|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
21-520 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 682.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKQCAAADEPEprfggpssstrrspthwllNNETETETDCGWAPFDKNNYQ 100
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPPP-------------------NIVLNNTTWCGWAPFDGKNGT 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 101 QLLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSV 180
Cdd:cd17344 62 ELLGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 181 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVGAMGIVCFLFLIEHPkdikcsstlpt 260
Cdd:cd17344 142 VACVGNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP----------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 261 hprasenginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgalriPGVIEFSLCL 340
Cdd:cd17344 211 ----------------------------------------------------------------------PGVIEFSLCL 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 341 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSK 420
Cdd:cd17344 221 FFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQ 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 421 MGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFY 500
Cdd:cd17344 301 VSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFY 380
|
490 500
....*....|....*....|
gi 1046876552 501 MLMFADACALLFLIRLIHKE 520
Cdd:cd17344 381 MLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
21-517 |
3.83e-100 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 308.09 E-value: 3.83e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 21 RAFIFMLTFLLYASFHLSRKPISIVKgelhkqcaaadepeprfggPSSSTRRSPTHWLLNNETETETDCGWAPF-DKNNY 99
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVK-------------------PSISAEWTPSNSNTSIELHEETWNANPLFpSQDDA 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 100 QQLLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGL----GYFYNIHslgFYVVTQIINGLVQTT 175
Cdd:cd17342 62 ALFLGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNKY---LYCILWVLNGLLQST 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 176 GWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVGAMGIVCFLFLIEHPkdikcs 255
Cdd:cd17342 139 GWPCVVAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP------ 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 256 stlpthprasenginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgalriPGVIE 335
Cdd:cd17342 213 ---------------------------------------------------------------------------PGVIP 217
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 336 FSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVF 415
Cdd:cd17342 218 YSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVY 297
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 416 SSV-SKMGLEATIamLLLSGALVSGPYALITTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPS- 493
Cdd:cd17342 298 SHSpSDKVLNAFV--MTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRl 375
|
490 500
....*....|....*....|....
gi 1046876552 494 GWSNVFYMLMFADACALLFLIRLI 517
Cdd:cd17342 376 GWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-517 |
7.05e-80 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 254.51 E-value: 7.05e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 21 RAFIFMLTFLLYASFHLSRKPISIVKGELHKqcaaadepeprfggpssstrrspthwllnnetetetdcgwapfDKNNYQ 100
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE-------------------------------------------EIGLSK 37
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 101 QLLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSV 180
Cdd:cd17312 38 DDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPC 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 181 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVGAMGIVCFLFLIEHPkdikcsstlp 259
Cdd:cd17312 113 VKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYgWRAAFLVPGIVGLVVAIILFFFLRDSP---------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 260 thprasenginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgalriPGVIEFSLC 339
Cdd:cd17312 183 -----------------------------------------------------------------------PYVWVLSLA 191
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 340 LLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYVFsS 417
Cdd:cd17312 192 YAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALF-W 270
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 418 VSKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshALSTVTAIIDGTGSVGAALGPLLAGLISPS-GWS 496
Cdd:cd17312 271 FFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWS 343
|
490 500
....*....|....*....|.
gi 1046876552 497 NVFYMLMFADACALLFLIRLI 517
Cdd:cd17312 344 TVFYFLISAALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
109-519 |
1.24e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 131.15 E-value: 1.24e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVGAMGIVCFLFLIehpkdikcsstlpthprasen 267
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 268 ginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgalripgviefsLCLLFAKLVS 347
Cdd:COG2271 187 ----------------------------------------------------------------------LAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 348 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSSVSkmGLEAT 426
Cdd:COG2271 197 YGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLP--SPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 427 IAMLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYMLMFA 505
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGyLLDATGYQAAFLLLAAL 346
|
410
....*....|....
gi 1046876552 506 DACALLFLIRLIHK 519
Cdd:COG2271 347 ALLAALLALLLLRE 360
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
103-514 |
1.15e-29 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 120.81 E-value: 1.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYnIHSLGFYVVTQIINGLVQTTGWPSVVT 182
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA-TSSVGLMFILLFLNGWFQGMGWPPSGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 183 CLSNWFGKGRRGLIMGIWN-SHTSVGNILGSLI---AGYWVSTCWGLSFIVPGAIVGAMGIVCFLFLIEHPKdikcSSTL 258
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPE----SEGL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 259 PThpraSENGINRFRVQKQTTHSEKNgpldpelqclllsdgksplhpshivvlpgdrtSSMAAISFTGALRIPGVIEFSL 338
Cdd:cd17345 195 PP----IEEYKGDYPEEADGEEEEQE--------------------------------LSAWEIFVKYVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 339 CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGLMLLLAAPTLYVFS 416
Cdd:cd17345 239 ANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 417 SVSKMGLEATIAMLLlsGALVSGPYALIttAVSADLGTHKSLKGNSHALSTVTAIIdgtgsVGAALGPLLAGLISP-SGW 495
Cdd:cd17345 319 LAPNVLVDLIALIAL--GFLIYGPVMLI--GLQALELVPKKAAGTAAGLTGLFGYL-----GGSVLATALIGIIVDhFGW 389
|
410
....*....|....*....
gi 1046876552 496 SNVFYMLMFADACALLFLI 514
Cdd:cd17345 390 NGGFIVLLASCILAIIFLA 408
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
103-499 |
1.72e-27 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 114.01 E-value: 1.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgyFYNihSLGFYVVTQIINGLVQTTGWPSVVT 182
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 183 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWV--STCWGLSFIVPGAIVGAMGIVCFLFLIEHPKDIKCSSTLPT 260
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEM 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 261 HPRASEnginrfrvQKQTTHSEKNGPLDPELQCLLLSdgksplhpshivvlpgdrtssmaaisftgalriPGVIEFSLCL 340
Cdd:TIGR00881 187 PNEEPD--------GDAEKKEEELTKKQIFLQYVLLN---------------------------------KVLWYISLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 341 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR-------ASTCGLMLLLAAPTLY 413
Cdd:TIGR00881 226 VFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGrrgplavFFMALIIVSLLVYWLN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 414 VFSSVSKMgleatIAMLLLSGALVSGPYALIttavsadlGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPL-LAGLISP 492
Cdd:TIGR00881 306 PAANPLMD-----LICLFALGFLVYGPQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLpLGYLADG 372
|
....*..
gi 1046876552 493 SGWSNVF 499
Cdd:TIGR00881 373 FGWAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
109-516 |
1.24e-25 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 108.04 E-value: 1.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVGAMGIVCFLFLiehpkdikcsstlpthprasen 267
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFgWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 268 ginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgalriPGVIEFSLCLLFAKLVS 347
Cdd:cd17319 179 ---------------------------------------------------------------RQVWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 348 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMGLEATI 427
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 428 AMLLLSGALVSGPYALITTaVSADLgthkslkGNSHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFA 505
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdATGSYTAAFLFLAAV 347
|
410
....*....|.
gi 1046876552 506 DACALLFLIRL 516
Cdd:cd17319 348 ALLAALLVLLL 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
113-520 |
1.39e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.87 E-value: 1.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 113 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 192
Cdd:COG2223 52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 193 RGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVGAMGIVCFLFLIEHPKDIKCSSTLPTHprasenginr 271
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 272 frvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaiSFTGALRIPGVIEFSLCLLFAKLVSYTFL 351
Cdd:COG2223 197 ---------------------------------------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 352 FWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMGLeATIAMLL 431
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL-FLVLFLL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 432 LsGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSNVFYMLMFADACA 509
Cdd:COG2223 305 L-GLALGGGNGAVFALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALldATGSYTAAFLVFAVLALVA 375
|
410
....*....|.
gi 1046876552 510 LLFLIRLIHKE 520
Cdd:COG2223 376 LVLTLLLYRRP 386
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
109-514 |
2.14e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.18 E-value: 2.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVStCWGLSFIVPGAIVGAMGIVCFLFLIEHPKDIKCSSTLPTHPraseng 268
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILAS-SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEE------ 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 269 inrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdRTSSMAAISFTGALRIPGVIEFSLCLLFAKLVSY 348
Cdd:cd06174 187 ----------------------------------------------ASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 349 TFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSkmGLEATIA 428
Cdd:cd06174 221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP--SLLLLLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 429 MLLLSGALVSGPYALITTAVSADLgthkslkgNSHALSTVTAIIDGTGSVGAALGPLLAGLISPS--GWSNVFYMLMFAD 506
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFALIAELF--------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtfGLTGAFLVLAVLL 370
|
....*...
gi 1046876552 507 ACALLFLI 514
Cdd:cd06174 371 LLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
102-484 |
5.42e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 88.24 E-value: 5.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 102 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVV 181
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 182 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVS-TCWGLSFIVPGAIVGAMGIVCFLFLIEHPKDIKcsstlpt 260
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKRP------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 261 hprasenginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlPGDRTSSMAAISFTGALRIPGVIEFSLCL 340
Cdd:pfam07690 181 ---------------------------------------------------KPAEEARLSLIVAWKALLRDPVLWLLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 341 LFAKLVSYTFLFWLPLYITnVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSK 420
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046876552 421 MGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSVGAALGP 484
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER--------GTASGLYNTAGSLGGALGP 344
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
113-513 |
3.56e-17 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 83.54 E-value: 3.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 113 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgYFyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 192
Cdd:cd17343 50 AYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GS---SSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQ 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 193 RGLIMGIWNSHTSVGNILGSLIAGYWV-STCWGLSFIVPGAIVGAMGIVCFLFLIEHPkdikcsstlpthpraSENGINR 271
Cdd:cd17343 125 FGTWWSVLSTSMNLAGSLGPILATLLAlSYGWRSTLSISGTVAVVMSVVCLLFIKNEP---------------SDVGLNN 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 272 FRVQKQTthsekngpldpelqclllsdgksplhpshivvlPGDRTSSMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFL 351
Cdd:cd17343 190 IEEEESK---------------------------------GKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 352 FWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCG----------LMLLLAAPTLYVFS-SVSK 420
Cdd:cd17343 237 DWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSrgnprmplalVFMAGLTVSLHLFRvHITS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 421 MGLEATIAML-LLSGALVSGPYALIttAVSADLGTHKSLKGNSHALSTVTAiidgtgSVGAALGPLLAGLISPS-GWSNV 498
Cdd:cd17343 317 DSSELFILLLgFLIGFSLYGPIAIF--GVIANESAPSHLCGTSHAIVALAA------NVGGVLAGLPFSYIAKHyDWRTA 388
|
410
....*....|....*
gi 1046876552 499 FYMLMFADACALLFL 513
Cdd:cd17343 389 FLLLEILCAITVVIL 403
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
109-482 |
2.91e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.02 E-value: 2.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVpGAIVGAMGIVCFLFLIEhpkdikcsstlPTHPRASEN 267
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWVFLV-NAVLALLALLLLLRLLP-----------ESRPAARAR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 268 GINRFRVqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgALRIPGVIEFSLCLLFAKLVS 347
Cdd:COG2814 196 LRGSLRE----------------------------------------------------LLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 348 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYVFSSvskmGLEAT 426
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFgRRRLLLIGLLLLALGLLLLALAG----SLWLL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1046876552 427 IAMLLLSGALVSGPYALITTAVSADLGThkslkgnsHALSTVTAIIDGTGSVGAAL 482
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQALVAELAPP--------EARGRASGLYNSAFFLGGPL 347
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
103-514 |
4.52e-16 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 80.52 E-value: 4.52e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 182
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 183 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIvgamGIVCFLFLIEHPKDIKCSSTLPTh 261
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHyGWRYGMMIAGII----AIVVGLFLCWRLRDKPQAMGLPS- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 262 prasengINRFRVQKQTTHSEKNGPLDPELQCLllsdGKSPLHPSHIVVLpgdrtssmaaisftgalripgviefSLCLL 341
Cdd:PRK11663 210 -------VGEWRHDALELAQQQEGAGLSRKEIL----TKYVLLNPYIWLL-------------------------SFSYV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 342 FAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAptLYVFSSVSKM 421
Cdd:PRK11663 254 LVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN--GNRGPMNLIFA--AGILLSVGSL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 422 GLEATIAMLLLSGAL------VSGPYALITTAvsADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSG 494
Cdd:PRK11663 330 WLMPFASYVMQAACFftigffVFGPQMLIGMA--AAECSHKEAAG------AATGFVGLFAYLGAALsGYPLAKVLEIWH 401
|
410 420
....*....|....*....|
gi 1046876552 495 WSNVFYMLMFADACALLFLI 514
Cdd:PRK11663 402 WTGFFVVISIAAGISALLLL 421
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
113-517 |
4.96e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.93 E-value: 4.96e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 113 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 192
Cdd:cd17325 43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 193 RGLIMGIWNSHTSVGNILGSLIAGYwVSTCWGLS--FIVPGAIVGAMGIVCFLFLIEHPKDikcsstlpthprasengin 270
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGL-LADALGYRapFLVCAALALLALVLALLLLPEPRPP------------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 271 rfrvqkqtthsekngpldpelqclllsdgksplhPSHIVVLPGDRTSSMAAISFTGALRIPGVIEFSLCLLFAKLVSYtf 350
Cdd:cd17325 178 ----------------------------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF-- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 351 lfwLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRaSTCGLMLLLAAPTLYVFSSVSkmgleaTIAML 430
Cdd:cd17325 222 ---LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT------SFWLL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 431 LLSGALVSGPYALITTAVSADLG--THKSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPS-GWSNVFYMLMFADA 507
Cdd:cd17325 292 LLLLALLGLGLGLVFPATLALLAdiVPPEGRG------TAMGLFNTAFSLGMVLGPLLGGFLYDAfGFATPFLAAAALLL 365
|
410
....*....|
gi 1046876552 508 CALLFLIRLI 517
Cdd:cd17325 366 LAAVLFLLLR 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
103-517 |
1.09e-14 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 75.52 E-value: 1.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVT 182
Cdd:cd17488 40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPPCAR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 183 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVST-CWGLSFIVPGAIVGAMGIVCFLFLIEHPkdikcsstlpth 261
Cdd:cd17488 115 LLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTyGWRAGMYVPGIIAILMGIVLCWRLRDRP------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 262 prasenginrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftgalriPGVIEFSLCLL 341
Cdd:cd17488 183 ---------------------------------------------------------------------PYIWLLAFCYV 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 342 FAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAPTLYV------F 415
Cdd:cd17488 194 LVYVVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK--GNRGPMNLIFALGLLVsvgalwL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 416 SSVSKMGLEATiaMLLLSGALVSGPYALIttAVSADLGTHKSLKGnshalsTVTAIIDGTGSVGAAL-GPLLAGLISPSG 494
Cdd:cd17488 272 VPVHSYWLLAT--CFFTIGFFVFGPQMLI--GMAAAECSHKDAAG------SATGFVGLFAYLGAALaGYPLAKVIESWG 341
|
410 420
....*....|....*....|...
gi 1046876552 495 WSNVFYMLMFADACALLFLIRLI 517
Cdd:cd17488 342 WSGFFIVISIAAAISGLLLLPLL 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
103-519 |
9.13e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.96 E-value: 9.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTqIINGLVQTTGWPSVVT 182
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLG-LGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 183 ClsnwfGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVGAMGIVCFLFLIehpkdikcsstlpthp 262
Cdd:COG0738 124 L-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL---------------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 263 rasenginRFRVQKQTTHSEKNGPldpelqclllsdgksplhpshivvlpgdrtssmAAISFTGALRIPGVIEFSLCLLF 342
Cdd:COG0738 183 --------RSKLPEIEEEEEEAAG---------------------------------SAASLKSLLKNPRLLLGGLAIFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 343 AKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYVFSSVSkmG 422
Cdd:COG0738 222 YVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAP--G 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 423 LEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshalSTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYML 502
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT---------AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
|
410
....*....|....*..
gi 1046876552 503 MFADACALLFLIRLIHK 519
Cdd:COG0738 370 PLVCYLLILLLALALKR 386
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
16-514 |
7.86e-12 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 67.38 E-value: 7.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 16 RDQWYRAFI--FMLTFLLYASFHLSRKPISIVKGELHKQcaaadepeprfggpssstrrspthwllNNETETEtdcgwap 93
Cdd:PRK09556 20 RKMWFKPFMqsYLVVFIGYLTMYLIRKNFKAAQNDMIST---------------------------YGLSTTE------- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 94 fdknnyqqlLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQ 173
Cdd:PRK09556 66 ---------LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQ 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 174 TTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLS----FIVPGAIVGAMGIVCFLFLIEHP 249
Cdd:PRK09556 137 STGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSP 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 250 KdikcsstlpthprasENGINRFRVQKQTTHSEKNGpldpELQCLLLSDGKsplhpshivvlpgdrtssmaaISFTGALR 329
Cdd:PRK09556 217 E---------------ELGWGKAEEIFGEPISEEDK----ETESTDMTKWQ---------------------IFVEYVLK 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 330 IPGVieFSLCL--LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE-KRASTCGLMLL 406
Cdd:PRK09556 257 NPVI--WLLCFanIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgRRALVACIALA 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 407 LAAPTLYVFSSVSKMGLeaTIAMLLLSGALVSGPYALI------------TTAVSADLGTHKSLKGNSHALSTVTAIIDG 474
Cdd:PRK09556 335 LIIFTLGVYQHATSEYM--YLASLFALGFLVFGPQLLIgvaavgfvpkkaIGVANGIKGTFAYLFGDSFAKVGLGMIADP 412
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1046876552 475 TGSVGAALGPLLaglispSGWSNVFYMLMFADACALLFLI 514
Cdd:PRK09556 413 TKNGTPIFGYTL------TGWAGTFAALDIAAIGCICLMA 446
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
91-513 |
1.12e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 66.49 E-value: 1.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 91 WAPFDKNNYQ----QLLGALDYAFLcAYAIGMYLSGIIGERLPIRYYLTFGMLASGAftALFGLGYFYNIHSLG-FYVVT 165
Cdd:cd17475 18 LAPFLQEDLHlslaQVGLLLSALNL-GVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLvLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 166 QIINGLVQTTGWPSVVTclsnWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVGAMGIVCFLF 244
Cdd:cd17475 95 GAGYGSVQPGGGRAIMR----WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYgWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 245 LIEHPkdikcsstlpthprasenginrfrvqkqtthsekNGPLDPELQCLLLSDGKSPLhpshivvlpgdRTSSMAAISF 324
Cdd:cd17475 171 YREPP----------------------------------AASAATESASTLLRSLKEVL-----------RNRDVWLIAI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 325 TGALRIpgviefslcllfakLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE--KRASTCG 402
Cdd:cd17475 206 AGALLV--------------APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggRRRPVLV 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 403 LMLLLAAPTLYVFSSVSKMGLEATIAMLL-LSGALVSGPYALITTAVSADLGTHKSlkgnSHALSTVTAIIdgtgSVGAA 481
Cdd:cd17475 272 ITAAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIGWNGLYLTLVAESAGPEQA----GTALGLANTIN----FIGIA 343
|
410 420 430
....*....|....*....|....*....|....
gi 1046876552 482 LGPLLAGLISP--SGWSNVFYMLMFADACALLFL 513
Cdd:cd17475 344 IGPPLFGLLVDatHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
101-514 |
2.67e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 65.33 E-value: 2.67e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 101 QLLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSV 180
Cdd:cd17328 34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APNFWQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 181 VTCLSNWFGKGRRGLIMGIWNSHTSVGNILG----SLIAGYWVStcWGLSFIVPGAIVGAMGIVCFLFLIEHPKdikcss 256
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATGG--WRWAFRVTGVLGVLLAILLLLFVREPPR------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 257 tlpthpRASENGinrfrvqkqtthsekngpldpelqclllsdgksplhpshiVVLPGDRTSSMAAISFTgaLRIPGVIEF 336
Cdd:cd17328 181 ------GAAEGG----------------------------------------VMAKSTATSFLADLKAL--AKNPSFILS 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 337 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFD----VGGIFGGILAGVISDRLEKRAST-----CGLMLLL 407
Cdd:cd17328 213 TLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKTPRadplvCAVGLLA 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 408 AAPTLYVFSSVSKMGLEATIAMLLLSGALVSGPYALITTAVSAD-LGTHKSLkgnSHALSTVTaiidgTGSVGAALGPLL 486
Cdd:cd17328 293 AAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVvIPTRRST---ASAIQILL-----SHLLGDAGSPYL 364
|
410 420
....*....|....*....|....*...
gi 1046876552 487 AGLISPSGWSNVFYMLMFADACALLFLI 514
Cdd:cd17328 365 IGLISDLLRQNKDSPLAEAASLQYALLL 392
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
113-516 |
1.42e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 63.35 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 113 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTG---WPSVVtclSNWFG 189
Cdd:COG2807 65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGnvlLPGLI---KRWFP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 190 KgRRGLIMGIWNSHTSVGNILGSLIAGYWV-STCWGLSFIVPGAIVGAMGIVCFLFLIEHPKDikcsstlpthpraseng 268
Cdd:COG2807 137 D-RVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAVWALLALLALLLWLPLLRRRPAA----------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 269 inrfrvqkqtthsekngpldpelqclllsdgksplhpshivvlpgdRTSSMAAISFTGALRIPGVIEFSLCLLFAKLVSY 348
Cdd:COG2807 199 ----------------------------------------------AAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 349 TFLFWLPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR---------ASTCGLMLLLAAPTlyvfssvs 419
Cdd:COG2807 233 AVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplllllglLGLAGLLGLLLAPG-------- 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 420 kmglEATIAMLLLSGALVSGPYALITTAVSADLGTHkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLI--SPSGWSN 497
Cdd:COG2807 304 ----SLPWLWAVLLGLGQGGLFPLALTLIGLRARTP-------AEAAALSGMAQSVGYLLAALGPLLVGALhdATGSWTA 372
|
410
....*....|....*....
gi 1046876552 498 VFYMLMFADACALLFLIRL 516
Cdd:COG2807 373 ALLLLAALAVLMLVAGLLA 391
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
113-444 |
2.85e-10 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 62.42 E-value: 2.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 113 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 192
Cdd:PRK11273 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 193 RGLIMGIWN-SHTSVGNILGSL-IAGYWVSTCWGLSFIVPGAivGAMGIVCFLFLIEhpKDIKCSSTLPthprASENGIN 270
Cdd:PRK11273 154 RGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAF--AAILVALFAFAMM--RDTPQSCGLP----PIEEYKN 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 271 RFRVQKQTTHSEkngpldpELqclllsdgksplhpshivvlpgdrtsSMAAISFTGALRIPGVIEFSLCLLFAKLVSYTF 350
Cdd:PRK11273 226 DYPDDYNEKHEQ-------EL--------------------------TAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 351 LFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGL-MLLLAAPTL-YVFSSVSKMGLEat 426
Cdd:PRK11273 273 LDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnRGATGVFfMTLVTIATIvYWLNPAGNPTVD-- 350
|
330
....*....|....*...
gi 1046876552 427 IAMLLLSGALVSGPYALI 444
Cdd:PRK11273 351 MACMIVIGFLIYGPVMLI 368
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
103-517 |
2.62e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 59.26 E-value: 2.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGL----VQTTGWP 178
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-----PSIYLFVVLMFLAGLgagiLDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 179 SVVTCLSNwfgkgRRGLIMGIWNSHTSVGNILGSLIAGY--WVSTCWGLSFIVPGAIVGAMGIVCFLFLiehpkdikcss 256
Cdd:cd17333 108 FVGALFEE-----SSATRLNVLHGFFGLGALIGPLIATSllTSELSWSWAYLIIGLIYLLLAILILLTL----------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 257 tLPTHPRASENginrfrVQKQTTHSEkngpldpelqclllsdgksplhpshivvlpgdrtssmaaiSFTGALRIPGVIEF 336
Cdd:cd17333 172 -FPELPSARNP------QQSVGAFSA----------------------------------------SASRLLRNPSIILG 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 337 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLekrASTCGLMLLLAAPTLYVFS 416
Cdd:cd17333 205 ALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI---KPHTLLVLSGSGALLGLLI 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 417 SVSKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKslkgnshalSTVTAIIDGTGSVGAALGPLLAGLISPSGWS 496
Cdd:cd17333 282 LLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAK---------GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGI 352
|
410 420
....*....|....*....|.
gi 1046876552 497 NVFyMLMFADACALLFLIRLI 517
Cdd:cd17333 353 QTA-MLLITILYAIIFVLALL 372
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
113-514 |
6.94e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.56 E-value: 6.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 113 AYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGR 192
Cdd:cd17324 46 GYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 193 RGLIMGIWNSHTSVGNILGSLIAGyWVSTCWGLSFIVpgAIVGAMGIVCFLFLIehpkdikcsSTLPTHPrasenginrf 272
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAF--LAIAVLALLAALLLW---------RLLPSLP---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 273 rvqkqtthsekngpldpelqclllsdgksplhpshivvlPGDRTSSMAAISFTGALRIPGVIE---FSLCLLFAKLVSYT 349
Cdd:cd17324 179 ---------------------------------------PKKPGSLGLLSSLLLLLRNPRLRLaylITFLLFGGFFALYT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 350 FLfwlPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAptLYVFSSVSKMGLEATIAM 429
Cdd:cd17324 220 YL---APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA--LLLLTLLGPSPLLLLVGL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 430 LLLSGALVSGPYALITTAVSAdlgthkslkgNSHALSTVTAIIDGTGSVGAALGPLLAGL-ISPSGWSNVFYMLMFADAC 508
Cdd:cd17324 295 VLWGLGFFAAHSALQTRVLRL----------APEARGLASSLYLAAYNLGGALGAALGGLvLDHGGWAGVGWVGAALLLL 364
|
....*.
gi 1046876552 509 ALLFLI 514
Cdd:cd17324 365 ALLLAL 370
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
94-514 |
8.53e-09 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 57.63 E-value: 8.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 94 FDKNNYQQllGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHsLGFYVVTQIINGLVQ 173
Cdd:cd17318 51 FDWSEKTQ--GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--TPLAARGG-YGALIVLRILQGLAQ 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 174 TTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTcWGLSFIVpgAIVGAMGIVCFLFLIehpkdik 253
Cdd:cd17318 126 GVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCES-LGWPSIF--YIFGGLGLLWCLLWF------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 254 csstlpthprasenginrfrvqkqtthsekngpldpelqclllsdgksplhpshIVVLPgdrtssMAAISFTGALRIPGV 333
Cdd:cd17318 196 ------------------------------------------------------FLVLP------VWAIVVAHFGHNWGF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 334 iefslcllfaklvsYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRastcGLMLLLAapTLY 413
Cdd:cd17318 216 --------------YTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSR----GILSTTT--VRK 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 414 VFSSvskmgleatIAMLLLSGALVSGPY---------ALITTAVSADLGTHKSLKGNSHALS-----TVTAIIDGTGSVG 479
Cdd:cd17318 276 LFTS---------IGFLGPGVFLIALGYlgsnatlavVFLTLSVGLSGACYSGFLVNHLDLApnyagTLMGITNTAATIA 346
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1046876552 480 AALGPLLAGLI-----SPSGWSNVFYMLMFADA-CALLFLI 514
Cdd:cd17318 347 GIISPLIVGAIvkndqTIGQWRIVFFISAAIYIlGAIFYLI 387
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
337-514 |
1.02e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 57.23 E-value: 1.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 337 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFS 416
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 417 SVSKMGLEATIAMLLLS--GALVSGPYALITTAVSAdlgthkslkgnSHALSTVTAIIDGTGSVGAALGPLLAG--LISP 492
Cdd:cd17316 263 LLSGSPTLLLLLLFILSffVGGVWGALYAYLAELFP-----------TEVRATGVGLSYNLGRLGGGGAPPLIAllLAST 331
|
170 180
....*....|....*....|..
gi 1046876552 493 SGWSNVFYMLMFADACALLFLI 514
Cdd:cd17316 332 GGTGVPALILALLAIVALIVAL 353
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
75-512 |
3.29e-08 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 55.90 E-value: 3.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 75 THWLLNNETETETDcgwAPFDKNNYQQ--LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGY 152
Cdd:TIGR00894 51 STDLACLSAENELD---NIKNPNFKWSgaLQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 153 fynihslGFYVVTQIINGLVQTTGWPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGY------WVSTCWGLS 226
Cdd:TIGR00894 128 -------GGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisgwlcESWGGWPMI 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 227 FIVPGAIVGAMGIVCFLFLIEHPKDikcsstlptHPRASEN---GINRfRVQKQTTHSEKNGPLDpelqclllsdgkspl 303
Cdd:TIGR00894 201 FYVFGIVGCAWSLLWFVFPADDPSI---------HPCISKFekkYINS-SLQGQKGSTRQSLPIK--------------- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 304 hpSHIVVLPgdrtssMAAISFTgalripgviefslclLFAKLVSYTFLF-WLPLYITNVDHLDAKKAGELSTLFDVGGIF 382
Cdd:TIGR00894 256 --AIPKSLP------VWAIWFA---------------IFGHFWLYTILPtYLPTFISWVLRVSGKENGLLSSLPYLFAWL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 383 GGILAGVISDRLEKR------------ASTCGLMLLLAAPTLYVFSSvskmGLEATIAMLLLSGALVSGPYALITTAvsa 450
Cdd:TIGR00894 313 CSIFAGYLADFLKSSktlsltaarkifNGIGGLGPGIFAYALPYLSA----AFYLTIIILTLANAVSSGPLAGVLIN--- 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046876552 451 dlgthkSLKGNSHALSTVTAIIDGTGSVGAALGPLLAGLI----SPSGWSNVFYMLMFADACALLF 512
Cdd:TIGR00894 386 ------SLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNIlsqdSKNVWLIVFLIMAFVNILCVIF 445
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
109-247 |
1.66e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.89 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVpGAIVGAMGIVCFLFLIE 247
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALgWRWIFLI-NAPLGLLALVLRLRLPE 190
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
336-520 |
2.66e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.81 E-value: 2.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 336 FSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYV 414
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFgRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 415 FSSVSKMGLEATIAMLLLSGALVSGPYALITTAVSAdlgthkslkgnsHALSTVTAIIDGTGSVGAALGPLLAGLISPS- 493
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP------------EERGRALGLVSAGFGLGAALGPLLGGLLASLf 148
|
170 180
....*....|....*....|....*..
gi 1046876552 494 GWSNVFYMLMFadACALLFLIRLIHKE 520
Cdd:pfam07690 149 GWRAAFLILAI--LSLLAAVLLLLPRP 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
103-488 |
4.07e-07 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 52.36 E-value: 4.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 103 LGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHSLGFYvvtQIINGLVQTTGWPSVVT 182
Cdd:TIGR00895 54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLIL---RFLAGLGLGGLMPNLNA 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 183 CLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVPGAIVGAMGIVCFLFLiehPKDIK-CSSTLPT 260
Cdd:TIGR00895 129 LVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFYVGGIAPLLLLLLLMRFL---PESIDfLVSKRPE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 261 HPRASENGINRFRVQKQTTHSEKNGpldpelqclllsdgksplhpshivVLPGDRTSSMAAIsFTGALripGVIEFSL-C 339
Cdd:TIGR00895 206 TVRRIVNAIAPQMQAEAQSALPEQK------------------------STQGTKRSVFKAL-FQGKT---ARITVLLwL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 340 LLFAKLVSYTFLF-WLPlYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAStcGLMLLLAAPTLY-VFSS 417
Cdd:TIGR00895 258 LYFMLLVGVYFLTnWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT--ALLLLLGAVFAVlVGST 334
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046876552 418 VSKMGLEATiaMLLLSGALVSGPYALittavsadLGTHKSLKGNSHALSTVTAIIDGTGSVGAALGPLLAG 488
Cdd:TIGR00895 335 LFSPTLLLL--LGAIAGFFVNGGQSG--------LYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
109-251 |
6.13e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 51.87 E-value: 6.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:cd17327 49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAgYWVSTC--------WGLSFIVPGAIVGAMGIVCFLFLIEHPKD 251
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLA-YGVFKIlgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPSK 193
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
354-520 |
2.57e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.88 E-value: 2.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 354 LPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYVFSSvskmgleaTIAMLLL 432
Cdd:cd17325 19 LPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFgRKRLLLLGLLLLAVSTLLFAFAT--------SYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 433 S---GALVSGPYALITTAVSADLGTHKSLkgnSHALSTVTAIIdgtgSVGAALGPLLAGLISP-SGWSNVFYMLMFADAC 508
Cdd:cd17325 90 ArflQGLASAAVWPAAMALIADIAPPEER---GRAMGIFSSAI----GLGFLIGPLLGGLLADaLGYRAPFLVCAALALL 162
|
170
....*....|..
gi 1046876552 509 ALLFLIRLIHKE 520
Cdd:cd17325 163 ALVLALLLLPEP 174
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
345-516 |
3.18e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.51 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 345 LVSYTFLFWLPlYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVfsSVSKMGLE 424
Cdd:cd17365 185 LLVYLLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALL--GVSPASLV 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 425 ATIAMLLLSGALVSGPYALItTAVSADLGThkslkgnSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGWS--NVFYML 502
Cdd:cd17365 262 LLYVLVFLAGACVNGAQVGL-YALAARFYP-------TEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGpeSVFLAL 333
|
170
....*....|....*.
gi 1046876552 503 M--FADACALLFLIRL 516
Cdd:cd17365 334 AipAALGALAVLLLRL 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
325-518 |
5.73e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 5.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 325 TGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcglm 404
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 405 LLLAAPTLYVFSSVSkMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnSHALSTVTAIIDGTGSVGAALGP 484
Cdd:COG2814 77 VLLLGLLLFALGSLL-CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP----PERRGRALGLLGAGLGLGPALGP 151
|
170 180 190
....*....|....*....|....*....|....*
gi 1046876552 485 LLAGLISPS-GWSNVFYMLMFADACALLFLIRLIH 518
Cdd:COG2814 152 LLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
319-494 |
1.09e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 319 MAAISFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRA 398
Cdd:cd17321 156 NVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 399 STCGLMLLLAAPTLYVFSSVSKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkgnshalSTVTAIIDGTGSV 478
Cdd:cd17321 236 VLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA--------GAASGILNTARQL 307
|
170
....*....|....*.
gi 1046876552 479 GAALGPLLAGLISPSG 494
Cdd:cd17321 308 GGALGVALLGALLTAG 323
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
120-490 |
1.22e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 120 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLVQTTGWPSVvTCLSNWFGKGRRGLIMGI 199
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 200 WNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVGAMGIVCFLFLIehpkdikcsstlptHPRASENGINRFRVQKQTT 279
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--------------PLKKPEAKKAAAKSSARST 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 280 HSEKNGPLdpelqclllsdgksplhpshivvlpgdrtSSMAAISFTGALRIPGVIEFSLCLLFAKLVSYTFlfwlplyit 359
Cdd:cd17478 190 LKGVWRAL-----------------------------LLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF--------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 360 nvdhldakkAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAPTLYVFSSVSkmgLEATIAMLLLSGALVSG 439
Cdd:cd17478 232 ---------AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL-LLAAPFLLLFLLTP---GIWSYILLVLAGFLLFA 298
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1046876552 440 PYALITTAVsadlgtHKSLKGNshaLSTVTAIIDGTGSVGAALGPLLAGLI 490
Cdd:cd17478 299 SFPVTVVLA------QELLPGN---VGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
336-517 |
1.78e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.04 E-value: 1.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 336 FSLCLLFAKLVSYTFLFWLPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVF 415
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 416 SSVSkmgleatIAMLLLSGALVSGPYALITTAVSADLGTHkslkGNSHALSTVTAIIDGTGSVGAALGPLLAGLISPSGW 495
Cdd:cd06174 80 FAPS-------FWLLLLGRFLLGLGSGLIDPAVLALIADL----FPERERGRALGLLQAFGSVGGILGPLLGGILASSLG 148
|
170 180
....*....|....*....|..
gi 1046876552 496 SNVFYMLMFADACALLFLIRLI 517
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLL 170
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
102-516 |
3.94e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 3.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 102 LLGALDYAFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTGWPSVV 181
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 182 TCLSNWFGKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTcWGLSFIVPGAIVGAMGIVCFLFLIEHPKDIKCSSTLPTH 261
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 262 PRASENGINRFRvqkqtthsekngpLDPELQCLLLSdgksplhpshivvlpgdrtssMAAISFTGALripgviefslcll 341
Cdd:cd06173 194 LRDLREGLRYLR-------------RSPLLRLLLLA---------------------LALFALLGGA------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 342 faklvsytFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYVFSSVSKM 421
Cdd:cd06173 227 --------LTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR-RRGRLLLIGALLLGLALLVLGLSPSL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 422 GLeaTIAMLLLSGalVSGPYALITTAVSADLGTHKSLKGnsHALSTVTAIIDGTGSVGAALGPLLAGLIspsGWSNVFYM 501
Cdd:cd06173 298 WL--LLAALFLLG--LAGGLFNVPLNTLLQLRVPDELRG--RVFSVYNALNSGAMPLGALLAGLLADAL---GLSAVFLL 368
|
410
....*....|....*
gi 1046876552 502 LMFADACALLFLIRL 516
Cdd:cd06173 369 AGALLLLAALLLLLL 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
109-517 |
5.01e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 45.64 E-value: 5.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:cd17474 42 AFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSFIVPGAIVGAmGIVCFLFLIEHPKdikcsstlPTHPRASENG 268
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV-AFLAILFLLPEPK--------EKAKSSSATK 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 269 INRFRVQKqtthsekngpldpelqclllsdgksplhpshivvlpgdRTSSMAAISFTGALRIpgviefslcLLFaklvsY 348
Cdd:cd17474 188 LRDLKKAL--------------------------------------RGRGLLTFLVSAFLYF---------FLY-----F 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 349 TFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISD-RLEKRASTCGLMLLLAApTLYVFSSVSKMGLeaTI 427
Cdd:cd17474 216 AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYAL-SLLLLGFVPSLAL--LL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 428 AMLLLSGALVSGPYALITTAVSAdlGTHKSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADA 507
Cdd:cd17474 293 IAIVLFGLGLGLNLPLLTTLVTE--LAPEEERG------TASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIA 364
|
410
....*....|
gi 1046876552 508 CALLFLIRLI 517
Cdd:cd17474 365 LAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
323-490 |
7.02e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 7.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 323 SFTGALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCG 402
Cdd:COG2211 220 SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 403 LMLLLAAPTLyVFSSVSKMGLEATIAMLLLSGALVSGPYALItTAVSADLGTHKSLKGNSHALSTVTAIIDGTGSVGAAL 482
Cdd:COG2211 300 GLLLAALGLL-LLFFLGPGNLWLLLVLAALAGIGLGAILVLP-WAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQAL 377
|
....*...
gi 1046876552 483 GPLLAGLI 490
Cdd:COG2211 378 AGALAGLL 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
341-514 |
7.45e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 7.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 341 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYVFSsvs 419
Cdd:cd17329 9 FLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVmLAGLLLRALGFALLGFA--- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 420 kMGLEATIAMLLLSGALvsgpYALITTAVSADLGTHKSLKGNSHALSTVTAIIdgtgSVGAALGPLLAGLISPSGWSNVF 499
Cdd:cd17329 86 -HSPWLFAIALVLTGFG----GGLFEPASEAMIADVTTPENRTRAFSLLYWAI----NLGVAIGPLLGGLLLLYSFRLLF 156
|
170
....*....|....*
gi 1046876552 500 ymlmFADACALLFLI 514
Cdd:cd17329 157 ----LAAAVLFLLAA 167
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
354-514 |
1.03e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.47 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 354 LPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS--TCGLMLLLAAPTLYVFSSVSKmgleATIAMLL 431
Cdd:cd17477 211 LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVllGCALLGALAALLLPLVPGLPL----ALLVLLF 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 432 LSGALVSGPYALITTAVSADLGthkslkgnSHALSTVTAIIDGTGSVGAALGPLLAGLIspSGWSNVFYMLMFADACALL 511
Cdd:cd17477 286 LWGGAAGPLYTLALALAGDRLP--------GDELVAANAALLLLYGLGSVIGPLLAGAL--MDAFGPHGLFLFLAAVALL 355
|
...
gi 1046876552 512 FLI 514
Cdd:cd17477 356 FLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-212 |
1.08e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 98 NYQQLLGALDYAFLCA-YAIGMYLSGIIGERLPIRYYLTFGMLasGAFTALFGLGYFYNIHSLGFYVVTQIINGLVQTTG 176
Cdd:pfam07690 231 GLSALLAGLLLGLGGLlGAIGRLLLGRLSDRLGRRRRLLLALL--LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
90 100 110
....*....|....*....|....*....|....*.
gi 1046876552 177 WPSVVTCLSNWFGKGRRGLIMGIWNSHTSVGNILGS 212
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
363-515 |
1.17e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 44.49 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 363 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMGLeatIAMLLLSGALVSGPYA 442
Cdd:COG2223 36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLL---LLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046876552 443 LITTAVSAdlGTHKSLKGnshalsTVTAIIDGTGSVGAALGPLLAG-LISPSGWSNVFYM---LMFADACALLFLIR 515
Cdd:COG2223 113 VGIALVSK--WFPPDRRG------LALGLAAGGGNLGAAVAAFLAPlLIAAFGWRNAFLIlgiLLLVVAVLAWLFLR 181
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
338-488 |
1.41e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.18 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 338 LCLLFAKLVSYTFLFWLP-LYITNvdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLM--LLLAAPTLYV 414
Cdd:PRK11551 227 ISYFFTLIVLYFLLNWLPsLLVGQ--GLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYagILASLAALAA 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046876552 415 FSSVSKMGLEATIAMLLLSGALvSGPYALITTAVSADL-GThkslkgnshALSTVTAIidgtGSVGAALGPLLAG 488
Cdd:PRK11551 305 APSFAGMLLAGFAAGLFVVGGQ-SVLYALAPLFYPTQVrGT---------GVGAAVAV----GRLGSMAGPLLAG 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
369-518 |
3.07e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 3.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 369 AGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSsvskmgLEATIAMLLLSGALVSGPYALITTAV 448
Cdd:cd17355 247 AAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLL------LPFPPLALLLFAALFGLGWGATVPLT 320
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046876552 449 SADLGThkslKGNSHALSTVTAIIDGTGSVGAALGPLLAGLI-SPSGwsnvFYMLMFADACALLFLIRLIH 518
Cdd:cd17355 321 AALAAR----YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLyDRTG----SYTAAWALAVALGLIAALLV 383
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
363-517 |
3.56e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.92 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 363 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSkmgleatIAMLLLSGALVSGPYA 442
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS-------FALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046876552 443 L---ITTAVSADLgTHKSLKGnsHALSTVTAIIdgtgSVGAALGPLLAGLISPS-GWSNVFYMLMFADACALLFLIRLI 517
Cdd:cd17324 103 GfwaIAAAYAADL-VPPEKRG--RAIGLVFSGL----TLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
109-245 |
3.61e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 42.93 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLgfyVVTQIINGLVQTTGWPSVVTCLSNWF 188
Cdd:cd17380 42 SFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLL---ILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVpgaiVGAMGIVCFLFL 245
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYgWPSVFYF----FGLLGLLWALVW 172
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
110-482 |
6.68e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 42.37 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 110 FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfyNIHSLGFYVVTQ-IINGLVQttgwPSVVTCLSNWF 188
Cdd:TIGR00711 46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP--NLELMIIFRVIQgFGGGPLI----PLSFSTLLNIY 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 189 GKGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTC-WGLSFIVpGAIVGAMGIVCFLFliehpkdikcssTLPTHPRASEN 267
Cdd:TIGR00711 120 PPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYhWRWIFLI-NVPIGIIVVVVAFF------------ILPRDKPAASE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 268 GINRFRVQKqtthsekngpLDPELQCLL--LSDGKSP--LHPSHIVVLPGDRTSSMAAISFTGALRIPGVIEFSL----- 338
Cdd:TIGR00711 187 NFDFLGLLL----------LSVGLGSLLygLSEGPERgwFDSNEILILSITGLVAIIAFVVWELTDDNPLVDLRLfkyrn 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 339 ------CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTlfdVGGIFGGI---LAGVISDRL-EKRASTCGLMLLLA 408
Cdd:TIGR00711 257 ftigcvYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHIL---PVGLAPMLsspIAGRMGDKIdPRKLVTIGLILYAV 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046876552 409 APTLYVFSSVSKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSlkGNSHALSTVTAIIdgTGSVGAAL 482
Cdd:TIGR00711 334 GFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKI--ARGSSLSNFTRQL--GGSIGTAL 403
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
337-518 |
8.32e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.90 E-value: 8.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 337 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcgLMLLLAAPTLYVFS 416
Cdd:cd17371 215 SLLATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN----NFALFALGSAISIL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 417 SVSKMGLEATIAMLLLS--GALVSGPYALITTAVSADLGThkSLKGnshalsTVTAIIDGTGSVGAALGPLLAGLISPSG 494
Cdd:cd17371 291 LYFFLPLSPTLILILGFplGFFASGPFSGMGAYLTELFPT--AVRA------TAQGFCYNVGRIIGALFPFLVGFLATSG 362
|
170 180
....*....|....*....|....*
gi 1046876552 495 -WSNVFYMLMFADACALLFLIRLIH 518
Cdd:cd17371 363 sLGTAIAVFAAVYYIAGLVLALLLP 387
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
331-515 |
1.75e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 40.68 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 331 PGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMlLLAAP 410
Cdd:PRK03699 205 IGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLA-GLALV 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 411 TLYVFSSVSKMGLEATIAMLLlsGALVSGPYALITTavsadLGTHKSlkgnSHALSTVTAIIDGTGSVGAALGPLLAGLI 490
Cdd:PRK03699 284 LMYLFVNTDDPSHLLYAILGL--GFFSSAIYTTIIT-----LGSQQT----KVASPKLVNFILTCGTIGTMLTFVVTSPI 352
|
170 180 190
....*....|....*....|....*....|..
gi 1046876552 491 -SPSGW------SNVFYMLMFADACALLFLIR 515
Cdd:PRK03699 353 vAHFGLqaalltANGLYAVVFVMCILLGFVSK 384
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
120-516 |
2.44e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 120 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSLGFYVVTQIINGLvqttGWPSVVTCLSNW----FGKGRRGL 195
Cdd:cd17489 50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLL-----ATSVALLLVLRLIHGI----GWGAFTTAAATLvadiIPPSRRGE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 196 IMGIWNSHTSVGNILGSLIaGYWVSTCWGLSFIVPGAIVGAMGIVCFLFLIehpkdikcsstlPTHPRASENGINRFRVQ 275
Cdd:cd17489 121 GIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLALLLVFLV------------KDPPPVAAEEAEAGTRA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 276 KqtthsekngpldpelqclllsdgksplhpshivvlpgdrtssmaaisftGALRIPGVIEFSLCLLFAKLVSYTFLFWLP 355
Cdd:cd17489 188 F-------------------------------------------------RRLVEKKVLPPALILFLASIAYGAISTFLP 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 356 LYitnVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLyvfssvskMGLEATIAMLLLSG 434
Cdd:cd17489 219 LY---AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKgPKTVIIPGLLLLALGLLL--------LSFAGSPWMLLLAA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 435 ALVSGPYALITTAVSADLG--THKSLKGnsHALSTVTAIIDgtgsVGAALGPLLAGLISPS-GWSNVFYMLMFADACALL 511
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVdlVPPHRRG--AANGTFFIFFD----LGIGLGGLLLGLVAELfGYRAMFLLAAVVVLLALV 361
|
....*
gi 1046876552 512 FLIRL 516
Cdd:cd17489 362 LYIFL 366
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
349-512 |
5.48e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 39.16 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 349 TFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMG------ 422
Cdd:cd17341 223 GFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGtnlvlf 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 423 LEATIAMLLLSGALVSGPYALITTAVSADLGthkslkgnshalsTVTAIIDGTGSVGAALGPLLAGLISPSGWSNVF--- 499
Cdd:cd17341 303 LALFVALGLGAGAGNGSVFRMVPFIFRRELG-------------AVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGafs 369
|
170
....*....|...
gi 1046876552 500 YMLMFADACALLF 512
Cdd:cd17341 370 LFGVLAVACTLLV 382
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
374-537 |
5.77e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 374 TLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMGLEATIAmLLLSGALVSGPYALITTAVSADLG 453
Cdd:cd17355 45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWG-LLGGGGAGTLAAVAFATVAAWWFE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 454 THKSLkgnshALSTVTAiidGTGSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLIRLIHKELSCPGSATVIQAP 533
Cdd:cd17355 124 RRRGL-----ALGILTA---GGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDAS 195
|
....
gi 1046876552 534 LKEH 537
Cdd:cd17355 196 PASP 199
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
109-217 |
5.84e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 5.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 109 AFLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFglgYFYNIHSLGFYVVTQIINGLVQTTGWPSVVTCLSN-- 186
Cdd:COG2211 272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADvv 348
|
90 100 110
....*....|....*....|....*....|....*.
gi 1046876552 187 -----WFGKGRRGLIMGIWNSHTSVGNILGSLIAGY 217
Cdd:COG2211 349 dydewKTGRRREGLYFGIFTFAIKLGQALAGALAGL 384
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
101-243 |
6.65e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 6.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 101 QLLGALDYA-FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSLGFYVVTQIINGL---VQTTG 176
Cdd:cd17370 233 AALIPLLYAlFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALG-----SSLWLLLLGFILWGLymgAQESI 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046876552 177 WPSVVTCLSnwfGKGRRGLIMGIWNSHTSVGNILGSLIAGY-WVSTCWGLSFIVpGAIVGAMGIVCFL 243
Cdd:cd17370 308 ERAAVADLV---PAELRGTAYGLFNTVVGIGWLLASLIAGYlWDLISPSAAFLF-SAVLALIALLLLL 371
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
376-490 |
7.34e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.93 E-value: 7.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 376 FDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYVFSSVSKMGLEATIAMLLLSGALVSGPYALITTAVSADLGTH 455
Cdd:cd17314 251 YGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTE 330
|
90 100 110
....*....|....*....|....*....|....*
gi 1046876552 456 KslkgnshaLSTVTAIIDGTGSVGAALGPLLAGLI 490
Cdd:cd17314 331 S--------FATLYGILLFAPAIGSILGPMLGAKF 357
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
338-520 |
7.54e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.75 E-value: 7.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 338 LCLLFAKLVSYT----FLFWLPLYITNVDHlDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR----ASTCGLMLLLAA 409
Cdd:cd06173 2 RLLWLAQLLSALgdwiFTVALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliLADLLRALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 410 PTLYVFSSVSKMGLEATIAMLLLSGALVSGP--YALITTAVSADlgthkslkgnshALSTVTAIIDGTGSVGAALGPLLA 487
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFFGParQALLPELVPKE------------QLVRANALNSLATQLARIIGPALG 148
|
170 180 190
....*....|....*....|....*....|....*.
gi 1046876552 488 G-LISPSGWSNVFY--MLMFADACALLFLIRLIHKE 520
Cdd:cd06173 149 GlLVALLGPGGAFAinALSFLLSALLLLFIRRPPPA 184
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
363-522 |
7.60e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.71 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 363 HLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAstcglMLLLAAPTLYVFSSVSkmGLEATIAMLLLSGA---LVSG 439
Cdd:cd17474 30 GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKK-----VLLPGLLLFGIGGLLC--GLSDSFALLLAGRAlqgIGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 440 PYALITTAVSADLGTHKSLkgnSHALSTVTAIIdgtgSVGAALGPLLAGLISPSGWSNVFYMLMFADACALLFLIRLIHK 519
Cdd:cd17474 103 GLGPLALTLIGDLFEGGER---AKAMGLYEAAL----GLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
...
gi 1046876552 520 ELS 522
Cdd:cd17474 176 PKE 178
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
308-490 |
8.15e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.69 E-value: 8.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 308 IVVLPGDRTSSMAAISFTGALRIPGVIEFSLCL--------------------LFAKLVSYTFLFWLPLYITNVDhLDAK 367
Cdd:cd17352 140 TFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVcglllrllkdptfvllalgvSFAMLGFFVPFVYLPSYAKSLG-IDES 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 368 KAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAApTLYVFSSVSKMGLEATIAMLLLSGALVSGPYALITTA 447
Cdd:cd17352 219 DAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLIL-GLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVI 297
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1046876552 448 VSADLGTHKslkgnshaLSTVTAIIDGTGSVGAALGPLLAGLI 490
Cdd:cd17352 298 LADLVGLEK--------LSNAYGLVLLFQGLAALVGPPIAGLL 332
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
326-516 |
8.71e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 8.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 326 GALRIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE-KRASTCGLM 404
Cdd:cd17503 173 RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGpRLLLLAGLL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 405 LLLAAptLYVFSSVS-KMGLEATIAMLLLSGALVSGPYALITTAVSADLGTHKSLKGN-----------SHALSTVTAII 472
Cdd:cd17503 253 LLALG--TLLLAFLTpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATalfntirqlggSIGTALLATLL 330
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1046876552 473 D-GTGSVGAALGPLLAGLIS----PSGWSNVFYMLMFADACALLFLIRL 516
Cdd:cd17503 331 TnRTQFHHSRLSELLAQQVQkqalIIAFNDAFLVSAILLLVGLLLALFL 379
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
328-513 |
9.52e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 38.36 E-value: 9.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 328 LRIPGVIEFSLCLLFAKLVSYTFLFWLPLYItnVDH-LDAKKAGELSTLFDVG-GIFGGILAGVISDRLEKRASTCGLML 405
Cdd:cd17485 204 LRRPGTRWLLLFLLLYKLGEQGALAMLPPFL--VDRgFSLSQIGLLSGVGGSLvSIAGSLLGGYLLKRRGRRRLLLLGGL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 406 LLAAPTLYvFSSVSKMGLEATIAMLLLSGALVSGPYALITTAV---------SADLGTHKSLkgnshaLSTVTAIidGTG 476
Cdd:cd17485 282 LRLLLLGL-YTLLALGGSGLNWVLLLASLALLHLVGGMITTALftlmmdcsqQAQAGTDYTL------LATVEVL--GKL 352
|
170 180 190
....*....|....*....|....*....|....*..
gi 1046876552 477 SVGAALGPLLAGLispsGWSNVFYMLMFADACALLFL 513
Cdd:cd17485 353 LFGSLAGFLADHL----GYAAAFLLFAILSALSVLLL 385
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
110-246 |
9.93e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 9.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046876552 110 FLCAYAIGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSLGFYVVTQIINGLvqtTGWPSVVTCLSNWFG 189
Cdd:cd17316 222 ISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVG---GVWGALYAYLAELFP 298
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1046876552 190 KGRRGLIMGIWNSHTSVGNILGSLIAGYWVSTCWGLSfiVPGAIVGAMGIVCFLFLI 246
Cdd:cd17316 299 TEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG--VPALILALLAIVALIVAL 353
|
|
| |
