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Conserved domains on  [gi|1207165097|ref|XP_021325681|]
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calmodulin-binding transcription activator 1 isoform X8 [Danio rerio]

Protein Classification

calmodulin-binding transcription activator( domain architecture ID 12224848)

calmodulin-binding transcription activator may act as a tumor suppressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 66-182 3.72e-74

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


:

Pssm-ID: 198144  Cd Length: 118  Bit Score: 241.92  E-value: 3.72e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097    66 LPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKY-RKDGYCWKKRKDGKTTREDHMKLKVQGV 144
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 1207165097   145 ECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVP 182
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1000-1079 4.78e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.54  E-value: 4.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1000 VTDYSPEWSYPEGGVKVLITGP-WQEDSSSYTCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAV-SNQIISNSVVF 1077
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVgGGGISSSPLTF 82


                   ..
gi 1207165097 1078 EY 1079
Cdd:pfam01833   83 TY 84
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
1184-1287 1.25e-08

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1184 IHSKTFRGMTLLHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLykWDRRA- 1262
Cdd:COG0666    113 VNARDKDGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL--LEAGAd 178

                           90       100
                   ....*....|....*....|....*
gi 1207165097 1263 LAIPDSLGRLPLSIARSRGHTKLAE 1287
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVK 203
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 66-182 3.72e-74

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 241.92  E-value: 3.72e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097    66 LPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKY-RKDGYCWKKRKDGKTTREDHMKLKVQGV 144
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 1207165097   145 ECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVP 182
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 70-181 3.15e-57

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 193.25  E-value: 3.15e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097   70 RHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKY-RKDGYCWKKRKDGKTTREDHMKLKVQGVECLY 148
Cdd:pfam03859    1 KTRWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1207165097  149 GCYVHSSIIPTFHRRCYWLLQNP-DIVLVHYLNV 181
Cdd:pfam03859   81 CYYAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1000-1079 4.78e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.54  E-value: 4.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1000 VTDYSPEWSYPEGGVKVLITGP-WQEDSSSYTCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAV-SNQIISNSVVF 1077
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVgGGGISSSPLTF 82


                   ..
gi 1207165097 1078 EY 1079
Cdd:pfam01833   83 TY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1184-1287 1.25e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1184 IHSKTFRGMTLLHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLykWDRRA- 1262
Cdd:COG0666    113 VNARDKDGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL--LEAGAd 178

                           90       100
                   ....*....|....*....|....*
gi 1207165097 1263 LAIPDSLGRLPLSIARSRGHTKLAE 1287
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVK 203
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1195-1287 3.09e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 3.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1195 LHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAA-VVLYKWDRRAlaipDSLGRLP 1273
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNL----KDNGRTA 64

                           90
                   ....*....|....
gi 1207165097 1274 LSIARSRGHTKLAE 1287
Cdd:pfam12796   65 LHYAARSGHLEIVK 78
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
 66-182 3.72e-74

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 241.92  E-value: 3.72e-74
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097    66 LPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKY-RKDGYCWKKRKDGKTTREDHMKLKVQGV 144
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80

                            90       100       110
                    ....*....|....*....|....*....|....*...
gi 1207165097   145 ECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVP 182
Cdd:smart01076   81 ECLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
 70-181 3.15e-57

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 193.25  E-value: 3.15e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097   70 RHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKY-RKDGYCWKKRKDGKTTREDHMKLKVQGVECLY 148
Cdd:pfam03859    1 KTRWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVEAIH 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1207165097  149 GCYVHSSIIPTFHRRCYWLLQNP-DIVLVHYLNV 181
Cdd:pfam03859   81 CYYAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1000-1079 4.78e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.54  E-value: 4.78e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1000 VTDYSPEWSYPEGGVKVLITGP-WQEDSSSYTCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAV-SNQIISNSVVF 1077
Cdd:pfam01833    3 ITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVgGGGISSSPLTF 82


                   ..
gi 1207165097 1078 EY 1079
Cdd:pfam01833   83 TY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1184-1287 1.25e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.43  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1184 IHSKTFRGMTLLHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLykWDRRA- 1262
Cdd:COG0666    113 VNARDKDGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL--LEAGAd 178

                           90       100
                   ....*....|....*....|....*
gi 1207165097 1263 LAIPDSLGRLPLSIARSRGHTKLAE 1287
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVK 203
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1178-1287 3.97e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.80  E-value: 3.97e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1178 AKSKHLIHSKTFRGMTLLHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYk 1257
Cdd:COG0666     74 LAAGADINAKDDGGNTLLHAAARNGDLEIVKLL------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL- 140

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1207165097 1258 wDRRA-LAIPDSLGRLPLSIARSRGHTKLAE 1287
Cdd:COG0666    141 -EAGAdVNAQDNDGNTPLHLAAANGNLEIVK 170
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1195-1287 3.09e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 3.09e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1195 LHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAA-VVLYKWDRRAlaipDSLGRLP 1273
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVkLLLEHADVNL----KDNGRTA 64

                           90
                   ....*....|....
gi 1207165097 1274 LSIARSRGHTKLAE 1287
Cdd:pfam12796   65 LHYAARSGHLEIVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1184-1257 2.25e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 2.25e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207165097 1184 IHSKTFRGMTLLHLAAGQGYATLIQTLIKwrtkHADsidlelevdpLNVDHFSCTPLMWACALGHLEAAVVLYK 1257
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE----HAD----------VNLKDNGRTALHYAARSGHLEIVKLLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1184-1287 5.01e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 47.26  E-value: 5.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207165097 1184 IHSKTFRGMTLLHLAAGQGYATLIQTLikwrtkhadsidLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKwDRRAL 1263
Cdd:COG0666    179 VNARDNDGETPLHLAAENGHLEIVKLL------------LEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADL 245

                           90       100
                   ....*....|....*....|....
gi 1207165097 1264 AIPDSLGRLPLSIARSRGHTKLAE 1287
Cdd:COG0666    246 NAKDKDGLTALLLAAAAGAALIVK 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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