binds EGF receptors (or ...
 36-162 2.64e-74

CBL proto-oncogene N-terminal domain 1; Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.


:

Pssm-ID: 426685  Cd Length: 125  Bit Score: 219.01  E-value: 2.64e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189765  36 ADRRTVEKTWKLMDKVVRLCQNPRLQLKNSPPYILDILPDTYQHLRLILCKYEEnqRLTQLSENDYFKVYIDSLMKKSKR 115
Cdd:pfam02262   1 IDRRTLDKAVKLLDKLVKLCQDPRLNLKNSPPYLLDLLPDTYQHLRLVAEKYRG--RLDALGENEYLRIYLANLLAKCKQ 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207189765 116 AIRLFKEAKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQ 162
Cdd:pfam02262  79 AAKLFKEGKEKMFDEGSRYRRQLTKLSLIFSHMLAELKALFPDGKFC 125
Cbl_N2 super family cl03701
CBL proto-oncogene N-terminus, EF hand-like domain; Cbl is an adaptor protein that binds EGF ...
 166-184 2.74e-06

CBL proto-oncogene N-terminus, EF hand-like domain; Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.


The actual alignment was detected with superfamily member pfam02761:

Pssm-ID: 460681  Cd Length: 84  Bit Score: 43.77  E-value: 2.74e-06
                          10
                  ....*....|....*....
gi 1207189765 166 FRITKADAAEFWRRSFGEK 184
Cdd:pfam02761   1 FRITKSEAAEFWKKSFGKR 19
 
Name Accession Description Interval E-value
Cbl_N pfam02262
CBL proto-oncogene N-terminal domain 1; Cbl is an adaptor protein that binds EGF receptors (or ...
 36-162 2.64e-74

CBL proto-oncogene N-terminal domain 1; Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.


Pssm-ID: 426685  Cd Length: 125  Bit Score: 219.01  E-value: 2.64e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189765  36 ADRRTVEKTWKLMDKVVRLCQNPRLQLKNSPPYILDILPDTYQHLRLILCKYEEnqRLTQLSENDYFKVYIDSLMKKSKR 115
Cdd:pfam02262   1 IDRRTLDKAVKLLDKLVKLCQDPRLNLKNSPPYLLDLLPDTYQHLRLVAEKYRG--RLDALGENEYLRIYLANLLAKCKQ 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207189765 116 AIRLFKEAKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQ 162
Cdd:pfam02262  79 AAKLFKEGKEKMFDEGSRYRRQLTKLSLIFSHMLAELKALFPDGKFC 125
Cbl_N2 pfam02761
CBL proto-oncogene N-terminus, EF hand-like domain; Cbl is an adaptor protein that binds EGF ...
 166-184 2.74e-06

CBL proto-oncogene N-terminus, EF hand-like domain; Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.


Pssm-ID: 460681  Cd Length: 84  Bit Score: 43.77  E-value: 2.74e-06
                          10
                  ....*....|....*....
gi 1207189765 166 FRITKADAAEFWRRSFGEK 184
Cdd:pfam02761   1 FRITKSEAAEFWKKSFGKR 19
 
Name Accession Description Interval E-value
Cbl_N pfam02262
CBL proto-oncogene N-terminal domain 1; Cbl is an adaptor protein that binds EGF receptors (or ...
 36-162 2.64e-74

CBL proto-oncogene N-terminal domain 1; Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.


Pssm-ID: 426685  Cd Length: 125  Bit Score: 219.01  E-value: 2.64e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207189765  36 ADRRTVEKTWKLMDKVVRLCQNPRLQLKNSPPYILDILPDTYQHLRLILCKYEEnqRLTQLSENDYFKVYIDSLMKKSKR 115
Cdd:pfam02262   1 IDRRTLDKAVKLLDKLVKLCQDPRLNLKNSPPYLLDLLPDTYQHLRLVAEKYRG--RLDALGENEYLRIYLANLLAKCKQ 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207189765 116 AIRLFKEAKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPGGQFQ 162
Cdd:pfam02262  79 AAKLFKEGKEKMFDEGSRYRRQLTKLSLIFSHMLAELKALFPDGKFC 125
Cbl_N2 pfam02761
CBL proto-oncogene N-terminus, EF hand-like domain; Cbl is an adaptor protein that binds EGF ...
 166-184 2.74e-06

CBL proto-oncogene N-terminus, EF hand-like domain; Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.


Pssm-ID: 460681  Cd Length: 84  Bit Score: 43.77  E-value: 2.74e-06
                          10
                  ....*....|....*....
gi 1207189765 166 FRITKADAAEFWRRSFGEK 184
Cdd:pfam02761   1 FRITKSEAAEFWKKSFGKR 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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