|
Name |
Accession |
Description |
Interval |
E-value |
| Adaptin_N |
pfam01602 |
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ... |
54-587 |
7.93e-160 |
|
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 484.05 E-value: 7.93e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 54 DLKEMLESNKES--LKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRA 131
Cdd:pfam01602 8 ELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVTNSIQKD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 132 LKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSLDPDQKEHLIEVIEKLLKDKSTLV 211
Cdd:pfam01602 88 LQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELLSDKDPGV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 212 AGSVVMAFEEVC-PDRI--DLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQfispwredaifdensektfydseee 288
Cdd:pfam01602 168 QSAAVALLYEICkNDRLylKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLD------------------------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 289 rrvdqskpyimDPDHRLLLRNTKPLLQSRNTAVVMAVCQLYWHLAPKHE-ISIITKSLVRLLRSHRE-VQYVVLQNIATM 366
Cdd:pfam01602 223 -----------PLLPKELLEDLLNLLQNSNNAVLYETANTIVHLAPAPElIVLAVNALGRLLSSPDEnLRYVALRNLNKI 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 367 SIQR-KGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKS-QDKAFAAATIQAIGRCATNISEV 444
Cdd:pfam01602 292 VMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEiADPDFKIELVRAIGRLAEKFPTD 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 445 TDTCLNGLVLLLSNRDETVVAESVVVIKKLLQTQPSQHSDIIKHMAKLFDNITVPMARASILWLMGEYCEHVP--KIAPD 522
Cdd:pfam01602 372 AEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPngSSPPD 451
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207160806 523 VLRKMAKSFTSEEDIVKLQTVNLAAKLYLTNSKQTK--LLTQYILNLGKYDQ-NYDIRDRTRFIRQLI 587
Cdd:pfam01602 452 LLRSILEVFVLESAKVRAAALTALAKLGLTSPEETTqnLIIQLLLTLATQDSlDLEVRDRAVEYLRLL 519
|
|
| COG5096 |
COG5096 |
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ... |
59-609 |
9.78e-69 |
|
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 227427 [Multi-domain] Cd Length: 757 Bit Score: 246.18 E-value: 9.78e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 59 LESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQL 138
Cdd:COG5096 28 LESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 139 IRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSLDPDQK--EHLIEVIEKLLKDKSTLVAGSVV 216
Cdd:COG5096 108 IRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYheLGLIDILKELVADSDPIVIANAL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 217 MAFEEVCPDRI-DLIHKNYRKLCNLLV----DVEEWGQVVIIHMLTRYartqfispwredAIFDENSEKTFydseEERrv 291
Cdd:COG5096 188 ASLAEIDPELAhGYSLEVILRIPQLDLlslsVSTEWLLLIILEVLTER------------VPTTPDSAEDF----EER-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 292 dqSKPYIMDPDHRLLLRNTKPLLqsRNTaVVMAVCQLYWHLAPKheisiitksLVRLL-RSHREVQYVVLQNIATMSIQR 370
Cdd:COG5096 250 --LSPPLQHNNAEVLLIAVKVIL--RLL-VFLPSNNLFLISSPP---------LVTLLaKPESLIQYVLRRNIQIDLEVC 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 371 KGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKSQDKA--FAAATIQAIGRCATNISEVTDTC 448
Cdd:COG5096 316 SKLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLSQILLELIYYIAENHIDaeMVSEAIKALGDLASKAESSVNDC 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 449 LNGLVLLLSN---RDETVVAE------------SVVVIKKLLQTQPSQHSDIIKHMAKLFDNITVP------MARASILW 507
Cdd:COG5096 396 ISELLELLEGvwiRGSYIVQEvrivdcisviriSVLVLRILPNEYPKILLRGLYALEETLELQSREpraksvTDKYLGAW 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 508 LMGEYCEHVPKIAPDVLRKMAKSFTSEEDIVKLQTVNLAAKLYLTN-SKQTKLLTQYILNLGKYDQNY----DIRDRTRF 582
Cdd:COG5096 476 LLGEFSDIIPRLEPELLRIAISNFVDETLEVQYTILMSSVKLIANSiRKAKQCNSELDQDVLRRCFDYvlvpDLRDRARM 555
|
570 580
....*....|....*....|....*..
gi 1207160806 583 IRQLIvpnekSGALSKYARRILMAPKP 609
Cdd:COG5096 556 YSRLL-----STPLPEFSDPILCEAKK 577
|
|
| AP3B1_C |
pfam14796 |
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ... |
831-974 |
2.00e-57 |
|
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.
Pssm-ID: 464319 Cd Length: 148 Bit Score: 194.79 E-value: 2.00e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 831 EKKEVSLLDLDDFAPT-PVTTPKSSILSP-SLLSDLQGLSISPTS-ALQASSPVFVPETSYELLHRMTGKGLSGQYRFTR 907
Cdd:pfam14796 1 KSNEDLLLDLDDFSPSsPVMTPSLGGFLSpSLATDLEGLSLTDSSsAIEVVSPSFVPTKTHELLHRMTGEGLSVEYRFTR 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207160806 908 QPCIYDSSMVSLQLTLSNSSEQPLENIHISQKSS-SAQNIHCFNAVERLEPQASVTVSIGVNFNDSTQ 974
Cdd:pfam14796 81 QPCIYSPKMVSVELTFTNTSDSEITNIHIGEKKLpAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
|
|
| PTZ00429 |
PTZ00429 |
beta-adaptin; Provisional |
54-579 |
9.25e-52 |
|
beta-adaptin; Provisional
Pssm-ID: 240415 [Multi-domain] Cd Length: 746 Bit Score: 195.54 E-value: 9.25e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 54 DLKEMLESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRALK 133
Cdd:PTZ00429 36 ELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPEKALLAVNTFLQDTT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 134 DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYS------LDPDQKEHLIevieKLLKDK 207
Cdd:PTZ00429 116 NSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHddmqlfYQQDFKKDLV----ELLNDN 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 208 STLV---AGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRyARTQfispwreDAIFDENsektfyd 284
Cdd:PTZ00429 192 NPVVasnAAAIVCEVNDYGSEKIESSNEWVNRLVYHLPECNEWGQLYILELLAA-QRPS-------DKESAET------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 285 seeerrvdqskpyimdpdhrlLLRNTKPLLQSRNTAVVMAVCQLYWHLAPKHEISIITK-------SLVRLLRSHREVQY 357
Cdd:PTZ00429 257 ---------------------LLTRVLPRMSHQNPAVVMGAIKVVANLASRCSQELIERctvrvntALLTLSRRDAETQY 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 358 VVLQNIATMSIQRKGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKSQDKAFAAATIQAIGRC 437
Cdd:PTZ00429 316 IVCKNIHALLVIFPNLLRTNLDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 438 ATNISEVTDTCLNGLVLLLSNRDEtVVAESVVVIKKLLQTQPSQ---HSDIIKHMAklfDNITVPMARASILWLMGEYCE 514
Cdd:PTZ00429 396 AIKVDSVAPDCANLLLQIVDRRPE-LLPQVVTAAKDIVRKYPELlmlDTLVTDYGA---DEVVEEEAKVSLLWMLGEYCD 471
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207160806 515 HVPKiAPDVLRKMAKSFTSEEDIVKLQTVNLAAKLYLTNSKQTKLLTQYILN-LGKYDQNYDIRDR 579
Cdd:PTZ00429 472 FIEN-GKDIIQRFIDTIMEHEQRVQLAILSAAVKMFLRDPQGMEPQLNRVLEtVTTHSDDPDVRDR 536
|
|
| SCC2 |
cd23958 |
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ... |
120-246 |
1.16e-03 |
|
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.
Pssm-ID: 467937 [Multi-domain] Cd Length: 1197 Bit Score: 43.05 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 120 LALLSISTFQR-----------ALKDPNQLIRASALRVLSSI--RVPII--VPIMMLAIKEAATDLSPYVRKTAAHAIQK 184
Cdd:cd23958 454 RALASQRPLSQsfdpilkqllsSLDEPAVTLRTKALKALSLVveADPSIlgDPDVQRAVEGRLLDSSASVREAAVELVGK 533
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207160806 185 LYSLDPDQKEHLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNY--RKLCNLLVDVEE 246
Cdd:cd23958 534 YISSRPDLAEQYYEMIAERILDTGVSVRKRVIKILRDIYLRTPDFEIKVDicVRLLRRINDEEE 597
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Adaptin_N |
pfam01602 |
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ... |
54-587 |
7.93e-160 |
|
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain] Cd Length: 523 Bit Score: 484.05 E-value: 7.93e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 54 DLKEMLESNKES--LKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRA 131
Cdd:pfam01602 8 ELARILNSFRDDprKKKNAVKKLLYLIMLGEDISFLFFEVVKLVASKDFTLKRLGYLYLMLLAEESPDLAILVTNSIQKD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 132 LKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSLDPDQKEHLIEVIEKLLKDKSTLV 211
Cdd:pfam01602 88 LQSPNQLIRGLALRTLSCIRVPELARDLAPDIKKLLVDRSPYVRKKAALAILKLYRKSPDLVRDFVPELKELLSDKDPGV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 212 AGSVVMAFEEVC-PDRI--DLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRYARTQfispwredaifdensektfydseee 288
Cdd:pfam01602 168 QSAAVALLYEICkNDRLylKLLPLLFRRLCNLLGVLNPWLQVKILRLLTRLAPLD------------------------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 289 rrvdqskpyimDPDHRLLLRNTKPLLQSRNTAVVMAVCQLYWHLAPKHE-ISIITKSLVRLLRSHRE-VQYVVLQNIATM 366
Cdd:pfam01602 223 -----------PLLPKELLEDLLNLLQNSNNAVLYETANTIVHLAPAPElIVLAVNALGRLLSSPDEnLRYVALRNLNKI 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 367 SIQR-KGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKS-QDKAFAAATIQAIGRCATNISEV 444
Cdd:pfam01602 292 VMKEpKAVQHLDLIIFCLKTDDDISIRLRALDLLYALVNESNVKEIVKELLKYVHEiADPDFKIELVRAIGRLAEKFPTD 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 445 TDTCLNGLVLLLSNRDETVVAESVVVIKKLLQTQPSQHSDIIKHMAKLFDNITVPMARASILWLMGEYCEHVP--KIAPD 522
Cdd:pfam01602 372 AEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNVPELREYILEHLCELLEDIESPEALAAALWILGEYGELIPngSSPPD 451
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207160806 523 VLRKMAKSFTSEEDIVKLQTVNLAAKLYLTNSKQTK--LLTQYILNLGKYDQ-NYDIRDRTRFIRQLI 587
Cdd:pfam01602 452 LLRSILEVFVLESAKVRAAALTALAKLGLTSPEETTqnLIIQLLLTLATQDSlDLEVRDRAVEYLRLL 519
|
|
| COG5096 |
COG5096 |
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ... |
59-609 |
9.78e-69 |
|
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 227427 [Multi-domain] Cd Length: 757 Bit Score: 246.18 E-value: 9.78e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 59 LESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRALKDPNQL 138
Cdd:COG5096 28 LESSNDYKKIDAMKKIIAQMSLGEDMSSLFPDVIKNVATRDVELKRLLYLYLERYAKLKPELALLAVNTIQKDLQDPNEE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 139 IRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSLDPDQK--EHLIEVIEKLLKDKSTLVAGSVV 216
Cdd:COG5096 108 IRGFALRTLSLLRVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYRLDKDLYheLGLIDILKELVADSDPIVIANAL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 217 MAFEEVCPDRI-DLIHKNYRKLCNLLV----DVEEWGQVVIIHMLTRYartqfispwredAIFDENSEKTFydseEERrv 291
Cdd:COG5096 188 ASLAEIDPELAhGYSLEVILRIPQLDLlslsVSTEWLLLIILEVLTER------------VPTTPDSAEDF----EER-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 292 dqSKPYIMDPDHRLLLRNTKPLLqsRNTaVVMAVCQLYWHLAPKheisiitksLVRLL-RSHREVQYVVLQNIATMSIQR 370
Cdd:COG5096 250 --LSPPLQHNNAEVLLIAVKVIL--RLL-VFLPSNNLFLISSPP---------LVTLLaKPESLIQYVLRRNIQIDLEVC 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 371 KGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKSQDKA--FAAATIQAIGRCATNISEVTDTC 448
Cdd:COG5096 316 SKLLDKVKKLFLIEYNDDIYIKLEKLDQLTRLADDQNLSQILLELIYYIAENHIDaeMVSEAIKALGDLASKAESSVNDC 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 449 LNGLVLLLSN---RDETVVAE------------SVVVIKKLLQTQPSQHSDIIKHMAKLFDNITVP------MARASILW 507
Cdd:COG5096 396 ISELLELLEGvwiRGSYIVQEvrivdcisviriSVLVLRILPNEYPKILLRGLYALEETLELQSREpraksvTDKYLGAW 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 508 LMGEYCEHVPKIAPDVLRKMAKSFTSEEDIVKLQTVNLAAKLYLTN-SKQTKLLTQYILNLGKYDQNY----DIRDRTRF 582
Cdd:COG5096 476 LLGEFSDIIPRLEPELLRIAISNFVDETLEVQYTILMSSVKLIANSiRKAKQCNSELDQDVLRRCFDYvlvpDLRDRARM 555
|
570 580
....*....|....*....|....*..
gi 1207160806 583 IRQLIvpnekSGALSKYARRILMAPKP 609
Cdd:COG5096 556 YSRLL-----STPLPEFSDPILCEAKK 577
|
|
| AP3B1_C |
pfam14796 |
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of ... |
831-974 |
2.00e-57 |
|
Clathrin-adaptor complex-3 beta-1 subunit C-terminal; This domain lies at the C-terminus of the clathrin-adaptor protein complex-3 beta-1 subunit. The AP-3 complex is associated with the Golgi region of the cell as well as with more peripheral structures. The AP-3 complex may be directly involved in trafficking to lysosomes or alternatively it may be involved in another pathway, but that mis-sorting in that pathway may indirectly lead to defects in pigment granules.
Pssm-ID: 464319 Cd Length: 148 Bit Score: 194.79 E-value: 2.00e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 831 EKKEVSLLDLDDFAPT-PVTTPKSSILSP-SLLSDLQGLSISPTS-ALQASSPVFVPETSYELLHRMTGKGLSGQYRFTR 907
Cdd:pfam14796 1 KSNEDLLLDLDDFSPSsPVMTPSLGGFLSpSLATDLEGLSLTDSSsAIEVVSPSFVPTKTHELLHRMTGEGLSVEYRFTR 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207160806 908 QPCIYDSSMVSLQLTLSNSSEQPLENIHISQKSS-SAQNIHCFNAVERLEPQASVTVSIGVNFNDSTQ 974
Cdd:pfam14796 81 QPCIYSPKMVSVELTFTNTSDSEITNIHIGEKKLpAGMRIHEFAEIESLEPGASATVVMGIDFCDSTQ 148
|
|
| PTZ00429 |
PTZ00429 |
beta-adaptin; Provisional |
54-579 |
9.25e-52 |
|
beta-adaptin; Provisional
Pssm-ID: 240415 [Multi-domain] Cd Length: 746 Bit Score: 195.54 E-value: 9.25e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 54 DLKEMLESNKESLKLEAMKRVVGLIANGKNASELFPAVVKNVASKNIELKKLVYVYLVRYAEEQQDLALLSISTFQRALK 133
Cdd:PTZ00429 36 ELQNDLNGTDSYRKKAAVKRIIANMTMGRDVSYLFVDVVKLAPSTDLELKKLVYLYVLSTARLQPEKALLAVNTFLQDTT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 134 DPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYS------LDPDQKEHLIevieKLLKDK 207
Cdd:PTZ00429 116 NSSPVVRALAVRTMMCIRVSSVLEYTLEPLRRAVADPDPYVRKTAAMGLGKLFHddmqlfYQQDFKKDLV----ELLNDN 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 208 STLV---AGSVVMAFEEVCPDRIDLIHKNYRKLCNLLVDVEEWGQVVIIHMLTRyARTQfispwreDAIFDENsektfyd 284
Cdd:PTZ00429 192 NPVVasnAAAIVCEVNDYGSEKIESSNEWVNRLVYHLPECNEWGQLYILELLAA-QRPS-------DKESAET------- 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 285 seeerrvdqskpyimdpdhrlLLRNTKPLLQSRNTAVVMAVCQLYWHLAPKHEISIITK-------SLVRLLRSHREVQY 357
Cdd:PTZ00429 257 ---------------------LLTRVLPRMSHQNPAVVMGAIKVVANLASRCSQELIERctvrvntALLTLSRRDAETQY 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 358 VVLQNIATMSIQRKGMFEPFMKSFYVRSTDATHIKTLKLEILTNLANEANISTILREFQTYVKSQDKAFAAATIQAIGRC 437
Cdd:PTZ00429 316 IVCKNIHALLVIFPNLLRTNLDSFYVRYSDPPFVKLEKLRLLLKLVTPSVAPEILKELAEYASGVDMVFVVEVVRAIASL 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 438 ATNISEVTDTCLNGLVLLLSNRDEtVVAESVVVIKKLLQTQPSQ---HSDIIKHMAklfDNITVPMARASILWLMGEYCE 514
Cdd:PTZ00429 396 AIKVDSVAPDCANLLLQIVDRRPE-LLPQVVTAAKDIVRKYPELlmlDTLVTDYGA---DEVVEEEAKVSLLWMLGEYCD 471
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207160806 515 HVPKiAPDVLRKMAKSFTSEEDIVKLQTVNLAAKLYLTNSKQTKLLTQYILN-LGKYDQNYDIRDR 579
Cdd:PTZ00429 472 FIEN-GKDIIQRFIDTIMEHEQRVQLAILSAAVKMFLRDPQGMEPQLNRVLEtVTTHSDDPDVRDR 536
|
|
| Cnd1 |
pfam12717 |
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ... |
138-259 |
3.69e-18 |
|
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.
Pssm-ID: 463677 [Multi-domain] Cd Length: 162 Bit Score: 82.89 E-value: 3.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 138 LIRASALRVLSSIRVPIIVPIMMLAIKEAATDLSPYVRKTAAHAIQKLYSLDPDQKEHLIEVIEKLLKDKSTLVAGSVVM 217
Cdd:pfam12717 1 LIRALAIRTMGCIRFPNLVEYLTEPLYRRLKDEDPYVRKTAAMCVAKLILPDMVKVKGFISELAKLLEDPNPMVVANALA 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1207160806 218 AFEEVCPDRIDLI----HKNYRKLCNLLVDVEEWGQVVIIHMLTRY 259
Cdd:pfam12717 81 ALTEISEKDPNAIynllPDIISKLSDALNECSEWGQIYILDFLASY 126
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
124-218 |
7.26e-09 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 55.41 E-value: 7.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 124 SISTFQRALKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAATDLSPYVRKTAAHAIQKLYslDPDQKEHLIEviekL 203
Cdd:COG1413 48 AVPALLEALKDPDPEVRAAAAEALGRIGDPEAVP----ALIAALKDEDPEVRRAAAEALGRLG--DPAAVPALLE----A 117
|
90
....*....|....*
gi 1207160806 204 LKDKSTLVAGSVVMA 218
Cdd:COG1413 118 LKDPDWEVRRAAARA 132
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
124-222 |
7.07e-08 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 52.32 E-value: 7.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 124 SISTFQRALKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAATDLSPYVRKTAAHAIQKLYSldpdqkEHLIEVIEKL 203
Cdd:COG1413 17 AVPALIAALADEDPDVRAAAARALGRLGDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGD------PEAVPALIAA 86
|
90
....*....|....*....
gi 1207160806 204 LKDKSTLVAGSVVMAFEEV 222
Cdd:COG1413 87 LKDEDPEVRRAAAEALGRL 105
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
53-185 |
2.69e-06 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 48.09 E-value: 2.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 53 EDLKEMLESNKESLKLEAMkRVVGLIANgknaSELFPAVVKNVASKNIELKKLVYVYLVRYAEEQqdlallSISTFQRAL 132
Cdd:COG1413 19 PALIAALADEDPDVRAAAA-RALGRLGD----PRAVPALLEALKDPDPEVRAAAAEALGRIGDPE------AVPALIAAL 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1207160806 133 KDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAATDLSPYVRKTAAHAIQKL 185
Cdd:COG1413 88 KDEDPEVRRAAAEALGRLGDPAAVP----ALLEALKDPDWEVRRAAARALGRL 136
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
129-218 |
6.22e-06 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 45.41 E-value: 6.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 129 QRALKDPNQLIRASALRVLSSIRVPIIVPimmlAIKEAATDLSPYVRKTAAHAIQKLYslDPDQKEHLIEViekLLKDKS 208
Cdd:pfam13646 6 QALLRDPDPEVRAAAIRALGRIGDPEAVP----ALLELLKDEDPAVRRAAAEALGKIG--DPEALPALLEL---LRDDDD 76
|
90
....*....|
gi 1207160806 209 TLVAGSVVMA 218
Cdd:pfam13646 77 DVVRAAAAEA 86
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
139-218 |
3.40e-04 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 41.92 E-value: 3.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 139 IRASALRVLSSIRVPIIVPimmlAIKEAATDLSPYVRKTAAHAIQKLYslDPDQKEHLIEviekLLKDKSTLVAGSVVMA 218
Cdd:COG1413 1 VRRAAARALGRLGDPAAVP----ALIAALADEDPDVRAAAARALGRLG--DPRAVPALLE----ALKDPDPEVRAAAAEA 70
|
|
| SCC2 |
cd23958 |
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid ... |
120-246 |
1.16e-03 |
|
Sister chromatid cohesion protein 2 and homologs; This family includes Sister chromatid cohesion protein 2 (Scc2) and its homolog (Scc2 homolog, also called Nipped-B-like protein or NIPBL). Scc2/NIPBL and Scc4 form a complex that is responsible for loading the cohesin protein onto sister chromatids during mitosis and meiosis. Cohesin is a ring-shaped protein complex that encircles the sister chromatids and helps to hold them together until they are ready to be separated during cell division. In addition to its role in chromosome segregation, cohesin also plays important roles in other cellular processes such as transcription, chromosome condensation, and DNA repair.
Pssm-ID: 467937 [Multi-domain] Cd Length: 1197 Bit Score: 43.05 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 120 LALLSISTFQR-----------ALKDPNQLIRASALRVLSSI--RVPII--VPIMMLAIKEAATDLSPYVRKTAAHAIQK 184
Cdd:cd23958 454 RALASQRPLSQsfdpilkqllsSLDEPAVTLRTKALKALSLVveADPSIlgDPDVQRAVEGRLLDSSASVREAAVELVGK 533
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207160806 185 LYSLDPDQKEHLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKNY--RKLCNLLVDVEE 246
Cdd:cd23958 534 YISSRPDLAEQYYEMIAERILDTGVSVRKRVIKILRDIYLRTPDFEIKVDicVRLLRRINDEEE 597
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
124-183 |
2.94e-03 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 38.09 E-value: 2.94e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207160806 124 SISTFQRALKDPNQLIRASALRVLSSIRVPIIVPIMMlaiKEAATDLSPYVRKTAAHAIQ 183
Cdd:pfam13646 32 AVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALL---ELLRDDDDDVVRAAAAEALA 88
|
|
| |
