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Conserved domains on  [gi|1190980679|ref|XP_020885683|]
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molybdopterin synthase catalytic subunit [Arabidopsis lyrata subsp. lyrata]

Protein Classification

molybdopterin synthase catalytic subunit( domain architecture ID 10791341)

molybdopterin synthase catalytic subunit is the catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin

CATH:  3.90.1170.40
EC:  2.8.1.12
Gene Ontology:  GO:0006777|GO:0030366|GO:1990140
PubMed:  35744859
SCOP:  4001136

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 29-139 7.67e-75

molybdopterin synthase catalytic subunit


:

Pssm-ID: 178014  Cd Length: 111  Bit Score: 220.33  E-value: 7.67e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  29 APQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSSVHR 108
Cdd:PLN02390    1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1190980679 109 ADGLDACKFLIDELKASVPIWKKEVYTNGEI 139
Cdd:PLN02390   81 ADALDACKFLIDELKASVPIWKKEVYDDGEV 111
 
Name Accession Description Interval E-value
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 29-139 7.67e-75

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 220.33  E-value: 7.67e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  29 APQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSSVHR 108
Cdd:PLN02390    1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1190980679 109 ADGLDACKFLIDELKASVPIWKKEVYTNGEI 139
Cdd:PLN02390   81 ADALDACKFLIDELKASVPIWKKEVYDDGEV 111
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 19-141 1.11e-53

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 167.31  E-value: 1.11e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  19 DVVKYIDYVSAPQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETS 98
Cdd:cd00756     2 DLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1190980679  99 VFIAVSSVHRADGLDACKFLIDELKASVPIWKKEVYTNGEIWK 141
Cdd:cd00756    82 VLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 26-142 2.16e-51

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 162.27  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  26 YVSAPQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSS 105
Cdd:COG0314    21 RASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVGRLEPGEPIVLVAVSS 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1190980679 106 VHRADGLDACKFLIDELKASVPIWKKEVYTNGEIWKE 142
Cdd:COG0314   101 AHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVE 137
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 19-124 3.27e-48

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 152.99  E-value: 3.27e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  19 DVVKYIDYVSAPQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETS 98
Cdd:pfam02391   7 DVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLPVGEAI 86

                          90       100
                  ....*....|....*....|....*.
gi 1190980679  99 VFIAVSSVHRADGLDACKFLIDELKA 124
Cdd:pfam02391  87 VLVAVSSPHRAEAFEACEYLIDELKA 112
 
Name Accession Description Interval E-value
PLN02390 PLN02390
molybdopterin synthase catalytic subunit
 29-139 7.67e-75

molybdopterin synthase catalytic subunit


Pssm-ID: 178014  Cd Length: 111  Bit Score: 220.33  E-value: 7.67e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  29 APQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSSVHR 108
Cdd:PLN02390    1 DPQAGAIATFSGTTRDTFEGKTVLELRYEAYVPMALRELRKICDEARSRWSLHKIAVAHRLGPVPVGETSVFVAVSSVHR 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1190980679 109 ADGLDACKFLIDELKASVPIWKKEVYTNGEI 139
Cdd:PLN02390   81 ADALDACKFLIDELKASVPIWKKEVYDDGEV 111
MoaE cd00756
MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor ...
 19-141 1.11e-53

MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. Moco contains a tricyclic pyranopterin, termed molybdopterin (MPT), which carries the cis-dithiolene group responsible for molybdenum ligation. This dithiolene group is generated by MPT synthase in the second major step in Moco biosynthesis. MPT synthase is a heterotetramer consisting of two large (MoaE) and two small (MoaD) subunits.


Pssm-ID: 238385 [Multi-domain]  Cd Length: 124  Bit Score: 167.31  E-value: 1.11e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  19 DVVKYIDYVSAPQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETS 98
Cdd:cd00756     2 DLAELLAALRDPEAGAVVTFVGTVRDHDEGKGVEALEYEAYPPMAEKELEEIAEEARERWGLLRVAIIHRVGRLPPGEAI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1190980679  99 VFIAVSSVHRADGLDACKFLIDELKASVPIWKKEVYTNGEIWK 141
Cdd:cd00756    82 VLVAVSSPHRKEAFEACEFLIDRLKHRAPIWKKEIFEGGEEWV 124
MoaE COG0314
Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; ...
 26-142 2.16e-51

Molybdopterin synthase catalytic subunit MoaE [Coenzyme transport and metabolism]; Molybdopterin synthase catalytic subunit MoaE is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440083 [Multi-domain]  Cd Length: 143  Bit Score: 162.27  E-value: 2.16e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  26 YVSAPQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSS 105
Cdd:COG0314    21 RASDPEAGAVVTFVGTVRDHNDGRRVTALEYEAYPPMAEKELAEIAEEAAERWGLLDVAVIHRVGRLEPGEPIVLVAVSS 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1190980679 106 VHRADGLDACKFLIDELKASVPIWKKEVYTNGEIWKE 142
Cdd:COG0314   101 AHRKEAFEACRFLIDRLKTRAPIWKKEIFEDGEEWVE 137
MoaE pfam02391
MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of ...
 19-124 3.27e-48

MoaE protein; This family contains the MoaE protein that is involved in biosynthesis of molybdopterin. Molybdopterin, the universal component of the pterin molybdenum cofactors, contains a dithiolene group serving to bind Mo. Addition of the dithiolene sulfurs to a molybdopterin precursor requires the activity of the converting factor. Converting factor contains the MoaE and MoaD proteins.


Pssm-ID: 460546  Cd Length: 113  Bit Score: 152.99  E-value: 3.27e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  19 DVVKYIDYVSAPQAGAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETS 98
Cdd:pfam02391   7 DVAEIAALVSDPEAGAVVTFVGTVRDHFDGKKVTALEYEAYPPMAEKELAEIAEEARERWPLLDVAIVHRVGRLPVGEAI 86

                          90       100
                  ....*....|....*....|....*.
gi 1190980679  99 VFIAVSSVHRADGLDACKFLIDELKA 124
Cdd:pfam02391  87 VLVAVSSPHRAEAFEACEYLIDELKA 112
moaE PRK10678
molybdopterin synthase catalytic subunit MoaE;
33-142 4.82e-25

molybdopterin synthase catalytic subunit MoaE;


Pssm-ID: 182642  Cd Length: 150  Bit Score: 95.20  E-value: 4.82e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  33 GAIATFSGTTRDMFEAKTVLELRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSSVHRADGL 112
Cdd:PRK10678   29 GAVVTFTGKVRNHNLGDSVKALTLEHYPGMTEKALAEIVDEARSRWPLGRVTVIHRVGELWPGDEIVFVGVTSAHRSSAF 108

                          90       100       110
                  ....*....|....*....|....*....|
gi 1190980679 113 DACKFLIDELKASVPIWKKEVYTNGEIWKE 142
Cdd:PRK10678  109 EAGQFIMDYLKTRAPFWKREATPEGDRWVE 138
PRK14493 PRK14493
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; ...
 29-140 1.01e-16

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoaE; Provisional


Pssm-ID: 237730 [Multi-domain]  Cd Length: 274  Bit Score: 75.81  E-value: 1.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190980679  29 APQAGAIATFSGTTR---DMFEAKTVLeLRYEAYVPMATRCLSSICTTARSTWDIHKIAVAHRLGPVPVGETSVFIAVSS 105
Cdd:PRK14493  156 ADKAGAIATFTGRVRakeDADDEPTEY-LEFEKYDGVADERMAAIREELKQRDGVFEVLLHHRTGVIEAGEDIVFVVVLA 234

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1190980679 106 VHRADGLDACKFLIDELKASVPIWKKEVYTNGEIW 140
Cdd:PRK14493  235 GHRQEAFRAVSDGIDRLKDEVPIFKKEVTVDEEFW 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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