nucleoporin p54 isoform X6 [Danio rerio]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Nup54 | pfam13874 | Nucleoporin complex subunit 54; This is the human Nup54 subunit of the nucleoporin complex, ... |
340-477 | 4.06e-62 | |||
Nucleoporin complex subunit 54; This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel. The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them. : Pssm-ID: 464011 [Multi-domain] Cd Length: 139 Bit Score: 200.50 E-value: 4.06e-62
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Nup54_C | pfam18437 | Nup54 C-terminal interacting domain; The mammalian nuclear pore complex (NPC) conducts ... |
493-531 | 1.51e-13 | |||
Nup54 C-terminal interacting domain; The mammalian nuclear pore complex (NPC) conducts nucleocytoplasmic transport and contains multiple copies of nucleoporins (nups). This is the C-terminal interacting domain found on Nup54. Nup45 is a splice variant of Nup58 with an identical alpha-helical region. Nup54 along with Nup62 and Nup58 are essential for nuclear transport. The C-terminal part of the alpha-helical region of Nup54 interacts with a C-terminal part of the alpha-helical region of Nup58. Interestingly, this region appears in two distinct conformations: a single helix and a helix-loop-helix, termed 'straight' and 'bent'. Whereas the straight conformer consists of a 34 residues long alpha helix (residues 460-493), the bent conformer is composed of two alpha helices, each 13 residues long, connected by a central loop (N helix, residues 460-472; C helix, residues 477-489). : Pssm-ID: 465767 Cd Length: 39 Bit Score: 64.75 E-value: 1.51e-13
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Nucleoporin_FG2 super family | cl37900 | Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
3-121 | 8.47e-04 | |||
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif. The actual alignment was detected with superfamily member pfam15967: Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 41.96 E-value: 8.47e-04
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Name | Accession | Description | Interval | E-value | |||
Nup54 | pfam13874 | Nucleoporin complex subunit 54; This is the human Nup54 subunit of the nucleoporin complex, ... |
340-477 | 4.06e-62 | |||
Nucleoporin complex subunit 54; This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel. The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them. Pssm-ID: 464011 [Multi-domain] Cd Length: 139 Bit Score: 200.50 E-value: 4.06e-62
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Nup54_C | pfam18437 | Nup54 C-terminal interacting domain; The mammalian nuclear pore complex (NPC) conducts ... |
493-531 | 1.51e-13 | |||
Nup54 C-terminal interacting domain; The mammalian nuclear pore complex (NPC) conducts nucleocytoplasmic transport and contains multiple copies of nucleoporins (nups). This is the C-terminal interacting domain found on Nup54. Nup45 is a splice variant of Nup58 with an identical alpha-helical region. Nup54 along with Nup62 and Nup58 are essential for nuclear transport. The C-terminal part of the alpha-helical region of Nup54 interacts with a C-terminal part of the alpha-helical region of Nup58. Interestingly, this region appears in two distinct conformations: a single helix and a helix-loop-helix, termed 'straight' and 'bent'. Whereas the straight conformer consists of a 34 residues long alpha helix (residues 460-493), the bent conformer is composed of two alpha helices, each 13 residues long, connected by a central loop (N helix, residues 460-472; C helix, residues 477-489). Pssm-ID: 465767 Cd Length: 39 Bit Score: 64.75 E-value: 1.51e-13
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YhaN | COG4717 | Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
371-517 | 7.53e-04 | |||
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.45 E-value: 7.53e-04
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Nucleoporin_FG2 | pfam15967 | Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
3-121 | 8.47e-04 | |||
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif. Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 41.96 E-value: 8.47e-04
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Name | Accession | Description | Interval | E-value | |||
Nup54 | pfam13874 | Nucleoporin complex subunit 54; This is the human Nup54 subunit of the nucleoporin complex, ... |
340-477 | 4.06e-62 | |||
Nucleoporin complex subunit 54; This is the human Nup54 subunit of the nucleoporin complex, equivalent to Nup57 of yeast. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucleoporins of the central channel, and as such they would form a zone of equal affinity spanning the central channel. The diffusion of importin-beta import complexes through the central channel may be a stochastic process as the affinities are similar, whereas movement from cytoplasmic fibrils to the central channel and from the central channel to the nuclear basket would be facilitated by the subtle differences in affinity between them. Pssm-ID: 464011 [Multi-domain] Cd Length: 139 Bit Score: 200.50 E-value: 4.06e-62
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Nup54_C | pfam18437 | Nup54 C-terminal interacting domain; The mammalian nuclear pore complex (NPC) conducts ... |
493-531 | 1.51e-13 | |||
Nup54 C-terminal interacting domain; The mammalian nuclear pore complex (NPC) conducts nucleocytoplasmic transport and contains multiple copies of nucleoporins (nups). This is the C-terminal interacting domain found on Nup54. Nup45 is a splice variant of Nup58 with an identical alpha-helical region. Nup54 along with Nup62 and Nup58 are essential for nuclear transport. The C-terminal part of the alpha-helical region of Nup54 interacts with a C-terminal part of the alpha-helical region of Nup58. Interestingly, this region appears in two distinct conformations: a single helix and a helix-loop-helix, termed 'straight' and 'bent'. Whereas the straight conformer consists of a 34 residues long alpha helix (residues 460-493), the bent conformer is composed of two alpha helices, each 13 residues long, connected by a central loop (N helix, residues 460-472; C helix, residues 477-489). Pssm-ID: 465767 Cd Length: 39 Bit Score: 64.75 E-value: 1.51e-13
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YhaN | COG4717 | Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
371-517 | 7.53e-04 | |||
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 42.45 E-value: 7.53e-04
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Nucleoporin_FG2 | pfam15967 | Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of ... |
3-121 | 8.47e-04 | |||
Nucleoporin FG repeated region; Nucleoporin_FG2, or nucleoporin p58/p45, is a family of chordate nucleoporins. The proteins carry many repeats of the FG sequence motif. Pssm-ID: 435043 [Multi-domain] Cd Length: 586 Bit Score: 41.96 E-value: 8.47e-04
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Blast search parameters | ||||
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