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Conserved domains on  [gi|1205933718|ref|XP_021308961|]
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F-box/kelch-repeat protein At1g30090 [Sorghum bicolor]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 19211583)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|10581972|31442578|24959344
SCOP:  4001927|3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
135-363 1.79e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.16  E-value: 1.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 135 TWHAIPAMPCrdracPRGFGCVATPGGDgadgaLLVCGGLvsDMDCPLHLVLKYDIYKNRWTVMTRM-LTARSFFAGGVI 213
Cdd:COG3055     2 TWSSLPDLPT-----PRSEAAAALLDGK-----VYVAGGL--SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 214 DGRVYVAGGYSADQ---FELNSAEVLDPEKGVWQPIASMGMNMASSDSAVIGGRLYVTEGCAWPFFSSpRGQVYDPKIDR 290
Cdd:COG3055    70 DGKLYVFGGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA-WVEVYDPATGT 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1205933718 291 WEV---MPvGMREGWTGlSVVIEGRLFVISEYErmkvkvYDAEADSWDsvSGPPMPERIMKPFSVScLDSKIVVVG 363
Cdd:COG3055   149 WTQlapLP-TPRDHLAA-AVLPDGKILVIGGRN------GSGFSNTWT--TLAPLPTARAGHAAAV-LGGKILVFG 213
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 57-92 5.36e-11

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 57.19  E-value: 5.36e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1205933718  57 LIPGLPDDAALNCLLRLPVSAHDACRLVCRRWRVLL 92
Cdd:cd22152     1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLL 36
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
135-363 1.79e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.16  E-value: 1.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 135 TWHAIPAMPCrdracPRGFGCVATPGGDgadgaLLVCGGLvsDMDCPLHLVLKYDIYKNRWTVMTRM-LTARSFFAGGVI 213
Cdd:COG3055     2 TWSSLPDLPT-----PRSEAAAALLDGK-----VYVAGGL--SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 214 DGRVYVAGGYSADQ---FELNSAEVLDPEKGVWQPIASMGMNMASSDSAVIGGRLYVTEGCAWPFFSSpRGQVYDPKIDR 290
Cdd:COG3055    70 DGKLYVFGGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA-WVEVYDPATGT 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1205933718 291 WEV---MPvGMREGWTGlSVVIEGRLFVISEYErmkvkvYDAEADSWDsvSGPPMPERIMKPFSVScLDSKIVVVG 363
Cdd:COG3055   149 WTQlapLP-TPRDHLAA-AVLPDGKILVIGGRN------GSGFSNTWT--TLAPLPTARAGHAAAV-LGGKILVFG 213
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 57-92 5.36e-11

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 57.19  E-value: 5.36e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1205933718  57 LIPGLPDDAALNCLLRLPVSAHDACRLVCRRWRVLL 92
Cdd:cd22152     1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLL 36
PHA03098 PHA03098
kelch-like protein; Provisional
 172-363 1.09e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 63.25  E-value: 1.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 172 GGLVSDMDCpLHLVLKYDIYKNRWTVMTRMLTARSFFAGGVIDGRVYVAGGYSADqFELNSAEVLDPEKGVWQPIASMGM 251
Cdd:PHA03098  301 GGMNKNNLS-VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGESKWREEPPLIF 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 252 NMASSDSAVIGGRLYVTEGCAWPFFSSPRGQVYDPKIDRW---EVMPVGMREGWT----GLSVVIEGrLFVISEYERMK- 323
Cdd:PHA03098  379 PRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWskgSPLPISHYGGCAiyhdGKIYVIGG-ISYIDNIKVYNi 457

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1205933718 324 VKVYDAEADSWDSVSGPPMPERIMkpfSVSCLDSKIVVVG 363
Cdd:PHA03098  458 VESYNPVTNKWTELSSLNFPRINA---SLCIFNNKIYVVG 494
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 204-250 7.12e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.16  E-value: 7.12e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1205933718 204 ARSFFAGGVIDGRVYVAGGYSADQFeLNSAEVLDPEKGVWQPIASMG 250
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQS-LNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
216-263 2.77e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 2.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1205933718  216 RVYVAGGYSADQFeLNSAEVLDPEKGVWQPIASMGMNMASSDSAVIGG 263
Cdd:smart00612   1 KIYVVGGFDGGQR-LKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 58-99 7.34e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 7.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1205933718  58 IPGLPDDAALNCLLRLPVSAHDACRLVCRRWRVLLADKARFF 99
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
61-99 5.34e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.42  E-value: 5.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1205933718   61 LPDDAALNCLLRLPVSAHDACRLVCRRWRVLLADKARFF 99
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
135-363 1.79e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 107.16  E-value: 1.79e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 135 TWHAIPAMPCrdracPRGFGCVATPGGDgadgaLLVCGGLvsDMDCPLHLVLKYDIYKNRWTVMTRM-LTARSFFAGGVI 213
Cdd:COG3055     2 TWSSLPDLPT-----PRSEAAAALLDGK-----VYVAGGL--SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQ 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 214 DGRVYVAGGYSADQ---FELNSAEVLDPEKGVWQPIASMGMNMASSDSAVIGGRLYVTEGCAWPFFSSpRGQVYDPKIDR 290
Cdd:COG3055    70 DGKLYVFGGFTGANpssTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVA-WVEVYDPATGT 148

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1205933718 291 WEV---MPvGMREGWTGlSVVIEGRLFVISEYErmkvkvYDAEADSWDsvSGPPMPERIMKPFSVScLDSKIVVVG 363
Cdd:COG3055   149 WTQlapLP-TPRDHLAA-AVLPDGKILVIGGRN------GSGFSNTWT--TLAPLPTARAGHAAAV-LGGKILVFG 213
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
195-389 1.34e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 104.85  E-value: 1.34e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 195 WTVMTRMLTARSFFAGGVIDGRVYVAGGYSADQfELNSAEVLDPEKGVWQPIASM-GMNMASSDSAVIGGRLYVT---EG 270
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGS-ASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFggfTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 271 CAWPFFSSPRGQVYDPKIDRWEVMPVGMREGWTGLSVVIEGRLFVISEYERMK----VKVYDAEADSWDSVsgPPMPERI 346
Cdd:COG3055    82 ANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGnvawVEVYDPATGTWTQL--APLPTPR 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1205933718 347 MKPFSVSCLDSKIVVVGrGLHVAIGHVQKEPAGDPDSRSSGYS 389
Cdd:COG3055   160 DHLAAAVLPDGKILVIG-GRNGSGFSNTWTTLAPLPTARAGHA 201
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
128-363 4.25e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.62  E-value: 4.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 128 VLDLGHLTWHAIPAMPcrdrACPRGFGCVATPGGDgadgaLLVCGG--LVSDMDCPLHLVLKYDIYKNRWTVMTRMLTAR 205
Cdd:COG3055    42 VYDPATNTWSELAPLP----GPPRHHAAAVAQDGK-----LYVFGGftGANPSSTPLNDVYVYDPATNTWTKLAPMPTPR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 206 SFFAGGVIDGRVYVAGGYSaDQFELNSAEVLDPEKGVWQPIASM-GMNMASSDSAVIGGRLYVTEgcawpffssprGQVY 284
Cdd:COG3055   113 GGATALLLDGKIYVVGGWD-DGGNVAWVEVYDPATGTWTQLAPLpTPRDHLAAAVLPDGKILVIG-----------GRNG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 285 DPKIDRWEVMPVGMREGWTGLSVVIEGRLFVI--SEYERMKVKVYDAEADSWDSVsgPPMPERIMKPFSVScLDSKIVVV 362
Cdd:COG3055   181 SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFggESGFSDEVEAYDPATNTWTAL--GELPTPRHGHAAVL-TDGKVYVI 257


                  .
gi 1205933718 363 G 363
Cdd:COG3055   258 G 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
135-295 1.57e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 73.27  E-value: 1.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 135 TWHAIPAMPCrdracPRGFGCVATPggdgaDGALLVCGGlvSDMDCPLHLVLKYDIYKNRWTVMTRMLTARSFFAGGVI- 213
Cdd:COG3055   101 TWTKLAPMPT-----PRGGATALLL-----DGKIYVVGG--WDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLp 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 214 DGRVYVAGGYSADQFE----------------------------------LNSAEVLDPEKGVWQPIASMGMNMASSDSA 259
Cdd:COG3055   169 DGKILVIGGRNGSGFSntwttlaplptaraghaaavlggkilvfggesgfSDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1205933718 260 VIGGRLYVTEGcawpffsSPRGQVYDPKIDRWEVMP 295
Cdd:COG3055   249 LTDGKVYVIGG-------ETKPGVRTPLVTSAEVYD 277
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 57-92 5.36e-11

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 57.19  E-value: 5.36e-11
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1205933718  57 LIPGLPDDAALNCLLRLPVSAHDACRLVCRRWRVLL 92
Cdd:cd22152     1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLL 36
PHA03098 PHA03098
kelch-like protein; Provisional
 172-363 1.09e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 63.25  E-value: 1.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 172 GGLVSDMDCpLHLVLKYDIYKNRWTVMTRMLTARSFFAGGVIDGRVYVAGGYSADqFELNSAEVLDPEKGVWQPIASMGM 251
Cdd:PHA03098  301 GGMNKNNLS-VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGESKWREEPPLIF 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 252 NMASSDSAVIGGRLYVTEGCAWPFFSSPRGQVYDPKIDRW---EVMPVGMREGWT----GLSVVIEGrLFVISEYERMK- 323
Cdd:PHA03098  379 PRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWskgSPLPISHYGGCAiyhdGKIYVIGG-ISYIDNIKVYNi 457

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1205933718 324 VKVYDAEADSWDSVSGPPMPERIMkpfSVSCLDSKIVVVG 363
Cdd:PHA03098  458 VESYNPVTNKWTELSSLNFPRINA---SLCIFNNKIYVVG 494
PHA03098 PHA03098
kelch-like protein; Provisional
 159-341 5.73e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 60.94  E-value: 5.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 159 PGGDGADGALLVCGGLvsDMDCPLHLVLKYDIYKNRWTVMTRMLTARSFFAGGVIDGRVYVAGGYSADQFELNSAEVLDP 238
Cdd:PHA03098  336 PGVTVFNNRIYVIGGI--YNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSL 413

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 239 EKGVWQPIASMGMNMASSDSAVIGGRLYVTEGCAwpFFSSPRG----QVYDPKIDRWEVMPVGMREGWTGLSVVIEGRLF 314
Cdd:PHA03098  414 NTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGIS--YIDNIKVynivESYNPVTNKWTELSSLNFPRINASLCIFNNKIY 491

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1205933718 315 VI----SEYERMKVKVYDAEADSWDSVSGPP 341
Cdd:PHA03098  492 VVggdkYEYYINEIEVYDDKTNTWTLFCKFP 522
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 204-250 7.12e-10

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 54.16  E-value: 7.12e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1205933718 204 ARSFFAGGVIDGRVYVAGGYSADQFeLNSAEVLDPEKGVWQPIASMG 250
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQS-LNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
216-263 2.77e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.48  E-value: 2.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1205933718  216 RVYVAGGYSADQFeLNSAEVLDPEKGVWQPIASMGMNMASSDSAVIGG 263
Cdd:smart00612   1 KIYVVGGFDGGQR-LKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
132-237 9.91e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 52.85  E-value: 9.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 132 GHLTWHAIPAMPCrdracPRGFGCVATPggdgaDGALLVCGGLVSdmdcPLHLVLKYDIYKNRWTVMTRMLTARSFFAGG 211
Cdd:COG3055   183 FSNTWTTLAPLPT-----ARAGHAAAVL-----GGKILVFGGESG----FSDEVEAYDPATNTWTALGELPTPRHGHAAV 248

                          90       100
                  ....*....|....*....|....*....
gi 1205933718 212 VIDGRVYVAGGYSADQF---ELNSAEVLD 237
Cdd:COG3055   249 LTDGKVYVIGGETKPGVrtpLVTSAEVYD 277
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 58-99 7.34e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.83  E-value: 7.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1205933718  58 IPGLPDDAALNCLLRLPVSAHDACRLVCRRWRVLLADKARFF 99
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
Kelch_6 pfam13964
Kelch motif;
212-249 9.34e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.63  E-value: 9.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1205933718 212 VIDGRVYVAGGYSADQFELNSAEVLDPEKGVWQPIASM 249
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPL 46
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 59-95 1.59e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 38.60  E-value: 1.59e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1205933718  59 PGLPDDAALNCLLRLPVSAHDACRLVCRRWRVLLADK 95
Cdd:cd22157     1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSP 37
Kelch_4 pfam13418
Galactose oxidase, central domain;
204-249 2.02e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 2.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1205933718 204 ARSFFAGGVI-DGRVYVAGGYSADQFELNSAEVLDPEKGVWQPIASM 249
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
FBOX smart00256
A Receptor for Ubiquitination Targets;
61-99 5.34e-04

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 37.42  E-value: 5.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1205933718   61 LPDDAALNCLLRLPVSAHDACRLVCRRWRVLLADKARFF 99
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
PRK14131 PRK14131
N-acetylneuraminate epimerase;
126-317 6.85e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 6.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 126 WKVLDLG--HLTWHAIPAMPCRDRAcprgfGCVATpggdGADGALLVCGGL-VSDMDCPLHL---VLKYDIYKNRWT-VM 198
Cdd:PRK14131   52 WYKLDLNapSKGWTKIAAFPGGPRE-----QAVAA----FIDGKLYVFGGIgKTNSEGSPQVfddVYKYDPKTNSWQkLD 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 199 TRmlTARSfFAGGVI----DGRVYVAGGYSADQF-----ELNSAevlDPEKGVWQPIASMGMNMASSDsaviggrlyvte 269
Cdd:PRK14131  123 TR--SPVG-LAGHVAvslhNGKAYITGGVNKNIFdgyfeDLAAA---GKDKTPKDKINDAYFDKKPED------------ 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1205933718 270 gcawpFFSSPRGQVYDPKIDRWEVMPVGMREGWTGLSVVIEG-RLFVIS 317
Cdd:PRK14131  185 -----YFFNKEVLSYDPSTNQWKNAGESPFLGTAGSAVVIKGnKLWLIN 228
PRK14131 PRK14131
N-acetylneuraminate epimerase;
209-298 6.98e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 6.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205933718 209 AGGVIDGRVYVAGGySADqfelNSAEVLD---PEKGvWQPIASM-GMNMASSDSAVIGGRLYVTEGCA-WPFFSSPRGQ- 282
Cdd:PRK14131   33 TGAIDNNTVYVGLG-SAG----TSWYKLDlnaPSKG-WTKIAAFpGGPREQAVAAFIDGKLYVFGGIGkTNSEGSPQVFd 106

                          90       100
                  ....*....|....*....|...
gi 1205933718 283 ---VYDPKIDRWEVM----PVGM 298
Cdd:PRK14131  107 dvyKYDPKTNSWQKLdtrsPVGL 129
Kelch smart00612
Kelch domain;
168-215 1.20e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.38  E-value: 1.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1205933718  168 LLVCGGLVSDMdcPLHLVLKYDIYKNRWTVMTRMLTARSFFAGGVIDG 215
Cdd:smart00612   2 IYVVGGFDGGQ--RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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