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Conserved domains on  [gi|1207187733|ref|XP_021327284|]
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ATP-dependent DNA helicase DDX31 [Danio rerio]

Protein Classification

DEADc_DDX31 and SF2_C_DEAD domain-containing protein( domain architecture ID 12783010)

protein containing domains DEADc_DDX31, SF2_C_DEAD, and DUF4217

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 165-367 1.33e-108

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


:

Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 329.16  E-value: 1.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQ 244
Cdd:cd17949     1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 245 SFQMFQKLLRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEK 324
Cdd:cd17949    81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1207187733 325 DLTVILNALN----------TAGPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17949   161 DITKILELLDdkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
153-604 1.06e-102

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 321.33  E-value: 1.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 153 SNTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiqpkvKRSDGPLA 232
Cdd:COG0513     1 MMSFADLGLSPPLLKALAE-LGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDP-----SRPRAPQA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 233 VVIVPTRELALQSFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIK-NTLSiaFSAVRWLIL 311
Cdd:COG0513    75 LILAPTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIErGALD--LSGVETLVL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 312 DEADRILDLGFEKDLTVILNALNTAgpyRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSeetveacpqaapqalsds 391
Cdd:COG0513   152 DEADRMLDMGFIEDIERILKLLPKE---RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 392 yAVPERLQQHVVVVPS--KLHLvcLAAFIlakcKFEQRQKLVIFISSCEAVEFLlnlfTAVLCE--IPSNTsskstscln 467
Cdd:COG0513   211 -ATAETIEQRYYLVDKrdKLEL--LRRLL----RDEDPERAIVFCNTKRGADRL----AEKLQKrgISAAA--------- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 468 fyrLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTP 547
Cdd:COG0513   271 ---LHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 548 SETAFVDV---LANHNISLSEMKMVDILSTLmKDERFKGRGKWDSKRSADAFEQEVRERA 604
Cdd:COG0513   348 DERRLLRAiekLIGQKIEEEELPGFEPVEEK-RLERLKPKIKEKLKGKKAGRGGRPGPKG 406
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
 608-668 5.48e-14

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


:

Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 67.04  E-value: 5.48e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207187733 608 QTDFENYVHASNESLQTAKSALQCFLRAYTTYPssLKHIFHIRMLHLGHAAKSFGLRDAPQ 668
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
 
Name Accession Description Interval E-value
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 165-367 1.33e-108

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 329.16  E-value: 1.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQ 244
Cdd:cd17949     1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 245 SFQMFQKLLRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEK 324
Cdd:cd17949    81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1207187733 325 DLTVILNALN----------TAGPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17949   161 DITKILELLDdkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
153-604 1.06e-102

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 321.33  E-value: 1.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 153 SNTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiqpkvKRSDGPLA 232
Cdd:COG0513     1 MMSFADLGLSPPLLKALAE-LGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDP-----SRPRAPQA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 233 VVIVPTRELALQSFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIK-NTLSiaFSAVRWLIL 311
Cdd:COG0513    75 LILAPTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIErGALD--LSGVETLVL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 312 DEADRILDLGFEKDLTVILNALNTAgpyRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSeetveacpqaapqalsds 391
Cdd:COG0513   152 DEADRMLDMGFIEDIERILKLLPKE---RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 392 yAVPERLQQHVVVVPS--KLHLvcLAAFIlakcKFEQRQKLVIFISSCEAVEFLlnlfTAVLCE--IPSNTsskstscln 467
Cdd:COG0513   211 -ATAETIEQRYYLVDKrdKLEL--LRRLL----RDEDPERAIVFCNTKRGADRL----AEKLQKrgISAAA--------- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 468 fyrLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTP 547
Cdd:COG0513   271 ---LHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 548 SETAFVDV---LANHNISLSEMKMVDILSTLmKDERFKGRGKWDSKRSADAFEQEVRERA 604
Cdd:COG0513   348 DERRLLRAiekLIGQKIEEEELPGFEPVEEK-RLERLKPKIKEKLKGKKAGRGGRPGPKG 406
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 152-550 1.99e-57

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 202.34  E-value: 1.99e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 152 TSNTFEELNLHPHLVATLhKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKrsdgpl 231
Cdd:PRK11776    2 SMTAFSTLPLPPALLANL-NELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQ------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 232 AVVIVPTRELALQSFQMFQKLLR--PFTWIVpgVLMGGEKKKAEKARLRKGINVLISTPGRLVDHI-KNTLSIafSAVRW 308
Cdd:PRK11776   75 ALVLCPTRELADQVAKEIRRLARfiPNIKVL--TLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLrKGTLDL--DALNT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 309 LILDEADRILDLGFEKDLTVILNAlntAGPYRQNVLLSATITEGLSRLASISMKDPVSVHVsegseETVEACPQaapqal 388
Cdd:PRK11776  151 LVLDEADRMLDMGFQDAIDAIIRQ---APARRQTLLFSATYPEGIAAISQRFQRDPVEVKV-----ESTHDLPA------ 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 389 sdsyavperLQQHvvvvpsklhlvclaaFIlaKCKFEQRQklvifisscEAVEFLLNLFTAVLCEIPSNT---------- 458
Cdd:PRK11776  217 ---------IEQR---------------FY--EVSPDERL---------PALQRLLLHHQPESCVVFCNTkkecqevada 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 459 -SSKSTSCLNfyrLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGA 537
Cdd:PRK11776  262 lNAQGFSALA---LHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGS 338

                         410
                  ....*....|...
gi 1207187733 538 QGSSLLFLTPSET 550
Cdd:PRK11776  339 KGLALSLVAPEEM 351
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 179-356 1.90e-49

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 170.89  E-value: 1.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQaiqpkvKRSDGPLAVVIVPTRELALQSFQMFQKLLRpFTW 258
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALD------KLDNGPQALVLAPTRELAEQIYEELKKLGK-GLG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLrKGINVLISTPGRLVDHIKNTlsIAFSAVRWLILDEADRILDLGFEKDLTVILNALNtagP 338
Cdd:pfam00270  74 LKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLP---K 147

                         170
                  ....*....|....*...
gi 1207187733 339 YRQNVLLSATITEGLSRL 356
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
DEXDc smart00487
DEAD-like helicases superfamily;
178-378 1.08e-42

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 153.42  E-value: 1.08e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733  178 MTSVQKQTIPVLMSG-KDAVVRSQTGSGKTLAYGIPMVQFLqaiqpkvKRSDGPLAVVIVPTRELALQSFQMFQKLLrPF 256
Cdd:smart00487   9 LRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL-------KRGKGGRVLVLVPTRELAEQWAEELKKLG-PS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733  257 TWIVPGVLMGGEKKKAEKARLRKG-INVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNT 335
Cdd:smart00487  81 LGLKVVGLYGGDSKREQLRKLESGkTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPK 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1207187733  336 AgpyRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSEETVE 378
Cdd:smart00487 160 N---VQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIE 199
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 398-545 3.02e-42

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 149.58  E-value: 3.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 398 LQQHVVVVPSKLHLVCLAAFILAKckfEQRQKLVIFISSCEAVEFLLNLFTavLCEIPSntsskstsclnfYRLHGNMRQ 477
Cdd:cd18787     1 IKQLYVVVEEEEKKLLLLLLLLEK---LKPGKAIIFVNTKKRVDRLAELLE--ELGIKV------------AALHGDLSQ 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 478 EERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFL 545
Cdd:cd18787    64 EERERALKKFRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
HELICc smart00490
helicase superfamily c-terminal domain;
466-536 4.01e-25

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 99.21  E-value: 4.01e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207187733  466 LNFYRLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIG 536
Cdd:smart00490  12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 461-536 9.41e-25

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 99.21  E-value: 9.41e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207187733 461 KSTSCLNFYRLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIG 536
Cdd:pfam00271  34 LEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
 608-668 5.48e-14

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 67.04  E-value: 5.48e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207187733 608 QTDFENYVHASNESLQTAKSALQCFLRAYTTYPssLKHIFHIRMLHLGHAAKSFGLRDAPQ 668
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 160-314 1.14e-07

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 55.23  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 160 NLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQpkvkRSDGPLAVVIVPTR 239
Cdd:COG1205    40 WLPPELRAALKK-RGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPV---LEALL----EDPGATALYLYPTK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 240 ELA---LQSFQ-MFQKL---LRPFTWIvpgvlmgGEKKKAEKARLRKGINVLISTP-----GRLVDHIKntlsIA--FSA 305
Cdd:COG1205   112 ALArdqLRRLReLAEALglgVRVATYD-------GDTPPEERRWIREHPDIVLTNPdmlhyGLLPHHTR----WArfFRN 180


                  ....*....
gi 1207187733 306 VRWLILDEA 314
Cdd:COG1205   181 LRYVVIDEA 189
PRK13766 PRK13766
Hef nuclease; Provisional
 475-534 2.70e-03

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 41.01  E-value: 2.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 475 MRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTAR 534
Cdd:PRK13766  407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR 466
 
Name Accession Description Interval E-value
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
 165-367 1.33e-108

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 329.16  E-value: 1.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQ 244
Cdd:cd17949     1 LVSHLKSKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVDRSDGTLALVLVPTRELALQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 245 SFQMFQKLLRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEK 324
Cdd:cd17949    81 IYEVLEKLLKPFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSFDVSNLRWLVLDEADRLLDMGFEK 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1207187733 325 DLTVILNALN----------TAGPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17949   161 DITKILELLDdkrskaggekSKPSRRQTVLVSATLTDGVKRLAGLSLKDPVYI 213
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
153-604 1.06e-102

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 321.33  E-value: 1.06e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 153 SNTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiqpkvKRSDGPLA 232
Cdd:COG0513     1 MMSFADLGLSPPLLKALAE-LGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDP-----SRPRAPQA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 233 VVIVPTRELALQSFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIK-NTLSiaFSAVRWLIL 311
Cdd:COG0513    75 LILAPTRELALQVAEELRKLAK-YLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIErGALD--LSGVETLVL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 312 DEADRILDLGFEKDLTVILNALNTAgpyRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSeetveacpqaapqalsds 391
Cdd:COG0513   152 DEADRMLDMGFIEDIERILKLLPKE---RQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPEN------------------ 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 392 yAVPERLQQHVVVVPS--KLHLvcLAAFIlakcKFEQRQKLVIFISSCEAVEFLlnlfTAVLCE--IPSNTsskstscln 467
Cdd:COG0513   211 -ATAETIEQRYYLVDKrdKLEL--LRRLL----RDEDPERAIVFCNTKRGADRL----AEKLQKrgISAAA--------- 270

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 468 fyrLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTP 547
Cdd:COG0513   271 ---LHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTP 347

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 548 SETAFVDV---LANHNISLSEMKMVDILSTLmKDERFKGRGKWDSKRSADAFEQEVRERA 604
Cdd:COG0513   348 DERRLLRAiekLIGQKIEEEELPGFEPVEEK-RLERLKPKIKEKLKGKKAGRGGRPGPKG 406
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
 165-368 1.31e-70

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 228.87  E-value: 1.31e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIqpKVKRSDGPLAVVIVPTRELALQ 244
Cdd:cd00268     1 LLKALKK-LGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPE--PKKKGRGPQALVLAPTRELAMQ 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 245 SFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEK 324
Cdd:cd00268    78 IAEVARKLGK-GTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERG-KLDLSNVKYLVLDEADRMLDMGFEE 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207187733 325 DLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSVH 368
Cdd:cd00268   156 DVEKILSALP---KDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
 152-550 1.99e-57

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 202.34  E-value: 1.99e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 152 TSNTFEELNLHPHLVATLhKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKrsdgpl 231
Cdd:PRK11776    2 SMTAFSTLPLPPALLANL-NELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLDVKRFRVQ------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 232 AVVIVPTRELALQSFQMFQKLLR--PFTWIVpgVLMGGEKKKAEKARLRKGINVLISTPGRLVDHI-KNTLSIafSAVRW 308
Cdd:PRK11776   75 ALVLCPTRELADQVAKEIRRLARfiPNIKVL--TLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLrKGTLDL--DALNT 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 309 LILDEADRILDLGFEKDLTVILNAlntAGPYRQNVLLSATITEGLSRLASISMKDPVSVHVsegseETVEACPQaapqal 388
Cdd:PRK11776  151 LVLDEADRMLDMGFQDAIDAIIRQ---APARRQTLLFSATYPEGIAAISQRFQRDPVEVKV-----ESTHDLPA------ 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 389 sdsyavperLQQHvvvvpsklhlvclaaFIlaKCKFEQRQklvifisscEAVEFLLNLFTAVLCEIPSNT---------- 458
Cdd:PRK11776  217 ---------IEQR---------------FY--EVSPDERL---------PALQRLLLHHQPESCVVFCNTkkecqevada 261

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 459 -SSKSTSCLNfyrLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGA 537
Cdd:PRK11776  262 lNAQGFSALA---LHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGS 338

                         410
                  ....*....|...
gi 1207187733 538 QGSSLLFLTPSET 550
Cdd:PRK11776  339 KGLALSLVAPEEM 351
PTZ00110 PTZ00110
helicase; Provisional
 155-547 1.34e-56

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 202.31  E-value: 1.34e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLVATLHKVlNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKVKRSDGPLAVV 234
Cdd:PTZ00110  131 SFEYTSFPDYILKSLKNA-GFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINA-QPLLRYGDGPIVLV 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 235 IVPTRELALQSFQMFQKLLRPFTwIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSiAFSAVRWLILDEA 314
Cdd:PTZ00110  209 LAPTRELAEQIREQCNKFGASSK-IRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVT-NLRRVTYLVLDEA 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 315 DRILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVsVHVSEGSeETVEACpqaapqalsdsyav 394
Cdd:PTZ00110  287 DRMLDMGFEPQIRKIVSQIR---PDRQTLMWSATWPKEVQSLARDLCKEEP-VHVNVGS-LDLTAC-------------- 347

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 395 pERLQQHVVVVPSKLHLVCLAAFIlaKCKFEQRQKLVIFISSCEAVEFL-----LNLFTAvLCeipsntsskstsclnfy 469
Cdd:PTZ00110  348 -HNIKQEVFVVEEHEKRGKLKMLL--QRIMRDGDKILIFVETKKGADFLtkelrLDGWPA-LC----------------- 406

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 470 rLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTP 547
Cdd:PTZ00110  407 -IHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYTFLTP 483
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
 173-367 1.20e-54

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 186.31  E-value: 1.20e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 173 LNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQaIQPKVKRsdGPLAVVIVPTRELALQSFQMFQKL 252
Cdd:cd17947     8 LGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLL-YRPKKKA--ATRVLVLVPTRELAMQCFSVLQQL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 253 LRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNA 332
Cdd:cd17947    85 AQ-FTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFDLDSIEILVLDEADRMLEEGFADELKEILRL 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1207187733 333 LNTAgpyRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17947   164 CPRT---RQTMLFSATMTDEVKDLAKLSLNKPVRV 195
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
 155-540 1.06e-53

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 191.31  E-value: 1.06e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIqPkvKRSDGPLAVV 234
Cdd:PRK11192    2 TFSELELDESLLEALQD-KGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDF-P--RRKSGPPRIL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 235 IV-PTRELALQSFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlsiAFS--AVRWLIL 311
Cdd:PRK11192   78 ILtPTRELAMQVADQARELAK-HTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEE---NFDcrAVETLIL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 312 DEADRILDLGFEKDLTVIlnALNTAGpYRQNVLLSATIT-EGLSRLASISMKDPVsvhvsegseeTVEACPQAAPQAlsd 390
Cdd:PRK11192  154 DEADRMLDMGFAQDIETI--AAETRW-RKQTLLFSATLEgDAVQDFAERLLNDPV----------EVEAEPSRRERK--- 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 391 syavpeRLQQHVVVVPSKLHLVCLAAFILakcKFEQRQKLVIFISSCEAVEFLLNLFTAVlcEIPSNTsskstsclnfyr 470
Cdd:PRK11192  218 ------KIHQWYYRADDLEHKTALLCHLL---KQPEVTRSIVFVRTRERVHELAGWLRKA--GINCCY------------ 274

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 471 LHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGS 540
Cdd:PRK11192  275 LEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGT 344
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
 177-367 2.94e-53

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 182.78  E-value: 2.94e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 177 SMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRsDGPLAVVIVPTRELALQSFQMFQKLLRP- 255
Cdd:cd17960    12 SMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKK-GQVGALIISPTRELATQIYEVLQSFLEHh 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 256 FTWIVPGVLMGGEKKKAE-KARLRKGINVLISTPGRLVDHI-KNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNAL 333
Cdd:cd17960    91 LPKLKCQLLIGGTNVEEDvKKFKRNGPNILVGTPGRLEELLsRKADKVKVKSLEVLVLDEADRLLDLGFEADLNRILSKL 170

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1207187733 334 ntagPyRQNV--LLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17960   171 ----P-KQRRtgLFSATQTDAVEELIKAGLRNPVRV 201
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
 178-364 4.43e-53

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 182.17  E-value: 4.43e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 178 MTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGplAVVIVPTRELALQSFQMFQKLLRpFT 257
Cdd:cd17942    13 MTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTG--VIIISPTRELALQIYGVAKELLK-YH 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 258 WIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNTAg 337
Cdd:cd17942    90 SQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQIIKLLPKR- 168

                         170       180
                  ....*....|....*....|....*..
gi 1207187733 338 pyRQNVLLSATITEGLSRLASISMKDP 364
Cdd:cd17942   169 --RQTMLFSATQTRKVEDLARISLKKK 193
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
 148-544 1.91e-51

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 188.62  E-value: 1.91e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 148 EKVFTSNTFEELNLHPHLVATLHKVlNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKV--K 225
Cdd:PRK04537    3 DKPLTDLTFSSFDLHPALLAGLESA-GFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLS-RPALadR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 226 RSDGPLAVVIVPTRELALQSFQMFQKL-----LRpFTWIvpgvlMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLS 300
Cdd:PRK04537   81 KPEDPRALILAPTRELAIQIHKDAVKFgadlgLR-FALV-----YGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 301 IAFSAVRWLILDEADRILDLGFEKDLTVILNALNTAGPyRQNVLLSATITEGLSRLASISMKDPVSVHVsegSEETVEAC 380
Cdd:PRK04537  155 VSLHACEICVLDEADRMFDLGFIKDIRFLLRRMPERGT-RQTLLFSATLSHRVLELAYEHMNEPEKLVV---ETETITAA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 381 pqaapqalsdsyavpeRLQQHvVVVPSKlhlvclaafilakckfEQRQKLVI-FISSCEAVEFLLNLFTAVLCEIPSNTS 459
Cdd:PRK04537  231 ----------------RVRQR-IYFPAD----------------EEKQTLLLgLLSRSEGARTMVFVNTKAFVERVARTL 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 460 SKstsclNFYR---LHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIG 536
Cdd:PRK04537  278 ER-----HGYRvgvLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLG 352


                  ....*...
gi 1207187733 537 AQGSSLLF 544
Cdd:PRK04537  353 EEGDAISF 360
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
 177-369 7.63e-51

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 175.94  E-value: 7.63e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 177 SMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLqaIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRpF 256
Cdd:cd17941    12 KMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKL--YRERWTPEDGLGALIISPTRELAMQIFEVLRKVGK-Y 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 257 TWIVPGVLMGGEKKKAEKARLrKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNALnta 336
Cdd:cd17941    89 HSFSAGLIIGGKDVKEEKERI-NRMNILVCTPGRLLQHMDETPGFDTSNLQMLVLDEADRILDMGFKETLDAIVENL--- 164

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1207187733 337 GPYRQNVLLSATITEGLSRLASISMKDPVSVHV 369
Cdd:cd17941   165 PKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
 161-362 4.00e-50

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 174.31  E-value: 4.00e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 161 LHPHLVATLHKvLNVSSMTSVQKQTI-PVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPlAVVIVPTR 239
Cdd:cd17964     1 LDPSLLKALTR-MGFETMTPVQQKTLkPILSTGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSGVS-ALIISPTR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 240 ELALQSFQMFQKLLRPFTWIVPGVLMGGEKKKAEKARLRK-GINVLISTPGRLVDHIKNTLS-IAFSAVRWLILDEADRI 317
Cdd:cd17964    79 ELALQIAAEAKKLLQGLRKLRVQSAVGGTSRRAELNRLRRgRPDILVATPGRLIDHLENPGVaKAFTDLDYLVLDEADRL 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1207187733 318 LDLGFEKDLTVILNALNTAGPY-RQNVLLSATITEGLSRLASISMK 362
Cdd:cd17964   159 LDMGFRPDLEQILRHLPEKNADpRQTLLFSATVPDEVQQIARLTLK 204
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 179-356 1.90e-49

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 170.89  E-value: 1.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQaiqpkvKRSDGPLAVVIVPTRELALQSFQMFQKLLRpFTW 258
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALD------KLDNGPQALVLAPTRELAEQIYEELKKLGK-GLG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLrKGINVLISTPGRLVDHIKNTlsIAFSAVRWLILDEADRILDLGFEKDLTVILNALNtagP 338
Cdd:pfam00270  74 LKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQER--KLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLP---K 147

                         170
                  ....*....|....*...
gi 1207187733 339 YRQNVLLSATITEGLSRL 356
Cdd:pfam00270 148 KRQILLLSATLPRNLEDL 165
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
 152-544 1.38e-48

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 177.09  E-value: 1.38e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 152 TSNTFEELNLHPHLVATLHKVlNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAygipmvqFLQAI--------QPK 223
Cdd:PRK04837    6 TEQKFSDFALHPQVVEALEKK-GFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMA-------FLTATfhyllshpAPE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 224 VKRSDGPLAVVIVPTRELALQSFQMfQKLLRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLsIAF 303
Cdd:PRK04837   78 DRKVNQPRALIMAPTRELAVQIHAD-AEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNH-INL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 304 SAVRWLILDEADRILDLGFEKDLTVILNALNTAGPyRQNVLLSATITEGLSRLASISMKDPvsvhvsegseetveacpqa 383
Cdd:PRK04837  156 GAIQVVVLDEADRMFDLGFIKDIRWLFRRMPPANQ-RLNMLFSATLSYRVRELAFEHMNNP------------------- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 384 apqalsdsyavperlqQHVVVVPSKlhlvclaafilakcKFEQRQKLVIFISSCEavEFLLNLFTAVLCEIP------SN 457
Cdd:PRK04837  216 ----------------EYVEVEPEQ--------------KTGHRIKEELFYPSNE--EKMRLLQTLIEEEWPdraiifAN 263

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 458 TSSkstSCLNFY--------R---LHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYV 526
Cdd:PRK04837  264 TKH---RCEEIWghlaadghRvglLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYV 340

                         410
                  ....*....|....*...
gi 1207187733 527 HRVGRTARIGAQGSSLLF 544
Cdd:PRK04837  341 HRIGRTGRAGASGHSISL 358
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
 179-542 1.51e-47

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 175.00  E-value: 1.51e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQ---SFQMFQKLLRp 255
Cdd:PRK10590   25 TPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVRALILTPTRELAAQigeNVRDYSKYLN- 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 256 ftwIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDhIKNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNt 335
Cdd:PRK10590  104 ---IRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLD-LEHQNAVKLDQVEILVLDEADRMLDMGFIHDIRRVLAKLP- 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 336 agPYRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSEETveacpqaapqalsdsyavpERLQQHVVVVPSKLHLVCLa 415
Cdd:PRK10590  179 --AKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTAS-------------------EQVTQHVHFVDKKRKRELL- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 416 AFILAKCKFEQrqkLVIFISSCEAVEFLlnlftAVLCEIPSNTSSKstsclnfyrLHGNMRQEERTEVFQEFSQCKTGIL 495
Cdd:PRK10590  237 SQMIGKGNWQQ---VLVFTRTKHGANHL-----AEQLNKDGIRSAA---------IHGNKSQGARTRALADFKSGDIRVL 299

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1207187733 496 LCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSL 542
Cdd:PRK10590  300 VATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEAL 346
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
 152-549 3.43e-46

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 174.65  E-value: 3.43e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 152 TSNTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKVKrsdGPL 231
Cdd:PRK11634    4 FETTFADLGLKAPILEALND-LGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPL---LHNLDPELK---APQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 232 AVVIVPTRELALQ---SFQMFQKLLRPFTWIvpgVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIK-NTLSIafSAVR 307
Cdd:PRK11634   77 ILVLAPTRELAVQvaeAMTDFSKHMRGVNVV---ALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKrGTLDL--SKLS 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 308 WLILDEADRILDLGFEKDLTVILNALNTAgpyRQNVLLSATITEGLSRLASISMKDPVSVHVsegsEETVEACPQaapqa 387
Cdd:PRK11634  152 GLVLDEADEMLRMGFIEDVETIMAQIPEG---HQTALFSATMPEAIRRITRRFMKEPQEVRI----QSSVTTRPD----- 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 388 LSDSYAVPERLQQHVVVVpsklhlvclaAFILAkckfEQRQKLVIFISSCEAvefllNLFTAVLCEipsnTSSKSTSCLN 467
Cdd:PRK11634  220 ISQSYWTVWGMRKNEALV----------RFLEA----EDFDAAIIFVRTKNA-----TLEVAEALE----RNGYNSAALN 276

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 468 fyrlhGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTP 547
Cdd:PRK11634  277 -----GDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVEN 351


                  ..
gi 1207187733 548 SE 549
Cdd:PRK11634  352 RE 353
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
 155-369 8.91e-46

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 162.66  E-value: 8.91e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLVatlhkvLNVSSM-----TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDG 229
Cdd:cd17967     1 SFEEAGLRELLL------ENIKRAgytkpTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLEDGPPSVGRGR 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 230 ----PLAVVIVPTRELALQSFQMFQKLLRPfTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLsIAFSA 305
Cdd:cd17967    75 rkayPSALILAPTRELAIQIYEEARKFSYR-SGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGR-ISLSS 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207187733 306 VRWLILDEADRILDLGFEKDLTVILNALN-TAGPYRQNVLLSATITEGLSRLASISMKDPVSVHV 369
Cdd:cd17967   153 IKFLVLDEADRMLDMGFEPQIRKIVEHPDmPPKGERQTLMFSATFPREIQRLAADFLKNYIFLTV 217
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
 156-365 4.14e-45

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 160.47  E-value: 4.14e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 156 FEELNLHPHLVATLhKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLqaiqpkvkRSD--GPLAV 233
Cdd:cd17955     1 FEDLGLSSWLVKQC-ASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL--------SEDpyGIFAL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 234 VIVPTRELALQSFQMFQKLLRPF----TWIVPGVLMGGEKKKaekarLRKGINVLISTPGRLVDHIKN--TLSIAFSAVR 307
Cdd:cd17955    72 VLTPTRELAYQIAEQFRALGAPLglrcCVIVGGMDMVKQALE-----LSKRPHIVVATPGRLADHLRSsdDTTKVLSRVK 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 308 WLILDEADRILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPV 365
Cdd:cd17955   147 FLVLDEADRLLTGSFEDDLATILSALP---PKRQTLLFSATLTDALKALKELFGNKPF 201
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
 179-367 6.42e-45

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 160.56  E-value: 6.42e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFL--QAIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPF 256
Cdd:cd17945    14 TPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYIsrLPPLDEETKDDGPYALILAPTRELAQQIEEETQKFAKPL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 257 TWIVPgVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLsIAFSAVRWLILDEADRILDLGFEKDLTVILNAL--- 333
Cdd:cd17945    94 GIRVV-SIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRL-LVLNQCTYVVLDEADRMIDMGFEPQVTKILDAMpvs 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1207187733 334 --------------NTAGPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17945   172 nkkpdteeaeklaaSGKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
 155-367 1.68e-44

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 158.63  E-value: 1.68e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVkrsdgpLAVV 234
Cdd:cd17954     1 TFKELGVCEELCEACEK-LGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQRF------FALV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 235 IVPTRELALQSFQMFQKL-----LRPftwivpGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWL 309
Cdd:cd17954    74 LAPTRELAQQISEQFEALgssigLKS------AVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFSLKSLKFL 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 310 ILDEADRILDLGFEKDLTVILNALNTAgpyRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17954   148 VMDEADRLLNMDFEPEIDKILKVIPRE---RTTYLFSATMTTKVAKLQRASLKNPVKI 202
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
 179-368 2.48e-44

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 157.96  E-value: 2.48e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTw 258
Cdd:cd17952    14 TPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMD-QRELEKGEGPIAVIVAPTRELAQQIYLEAKKFGKAYN- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNtagP 338
Cdd:cd17952    92 LRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKK-ATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGHVR---P 167

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207187733 339 YRQNVLLSATITEGLSRLASISMKDPVSVH 368
Cdd:cd17952   168 DRQTLLFSATFKKKIEQLARDILSDPIRVV 197
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
 72-545 4.20e-44

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 165.47  E-value: 4.20e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733  72 QTPRSPSQRSNNRDTEESPVQRENSEAKSPSkvktfPKKAPTEHEDHGRPFiktsslfRNNPEIPDVLSPAVNQVKEKVF 151
Cdd:PRK01297   17 PAPAPPSPAAAPAPPPPAKTAAPATKAAAPA-----AAAPRAEKPKKDKPR-------RERKPKPASLWKLEDFVVEPQE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 152 TSNTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMV-QFLQAIQPKVKRSDGP 230
Cdd:PRK01297   85 GKTRFHDFNLAPELMHAIHD-LGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIInQLLQTPPPKERYMGEP 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 231 LAVVIVPTRELALQsFQMFQKLLRPFTWIVPGVLMGG----EKKKAEKARLrkgINVLISTPGRLVDHIKNTlSIAFSAV 306
Cdd:PRK01297  164 RALIIAPTRELVVQ-IAKDAAALTKYTGLNVMTFVGGmdfdKQLKQLEARF---CDILVATPGRLLDFNQRG-EVHLDMV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 307 RWLILDEADRILDLGFEKDLTVILNALNTAGPyRQNVLLSATITEGLSRLASISMKDPVsvhvsegseeTVEACPQaapQ 386
Cdd:PRK01297  239 EVMVLDEADRMLDMGFIPQVRQIIRQTPRKEE-RQTLLFSATFTDDVMNLAKQWTTDPA----------IVEIEPE---N 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 387 ALSDSyavperLQQHVVVVPSKLHLVCLAAfILAKCKFEqrqKLVIFISSCEAVEFLLNLFTavlceipsntssksTSCL 466
Cdd:PRK01297  305 VASDT------VEQHVYAVAGSDKYKLLYN-LVTQNPWE---RVMVFANRKDEVRRIEERLV--------------KDGI 360

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207187733 467 NFYRLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFL 545
Cdd:PRK01297  361 NAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFA 439
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
 155-367 6.38e-44

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 157.08  E-value: 6.38e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLV-ATLHKVLNVSsmTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVkrsdGPLAV 233
Cdd:cd17959     2 GFQSMGLSPPLLrAIKKKGYKVP--TPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTV----GARAL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 234 VIVPTRELALQSFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVdHIKNTLSIAFSAVRWLILDE 313
Cdd:cd17959    76 ILSPTRELALQTLKVTKELGK-FTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLL-HLLVEMNLKLSSVEYVVFDE 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207187733 314 ADRILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17959   154 ADRLFEMGFAEQLHEILSRLP---ENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
 179-369 7.71e-44

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 156.60  E-value: 7.71e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQaiqpKVKRSDGPLAVVIVPTRELALQSFQMFQKLLR--PF 256
Cdd:cd17957    14 TPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLG----KPRKKKGLRALILAPTRELASQIYRELLKLSKgtGL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 257 TWIVpgVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNta 336
Cdd:cd17957    90 RIVL--LSKSLEAKAKDGPKSITKYDILVSTPLRLVFLLKQG-PIDLSSVEYLVLDEADKLFEPGFREQTDEILAACT-- 164

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1207187733 337 GPYRQNVLLSATITEGLSRLASISMKDPVSVHV 369
Cdd:cd17957   165 NPNLQRSLFSATIPSEVEELARSVMKDPIRIIV 197
DEXDc smart00487
DEAD-like helicases superfamily;
178-378 1.08e-42

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 153.42  E-value: 1.08e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733  178 MTSVQKQTIPVLMSG-KDAVVRSQTGSGKTLAYGIPMVQFLqaiqpkvKRSDGPLAVVIVPTRELALQSFQMFQKLLrPF 256
Cdd:smart00487   9 LRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEAL-------KRGKGGRVLVLVPTRELAEQWAEELKKLG-PS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733  257 TWIVPGVLMGGEKKKAEKARLRKG-INVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNT 335
Cdd:smart00487  81 LGLKVVGLYGGDSKREQLRKLESGkTDILVTTPGRLLDLLEND-KLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPK 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1207187733  336 AgpyRQNVLLSATITEGLSRLASISMKDPVSVHVSEGSEETVE 378
Cdd:smart00487 160 N---VQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPIE 199
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
 398-545 3.02e-42

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 149.58  E-value: 3.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 398 LQQHVVVVPSKLHLVCLAAFILAKckfEQRQKLVIFISSCEAVEFLLNLFTavLCEIPSntsskstsclnfYRLHGNMRQ 477
Cdd:cd18787     1 IKQLYVVVEEEEKKLLLLLLLLEK---LKPGKAIIFVNTKKRVDRLAELLE--ELGIKV------------AALHGDLSQ 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 478 EERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFL 545
Cdd:cd18787    64 EERERALKKFRSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
 179-368 2.11e-41

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 149.83  E-value: 2.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTw 258
Cdd:cd17966    14 TAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINA-QPPLERGDGPIVLVLAPTRELAQQIQQEANKFGGSSR- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNtagP 338
Cdd:cd17966    92 LRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQG-KTNLRRVTYLVLDEADRMLDMGFEPQIRKIVDQIR---P 167

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207187733 339 YRQNVLLSATITEGLSRLASISMKDPVSVH 368
Cdd:cd17966   168 DRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
 171-367 4.17e-41

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 149.84  E-value: 4.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 171 KVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKVKRSDGPLAVVIVPTRELALQSFQMFQ 250
Cdd:cd17953    28 KKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKD-QRPVKPGEGPIGLIMAPTRELALQIYVECK 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 251 KLLRPFTWIVPGVlMGGEKKKAEKARLRKGINVLISTPGRLVD-------HIKNTLSIAFsavrwLILDEADRILDLGFE 323
Cdd:cd17953   107 KFSKALGLRVVCV-YGGSGISEQIAELKRGAEIVVCTPGRMIDiltanngRVTNLRRVTY-----VVLDEADRMFDMGFE 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1207187733 324 KDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17953   181 PQIMKIVNNIR---PDRQTVLFSATFPRKVEALARKVLHKPIEI 221
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
 154-358 9.04e-41

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 150.12  E-value: 9.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 154 NTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFL-----QAIQPKVKRSd 228
Cdd:cd18052    43 LTFEEANLCETLLKNIRK-AGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMmkeglTASSFSEVQE- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 229 gPLAVVIVPTRELALQSFqmfqKLLRPF---TWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLsIAFSA 305
Cdd:cd18052   121 -PQALIVAPTRELANQIF----LEARKFsygTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGK-ISLSK 194

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207187733 306 VRWLILDEADRILDLGFEKDLTVILNALN-TAGPYRQNVLLSATITEGLSRLAS 358
Cdd:cd18052   195 LKYLILDEADRMLDMGFGPEIRKLVSEPGmPSKEDRQTLMFSATFPEEIQRLAA 248
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
 155-545 8.97e-40

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 154.18  E-value: 8.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLVATLhKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPK-VKRSDGPLAV 233
Cdd:PLN00206  122 SFSSCGLPPKLLLNL-ETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRCCTIRSGhPSEQRNPLAM 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 234 VIVPTRELALQ---SFQMFQKLLrPF-TWIVpgvlMGGEKKKAEKARLRKGINVLISTPGRLVDHI-KNTLSIAFSAVrw 308
Cdd:PLN00206  201 VLTPTRELCVQvedQAKVLGKGL-PFkTALV----VGGDAMPQQLYRIQQGVELIVGTPGRLIDLLsKHDIELDNVSV-- 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 309 LILDEADRILDLGFEKDLTVILNALNTAgpyrQNVLLSATITEGLSRLASISMKDPVSVHVSEgseetveacPQAAPQAL 388
Cdd:PLN00206  274 LVLDEVDCMLERGFRDQVMQIFQALSQP----QVLLFSATVSPEVEKFASSLAKDIILISIGN---------PNRPNKAV 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 389 sdsyavperlQQHVVVVPSKLHLVCLAAFILAKCKFeqRQKLVIFISSCEAVEFLLNLFTAVlceipsnTSSKSTSclnf 468
Cdd:PLN00206  341 ----------KQLAIWVETKQKKQKLFDILKSKQHF--KPPAVVFVSSRLGADLLANAITVV-------TGLKALS---- 397

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207187733 469 yrLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFL 545
Cdd:PLN00206  398 --IHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFV 472
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
 169-364 1.03e-38

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 143.54  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 169 LHKVLNVSSMTS---VQKQTIPVLMSG---------KDAVVRSQTGSGKTLAYGIPMVQFL-QAIQPKVKrsdgplAVVI 235
Cdd:cd17956     1 LLKNLQNNGITSafpVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALsKRVVPRLR------ALIV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 236 VPTRELALQSFQMFQKLLRPFTWIVpgVLMGGEKK-KAEKARLRKG--------INVLISTPGRLVDHIKNTLSIAFSAV 306
Cdd:cd17956    75 VPTKELVQQVYKVFESLCKGTGLKV--VSLSGQKSfKKEQKLLLVDtsgrylsrVDILVATPGRLVDHLNSTPGFTLKHL 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207187733 307 RWLILDEADRILDLGFEKDLTVILNALNTAGPYR-----------------QNVLLSATITEGLSRLASISMKDP 364
Cdd:cd17956   153 RFLVIDEADRLLNQSFQDWLETVMKALGRPTAPDlgsfgdanllersvrplQKLLFSATLTRDPEKLSSLKLHRP 227
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
 161-367 1.59e-38

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 141.95  E-value: 1.59e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 161 LHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRE 240
Cdd:cd17961     1 LDPRLLKAIAK-LGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEEQGTRALILVPTRE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 241 LALQSFQMFQKLL---RPFTWIVPgvLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRI 317
Cdd:cd17961    80 LAQQVSKVLEQLTaycRKDVRVVN--LSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLLLLSTLKYLVIDEADLV 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1207187733 318 LDLGFEKDLTVILNALntagPYR-QNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17961   158 LSYGYEEDLKSLLSYL----PKNyQTFLMSATLSEDVEALKKLVLHNPAIL 204
PTZ00424 PTZ00424
helicase 45; Provisional
 154-568 3.82e-35

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 138.04  E-value: 3.82e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 154 NTFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKVKRSDgplAV 233
Cdd:PTZ00424   28 DSFDALKLNEDLLRGIYS-YGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAA---LQLIDYDLNACQ---AL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 234 VIVPTRELAlQSFQMFQKLLRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIkNTLSIAFSAVRWLILDE 313
Cdd:PTZ00424  101 ILAPTRELA-QQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMI-DKRHLRVDDLKLFILDE 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 314 ADRILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSVHVSEgSEETVEACPQAAPQALSDSYA 393
Cdd:PTZ00424  179 ADEMLSRGFKGQIYDVFKKLP---PDVQVALFSATMPNEILELTTKFMRDPKRILVKK-DELTLEGIRQFYVAVEKEEWK 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 394 VPERLQQHVVVVPSKLHLVClaafilakckfEQRQKLVIFISSCEAVEFllnlftavlceipsntsskSTSCLnfyrlHG 473
Cdd:PTZ00424  255 FDTLCDLYETLTITQAIIYC-----------NTRRKVDYLTKKMHERDF-------------------TVSCM-----HG 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 474 NMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTPSETAFV 553
Cdd:PTZ00424  300 DMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQL 379

                         410
                  ....*....|....*.
gi 1207187733 554 DVLANH-NISLSEMKM 568
Cdd:PTZ00424  380 KEIERHyNTQIEEMPM 395
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
 179-367 8.19e-35

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 131.05  E-value: 8.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIP-MVQFLQAIQPKVKRsDGPLAVVIVPTRELALQSFQMFQKLLrpFT 257
Cdd:cd17958    14 SPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPgFIHLDLQPIPREQR-NGPGVLVLTPTRELALQIEAECSKYS--YK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 258 WIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNtag 337
Cdd:cd17958    91 GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNN-VINLKSITYLVLDEADRMLDMGFEPQIRKILLDIR--- 166

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207187733 338 PYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17958   167 PDRQTIMTSATWPDGVRRLAQSYLKDPMIV 196
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
 165-363 6.18e-34

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 130.05  E-value: 6.18e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLHKvLNVSSMTSVQKQTIPV-LMSGKDAVVRSQTGSGKTLAYGIPMVQFL---QAIQPKVKRSDGPLAVVIVPTRE 240
Cdd:cd17946     1 ILRALAD-LGFSEPTPIQALALPAaIRDGKDVIGAAETGSGKTLAFGIPILERLlsqKSSNGVGGKQKPLRALILTPTRE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 241 LALQSFQMFQKLLRpFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIK--NTLSIAFSAVRWLILDEADRIL 318
Cdd:cd17946    80 LAVQVKDHLKAIAK-YTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQegNEHLANLKSLRFLVLDEADRML 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1207187733 319 DLGFEKDLTVILNALN----TAGPYRQNVLLSATITEGLS-RLASISMKD 363
Cdd:cd17946   159 EKGHFAELEKILELLNkdraGKKRKRQTFVFSATLTLDHQlPLKLNSKKK 208
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
 156-369 8.37e-34

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 129.74  E-value: 8.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 156 FEELNLhPHLVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKVKRSDGPLAVVI 235
Cdd:cd18049    26 FYEANF-PANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINH-QPFLERGDGPICLVL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 236 VPTRELALQSFQMFQKLLRPfTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEAD 315
Cdd:cd18049   104 APTRELAQQVQQVAAEYGRA-CRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAG-KTNLRRCTYLVLDEAD 181

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207187733 316 RILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSVHV 369
Cdd:cd18049   182 RMLDMGFEPQIRKIVDQIR---PDRQTLMWSATWPKEVRQLAEDFLKDYIHINI 232
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
 179-367 1.99e-33

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 127.46  E-value: 1.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFlqAIQPKVK----RSDGPLAVVIVPTRELALQSFQMFQKLLR 254
Cdd:cd17951    14 TPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMF--ALEQEKKlpfiKGEGPYGLIVCPSRELARQTHEVIEYYCK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 255 PFT-----WIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIkNTLSIAFSAVRWLILDEADRILDLGFEKDLTVI 329
Cdd:cd17951    92 ALQeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDML-NKKKINLDICRYLCLDEADRMIDMGFEEDIRTI 170

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1207187733 330 LNalNTAGPyRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17951   171 FS--YFKGQ-RQTLLFSATMPKKIQNFAKSALVKPVTV 205
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
 156-367 2.24e-32

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 124.36  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 156 FEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIqpkvkrsdgplavVI 235
Cdd:cd17938     1 FEELGVMPELIKAVEE-LDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVVAL-------------IL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 236 VPTRELALQSFQMFQKLLRPFT--WIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDE 313
Cdd:cd17938    67 EPSRELAEQTYNCIENFKKYLDnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTG-KLDLSSVRFFVLDE 145

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 314 ADRILDLGFEKDLTVILNAL--NTAGPYR-QNVLLSATI-TEGLSRLASISMKDPVSV 367
Cdd:cd17938   146 ADRLLSQGNLETINRIYNRIpkITSDGKRlQVIVCSATLhSFEVKKLADKIMHFPTWV 203
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
 165-358 7.37e-32

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 124.02  E-value: 7.37e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLhKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRS-DGPLAVVIVPTRELAL 243
Cdd:cd17948     1 LVEIL-QRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGPfNAPRGLVITPSRELAE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 244 QSFQMFQKLLRPFTwIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLsIAFSAVRWLILDEADRILDLGFE 323
Cdd:cd17948    80 QIGSVAQSLTEGLG-LKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRI-YSLEQLRHLVLDEADTLLDDSFN 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1207187733 324 KDLTVIL--------NALNTAGPYR--QNVLLSATITEGLSRLAS 358
Cdd:cd17948   158 EKLSHFLrrfplasrRSENTDGLDPgtQLVLVSATMPSGVGEVLS 202
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
 179-369 1.67e-31

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 123.97  E-value: 1.67e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiQPKVKRSDGPLAVVIVPTRELALQSFQM---FQKLLRp 255
Cdd:cd18050    86 TPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINH-QPYLERGDGPICLVLAPTRELAQQVQQVaddYGKSSR- 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 256 ftwIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNt 335
Cdd:cd18050   164 ---LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAG-KTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIR- 238

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1207187733 336 agPYRQNVLLSATITEGLSRLASISMKDPVSVHV 369
Cdd:cd18050   239 --PDRQTLMWSATWPKEVRQLAEDFLRDYVQINI 270
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
 154-357 4.72e-31

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 122.07  E-value: 4.72e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 154 NTFEELNLHpHLVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKV--------- 224
Cdd:cd18051    21 ETFSDLDLG-EIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQGPGEslpsesgyy 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 225 -KRSDGPLAVVIVPTRELALQSFQMFQKllrpFTW---IVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlS 300
Cdd:cd18051   100 gRRKQYPLALVLAPTRELASQIYDEARK----FAYrsrVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERG-K 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 301 IAFSAVRWLILDEADRILDLGFEKDLTVILNALNTAGP-YRQNVLLSATITEGLSRLA 357
Cdd:cd18051   175 IGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPTgERQTLMFSATFPKEIQMLA 232
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
 181-348 2.52e-30

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 118.55  E-value: 2.52e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 181 VQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKvkrSDGPLAVVIVPTRELALQSFQMFQKLLRpFTWIV 260
Cdd:cd17940    25 IQEESIPIALSGRDILARAKNGTGKTGAYLIPI---LEKIDPK---KDVIQALILVPTRELALQTSQVCKELGK-HMGVK 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 261 PGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTLsIAFSAVRWLILDEADRILDLGFEKDLTVILNALNtagPYR 340
Cdd:cd17940    98 VMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGV-ADLSHCKTLVLDEADKLLSQDFQPIIEKILNFLP---KER 173


                  ....*...
gi 1207187733 341 QNVLLSAT 348
Cdd:cd17940   174 QILLFSAT 181
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
 179-367 3.58e-30

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 117.75  E-value: 3.58e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLqaiqpkVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTW 258
Cdd:cd17943    14 SPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESL------DLERRHPQVLILAPTREIAVQIHDVFKKIGKKLEG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLrKGINVLISTPGRLVDHIKNtLSIAFSAVRWLILDEADRILDLGFEKDLTVILNALntaGP 338
Cdd:cd17943    88 LKCEVFIGGTPVKEDKKKL-KGCHIAVGTPGRIKQLIEL-GALNVSHVRLFVLDEADKLMEGSFQKDVNWIFSSL---PK 162

                         170       180
                  ....*....|....*....|....*....
gi 1207187733 339 YRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17943   163 NKQVIAFSATYPKNLDNLLARYMRKPVLV 191
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
 175-362 4.91e-29

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 114.94  E-value: 4.91e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 175 VSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLR 254
Cdd:cd17944    10 VTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVLVLAPTRELANQVTKDFKDITR 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 255 PFTwivPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALN 334
Cdd:cd17944    90 KLS---VACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNG-RLDLTKLKHVVLDEVDQMLDMGFAEQVEEILSVSY 165

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207187733 335 TAGPYR--QNVLLSATITEGLSRLASISMK 362
Cdd:cd17944   166 KKDSEDnpQTLLFSATCPDWVYNVAKKYMK 195
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
 179-367 6.40e-29

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 114.18  E-value: 6.40e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPmvqflqAIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTW 258
Cdd:cd17962    14 TPIQMQMIPVGLLGRDILASADTGSGKTAAFLLP------VIIRCLTEHRNPSALILTPTRELAVQIEDQAKELMKGLPP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRILDLGFEKDLTVILNALNTAgp 338
Cdd:cd17962    88 MKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQS-SVELDNIKIVVVDEADTMLKMGFQQQVLDILENISHD-- 164

                         170       180
                  ....*....|....*....|....*....
gi 1207187733 339 yRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17962   165 -HQTILVSATIPRGIEQLAGQLLQNPVRI 192
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
 179-365 1.14e-26

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 107.80  E-value: 1.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKrsdgplAVVIVPTRELALQSFQMFqKLLRPFTW 258
Cdd:cd17939    21 SAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQ------ALVLAPTRELAQQIQKVV-KALGDYMG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIK-NTLSIAFsaVRWLILDEADRILDLGFEKDLTVILNALNTAG 337
Cdd:cd17939    94 VKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQrRSLRTDK--IKMFVLDEADEMLSRGFKDQIYDIFQFLPPET 171

                         170       180
                  ....*....|....*....|....*...
gi 1207187733 338 pyrQNVLLSATITEGLSRLASISMKDPV 365
Cdd:cd17939   172 ---QVVLFSATMPHEVLEVTKKFMRDPV 196
HELICc smart00490
helicase superfamily c-terminal domain;
466-536 4.01e-25

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 99.21  E-value: 4.01e-25
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207187733  466 LNFYRLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIG 536
Cdd:smart00490  12 IKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 461-536 9.41e-25

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 99.21  E-value: 9.41e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207187733 461 KSTSCLNFYRLHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIG 536
Cdd:pfam00271  34 LEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
 181-367 1.90e-22

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 95.72  E-value: 1.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 181 VQKQTIPVLMSG--KDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKVKRsdgPLAVVIVPTRELALQSFQMFQKLLRpFTW 258
Cdd:cd17963    20 IQETALPLILSDppENLIAQSQSGTGKTAAFVLAM---LSRVDPTLKS---PQALCLAPTRELARQIGEVVEKMGK-FTG 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMggekkKAEKARLRKGIN--VLISTPGRLVDHIKnTLSIAFSAVRWLILDEADRILDL-GFEKDLTVILNALnt 335
Cdd:cd17963    93 VKVALAV-----PGNDVPRGKKITaqIVIGTPGTVLDWLK-KRQLDLKKIKILVLDEADVMLDTqGHGDQSIRIKRML-- 164

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1207187733 336 aGPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd17963   165 -PRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
 156-367 3.18e-22

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 95.23  E-value: 3.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 156 FEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKVKRsdgPLAVVI 235
Cdd:cd18045     1 FETMGLREDLLRGIYA-YGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISV---LQCLDIQVRE---TQALIL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 236 VPTRELALQSfqmfQKL---LRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHIKNTlSIAFSAVRWLILD 312
Cdd:cd18045    74 SPTRELAVQI----QKVllaLGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRR-SLRTRHIKMLVLD 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207187733 313 EADRILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd18045   149 EADEMLNKGFKEQIYDVYRYLP---PATQVVLVSATLPQDILEMTNKFMTDPIRI 200
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
 156-367 3.06e-20

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 89.43  E-value: 3.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 156 FEELNLHPHLVATLHkVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKVKrsdGPLAVVI 235
Cdd:cd18046     1 FDDMNLKESLLRGIY-AYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISI---LQQIDTSLK---ATQALVL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 236 VPTRELALQsfqmFQKL---LRPFTWIVPGVLMGGEKKKAEKARLRKGINVLISTPGRLVDHI-KNTLSIafSAVRWLIL 311
Cdd:cd18046    74 APTRELAQQ----IQKVvmaLGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMInRRYLRT--DYIKMFVL 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207187733 312 DEADRILDLGFEKDLTVILNALNtagPYRQNVLLSATITEGLSRLASISMKDPVSV 367
Cdd:cd18046   148 DEADEMLSRGFKDQIYDIFQKLP---PDTQVVLLSATMPNDVLEVTTKFMRDPIRI 200
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
 179-369 1.49e-19

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 87.79  E-value: 1.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 179 TSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVKrsdgplAVVIVPTRELALQSFQMFQKLLRPFTW 258
Cdd:cd17950    26 SEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLEPVDGQVS------VLVICHTRELAFQISNEYERFSKYMPN 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 259 IVPGVLMGGEKKKAEKARLR-KGINVLISTPGRLVDHIKNTlSIAFSAVRWLILDEADRIL-DLGFEKDLTVILnalnTA 336
Cdd:cd17950   100 VKTAVFFGGVPIKKDIEVLKnKCPHIVVGTPGRILALVREK-KLKLSHVKHFVLDECDKMLeQLDMRRDVQEIF----RA 174

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1207187733 337 GPYRQNVLL-SATITEGLSRLASISMKDPVSVHV 369
Cdd:cd17950   175 TPHDKQVMMfSATLSKEIRPVCKKFMQDPLEIFV 208
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
 192-348 1.37e-18

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 82.84  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 192 GKDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKVkrsdgplaVVIVPTRELALQSFQMFQKLlrpFTWIVPGVLMGGEKKK 271
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAALLLLLKKGKKV--------LVLVPTKALALQTAERLREL---FGPGIRVAVLVGGSSA 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207187733 272 AEKARLRKG-INVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRILDLGFEKDLTVILNaLNTAGPYRQNVLLSAT 348
Cdd:cd00046    70 EEREKNKLGdADIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAV-RKAGLKNAQVILLSAT 146
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
 156-349 1.07e-17

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 83.19  E-value: 1.07e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 156 FEELNLHPHLVATL--------HKVLNVSSMTSVQKQTIPVLMS---GKDAVVRS-------------QTGSGKTLAYGI 211
Cdd:cd17965     1 FDQLKLLPSVREAIikeilkgsNKTDEEIKPSPIQTLAIKKLLKtlmRKVTKQTSneepklevfllaaETGSGKTLAYLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 212 PMVQFL--QAIQPK---------VKRSDGPLAVVIVPTRELALQSFQMFQKL-------LRPFTWIvpgvlMGGEKKKAE 273
Cdd:cd17965    81 PLLDYLkrQEQEPFeeaeeeyesAKDTGRPRSVILVPTHELVEQVYSVLKKLshtvklgIKTFSSG-----FGPSYQRLQ 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207187733 274 KArLRKGINVLISTPGRLVDHIKNTLSIaFSAVRWLILDEADRILDLGFEKDLTVILNAlntAGPYRQNVLLSATI 349
Cdd:cd17965   156 LA-FKGRIDILVTTPGKLASLAKSRPKI-LSRVTHLVVDEADTLFDRSFLQDTTSIIKR---APKLKHLILCSATI 226
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
192-633 1.03e-14

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 77.76  E-value: 1.03e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 192 GKDAVVRSQTGSGKTLAygipMVQFLQAIQPKVKrsdgplAVVIVPTRELALQSFQMFQKLLrpftwivPGVLMGGEKKK 271
Cdd:COG1061   100 GGRGLVVAPTGTGKTVL----ALALAAELLRGKR------VLVLVPRRELLEQWAEELRRFL-------GDPLAGGGKKD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 272 AEKarlrkgiNVLISTPGRLVDHIK-NTLSIAFSAVrwlILDEADRILDLGFEKdltvILNALNtaGPYRqnVLLSAT-- 348
Cdd:COG1061   163 SDA-------PITVATYQSLARRAHlDELGDRFGLV---IIDEAHHAGAPSYRR----ILEAFP--AAYR--LGLTATpf 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 349 ----ITEGLSRLA----SISMKD--------PVSVHVSEGSEETVEACPQAAPQALSDSYAVPERLQQHVVVVpsklhlv 412
Cdd:COG1061   225 rsdgREILLFLFDgivyEYSLKEaiedgylaPPEYYGIRVDLTDERAEYDALSERLREALAADAERKDKILRE------- 297

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 413 claafILAKCKfeQRQKLVIFISSCEAVEFLLNLFTAVLCEIPsntsskstsclnfyRLHGNMRQEERTEVFQEFSQCKT 492
Cdd:COG1061   298 -----LLREHP--DDRKTLVFCSSVDHAEALAELLNEAGIRAA--------------VVTGDTPKKEREEILEAFRDGEL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 493 GILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLtpsetafvDVLANHnislsemkmVDIL 572
Cdd:COG1061   357 RILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVY--------DFVGND---------VPVL 419

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207187733 573 STLMKDERFKGRGKWDSKRSADAFEQEVRERATLLQTDFENYVHASNESLQTAKSALQCFL 633
Cdd:COG1061   420 EELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKGELEEELLEELELLEDALLLVL 480
DUF4217 pfam13959
Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many ...
 608-668 5.48e-14

Domain of unknown function (DUF4217); This short domain is found at the C-terminus of many helicase proteins.


Pssm-ID: 464056 [Multi-domain]  Cd Length: 59  Bit Score: 67.04  E-value: 5.48e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207187733 608 QTDFENYVHASNESLQTAKSALQCFLRAYTTYPssLKHIFHIRMLHLGHAAKSFGLRDAPQ 668
Cdd:pfam13959   1 QLQLEKLVLKDRELKELAQKAFVSYVRAYSKHL--AKSIFNVKKLDLGHLAKSFGLLRAPK 59
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
 155-364 4.60e-13

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 68.59  E-value: 4.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 155 TFEELNLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSG--KDAVVRSQTGSGKTLAYGIPMvqfLQAIQPKVKRSDgplA 232
Cdd:cd18047     2 SFEELRLKPQLLQGVYA-MGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAM---LSQVEPANKYPQ---C 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 233 VVIVPTRELALQSFQMFQKLLRPFTWIVPGVLMGGEkkkaekaRLRKGI----NVLISTPGRLVDHIKNTLSIAFSAVRW 308
Cdd:cd18047    75 LCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGN-------KLERGQkiseQIVIGTPGTVLDWCSKLKFIDPKKIKV 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207187733 309 LILDEADRILDLGFEKDLTVILNALNTAGPyrQNVLLSATITEGLSRLASISMKDP 364
Cdd:cd18047   148 FVLDEADVMIATQGHQDQSIRIQRMLPRNC--QMLLFSATFEDSVWKFAQKVVPDP 201
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 177-349 6.16e-11

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 61.89  E-value: 6.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 177 SMTSVQKQTIPVLM-SGKDAVVRSQTGSGKTLAYGIPMVQFLqaiqpkvkRSDGPLAVVIVPTRELALQSFQMFQKLLRP 255
Cdd:cd17921     1 LLNPIQREALRALYlSGDSVLVSAPTSSGKTLIAELAILRAL--------ATSGGKAVYIAPTRALVNQKEADLRERFGP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 256 FTwIVPGVLMGGEKKKAEKARLRkgiNVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADrilDLGFEK---DLTVILNA 332
Cdd:cd17921    73 LG-KNVGLLTGDPSVNKLLLAEA---DILVATPEKLDLLLRNGGERLIQDVRLVVVDEAH---LIGDGErgvVLELLLSR 145

                         170
                  ....*....|....*..
gi 1207187733 333 LNTAGPYRQNVLLSATI 349
Cdd:cd17921   146 LLRINKNARFVGLSATL 162
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
 150-364 1.94e-10

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 61.58  E-value: 1.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 150 VFTSNTFEELNLHPHLVATLHkVLNVSSMTSVQKQTIPVLMSG--KDAVVRSQTGSGKTLAYGIPMVQFLQAIQPKvkrs 227
Cdd:cd18048    14 LFSVKSFEELHLKEELLRGIY-AMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVDALKLY---- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 228 dgPLAVVIVPTRELALQSFQMFQKLLRPFTWI-VPGVLMGGEKKKAekARLRKGInvLISTPGRLVDHIKNTLSIAFSAV 306
Cdd:cd18048    89 --PQCLCLSPTFELALQTGKVVEEMGKFCVGIqVIYAIRGNRPGKG--TDIEAQI--VIGTPGTVLDWCFKLRLIDVTNI 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207187733 307 RWLILDEADRILDLGFEKDLTVilnALNTAGPYR-QNVLLSATITEGLSRLASISMKDP 364
Cdd:cd18048   163 SVFVLDEADVMINVQGHSDHSV---RVKRSMPKEcQMLLFSATFEDSVWAFAERIVPDP 218
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
 410-534 1.28e-08

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 54.28  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 410 HLVCLAAFILAKCKFEQRQKLVIFISSCEAVEFLLNLFTAVLCEIPSNT-----SSKSTSclnfyrlhgNMRQEERTEVF 484
Cdd:cd18801    13 KLEEIVKEHFKKKQEGSDTRVIIFSEFRDSAEEIVNFLSKIRPGIRATRfigqaSGKSSK---------GMSQKEQKEVI 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1207187733 485 QEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTAR 534
Cdd:cd18801    84 EQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
 160-314 1.14e-07

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 55.23  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 160 NLHPHLVATLHKvLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMvqfLQAIQpkvkRSDGPLAVVIVPTR 239
Cdd:COG1205    40 WLPPELRAALKK-RGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPV---LEALL----EDPGATALYLYPTK 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 240 ELA---LQSFQ-MFQKL---LRPFTWIvpgvlmgGEKKKAEKARLRKGINVLISTP-----GRLVDHIKntlsIA--FSA 305
Cdd:COG1205   112 ALArdqLRRLReLAEALglgVRVATYD-------GDTPPEERRWIREHPDIVLTNPdmlhyGLLPHHTR----WArfFRN 180


                  ....*....
gi 1207187733 306 VRWLILDEA 314
Cdd:COG1205   181 LRYVVIDEA 189
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
475-598 1.39e-07

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 55.12  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 475 MRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGaQGSsllfltpsetafVD 554
Cdd:COG1111   395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKR-EGR------------VV 461

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207187733 555 VL--------ANHNISLS-EMKMVDILSTLMK--DERFKGRGKWDSKRSADAFEQ 598
Cdd:COG1111   462 VLiakgtrdeAYYWSSRRkEKKMKSILKKLKKllDKQEKEKLKESAQATLDEFES 516
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
175-536 3.90e-07

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 53.36  E-value: 3.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 175 VSSMTSVQKQTIP-VLMSGKDAVVRSQTGSGKTLAYGIPMVQFLQAiqpkvkrsdGPLAVVIVPTRELALQSFQMFQKLL 253
Cdd:COG1204    20 IEELYPPQAEALEaGLLEGKNLVVSAPTASGKTLIAELAILKALLN---------GGKALYIVPLRALASEKYREFKRDF 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 254 RPFTWIVpGVLMGGEKKKAEKARLRkgiNVLISTPGR---LVDHIKNTLsiafSAVRWLILDEA------DRildlGFek 324
Cdd:COG1204    91 EELGIKV-GVSTGDYDSDDEWLGRY---DILVATPEKldsLLRNGPSWL----RDVDLVVVDEAhliddeSR----GP-- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 325 DLTVILNALNTAGPYRQNVLLSATI--TEGLSRL--ASISMKD--PV----------SVHVSEGSEETVEACPQAAPQAL 388
Cdd:COG1204   157 TLEVLLARLRRLNPEAQIVALSATIgnAEEIAEWldAELVKSDwrPVplnegvlydgVLRFDDGSRRSKDPTLALALDLL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 389 SDSyavperlQQHVVVVPSKLHLVCLAAFIlakckfeqRQKLVIFISSCEAVEflLNLFTAVLCEIPSNTSSKST--SCL 466
Cdd:COG1204   237 EEG-------GQVLVFVSSRRDAESLAKKL--------ADELKRRLTPEEREE--LEELAEELLEVSEETHTNEKlaDCL 299

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 467 N----FYrlHGNMRQEERTEVFQEFsqcKTG---ILLCTDVAARGLDLPQVTWIV-----QYNPPVSAAEYVHRVGRTAR 534
Cdd:COG1204   300 EkgvaFH--HAGLPSELRRLVEDAF---REGlikVLVATPTLAAGVNLPARRVIIrdtkrGGMVPIPVLEFKQMAGRAGR 374


                  ..
gi 1207187733 535 IG 536
Cdd:COG1204   375 PG 376
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
 192-313 4.66e-07

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 50.27  E-value: 4.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 192 GKDAVVRSQTGSGKTLAygipmvQFLQAIQPKVKRSDGPLAVV-IVPTRELALqsfQMFQKLLRPFTWIVPGVLMG---G 267
Cdd:cd17922     1 GRNVLIAAPTGSGKTEA------AFLPALSSLADEPEKGVQVLyISPLKALIN---DQERRLEEPLDEIDLEIPVAvrhG 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1207187733 268 EKKKAEKARLRKGI-NVLISTPGRLVDHIKNT-LSIAFSAVRWLILDE 313
Cdd:cd17922    72 DTSQSEKAKQLKNPpGILITTPESLELLLVNKkLRELFAGLRYVVVDE 119
PRK13767 PRK13767
ATP-dependent helicase; Provisional
 177-313 5.67e-07

ATP-dependent helicase; Provisional


Pssm-ID: 237497 [Multi-domain]  Cd Length: 876  Bit Score: 52.97  E-value: 5.67e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 177 SMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAygipmvQFLQAIQPKVKRS------DGPLAVVIVPTRELAlqsFQMFQ 250
Cdd:PRK13767   32 TFTPPQRYAIPLIHEGKNVLISSPTGSGKTLA------AFLAIIDELFRLGregeleDKVYCLYVSPLRALN---NDIHR 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 251 KLLRPFTWI----------VPGVLMG---GEKKKAEKAR-LRKGINVLISTPgrlvdhikNTLSIAFSA---------VR 307
Cdd:PRK13767  103 NLEEPLTEIreiakergeeLPEIRVAirtGDTSSYEKQKmLKKPPHILITTP--------ESLAILLNSpkfreklrtVK 174


                  ....*.
gi 1207187733 308 WLILDE 313
Cdd:PRK13767  175 WVIVDE 180
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 490-546 7.26e-07

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 47.31  E-value: 7.26e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207187733 490 CKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLT 546
Cdd:cd18785    21 SSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILFV 77
SF2_C_RecG cd18811
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ...
 471-549 1.04e-06

C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350198 [Multi-domain]  Cd Length: 159  Bit Score: 49.26  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 471 LHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVH----RVGRtariGAQGSSLLFLT 546
Cdd:cd18811    67 LHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHqlrgRVGR----GDHQSYCLLVY 142


                  ...
gi 1207187733 547 PSE 549
Cdd:cd18811   143 KDP 145
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
 191-314 1.20e-06

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 49.51  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 191 SGKDAVVRSQTGSGKTLAYGIPMVQFLqAIQPKVKrsdgplAVVIVPTRELALQSFQMFQKLLRPFTW-IVPGVLMGGEK 269
Cdd:cd17923    14 AGRSVVVTTGTASGKSLCYQLPILEAL-LRDPGSR------ALYLYPTKALAQDQLRSLRELLEQLGLgIRVATYDGDTP 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1207187733 270 KKAEKARLRKGINVLISTPGRL---VDHIKNTLSIAFSAVRWLILDEA 314
Cdd:cd17923    87 REERRAIIRNPPRILLTNPDMLhyaLLPHHDRWARFLRNLRYVVLDEA 134
SF2_C_RecG_TRCF cd18792
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ...
 471-551 1.60e-06

C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350179 [Multi-domain]  Cd Length: 160  Bit Score: 48.42  E-value: 1.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 471 LHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVH----RVGRtariGAQGSSLLFLT 546
Cdd:cd18792    66 LHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLHqlrgRVGR----GKHQSYCYLLY 141


                  ....*
gi 1207187733 547 PSETA 551
Cdd:cd18792   142 PDPKK 146
DEXHc_RecQ4-like cd18018
DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) ...
 166-314 1.20e-05

DEAH-box helicase domain of RecQ4 and similar proteins; ATP-dependent DNA helicase Q4 (RecQ4) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations cause Rothmund-Thomson/RAPADILINO/Baller-Gerold syndrome.


Pssm-ID: 350776 [Multi-domain]  Cd Length: 201  Bit Score: 46.87  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 166 VATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPmVQFLQAIQPKvkrsdgpLAVVIVPTreLALQS 245
Cdd:cd18018     1 LKLLRRVFGHPSFRPGQEEAIARLLSGRSTLVVLPTGAGKSLCYQLP-ALLLRRRGPG-------LTLVVSPL--IALMK 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207187733 246 FQMfQKLLRpftwIVPGVL----MGGEKKKAEKARLRKG-INVLISTPGRLVDH-----IKNTLSIAFSAVrwlilDEA 314
Cdd:cd18018    71 DQV-DALPR----AIKAAAlnssLTREERRRILEKLRAGeVKILYVSPERLVNEsfrelLRQTPPISLLVV-----DEA 139
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 189-349 2.36e-05

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 45.40  E-value: 2.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 189 LMSGKDAVVRSQTGSGKTLAYGIPMVQFLqaiqpkvkrSDGPLAVVIVPTRELALQSFQMFQKLLRPFTWIvpGVLMGge 268
Cdd:cd18028    14 LLKGENLLISIPTASGKTLIAEMAMVNTL---------LEGGKALYLVPLRALASEKYEEFKKLEEIGLKV--GISTG-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 269 kKKAEKARLRKGINVLISTPGRLVDHIKNTLSIAfSAVRWLILDEADRILDLGFEKDLTVILNALNTAGPYRQNVLLSAT 348
Cdd:cd18028    81 -DYDEDDEWLGDYDIIVATYEKFDSLLRHSPSWL-RDVGVVVVDEIHLISDEERGPTLESIVARLRRLNPNTQIIGLSAT 158


                  .
gi 1207187733 349 I 349
Cdd:cd18028   159 I 159
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 395-507 2.51e-05

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 44.39  E-value: 2.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 395 PERlqqHVVVVPSKLHLVCLaafILAKCKfEQRQKLVIFissCEAVEFLlNLFTAVLCEIPsntsskstscLNFYRLHGN 474
Cdd:cd18793     2 PPK---IEEVVSGKLEALLE---LLEELR-EPGEKVLIF---SQFTDTL-DILEEALRERG----------IKYLRLDGS 60

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207187733 475 MRQEERTEVFQEFSQCKTG--ILLCTDVAARGLDL 507
Cdd:cd18793    61 TSSKERQKLVDRFNEDPDIrvFLLSTKAGGVGLNL 95
DDXDc_reverse_gyrase cd17924
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ...
 176-350 3.04e-05

DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350682 [Multi-domain]  Cd Length: 189  Bit Score: 45.40  E-value: 3.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 176 SSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTlAYGIPMVQFLQAiqpKVKRSdgplaVVIVPTRELALQSFQMFQKLLRP 255
Cdd:cd17924    16 FPPWGAQRTWAKRLLRGKSFAIIAPTGVGKT-TFGLATSLYLAS---KGKRS-----YLIFPTKSLVKQAYERLSKYAEK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 256 FTWIVPGVLMGGEKKKAEKARLRKGI-----NVLISTPGRLVDHIKNTLSIAFSAVrwlILDEADRILDLGfeKDLTVIL 330
Cdd:cd17924    87 AGVEVKILVYHSRLKKKEKEELLEKIekgdfDILVTTNQFLSKNFDLLSNKKFDFV---FVDDVDAVLKSS--KNIDRLL 161

                         170       180
                  ....*....|....*....|
gi 1207187733 331 NALNtagpYRQNVLLSATIT 350
Cdd:cd17924   162 KLLG----FGQLVVSSATGR 177
DEXHc_RecQ2_BLM cd18016
DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom ...
 165-364 6.91e-05

DEAH-box helicase domain of RecQ2; ATP-dependent DNA helicase Q2 (RecQ2, also called Bloom syndrome protein homolog or BLM) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region. Mutations in RecQ2 cause Bloom syndrome.


Pssm-ID: 350774 [Multi-domain]  Cd Length: 208  Bit Score: 44.82  E-value: 6.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 165 LVATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVqflqaIQPKVkrsdgplAVVIVPTRELALQ 244
Cdd:cd18016     5 MMKIFHKKFGLHQFRTNQLEAINAALLGEDCFVLMPTGGGKSLCYQLPAC-----VSPGV-------TVVISPLRSLIVD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 245 SFQMFQKLlrpftwIVPGVLMGGEKKKAEKAR----LRKG---INVLISTP------GRLVDHIKNTLSIAFSAvRWLIl 311
Cdd:cd18016    73 QVQKLTSL------DIPATYLTGDKTDAEATKiylqLSKKdpiIKLLYVTPekisasNRLISTLENLYERKLLA-RFVI- 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207187733 312 DEADRILDLG--FEKDLTViLNALNTAGPYRQNVLLSATITEGLSR--LASISMKDP 364
Cdd:cd18016   145 DEAHCVSQWGhdFRPDYKR-LNMLRQKFPSVPMMALTATATPRVQKdiLNQLKMLRP 200
DEXHc_RecQ1 cd18015
DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ ...
 167-214 1.38e-04

DEXH-box helicase domain of RecQ1; ATP-dependent DNA helicase Q1 (RecQ1) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350773 [Multi-domain]  Cd Length: 209  Bit Score: 43.89  E-value: 1.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207187733 167 ATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMV 214
Cdd:cd18015     8 DTLKNVFKLEKFRPLQLETINATMAGRDVFLVMPTGGGKSLCYQLPAL 55
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 472-544 2.07e-04

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 41.81  E-value: 2.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207187733 472 HGNMRQEERTEVFQEFSQCKTGILLCTdVA-ARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLF 544
Cdd:cd18794    61 HAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGMGIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILF 133
DEXHc_RIG-I cd17927
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ...
 190-316 3.60e-04

DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350685 [Multi-domain]  Cd Length: 201  Bit Score: 42.42  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 190 MSGKDAVVRSQTGSGKTLAYGIPMVQFLQaiqpKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTWIVPGvLMGGEK 269
Cdd:cd17927    15 LKGKNTIICLPTGSGKTFVAVLICEHHLK----KFPAGRKGKVVFLANKVPLVEQQKEVFRKHFERPGYKVTG-LSGDTS 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1207187733 270 KKAEKARLRKGINVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADR 316
Cdd:cd17927    90 ENVSVEQIVESSDVIIVTPQILVNDLKSGTIVSLSDFSLLVFDECHN 136
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
 201-348 3.63e-04

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 41.52  E-value: 3.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 201 TGSGKTLaygipmVQFLQAIQPKVKRsdgplAVVIVPTRELAlqsFQMFQKLLRPFTWIVPGVLMGGEKKKAEkarlrkG 280
Cdd:cd17926    27 TGSGKTL------TALALIAYLKELR-----TLIVVPTDALL---DQWKERFEDFLGDSSIGLIGGGKKKDFD------D 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 281 INVLISTPGRLVDHIKNTLSIA--FSAvrwLILDEADRILDLGFEKDLTvilnalNTAGPYRqnVLLSAT 348
Cdd:cd17926    87 ANVVVATYQSLSNLAEEEKDLFdqFGL---LIVDEAHHLPAKTFSEILK------ELNAKYR--LGLTAT 145
DEXHc_RecG cd17992
DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in ...
 202-287 5.35e-04

DEXH/Q-box helicase domain of RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. It is a member of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350750 [Multi-domain]  Cd Length: 225  Bit Score: 42.13  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 202 GSGKTLAYGIPMvqfLQAIQpkvkrsDGPLAVVIVPTRELALQSFQMFQKLLRPFTwIVPGVLMGGEKKKAEK---ARLR 278
Cdd:cd17992    76 GSGKTVVAALAM---LAAVE------NGYQVALMAPTEILAEQHYDSLKKLLEPLG-IRVALLTGSTKAKEKReilEKIA 145

                          90
                  ....*....|
gi 1207187733 279 KG-INVLIST 287
Cdd:cd17992   146 SGeIDIVIGT 155
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
176-313 7.22e-04

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 440814 [Multi-domain]  Cd Length: 850  Bit Score: 43.17  E-value: 7.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 176 SSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAygipmvQFLQAIQ------PKVKRSDGPLAVVIVPTRELA------L 243
Cdd:COG1201    23 GAPTPPQREAWPAIAAGESTLLIAPTGSGKTLA------AFLPALDelarrpRPGELPDGLRVLYISPLKALAndiernL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 244 QSF--QMFQKLLRPFTWIVPGVlMGGEKKKAEKARLRKGI-NVLISTPgrlvdhikNTLSI---------AFSAVRWLIL 311
Cdd:COG1201    97 RAPleEIGEAAGLPLPEIRVGV-RTGDTPASERQRQRRRPpHILITTP--------ESLALlltspdareLLRGVRTVIV 167


                  ..
gi 1207187733 312 DE 313
Cdd:COG1201   168 DE 169
ResIII pfam04851
Type III restriction enzyme, res subunit;
201-340 1.13e-03

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 40.35  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 201 TGSGKTLAYGIPMVQFLQaiQPKVKRsdgplAVVIVPTRELALQSFQMFQKLLrPFTWIVPGVLMGGEKKkaekaRLRKG 280
Cdd:pfam04851  32 TGSGKTLTAAKLIARLFK--KGPIKK-----VLFLVPRKDLLEQALEEFKKFL-PNYVEIGEIISGDKKD-----ESVDD 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 281 INVLISTP---GRLVDHIKNTLSIAFSAVrwLILDEADRILDLGFEKdltvILNALN-------TAGPYR 340
Cdd:pfam04851  99 NKIVVTTIqslYKALELASLELLPDFFDV--IIIDEAHRSGASSYRN----ILEYFKpafllglTATPER 162
SF2_C_dicer cd18802
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ...
 475-546 1.47e-03

C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350189 [Multi-domain]  Cd Length: 142  Bit Score: 39.50  E-value: 1.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207187733 475 MRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRtARigAQGSSLLFLT 546
Cdd:cd18802    74 MTQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-AR--APNSKYILMV 142
SF2_C_TRCF cd18810
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ...
 471-536 1.67e-03

C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350197 [Multi-domain]  Cd Length: 151  Bit Score: 39.63  E-value: 1.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 471 LHGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVH----RVGRTARIG 536
Cdd:cd18810    57 AHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIIERADKFGLAQLYqlrgRVGRSKERA 126
PRK13766 PRK13766
Hef nuclease; Provisional
 475-534 2.70e-03

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 41.01  E-value: 2.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 475 MRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTAR 534
Cdd:PRK13766  407 MSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR 466
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
 472-545 4.20e-03

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 38.40  E-value: 4.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207187733 472 HGNMRQEERTEVFQEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFL 545
Cdd:cd18796    75 HGSLSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGAASKGRLV 148
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
 167-314 5.32e-03

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 38.67  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 167 ATLHKVLNVSSMTSVQKQTIPVLMSGKDAVVRSQTGSGKTLAYGIPMVQFlqaiqpkvkrsdGPLAVVIVPTreLALQSF 246
Cdd:cd17920     2 QILKEVFGYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALLL------------DGVTLVVSPL--ISLMQD 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187733 247 QMFQKLLRPftwiVPGVLMGGEKKKAEK----ARLRKG-INVLISTPGRLV--------DHIKNTLSIAFSAVrwlilDE 313
Cdd:cd17920    68 QVDRLQQLG----IRAAALNSTLSPEEKrevlLRIKNGqYKLLYVTPERLLspdflellQRLPERKRLALIVV-----DE 138


                  .
gi 1207187733 314 A 314
Cdd:cd17920   139 A 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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