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Conserved domains on  [gi|1207186328|ref|XP_021326786|]
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uncharacterized protein si:ch211-14k19.8 isoform X1 [Danio rerio]

Protein Classification

Herpes_BLLF1 and EGF_CA domain-containing protein( domain architecture ID 13556415)

Herpes_BLLF1 and EGF_CA domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
280-553 7.78e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 7.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  280 STAPNAAKTSTLLDTNdvAFTELHRGSSQPTHTHAFTQIQSK-----TAKRGDLSSIFPTSSYMTVSPPNIEPF---NQT 351
Cdd:pfam05109  422 SKAPESTTTSPTLNTT--GFAAPNTTTGLPSSTHVPTNLTAPastgpTVSTADVTSPTPAGTTSGASPVTPSPSprdNGT 499
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  352 STEA-DFISDSATKDKPTTRTGFNRDVFTMSEKIVTNPFHGNFWSSNTITDDSQSIASESDrtdrSPRSTNPNKTInEDL 430
Cdd:pfam05109  500 ESKApDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTP----AVTTPTPNATI-PTL 574
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  431 FMTTSTLATVSRFPNQTNPL---TFPDSETTEYS--GYSA-----SPPTNVTTDIepttssstlatsealttqslhTVQS 500
Cdd:pfam05109  575 GKTSPTSAVTTPTPNATSPTvgeTSPQANTTNHTlgGTSStpvvtSPPKNATSAV---------------------TTGQ 633
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207186328  501 HHTSAQETSSASAPvfdlTSHNNNKISAFTTFSSTDVTPIESTSTPVVDEGFS 553
Cdd:pfam05109  634 HNITSSSTSSMSLR----PSSISETLSPSTSDNSTSHMPLLTSAHPTGGENIT 682
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
960-986 3.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.98e-03
                           10        20
                   ....*....|....*....|....*..
gi 1207186328  960 CHSEYCKHQGICVhRLGQQPICQCPVG 986
Cdd:pfam00008    1 CAPNPCSNGGTCV-DTPGGYTCICPEG 26
 
Name Accession Description Interval E-value
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
280-553 7.78e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 7.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  280 STAPNAAKTSTLLDTNdvAFTELHRGSSQPTHTHAFTQIQSK-----TAKRGDLSSIFPTSSYMTVSPPNIEPF---NQT 351
Cdd:pfam05109  422 SKAPESTTTSPTLNTT--GFAAPNTTTGLPSSTHVPTNLTAPastgpTVSTADVTSPTPAGTTSGASPVTPSPSprdNGT 499
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  352 STEA-DFISDSATKDKPTTRTGFNRDVFTMSEKIVTNPFHGNFWSSNTITDDSQSIASESDrtdrSPRSTNPNKTInEDL 430
Cdd:pfam05109  500 ESKApDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTP----AVTTPTPNATI-PTL 574
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  431 FMTTSTLATVSRFPNQTNPL---TFPDSETTEYS--GYSA-----SPPTNVTTDIepttssstlatsealttqslhTVQS 500
Cdd:pfam05109  575 GKTSPTSAVTTPTPNATSPTvgeTSPQANTTNHTlgGTSStpvvtSPPKNATSAV---------------------TTGQ 633
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207186328  501 HHTSAQETSSASAPvfdlTSHNNNKISAFTTFSSTDVTPIESTSTPVVDEGFS 553
Cdd:pfam05109  634 HNITSSSTSSMSLR----PSSISETLSPSTSDNSTSHMPLLTSAHPTGGENIT 682
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
960-986 3.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.98e-03
                           10        20
                   ....*....|....*....|....*..
gi 1207186328  960 CHSEYCKHQGICVhRLGQQPICQCPVG 986
Cdd:pfam00008    1 CAPNPCSNGGTCV-DTPGGYTCICPEG 26
 
Name Accession Description Interval E-value
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
280-553 7.78e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 7.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  280 STAPNAAKTSTLLDTNdvAFTELHRGSSQPTHTHAFTQIQSK-----TAKRGDLSSIFPTSSYMTVSPPNIEPF---NQT 351
Cdd:pfam05109  422 SKAPESTTTSPTLNTT--GFAAPNTTTGLPSSTHVPTNLTAPastgpTVSTADVTSPTPAGTTSGASPVTPSPSprdNGT 499
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  352 STEA-DFISDSATKDKPTTRTGFNRDVFTMSEKIVTNPFHGNFWSSNTITDDSQSIASESDrtdrSPRSTNPNKTInEDL 430
Cdd:pfam05109  500 ESKApDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTP----AVTTPTPNATI-PTL 574
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207186328  431 FMTTSTLATVSRFPNQTNPL---TFPDSETTEYS--GYSA-----SPPTNVTTDIepttssstlatsealttqslhTVQS 500
Cdd:pfam05109  575 GKTSPTSAVTTPTPNATSPTvgeTSPQANTTNHTlgGTSStpvvtSPPKNATSAV---------------------TTGQ 633
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207186328  501 HHTSAQETSSASAPvfdlTSHNNNKISAFTTFSSTDVTPIESTSTPVVDEGFS 553
Cdd:pfam05109  634 HNITSSSTSSMSLR----PSSISETLSPSTSDNSTSHMPLLTSAHPTGGENIT 682
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
960-986 3.98e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 3.98e-03
                           10        20
                   ....*....|....*....|....*..
gi 1207186328  960 CHSEYCKHQGICVhRLGQQPICQCPVG 986
Cdd:pfam00008    1 CAPNPCSNGGTCV-DTPGGYTCICPEG 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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