NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1191012150|ref|XP_020867383|]
View 

traB domain-containing protein isoform X2 [Arabidopsis lyrata subsp. lyrata]

Protein Classification

TraB domain-containing protein( domain architecture ID 12999407)

TraB domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
 51-195 3.54e-31

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


:

Pssm-ID: 350608  Cd Length: 177  Bit Score: 113.44  E-value: 3.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  51 FSSKLSSVADRPFGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWgekfnlvmavtraitsssgisaaelkeqe 130
Cdd:cd14726    73 FQKKIGKELGVKPGAEFRAAIEEAEEVGAPVVLGDRDIQITLKRAWDVLEE----------------------------- 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191012150 131 tdesngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRSKAvnGCKTVVGVIGKGHMNGVIYAL 195
Cdd:cd14726   124 ---------LLSELAEEFPELKEVLIDERDQYLAHSLRRAAA--GGKKVVAVVGAGHVPGIERLL 177
 
Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
 51-195 3.54e-31

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


Pssm-ID: 350608  Cd Length: 177  Bit Score: 113.44  E-value: 3.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  51 FSSKLSSVADRPFGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWgekfnlvmavtraitsssgisaaelkeqe 130
Cdd:cd14726    73 FQKKIGKELGVKPGAEFRAAIEEAEEVGAPVVLGDRDIQITLKRAWDVLEE----------------------------- 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191012150 131 tdesngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRSKAvnGCKTVVGVIGKGHMNGVIYAL 195
Cdd:cd14726   124 ---------LLSELAEEFPELKEVLIDERDQYLAHSLRRAAA--GGKKVVAVVGAGHVPGIERLL 177
COG1916 COG1916
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];
64-208 2.13e-29

Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];


Pssm-ID: 441520  Cd Length: 392  Bit Score: 114.12  E-value: 2.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  64 GDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWGEKFNLVMAVTRAITSSSGISAAE---LKEQETDESngslqL 140
Cdd:COG1916   101 GAEMKAAIEAAEERGAPVALIDRDIQITLKRAWRNMGFWEKLKLLAGLIASLFSREEISEEEiekLKEGDVLEA-----L 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191012150 141 YERLSFSYPSLLLPLIHERDTYLAWSLKRskAVNGCKTVVGVIGKGHMNGVIYALVSDSGDLRFKDLV 208
Cdd:COG1916   176 FEEFAEFSPKLKEVLIDERDAYLAHKLRE--APARGKKVVAVVGAGHLPGIERYLEEPETLPDLAELE 241
TraB_PrgY_gumN pfam01963
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ...
 69-190 7.50e-08

TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.


Pssm-ID: 426534  Cd Length: 262  Bit Score: 51.97  E-value: 7.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  69 AARKASEEVGAQLVLGDRPIEITLQRAWNSLKWGEKFNLVMAVtraITSSSGISAAELKE--QETDESN----------- 135
Cdd:pfam01963 112 LAELAKQKAGLDPDLVDRYLAKTAKRAGKPVGGLETVEEQLAL---LSLPDEEQLEMLEEtlDELEKGEdlletlveawa 188

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191012150 136 ----GSLQLYERLSFSYPSLLLPLIHERDTYLAWSLKrsKAVNGCKTVVGVIGKGHMNG 190
Cdd:pfam01963 189 egdlEALELEAELKEAYPELYEVLLDERNRYWAEKIE--ALLKEGGTVFVAVGAGHLPG 245
 
Name Accession Description Interval E-value
TraB_PrgY-like cd14726
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ...
 51-195 3.54e-31

TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein.


Pssm-ID: 350608  Cd Length: 177  Bit Score: 113.44  E-value: 3.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  51 FSSKLSSVADRPFGDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWgekfnlvmavtraitsssgisaaelkeqe 130
Cdd:cd14726    73 FQKKIGKELGVKPGAEFRAAIEEAEEVGAPVVLGDRDIQITLKRAWDVLEE----------------------------- 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191012150 131 tdesngslqLYERLSFSYPSLLLPLIHERDTYLAWSLKRSKAvnGCKTVVGVIGKGHMNGVIYAL 195
Cdd:cd14726   124 ---------LLSELAEEFPELKEVLIDERDQYLAHSLRRAAA--GGKKVVAVVGAGHVPGIERLL 177
COG1916 COG1916
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];
64-208 2.13e-29

Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown];


Pssm-ID: 441520  Cd Length: 392  Bit Score: 114.12  E-value: 2.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  64 GDEFRAARKASEEVGAQLVLGDRPIEITLQRAWNSLKWGEKFNLVMAVTRAITSSSGISAAE---LKEQETDESngslqL 140
Cdd:COG1916   101 GAEMKAAIEAAEERGAPVALIDRDIQITLKRAWRNMGFWEKLKLLAGLIASLFSREEISEEEiekLKEGDVLEA-----L 175

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191012150 141 YERLSFSYPSLLLPLIHERDTYLAWSLKRskAVNGCKTVVGVIGKGHMNGVIYALVSDSGDLRFKDLV 208
Cdd:COG1916   176 FEEFAEFSPKLKEVLIDERDAYLAHKLRE--APARGKKVVAVVGAGHLPGIERYLEEPETLPDLAELE 241
TraB_PrgY_gumN pfam01963
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ...
 69-190 7.50e-08

TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone.


Pssm-ID: 426534  Cd Length: 262  Bit Score: 51.97  E-value: 7.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191012150  69 AARKASEEVGAQLVLGDRPIEITLQRAWNSLKWGEKFNLVMAVtraITSSSGISAAELKE--QETDESN----------- 135
Cdd:pfam01963 112 LAELAKQKAGLDPDLVDRYLAKTAKRAGKPVGGLETVEEQLAL---LSLPDEEQLEMLEEtlDELEKGEdlletlveawa 188

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191012150 136 ----GSLQLYERLSFSYPSLLLPLIHERDTYLAWSLKrsKAVNGCKTVVGVIGKGHMNG 190
Cdd:pfam01963 189 egdlEALELEAELKEAYPELYEVLLDERNRYWAEKIE--ALLKEGGTVFVAVGAGHLPG 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH